Patents by Inventor Steven L. Richheimer

Steven L. Richheimer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190263852
    Abstract: Provided are deglycosylation methods designed to optimize the yield of a Veratrum alkaloid from Veratrum plant material and/or from an extract of Veratrum plant material.
    Type: Application
    Filed: August 30, 2018
    Publication date: August 29, 2019
    Inventors: Gamini Senerath Jayatilake, Steven L. Richheimer, David A. Mann
  • Publication number: 20160168193
    Abstract: Provided are deglycosylation methods designed to optimize the yield of a Veratrum alkaloid from Veratrum plant material and/or from an extract of Veratrum plant material.
    Type: Application
    Filed: February 22, 2016
    Publication date: June 16, 2016
    Inventors: Gamini Senerath Jayatilake, Steven L. Richheimer, David A. Mann
  • Patent number: 7682637
    Abstract: A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 ?g/mL.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: March 23, 2010
    Assignee: Phenolics, LLC
    Inventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
  • Publication number: 20100003728
    Abstract: Provided are deglycosylation methods designed to optimize the yield of Veratrum alkaloid from Veratrum plant material and/or from an extract of Veratrum plant material.
    Type: Application
    Filed: July 1, 2009
    Publication date: January 7, 2010
    Inventors: Gamini Senerath Jayatilake, Steven L. Richheimer, David A. Mann
  • Publication number: 20090099373
    Abstract: This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin.
    Type: Application
    Filed: October 30, 2008
    Publication date: April 16, 2009
    Applicant: PHENOLICS, LLC
    Inventors: David T. BAILEY, Delano R. Freeberg, Dennis Gertenbach, Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, F. Joseph Daugherty
  • Patent number: 7462370
    Abstract: This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: December 9, 2008
    Assignee: Phenolics, LLC
    Inventors: David T. Bailey, Delano R. Freeberg, Dennis Gertenbach, Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, F. Joseph Daugherty
  • Publication number: 20080207770
    Abstract: Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens.
    Type: Application
    Filed: November 30, 2007
    Publication date: August 28, 2008
    Applicant: PHENOLICS, LLC
    Inventors: Gerald T. GOURDIN, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
  • Publication number: 20080199548
    Abstract: A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 ?g/mL.
    Type: Application
    Filed: August 7, 2007
    Publication date: August 21, 2008
    Applicant: PHENOLICS, LLC
    Inventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
  • Patent number: 7306815
    Abstract: Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: December 11, 2007
    Assignee: Phenolics, LLC
    Inventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
  • Patent number: 7141611
    Abstract: This invention provides an isolated mixture of higher molecular weight primary aliphatic alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms and having enhanced purity. This invention also provides a process for obtaining the alcohol mixture by extracting a natural product with organic solvents with or without saponification of the natural product. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering total cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels and therefore is effective in treating hypercholesterolemia. The composition may be used to reduce the risk of coronary heart disease, to inhibit the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis), and can be used as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: November 28, 2006
    Assignee: Wyeth
    Inventors: William R. Gamble, Zhengjie Liu, David T. Bailey, Pedro P. Perez, Dean P. Stull, Steven L. Richheimer, Rebecca L. Nichols, Rod Lenoble
  • Patent number: 6960360
    Abstract: This invention provides a process for the preparation of compositions enriched in total phenols from a crude plant extract. The process includes a novel column purification step using a brominated polystyrene resin. This invention also includes compositions enriched in total phenols. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols and having HPLC chromatograms substantially as set forth in FIGS. 10-13. This invention encompasses methods of using the total phenol-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: November 1, 2005
    Assignee: Phenolics, LLC
    Inventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
  • Patent number: 6780442
    Abstract: This invention includes both a one-column process and a two-column process for the preparation of compositions enriched for anthocyanins from a crude plant extract. Both processes include a novel column purification step using a brominated polystyrene resin. This invention also includes extracts enriched for anthocyanins.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: August 24, 2004
    Assignee: Hauser, Inc.
    Inventors: David T. Bailey, Delano R. Freeberg, Dennis Gertenbach, Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, F. Joseph Daugherty
  • Publication number: 20040019119
    Abstract: This invention provides an isolated mixture of higher molecular weight primary aliphatic alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms and having enhanced purity. This invention also provides a process for obtaining the alcohol mixture by extracting a natural product with organic solvents with or without saponification of the natural product. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering total cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels and therefore is effective in treating hypercholesterolemia. The composition may be used to reduce the risk of coronary heart disease, to inhibit the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis), and can be used as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.
    Type: Application
    Filed: July 18, 2003
    Publication date: January 29, 2004
    Inventors: William R. Gamble, Zhengjie Liu, David T. Bailey, Pedro P. Perez, Dean P. Stull, Steven L. Richheimer, Rebecca L. Nichols, Rod Lenoble
  • Publication number: 20030149252
    Abstract: This invention provides a process for the preparation of compositions enriched in total phenols from a crude plant extract. The process includes a novel column purification step using a brominated polystyrene resin. This invention also includes compositions enriched in total phenols. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols and having HPLC chromatograms substantially as set forth in FIGS. 10-13. This invention encompasses methods of using the total phenol-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease.
    Type: Application
    Filed: November 22, 2002
    Publication date: August 7, 2003
    Inventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
  • Publication number: 20030138537
    Abstract: The present invention provides an improved process for preparing a water-soluble extract containing one or more naturally occurring antioxidants (from plant materials from the Labiatae family. The process produces an extract that is essentially odorless, flavorless and colorless when used at a concentration between about 5 and 1000 ppm.
    Type: Application
    Filed: December 19, 2001
    Publication date: July 24, 2003
    Inventors: David T. Bailey, Rebecca L. Nichols, Steven L. Richheimer
  • Patent number: 6596776
    Abstract: The present invention relates to a naturally obtained mixture of higher molecular weight primary aliphatic alcohols which contain 20 to 34 carbon atoms. This invention also relates to the process for obtaining the alcohol mixture by extraction and purification with organic solvents from a natural product, such as beeswax with and without saponification of the natural product. The alcohol mixture obtained from beeswax has enhanced purity and contains a mixture of alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels so that it is effective in treating hypercholesterolemia.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: July 22, 2003
    Assignee: Hauser, Inc.
    Inventors: William R. Gamble, Zhengjie Liu, David T. Bailey, Pedro P. Perez, Dean P. Stull, Steven L. Richheimer, Rebecca L. Nichols, Rod Lenoble
  • Publication number: 20030096876
    Abstract: The present invention relates to a naturally obtained mixture of higher molecular weight primary aliphatic alcohols which contain 20 to 34 carbon atoms. This invention also relates to the process for obtaining the alcohol mixture by extraction and purification with organic solvents from a natural product, such as beeswax with and without saponification of the natural product. The alcohol mixture obtained from beeswax has enhanced purity and contains a mixture of alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering cholesterol and LDL-cholesterol and increasing HDL-cholesterol levels so that it is effective in treating hypercholesterolemia.
    Type: Application
    Filed: April 25, 2002
    Publication date: May 22, 2003
    Inventors: William R. Gamble, Zhengjie Liu, David T. Bailey, Pedro P. Perez, Dean P. Stull, Steven L. Richheimer, Rebecca L. Nichols, Rod Lenoble
  • Publication number: 20020099099
    Abstract: The present invention relates to a naturally obtained mixture of higher molecular weight primary aliphatic alcohols which contain 20 to 34 carbon atoms. This invention also relates to the process for obtaining the alcohol mixture by extraction and purification with organic solvents from a natural product, such as beeswax with and without saponification of the natural product. The alcohol mixture obtained from beeswax has enhanced purity and contains a mixture of alcohols having 20, 22, 24, 26, 27, 28, 30, 32 and 34 carbon atoms. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering cholesterol levels so that it is effective in treating hypercholesterolemia.
    Type: Application
    Filed: September 7, 2001
    Publication date: July 25, 2002
    Inventors: William R. Gamble, Zhengjie Liu, David T. Bailey, Pedro P. Perez, Dean P. Stull, Steven L. Richheimer, Rebecca L. Nichols, Rod Lenoble
  • Publication number: 20020082459
    Abstract: The process of the present invention relates to the isolation and purification of both a natural mixed carotenoid product and an all-trans-&bgr;-carotene product from various different biomass sources, preferably from algae of the genus Dunaliella. More particularly, the present invention relates to a single solvent process whereby both natural and colorant products lie along the same process line. The nutritional product contains the natural array of carotenes and xanthophylls found in the plant material, while the colorant product contains primarily trans-&bgr;-carotene.
    Type: Application
    Filed: November 16, 2001
    Publication date: June 27, 2002
    Inventors: David T. Bailey, Randall J. Daughenbaugh, Robert Arslanian, Leonard A. Kaufmann, Steven L. Richheimer, Zhengjie Z. Liu, James M. Piffarerio, Chris J. Kurtz
  • Patent number: 6399579
    Abstract: Compositions for maintaining normal sexual function and treating sexual dysfunction in males and females comprising at least 15% by weight icariside I or at least 3.5% by weight anhydroicaritin, derived from extracts of plants belonging the Epimedium genus, and methods for preparing the same, are provided. The methods comprise subjecting an Epimedium extract to mild acid hydrolysis. Methods for maintaining normal sexual function and treating sexual dysfunction in both males and females are also provided, comprising oral administration of an effective amount of a novel composition of this invention comprising at least 15% by weight icariside I or at least 3.5% by weight anhydroicaritin.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: June 4, 2002
    Assignee: Hauser, Inc.
    Inventors: Rod Lenoble, Steven L. Richheimer, David Bailey, Coralee G. Mannila, Rebecca L. Nichols