Patents by Inventor SUMIRE HONDA MALCA

SUMIRE HONDA MALCA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11781164
    Abstract: The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-demethylated and/or O-demethylated reticuline and/or derivatives thereof, comprising cultivating the recombinant host of the invention in a culture medium under conditions in which the one or more genes encoding the cytochrome P450 enzymes is/are expressed. The reticuline and derivatives thereof are useful for providing access to naturally unavailable and chemically difficult-to-produce starting materials for opioids.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: October 10, 2023
    Assignee: RIVER STONE BIOTECH, LLC
    Inventors: Markus Schwab, Sumire Honda Malca, Philipp Friedrich Berninger, Jon Richard Heal, Joseph Michael Sheridan, Laura Tatjer Recorda, Rubini Maya Kannangara, Esben Halkjaer Hansen, Angela Manuela Ribeiro de Carvalho
  • Publication number: 20230068713
    Abstract: The present invention relates to host cells and their use wherein the host cells are capable of producing D-ribulose and incapable of or have a reduced capability of converting D-ribulose to a molecule other than ribitol, wherein the host cells comprise a heterologous nucleic acid sequence encoding a polypeptide capable of converting D-ribulose to ribitol with a cofactor preference for NADPH.
    Type: Application
    Filed: December 17, 2020
    Publication date: March 2, 2023
    Inventors: Astrid SCHÄFER, Yiming CHANG, Sumire Honda MALCA
  • Publication number: 20210230655
    Abstract: The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-demethylated and/or O-demethylated reticuline and/or derivatives thereof, comprising cultivating the recombinant host of the invention in a culture medium under conditions in which the one or more genes encoding the cytochrome P450 enzymes is/are expressed. The reticuline and derivatives thereof are useful for providing access to naturally unavailable and chemically difficult-to-produce starting materials for opioids.
    Type: Application
    Filed: June 18, 2018
    Publication date: July 29, 2021
    Inventors: Markus Schwab, Sumire Honda Malca, Philipp Friedrich Berninger, Jon Richard Heal, Joseph Michael Sheridan, Laura Tatjer Recorda, Rubini Maya Kannangara, Esben Halkjaer Hansen, Angela Manuela Ribeiro de Carvalho
  • Patent number: 10829742
    Abstract: The present invention relates to a recombinant microbial host for the production of xylitol, the recombinant microbial host containing a nucleic acid sequence encoding a NAD+-specific D-arabitol 4-oxidoreductase (EC 1.1.1.11) using D-arabitol as substrate and producing D-xylulose as product, and a nucleic acid sequence encoding a NADPH-specific xylitol dehydrogenase using D-xylulose as substrate and producing xylitol as product.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: November 10, 2020
    Assignee: ROQUETTE FRERES
    Inventors: Astrid Schaefer, Melanie Diefenbacher, Yiming Chang, Sumire Honda Malca, Markus Schwab, Sophie Defretin, Tania Gerard, Arnaud Heysen, Friederike Thor
  • Publication number: 20200032224
    Abstract: The present invention relates to a recombinant microbial host for the production of xylitol, the recombinant microbial host containing a nucleic acid sequence encoding a NAD+-specific D-arabitol 4-oxidoreductase (EC 1.1.1.11) using D-arabitol as substrate and producing D-xylulose as product, and a nucleic acid sequence encoding a NADPH-specific xylitol dehydrogenase using D-xylulose as substrate and producing xylitol as product.
    Type: Application
    Filed: September 13, 2019
    Publication date: January 30, 2020
    Applicant: ROQUETTE FRERES
    Inventors: Astrid SCHAEFER, Melanie DIEFENBACHER, Yiming CHANG, Sumire HONDA MALCA, Markus SCHWAB, Sophie DEFRETIN, Tania GERARD, Arnaud HEYSEN, Friederike THOR
  • Patent number: 10494614
    Abstract: The present invention relates to a recombinant microbial host for the production of xylitol, the recombinant microbial host containing a nucleic acid sequence encoding an NAD+-specific D-arabitol 4-oxidoreductase (EC 1.1.1.11) using D-arabitol as substrate and producing D-xylulose as product, and a nucleic acid sequence encoding an NADPH-specific xylitol dehydrogenase using D-xylulose as substrate and producing xylitol as product.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: December 3, 2019
    Assignee: ROQUETTE FRERES
    Inventors: Astrid Schaefer, Melanie Diefenbacher, Yiming Chang, Sumire Honda Malca, Markus Schwab, Sophie Defretin, Tania Gerard, Arnaud Heysen, Friederike Thor
  • Publication number: 20180327723
    Abstract: The invention relates to methods for producing glycosylated nootkatol. In particular, a recombinant host comprising a gene encoding a UDP-glycosyltransferase polypeptide capable of glycosylating nootkatol is disclosed. Glycosylation of nootkatol detoxifies nootkatol, allowing for greater production of (glycosylated-)nootkatol, a precursor of nootkatone, and therefore greater production of nootkatone. The invention also relates to methods of converting non-toxic, glycosylated nootkatol produced by a recombinant host to nootkatol, wherein the nootkatol can subsequently be converted to large quantities of nootkatone to be used in flavorings, perfumes, and/or insect repellents.
    Type: Application
    Filed: November 14, 2016
    Publication date: November 15, 2018
    Inventors: Dayal Saran, Jorgen Hansen, Philippe Prochasson, Patrick Roussel, Laura Occhipinti, Alexei Ouspenski, Sumire Honda Malca
  • Publication number: 20170130209
    Abstract: The present invention relates to a recombinant microbial host for the production of xylitol, the recombinant microbial host containing a nucleic acid sequence encoding an NAD+-specific D-arabitol 4-oxidoreductase (EC 1.1.1.11) using D-arabitol as substrate and producing D-xylulose as product, and a nucleic acid sequence encoding an NADPH-specific xylitol dehydrogenase using D-xylulose as substrate and producing xylitol as product.
    Type: Application
    Filed: June 17, 2015
    Publication date: May 11, 2017
    Inventors: ASTRID SCHAEFER, MELANIE DIEFENBACHER, YIMING CHANG, SUMIRE HONDA MALCA, MARKUS SCHWAB, SOPHIE DEFRETIN, TANIA GERARD, ARNAUD HEYSEN, FRIEDERIKE THOR