Patents by Inventor Susan Drapeau

Susan Drapeau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7892532
    Abstract: The invention provides fusion polypeptides comprising protein transduction domains and osteoinductive polypeptides, as well as methods of using such polypeptides to induce osteogenesis and to promote proteoglycan synthesis. The invention also provides osteoinductive peptides which have demonstrated the ability to induce bone formation in vivo.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: February 22, 2011
    Inventors: Frances Louisa Titus, Jeffrey C. Marx, Scott D. Boden, Sangwook T. (Tim) Yoon, Susan Drapeau
  • Publication number: 20090287165
    Abstract: Devices for delivery of a pharmaceutical depot is provided. Exemplary device may comprise a cannula defining a working channel between a distal end and a proximal end, wherein the distal end comprises an atraumatic tip. The atraumatic tip may comprise a rounded tip or a soft tip. The cannulated delivery device may include a docking member proximally adjacent to the distal end of the lumen. Methods of using such devices to deliver pharmaceutical depot into a joint space are also provided.
    Type: Application
    Filed: May 15, 2008
    Publication date: November 19, 2009
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Susan Drapeau, Nelson Scarborough
  • Publication number: 20080166755
    Abstract: The invention provides fusion polypeptides comprising protein transduction domains and osteoinductive polypeptides, as well as methods of using such polypeptides to induce osteogenesis and to promote proteoglycan synthesis. The invention also provides osteoinductive peptides which have demonstrated the ability to induce bone formation in vivo.
    Type: Application
    Filed: March 23, 2004
    Publication date: July 10, 2008
    Inventors: Frances Titus, Jeffrey Marx, Scott Boden, Sangwook Yoon, Susan Drapeau
  • Publication number: 20070259030
    Abstract: A method for the use and delivery of tissue inhibitors of matrix metalloproteinase (TIMPs) to control the activity of the matrix metalloproteinase (MMPs) in the extracellular matrix (ECM) in order to treat and prevent extracellular matrix degradation in an injured tendon or ligament is presented. Accelerated breakdown of the extracellular matrix occurs in various pathological processes, including inflammation, chronic degenerative diseases and tumor invasion. Four members of the tissue inhibitor of metalloproteinase (TIMP) family have been characterized so far, designated as TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Various introduction amounts, timing and combinations are capable of inhibiting the activities of all known matrix metalloproteinase (MMPs) and as such play a key role in maintaining the balance between (ECM) deposition and degradation in different physiological processes.
    Type: Application
    Filed: May 5, 2006
    Publication date: November 8, 2007
    Inventor: Susan Drapeau
  • Publication number: 20070254041
    Abstract: Described are medical implant devices that include particulate collagen and particulate demineralized bone matrix. These and potentially other materials are held together in a three-dimensionally stable structure such as a porous, resilient sheet, by an ionically-crosslinked polysaccharide gel. Also described are methods for making and using such medical devices.
    Type: Application
    Filed: May 1, 2006
    Publication date: November 1, 2007
    Inventors: Susan Drapeau, Kathy Chamness, William McKay
  • Publication number: 20070253928
    Abstract: The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
    Type: Application
    Filed: April 28, 2006
    Publication date: November 1, 2007
    Inventors: Josee Roy, Susan Drapeau, Jeffrey Marx
  • Publication number: 20070254042
    Abstract: Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising a polysaccharide. Also described are methods for making and using such medical compositions.
    Type: Application
    Filed: May 1, 2006
    Publication date: November 1, 2007
    Inventors: Susan Drapeau, Kathy Chamness, William McKay
  • Publication number: 20070253930
    Abstract: The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
    Type: Application
    Filed: April 28, 2006
    Publication date: November 1, 2007
    Inventors: Josee Roy, Susan Drapeau, Jeffrey Marx
  • Publication number: 20070253960
    Abstract: The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disc includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disc. Disruption of vascular elements includes causing the vascular extensions to retract from the disc, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
    Type: Application
    Filed: April 28, 2006
    Publication date: November 1, 2007
    Inventors: Josee Roy, Susan Drapeau, Jeffrey Marx
  • Publication number: 20070250114
    Abstract: A flexible tissue sheath for treating a lacerated fibrous connective tissue is disclosed and can include a hollow body that can define an interior surface and an exterior surface. At least one tissue engagement structure can extend from the hollow body. The tissue engagement structure can engage an end of the lacerated fibrous connective tissue and substantially prevent the end of the lacerated fibrous connective tissue from withdrawing from the hollow body.
    Type: Application
    Filed: April 20, 2006
    Publication date: October 25, 2007
    Applicant: SDGI HOLDINGS, INC.
    Inventor: Susan Drapeau
  • Publication number: 20070238992
    Abstract: An implantable sensor for detecting changes in tissue density is disclosed. The implantable sensor includes a transducer adapted for detecting indicators of tissue density. The implantable sensor includes memory for storing data corresponding to the tissue density indicators detected by the sensor. A telemetry circuit is configured for transmitting the tissue density data outside of the body.
    Type: Application
    Filed: February 1, 2006
    Publication date: October 11, 2007
    Applicant: SDGI Holdings, Inc.
    Inventors: William Donofrio, Jeffrey Nycz, Can Cinbis, Matthew Morrison, Susan Drapeau, Qingshan (Sam) Ye
  • Publication number: 20070233264
    Abstract: Each of an osteochondral plug graft and a kit comprises a trapezoid shaped construct configured for osteochondral implanting. An osteochondral regeneration method comprises forming a recipient socket in a chondral area of an articular joint in need of repair; harvesting a trapezoid shaped graft from another chondral area; and implanting the trapezoid shaped graft into the recipient socket.
    Type: Application
    Filed: March 28, 2006
    Publication date: October 4, 2007
    Inventors: Jeffrey Nycz, Keith Kinnane, Susan Drapeau, Daniel Shimko, Jeetendra Bharadwaj
  • Publication number: 20070179568
    Abstract: Methods and systems for detecting a biological response indicative of osteolysis or osteolytic pre-conditions in bone.
    Type: Application
    Filed: January 31, 2006
    Publication date: August 2, 2007
    Applicant: SDGI Holdings, Inc.
    Inventors: Jeffrey Nycz, Susan Drapeau, William Donofrio
  • Publication number: 20070009493
    Abstract: The invention provides a method of treatment joint and disk disease comprising administering to the subject in need thereof a novel composition comprising a substantially purified plurality of cells enhanced with at least one bioactive factor capable of causing at least a portion of the plurality of cells to express an increased amount of at least one chondrogenic marker.
    Type: Application
    Filed: May 30, 2006
    Publication date: January 11, 2007
    Inventors: Susan Drapeau, Sangwook Yoon
  • Publication number: 20060259006
    Abstract: Described are novel methods for delivering a medical agent to a plurality of locations within a patient tissue volume such as the interior space of a spinal disc, and also for removing material therefrom during medical agent delivery to enhance the delivery. Also described are medical delivery devices such as needle assemblies configured to facilitate the regional delivery of medical agents to patient tissue.
    Type: Application
    Filed: April 29, 2005
    Publication date: November 16, 2006
    Inventors: William McKay, Susan Drapeau
  • Publication number: 20050020506
    Abstract: A composition comprising a collagen protein and demineralized bone matrix is described wherein the composition is chemically cross-linked with a carbodiimide such as N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC). The crosslinking reaction can be conducted in the presence of N-hydroxysuccinimide (NHS). The collagen can be in a porous matrix or scaffolding. The DBM can be in the form of particles dispersed in the collagen. A method of making the composition is also described wherein a collagen slurry is cast into the desired shape, freeze dried to form a porous scaffolding and infitrated with a solution comprising the cross-linking agent. The composition can be used as an implant for tissue (e.g., soft tissue or bone) engineering.
    Type: Application
    Filed: July 25, 2003
    Publication date: January 27, 2005
    Inventors: Susan Drapeau, Mark Torrianni, Frank Everaerts, William McKay
  • Publication number: 20040197867
    Abstract: The invention provides fusion polypeptides comprising protein transduction domains and osteoinductive polypeptides, as well as methods of using such polypeptides to induce osteogenesis and to promote proteoglycan synthesis. The invention also provides osteoinductive peptides which have demonstrated the ability to induce bone formation in vivo.
    Type: Application
    Filed: March 23, 2004
    Publication date: October 7, 2004
    Inventors: Frances Louisa Titus, Jeffrey C. Marx, Scott D. Boden, Sangwook T. (Tim) Yoon, Susan Drapeau