Patents by Inventor Stephen Kieffer-Higgins

Stephen Kieffer-Higgins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060194264
    Abstract: This invention provides methods and apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based, analytical system comprising a platform for performing an affinity-binding based assay for specifically binding particulates including microbial cells, and a detection means for detecting the particulates specifically bound to a defined surface or chamber comprising the platform. Methods for using the analytical systems of the invention are also provided.
    Type: Application
    Filed: October 11, 2005
    Publication date: August 31, 2006
    Inventors: Norman Sheppard, Alec Mian, Gregory Kellogg, Stephen Kieffer-Higgins, Bruce Carvalho
  • Publication number: 20050069913
    Abstract: This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The microsystem, platforms of the invention are also optionally provided having system informatics and data acquisition, analysis and storage and retrieval informatics encoded on the surface of the disk opposite to the surface containing the fluidic components. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.
    Type: Application
    Filed: March 23, 2004
    Publication date: March 31, 2005
    Inventors: Alec Mian, Stephen Kieffer-Higgins, George Corey
  • Publication number: 20040259237
    Abstract: This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The invention specifically provides devices and methods for performing miniaturized in vitro amplification assays such as the polymerase chain reaction. Methods specific for the apparatus of the invention for performing PCR are provided.
    Type: Application
    Filed: March 16, 2004
    Publication date: December 23, 2004
    Inventors: Gregory J. Kellogg, Charles Able, Todd Arnold, Bruce L. Carvalho, Hsin-Chiang Lin, Stephen Kieffer-Higgins, Norman F. Sheppard, Mikayla Kob, Shari Ommert
  • Patent number: 6706519
    Abstract: This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The invention specifically provides devices and methods for performing miniaturized in vitro amplification assays such as the polymerase chain reaction. Methods specific for the apparatus of the invention for performing PCR are provided.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: March 16, 2004
    Assignee: Tecan Trading AG
    Inventors: Gregory J. Kellogg, Charles Able, Todd Arnold, Bruce L. Carvalho, Hsin-Chiang Lin, Stephen Kieffer-Higgins, Norman F. Sheppard, Mikayla Kob, Shari Ommert
  • Patent number: 5149625
    Abstract: This invention features vectors and a method for sequencing DNA. The method includes the steps of:a) ligating the DNA into a vector comprising a tag sequence, the tag sequence includes at least 15 bases, wherein the tag sequence will not hybridize to the DNA under stringent hybridization conditions and is unique in the vector, to form a hybrid vector,b) treating the hybrid vector in a plurality of vessels to produce fragments comprising the tag sequence, wherein the fragments differ in length and terminate at a fixed known base or bases, wherein the fixed known base or bases differs in each vessel,c) separating the fragments from each vessel according to their size,d) hybridizing the fragments with an oligonucleotide able to hybridize specifically with the tag sequence, ande) detecting the pattern of hybridization of the tag sequence, wherein the pattern reflects the nucleotide sequence of the DNA.
    Type: Grant
    Filed: March 28, 1990
    Date of Patent: September 22, 1992
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Stephen Kieffer-Higgins