Patents by Inventor Suguru YAMASAKI
Suguru YAMASAKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230313133Abstract: An object of the present invention is to provide a complex containing two or more neural retina-containing cell aggregates, and a method for manufacturing the same. The complex of the present invention is a complex comprising: two or more cell aggregates each containing a neural retina derived from a pluripotent stem cell; and a matrix, the two or more cell aggregates being arranged in the matrix. The method for manufacturing the complex of the present invention is a method for manufacturing a complex in which two or more neural retina-containing cell aggregates are arranged in a matrix, comprising: (1) a first step of preparing two or more cell aggregates of neural retinas from a pluripotent stem cell; and (2) a second step of contacting the two or more cell aggregates in a predetermined arrangement with the matrix or a precursor of the matrix, followed by the gelation of the matrix.Type: ApplicationFiled: September 10, 2021Publication date: October 5, 2023Applicants: Riken, Sumitomo Pharma Co., Ltd.Inventors: Michiko Mandai, Masayo Takahashi, Suguru Yamasaki
-
Patent number: 11684698Abstract: A sphere-like cell aggregate according to one embodiment of the present invention comprises: a core part containing neural retina; and a covering part continuously or discontinuously covering at least a portion of a surface of the core part.Type: GrantFiled: September 7, 2018Date of Patent: June 27, 2023Assignees: Riken, Sumitomo Pharma Co., Ltd.Inventors: Masayo Takahashi, Michiko Mandai, Suguru Yamasaki
-
Publication number: 20220249572Abstract: Provided is a composite comprising a neural retina, a retinal pigment epithelial cell sheet, and a hydrogel.Type: ApplicationFiled: April 24, 2020Publication date: August 11, 2022Applicants: Riken, Sumitomo Dainippon Pharma Co., Ltd., Sumitomo Chemical Company, LimitedInventors: Yuji Tanaka, Michiko Mandai, Masayo Takahashi, Suguru Yamasaki
-
Patent number: 11371016Abstract: The present invention provides a method for producing a retinal cell or a retinal tissue, including the following steps (1)-(3): (1) a first step of culturing pluripotent stem cells in the absence of feeder cells in a medium containing 1) a TGF? family signal transduction pathway inhibiting substance and/or a Sonic hedgehog signal transduction pathway activating substance, and 2) a factor for maintaining undifferentiated state, (2) a second step of culturing the cells obtained in the first step in suspension in a medium containing a Wnt signal transduction pathway inhibiting substance to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence or absence of a Wnt signal transduction pathway inhibiting substance in a medium containing a BMP signal transduction pathway activating substance to obtain an aggregate containing a retinal cell or a retinal tissue.Type: GrantFiled: April 21, 2017Date of Patent: June 28, 2022Assignees: SUMITOMO PHARMA CO., LTD., RIKEN, SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Atsushi Kuwahara, Suguru Yamasaki, Yoshiki Sasai, Masayo Takahashi
-
Publication number: 20220170098Abstract: The method disclosed herein is for evaluating the quality of a transplant neural retina by sampling a part or the whole of a cell aggregate containing a neural retina having an epithelial structure derived from a pluripotent stem cell as a sample for quality evaluation.Type: ApplicationFiled: March 13, 2020Publication date: June 2, 2022Applicants: Sumitomo Dainippon Pharma Co., Ltd., Riken, Sumitomo Chemical Company, LimitedInventors: Atsushi Kuwahara, Kenji Watari, Keizo Matsushita, Suguru Yamasaki, Michiko Mandai, Masayo Takahashi
-
Publication number: 20220119764Abstract: The present invention provides a method for producing retinal cells or a retinal tissue, comprising the following steps (1)-(3): (1) a first step of culturing human pluripotent stem cells in the absence of feeder cells and in a medium comprising a factor for maintaining undifferentiated state, (2) a second step of culturing the pluripotent stem cells obtained in the first step in suspension in the presence of a Sonic hedgehog signal transduction pathway activating substance to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence of a 1) a BMP signal transduction pathway activating substance to obtain an aggregate containing retinal cells or a retinal tissue.Type: ApplicationFiled: January 3, 2022Publication date: April 21, 2022Applicants: SUMITOMO DAINIPPON PHARMA CO., LTD., RIKEN, SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Atsushi KUWAHARA, Suguru YAMASAKI, Yasushi HIRAMINE, Yoshiki SASAI (deceased), Masayo TAKAHASHI
-
Publication number: 20220112457Abstract: The present invention provides a method for producing neural cells or a neural tissue, including the following steps (1)-(3): (1) a first step of culturing pluripotent stem cells in the absence of feeder cells and in a medium containing 1) a TGF? family signal transduction pathway inhibiting substance and/or a Sonic hedgehog signal transduction pathway activating substance, and 2) a factor for maintaining undifferentiated state, (2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence or absence of a differentiation-inducing factor to obtain an aggregate containing neural cells or a neural tissue.Type: ApplicationFiled: December 22, 2021Publication date: April 14, 2022Applicants: SUMITOMO DAINIPPON PHARMA CO., LTD., RIKEN, SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Atsushi KUWAHARA, Suguru YAMASAKI, Yasushi HIRAMINE, Yoshiki SASAI (deceased), Masayo TAKAHASHI
-
Patent number: 11214772Abstract: The present invention provides a method for producing retinal cells or a retinal tissue, comprising the following steps (1)-(3): (1) a first step of culturing human pluripotent stem cells in the absence of feeder cells and in a medium comprising a factor for maintaining undifferentiated state, (2) a second step of culturing the pluripotent stem cells obtained in the first step in suspension in the presence of a Sonic hedgehog signal transduction pathway activating substance to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence of a 1) a BMP signal transduction pathway activating substance to obtain an aggregate containing retinal cells or a retinal tissue.Type: GrantFiled: October 23, 2015Date of Patent: January 4, 2022Assignees: SUMITOMO DAINIPPON PHARMA CO., LTD., RIKEN, SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Atsushi Kuwahara, Suguru Yamasaki, Yasushi Hiramine, Yoshiki Sasai, Masayo Takahashi
-
Patent number: 11214771Abstract: The present invention provides a method for producing neural cells or a neural tissue, including the following steps (1)-(3): (1) a first step of culturing pluripotent stem cells in the absence of feeder cells and in a medium containing 1) a TGF? family signal transduction pathway inhibiting substance and/or a Sonic hedgehog signal transduction pathway activating substance, and 2) a factor for maintaining undifferentiated state, (2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence or absence of a differentiation-inducing factor to obtain an aggregate containing neural cells or a neural tissue.Type: GrantFiled: October 23, 2015Date of Patent: January 4, 2022Assignees: SUMITOMO DAINIPPON PHARMA CO., LTD., RIKEN, SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Atsushi Kuwahara, Suguru Yamasaki, Yasushi Hiramine, Yoshiki Sasai, Masayo Takahashi
-
Publication number: 20200206387Abstract: A sphere-like cell aggregate according to one embodiment of the present invention comprises: a core part containing neural retina; and a covering part continuously or discontinuously covering at least a portion of a surface of the core part.Type: ApplicationFiled: September 7, 2018Publication date: July 2, 2020Applicants: Riken, Sumitomo Dainippon Pharma Co., Ltd.Inventors: Masayo Takahashi, Michiko Mandai, Suguru Yamasaki
-
Publication number: 20190351103Abstract: An object of the present invention is to provide a cell population suitable for transplant of retinal tissue and a method of production thereof. The present invention provides a cell population for transplant, comprising retinal cells with a modified bipolar cell-regulating gene and a method of production thereof.Type: ApplicationFiled: November 24, 2017Publication date: November 21, 2019Applicants: Riken, Sumitomo Dainippon Pharma Co., Ltd.Inventors: Michiko MANDAI, Masayo TAKASHI, Suguru YAMASAKI
-
Publication number: 20190127690Abstract: The present invention provides a method for producing a retinal cell or a retinal tissue, including the following steps (1)-(3): (1) a first step of culturing pluripotent stem cells in the absence of feeder cells in a medium containing 1) a TGF? family signal transduction pathway inhibiting substance and/or a Sonic hedgehog signal transduction pathway activating substance, and 2) a factor for maintaining undifferentiated state, (2) a second step of culturing the cells obtained in the first step in suspension in a medium containing a Wnt signal transduction pathway inhibiting substance to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence or absence of a Wnt signal transduction pathway inhibiting substance in a medium containing a BMP signal transduction pathway activating substance to obtain an aggregate containing a retinal cell or a retinal tissue.Type: ApplicationFiled: April 21, 2017Publication date: May 2, 2019Applicants: SUMITOMO DAINIPPON PHARMA CO., LTD., RIKEN, SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Atsushi KUWAHARA, Suguru YAMASAKI, Yoshiki SASAI (Deceased), Masayo TAKAHASHI
-
Publication number: 20170313976Abstract: The present invention provides a method for producing neural cells or a neural tissue, including the following steps (1)-(3): (1) a first step of culturing pluripotent stem cells in the absence of feeder cells and in a medium containing 1) a TGF? family signal transduction pathway inhibiting substance and/or a Sonic hedgehog signal transduction pathway activating substance, and 2) a factor for maintaining undifferentiated state, (2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence or absence of a differentiation-inducing factor to obtain an aggregate containing neural cells or a neural tissue.Type: ApplicationFiled: October 23, 2015Publication date: November 2, 2017Applicants: SUMITOMO DAINIPPON PHARMA CO., LTD., RIKEN, SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Atsushi KUWAHARA, Suguru YAMASAKI, Yasushi HIRAMINE, Yoshiki SASAI, Masayo TAKAHASHI
-
Publication number: 20170313981Abstract: The present invention provides a method for producing retinal cells or a retinal tissue, comprising the following steps (1)-(3): (1) a first step of culturing human pluripotent stem cells in the absence of feeder cells and in a medium comprising a factor for maintaining undifferentiated state, (2) a second step of culturing the pluripotent stem cells obtained in the first step in suspension in the presence of a Sonic hedgehog signal transduction pathway activating substance to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence of a 1) a BMP signal transduction pathway activating substance to obtain an aggregate containing retinal cells or a retinal tissue.Type: ApplicationFiled: October 23, 2015Publication date: November 2, 2017Applicants: SUMITOMO DAINIPPON PHARMA CO., LTD., RIKEN, SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Atsushi KUWAHARA, Suguru YAMASAKI, Yasushi HIRAMINE, Yoshiki SASAI, Masayo TAKAHASHI
-
Patent number: 9771987Abstract: A disk brake includes a caliper, and a driving unit disposed in a housing attached to the caliper. An attachment portion used to attach the housing to the caliper and a connector used to supply power to the electric motor are protrudingly provided at the housing. The attachment portion is formed in such a manner that a distance between a center of the disk rotor and a portion of the attachment portion located farthest away from the center of the disk rotor in a radial direction is longer than a distance between the center of the disk rotor and a portion of the connector located farthest away from the center of the disk rotor in the radial direction, and a width of the connector in an axial direction of the disk rotor falls within a range of a width of the attachment portion in the axial direction.Type: GrantFiled: August 21, 2015Date of Patent: September 26, 2017Assignee: HITACHI AUTOMOTIVE SYSTEMS, LTD.Inventors: Suguru Yamasaki, Shinji Suzuki
-
Publication number: 20160069403Abstract: A disk brake includes a caliper, and a driving unit disposed in a housing attached to the caliper. An attachment portion used to attach the housing to the caliper and a connector used to supply power to the electric motor are protrudingly provided at the housing. The attachment portion is formed in such a manner that a distance between a center of the disk rotor and a portion of the attachment portion located farthest away from the center of the disk rotor in a radial direction is longer than a distance between the center of the disk rotor and a portion of the connector located farthest away from the center of the disk rotor in the radial direction, and a width of the connector in an axial direction of the disk rotor falls within a range of a width of the attachment portion in the axial direction.Type: ApplicationFiled: August 21, 2015Publication date: March 10, 2016Inventors: Suguru YAMASAKI, Shinji SUZUKI