Patents by Inventor Subhakar Dey

Subhakar Dey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130184181
    Abstract: This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination and/or quantification by mass spectrometry using compounds comprising a reporter moiety and a non-encoded detectable label. The compounds can be used in sets for the analysis of mixtures of labeled analytes.
    Type: Application
    Filed: December 20, 2012
    Publication date: July 18, 2013
    Inventors: Subhasish Purkayastha, Subhakar Dey
  • Patent number: 8372653
    Abstract: A molecule identification and quantitation method is provided wherein a mass tag is conjugated to an analyte and the signature ion of the mass tag remains attached to the analyte after tandem mass spectrometry fragmentation (MS-MS or MS2). Rather than losing the signature ion, a mass-balance part of the structure can be lost as a charge neutral group under tandem mass spectrometry fragmentation. The signature ion can be used for quantitation and, upon further fragmentation, can also provide ion-signals characteristic of the analyte and useful in identifying the analyte. In some embodiments, the ion-signals generated from a third mass spectrometry fragmentation (MS3) can be compared with a known mass spectrum, for example, from a look-up table, from a library, or from a database, to provide an unambiguous identification of the analyte.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: February 12, 2013
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Subhakar Dey, Subhasish Purkayastha
  • Patent number: 8362242
    Abstract: This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination and/or quantification by mass spectrometry using compounds comprising a reporter moiety and a non-encoded detectable label. The compounds can be used in sets for the analysis of mixtures of labeled analytes.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: January 29, 2013
    Assignee: DH Technologies Development PTE. Ltd.
    Inventors: Subhasish Purkayastha, Subhakar Dey
  • Patent number: 8236565
    Abstract: In various aspects, the present teachings provide labeling reagents and sets of labeling reagents for the relative quantitation, absolute quantitation, or both, of hydroxylated compounds including, but not limited to, hydroxylated ring containing compounds, steroids and sterols. In various aspects, the present teachings also provide methods for the analysis hydroxylated compounds including, but not limited to, hydroxylated ring containing compounds, steroids and sterols my MS/MS methods.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: August 7, 2012
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Subhasish Purkayastha, Subhakar Dey, Sasi Pillai
  • Publication number: 20120196378
    Abstract: This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination by mass spectrometry using labeling reagents that comprise a nucleophilic reactive group that reacts with a functional group of an analyte to produce a labeled analyte. The labeling reagents can be used as isobaric sets, mass differential labeling sets or in a combination of isobaric and mass differential labeling sets.
    Type: Application
    Filed: January 31, 2011
    Publication date: August 2, 2012
    Inventors: Subhasish Purkayastha, Subhakar Dey, Scott B. Daniels
  • Publication number: 20110183420
    Abstract: A molecule identification and quantitation method is provided wherein a mass tag is conjugated to an analyte and the signature ion of the mass tag remains attached to the analyte after tandem mass spectrometry fragmentation (MS-MS or MS2). Rather than losing the signature ion, a mass-balance part of the structure can be lost as a charge neutral group under tandem mass spectrometry fragmentation. The signature ion can be used for quantitation and, upon further fragmentation, can also provide ion-signals characteristic of the analyte and useful in identifying the analyte. In some embodiments, the ion-signals generated from a third mass spectrometry fragmentation (MS3) can be compared with a known mass spectrum, for example, from a look-up table, from a library, or from a database, to provide an unambiguous identification of the analyte.
    Type: Application
    Filed: January 24, 2011
    Publication date: July 28, 2011
    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
    Inventors: Subhakar DEY, Subhasish PURKAYASTHA
  • Publication number: 20110183429
    Abstract: Quantification of vitamin D2, vitamin D3, and the monohydroxy and diihydroxy metabolites of vitamin D2 and vitamin D3, can comprise labeling analytes with mass spectrometry (MS) tagging reagents and performing LC-MSMS analysis of the labeled analytes. The labeled analytes can include a labeled standard and can have distinct retention times on a reversed phase column, as well as distinct masses. Under high energy collisions, reporter groups can be generated. The intensity or the peak area detected for each reporter group can be used for quantitation. In some embodiments, a one-step tagging reagent is used that is a dienophile-containing, labeled Diels Alder reagent.
    Type: Application
    Filed: January 25, 2011
    Publication date: July 28, 2011
    Inventors: Subhakar DEY, Sasi PILLAI, Brian WILLIAMSON, Subhasish PURKAYASTHA
  • Patent number: 7906341
    Abstract: This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination by mass spectrometry using labeling reagents that comprise a nucleophilic reactive group that reacts with a functional group of an analyte to produce a labeled analyte. The labeling reagents can be used as isobaric sets, mass differential labeling sets or in a combination of isobaric and mass differential labeling sets.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: March 15, 2011
    Assignee: DH Technologies Development Pte, Ltd.
    Inventors: Subhasish Purkayastha, Subhakar Dey, Scott B. Daniels
  • Patent number: 7892737
    Abstract: This invention is related to methods, kits and compositions pertaining to stability modulation of PNA oligomer/nucleic acid complexes.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: February 22, 2011
    Assignee: Life Technologies Corporation
    Inventors: Subhakar Dey, Eric G. Anderson
  • Publication number: 20110028685
    Abstract: This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination and/or quantification by mass spectrometry using compounds comprising a reporter moiety and a non-encoded detectable label. The compounds can be used in sets for the analysis of mixtures of labeled analytes.
    Type: Application
    Filed: June 28, 2007
    Publication date: February 3, 2011
    Applicant: Applera Corporation.
    Inventors: Subhasish Purkayastha, Subhakar Dey
  • Publication number: 20110003395
    Abstract: Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.
    Type: Application
    Filed: June 1, 2010
    Publication date: January 6, 2011
    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
    Inventors: Subhakar DEY, Sasi PILLAI, Brian L. WILLIAMSON, Subhasish PURKAYASTHA, Michal Weinstock
  • Publication number: 20100311175
    Abstract: This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
    Type: Application
    Filed: November 13, 2009
    Publication date: December 9, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Xiongwei YAN, Pau Miau Yuan, Sylvia W. Yuen, Kuo-Liang Hsi, Joe Y. Lam, Krishna G. Upadhya, Subhakar Dey, Darryl J.C. Pappin, Sasi Pillai, Helena Huang, Subhasish Purkayastha
  • Publication number: 20100190660
    Abstract: This invention pertains to the field of PNA dimer and PNA oligomer synthesis.
    Type: Application
    Filed: September 4, 2009
    Publication date: July 29, 2010
    Applicant: Boston Probes, Inc.
    Inventors: Ralph A. Casale, James M. Coull, Subhakar Dey, Kevin Z. Gan, Bruce A. Kowalczyk
  • Publication number: 20090227791
    Abstract: In some embodiments, this invention pertains to active esters of N-substituted piperazine acetic acid, including isotopically enriched versions thereof. In some embodiments, this invention pertains to methods for the preparation of active esters of N-substituted piperazine acetic acid, including isotopically enriched versions thereof.
    Type: Application
    Filed: March 5, 2009
    Publication date: September 10, 2009
    Inventors: Subhakar Dey, Darryl J.C. Pappin, Subhasish Purkayastha, Sasi Pillai, James M. Coull
  • Publication number: 20090176984
    Abstract: In some embodiments, this invention pertains to isotopically enriched N-substituted piperazine acetic acids. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazine acetic acids.
    Type: Application
    Filed: February 29, 2008
    Publication date: July 9, 2009
    Inventors: Subhakar Dey, Darryl J.C. Pappin, Subhasish Purkayastha, Sasi Pillai, James M. Coull
  • Publication number: 20080241955
    Abstract: This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination by mass spectrometry using labeling reagents that comprise a nucleophilic reactive group that reacts with a functional group of an analyte to produce a labeled analyte. The labeling reagents can be used as isobaric sets, mass differential labeling sets or in a combination of isobaric and mass differential labeling sets.
    Type: Application
    Filed: June 28, 2007
    Publication date: October 2, 2008
    Applicant: Applera Corporation
    Inventors: Subhasish Purkayastha, Subhakar Dey, Scott B. Daniels
  • Patent number: 7355045
    Abstract: In some embodiments, this invention pertains to isotopically enriched N-substituted piperazine acetic acids. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazine acetic acids.
    Type: Grant
    Filed: January 5, 2004
    Date of Patent: April 8, 2008
    Assignee: Applera Corporation
    Inventors: Subhakar Dey, Darryl J. C. Pappin, Subhasish Purkayastha, Sasi Pillai, James M. Coull
  • Publication number: 20070218560
    Abstract: This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination by mass spectrometry.
    Type: Application
    Filed: January 22, 2007
    Publication date: September 20, 2007
    Applicant: Applera Corporation.
    Inventors: Sasi Pillai, Subhakar Dey, Subhasish Purkayastha, Darryl Pappin
  • Publication number: 20070048752
    Abstract: This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
    Type: Application
    Filed: February 15, 2006
    Publication date: March 1, 2007
    Applicant: Applera Corporation
    Inventors: Xiongwei Yan, Pau-Miau Yuan, Sylvia Yuen, Kuo-Liang Hsi, Joe Lam, Krishna Upadhya, Subhakar Dey, Darryl Pappin, Sasi Pillai, Helena Huang, Subhasish Purkayastha
  • Publication number: 20070003966
    Abstract: This invention is related to methods, kits and compositions pertaining to stability modulation of PNA oligomer/nucleic acid complexes.
    Type: Application
    Filed: June 29, 2006
    Publication date: January 4, 2007
    Applicant: Applera Corporation
    Inventors: Subhakar Dey, Eric Anderson