Patents by Inventor Steven Kiyoshi Yoshinaga

Steven Kiyoshi Yoshinaga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8470317
    Abstract: Novel polypeptides which comprise a receptor-ligand pair involved in T-cell, activation are disclosed. Nucleic acid molecules encoding said polypeptides, and vectors and host cells for expressing same are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: June 25, 2013
    Assignee: Amgen Inc.
    Inventor: Steven Kiyoshi Yoshinaga
  • Publication number: 20110104757
    Abstract: This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RP1 antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RP1 antibodies are also provided.
    Type: Application
    Filed: December 22, 2010
    Publication date: May 5, 2011
    Applicant: Amgen Inc.
    Inventors: Gerald Siu, Wenyan Shen, Steven Kiyoshi Yoshinaga, Haichun Huang
  • Patent number: 7868140
    Abstract: This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RP1 antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RP1 antibodies are also provided.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: January 11, 2011
    Assignees: Amgen Inc., Medarex Inc.
    Inventors: Gerald Siu, Wenyan Shen, Steven Kiyoshi Yoshinaga, Haichun Huang
  • Publication number: 20090208504
    Abstract: Novel polypeptides which comprise a receptor-ligand pair involved in T-cell, activation are disclosed. Nucleic acid molecules encoding said polypeptides, and vectors and host cells for expressing same are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
    Type: Application
    Filed: September 25, 2008
    Publication date: August 20, 2009
    Inventor: Steven Kiyoshi Yoshinaga
  • Patent number: 7482325
    Abstract: The present invention provides B7 Related Protein-2 (B7RP-2) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing B7RP-2 polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with B7RP-2 polypeptides.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: January 27, 2009
    Assignee: Amgen Inc.
    Inventors: Steven Kiyoshi Yoshinaga, Woong-Kyung Suh, Tak Wah Mak
  • Publication number: 20090004237
    Abstract: The present invention provides B7-Like (B7-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing B7-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with B7-L polypeptides.
    Type: Application
    Filed: June 27, 2008
    Publication date: January 1, 2009
    Applicant: AMGEN, INC.
    Inventors: Gary M. Fox, John K. Sullivan, Paige Holst, Steven Kiyoshi Yoshinaga
  • Patent number: 7435796
    Abstract: Novel polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding said polypeptides, and vectors and host cells for expressing same are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: October 14, 2008
    Assignee: Amgen Inc.
    Inventor: Steven Kiyoshi Yoshinaga
  • Patent number: 7414122
    Abstract: The present invention provides B7-Like (B7-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing B7-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with B7-L polypeptides.
    Type: Grant
    Filed: November 29, 2004
    Date of Patent: August 19, 2008
    Assignee: Amgen Inc.
    Inventors: Gary M. Fox, John K Sullivan, Paige Holst, Steven Kiyoshi Yoshinaga
  • Publication number: 20080166352
    Abstract: This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RP1 antibodies Methods of detecting the amount of B7RP1 in a sample using anti-B7RP1 antibodies are also provided.
    Type: Application
    Filed: July 18, 2006
    Publication date: July 10, 2008
    Applicant: AMGEN INC.
    Inventors: Gerald Siu, Wenyan Shen, Steven Kiyoshi Yoshinaga, Haichun Huang
  • Publication number: 20030039999
    Abstract: The present invention provides B7 Related Protein-2 (B7RP-2) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing B7RP-2 polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with B7RP-2 polypeptides.
    Type: Application
    Filed: May 28, 2002
    Publication date: February 27, 2003
    Applicant: Amgen, Inc.
    Inventors: Steven Kiyoshi Yoshinaga, Woong-Kyung Suh, Tak Wah Mak
  • Publication number: 20020107363
    Abstract: The present invention provides B7-Like (B7-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing B7-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with B7-L polypeptides.
    Type: Application
    Filed: September 19, 2001
    Publication date: August 8, 2002
    Applicant: Amgen, Inc.
    Inventors: Gary M. Fox, John K. Sullivan, Paige Holst, Steven Kiyoshi Yoshinaga
  • Patent number: 5929032
    Abstract: The survival and proliferation of Schwann cells can be promoted by culturing such cells in the presence of peptides derived from the EGF-like domain of proteins from the NDF/heregulin family. Colon epithelial cells can be stimulated to multiply and differentiate by culturing such cells in the presence of the same peptides.
    Type: Grant
    Filed: December 5, 1996
    Date of Patent: July 27, 1999
    Assignee: Amgen Inc.
    Inventors: Josette Fran.cedilla.oise Carnahan, Shinichi Hara, Hsieng Sen Lu, John Philip Mayer, Steven Kiyoshi Yoshinaga
  • Patent number: 5686415
    Abstract: Colon epithelial cells are stimulated to multiply, grow and mature by contacting them in vivo with peptides derived from the EGF-like domain of proteins of the NDF/heregulin family.
    Type: Grant
    Filed: December 5, 1996
    Date of Patent: November 11, 1997
    Assignee: Amgen Inc.
    Inventors: Josette Fran.cedilla.oise Carnahan, Shinichi Hara, Hsieng Sen Lu, John Philip Mayer, Steven Kiyoshi Yoshinaga
  • Patent number: 5670342
    Abstract: Novel peptides are described which are biologically active derivatives of the EGF-like domain of NDF/heregulins and which stimulate the proliferation and differentiation of colon epithelial cells and support the survival and growth of Schwann cells.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: September 23, 1997
    Assignee: Amgen Inc.
    Inventors: Josette Francoise Carnahan, Shinichi Hara, Hsieng Sen Lu, John Philip Mayer, Steven Kiyoshi Yoshinaga