Patents by Inventor Stephen M. Taylor

Stephen M. Taylor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190345157
    Abstract: The present invention relates to compounds of Formulae (I) and (II) as defined herein, and salts and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formulae (I) and (II), and to the use of compounds of Formulae (I) and (II) in the treatment or prevention of filarial worm infection, as well as other diseases or conditions in which filarial worm infection is implicated.
    Type: Application
    Filed: January 17, 2018
    Publication date: November 14, 2019
    Inventors: Stephen A. Ward, Mark J. Taylor, Paul M. O'Neil, Weiqian David Hong, Farid Benayoud
  • Patent number: 10365220
    Abstract: Raman spectra of cells, such as normal human T- and B-cells from peripheral blood or human tonsil and the corresponding transformed cells are obtained by optically trapping the cells and obtaining their Raman spectra. The trapped cells can be subjected to one, two, or more different excitation wavelengths, and each wavelength of the corresponding Raman spectra can be stored in a separate channel. In preferred embodiments, two spectra are subtracted from each other to give a difference spectrum and each channel is analyzed independently to characterize the trapped cell. Alternatively, the Raman spectrum can be subjected to Principal Component Analysis (PCA) in order to characterize the trapped cell. The trapped cell thus classified can be sorted, or further manipulated.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: July 30, 2019
    Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: James W. Chan, Thomas R. Huser, Stephen M. Lane, John C. Rutledge, Douglas S. Taylor, Theodore Zwerdling, Ronald Li
  • Patent number: 6465614
    Abstract: High-affinity response-selective C-terminal analogs of C5a anaphylatoxin are provided. Whereas natural C5a has considerable flexibility in the C-terminal region, the analogs of the invention possess a backbone conformation which is constrained at the C-terminus to a &bgr;-turn. The stabilized &bgr;-turn confers a marked increase in potency of the analogs; the particular &bgr;-turn motif further confers the capability to selectively elicit certain biological responses associated with C5a. Exemplary compounds of the invention are decapeptide analogs of the formula: A1-Ser-Phe-Lys-A2-A3-A4-A5-A6-A7, with the constrained &bgr;-turn being localized in the region of A4-A7.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: October 15, 2002
    Assignee: The Board of Regents of the University of Nebraska
    Inventors: Sam D. Sanderson, Simon A. Sherman, Leonid Kirnarsky, Stephen M. Taylor
  • Patent number: 5942599
    Abstract: High-affinity response-selective C-terminal analogs of C5a anaphylatoxin are provided. Whereas natural C5a has considerable flexibility in the C-terminal region, the analogs of the invention possess a backbone conformation which is constrained at the C-terminus to a .beta.-turn. The stabilized .beta.-turn confers a marked increase in in potency of the analogs; the particular .beta.-turn motif further confers the capability to selectively elicit certain biological responses associated with C5a. Exemplary compounds of the invention are decapeptide analogs of the formula: A1-Ser-Phe-Lys-A2-A3-A4-A5-A6-A7, with the constrained .beta.-turn being localized in the region of A4-A7.
    Type: Grant
    Filed: December 4, 1997
    Date of Patent: August 24, 1999
    Assignees: Board of Regents of the University of Nebraska, The University of Queensland
    Inventors: Sam D. Sanderson, Simon A. Sherman, Leonid Kirnarsky, Stephen M. Taylor
  • Patent number: 5696230
    Abstract: High-affinity response-selective C-terminal analogs of C5a anaphylatoxin are provided. Whereas natural C5a has considerable flexibility in the C-terminal region, the analogs of the invention possess a backbone conformation which is constrained at the C-terminus to a .beta.-turn. The stabilized .beta.-turn confers a marked increase in in potency of the analogs; the particular .beta.-turn motif further confers the capability to selectively elicit certain biological responses associated with C5a. Exemplary compounds of the invention are decapeptide analogs of the formula: A1-Ser-Phe-Lys-A2-A3-A4-A5-A6-A7, with the constrained .beta.-turn being localized in the region of A4-A7.
    Type: Grant
    Filed: August 31, 1994
    Date of Patent: December 9, 1997
    Assignees: The Board of Regents of the University of Nebraska, The University of Queensland
    Inventors: Sam D. Sanderson, Simon A. Sherman, Leonid Kirnarsky, Stephen M. Taylor
  • Patent number: 5319920
    Abstract: A lubrication supply and return system for the center and rear bearing assemblies of a marine or industrial gas turbine engine. The supply line for both bearing assemblies and the return lines for the rear bearing assembly are mounted off-engine in an elongated tray which is supported by the engine and is capable of forward thermal expansion. The tray mounted supply line is connected to the supply pump and the center bearing assembly by flexible hoses. The tray supported return lines are attached to the scavenge pump by flexible hoses. The return lines from the center bearing assembly to the scavenge pump have flexible hose portions supported by the tray.
    Type: Grant
    Filed: May 28, 1992
    Date of Patent: June 14, 1994
    Assignee: General Electric Company
    Inventor: Stephen M. A. Taylor
  • Patent number: 5271218
    Abstract: A manifold system for a marine or industrial gas turbine engine, the system being independent of the engine. An annular steam manifold and an annular gaseous fuel manifold are provided transversely surrounding and substantially coaxial with the engine. The manifolds have a plurality of outlets, each connected by a flexible metal hose to its respective one of the engines' fuel nozzles. Each manifold is supported by a pair of stanchions mounted on the engine's foundation assembly and a pair of brackets attached to each stanchion. The brackets provide limited vertical, lateral, axial and tilt adjustments of the manifolds.
    Type: Grant
    Filed: May 28, 1992
    Date of Patent: December 21, 1993
    Assignee: Gerneral Electric Company
    Inventor: Stephen M. A. Taylor
  • Patent number: 5000835
    Abstract: In a refinery operation for producing asphalt, a metal organic acid salt is used to reduce H.sub.2 S caused by thermal decomposition of hydrocarbons in the asphalt.
    Type: Grant
    Filed: October 2, 1989
    Date of Patent: March 19, 1991
    Assignee: Exxon Chemical Patents, Inc.
    Inventors: Stephen M. Taylor, John P. Gorman