Patents by Inventor Susan Mary Cramp

Susan Mary Cramp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators
    Patent number: 9561230
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2. For example, the invention relates in part to tricyclic sulfonamide compounds represented by Formula I: or pharmaceutically acceptable salts or stereoisomers thereof, wherein A, B, D, RA1, RA2, Y, X and n are as defined herein.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: February 7, 2017
    Assignee: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • TRICYCLIC SULFONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20160256469
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: October 8, 2015
    Publication date: September 8, 2016
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Tetrazole compounds and methods of making and using same
    Patent number: 9321740
    Abstract: Described herein are tetrazole compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tetrazole compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: April 26, 2016
    Assignee: Zafgen, Inc.
    Inventors: Hazel Joan Dyke, Thomas David Pallin, Susan Mary Cramp
  • Partially saturated tricyclic compounds and methods of making and using same
    Patent number: 9290472
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: March 22, 2016
    Assignee: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Tricyclic compounds and methods of making and using same
    Patent number: 9266896
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: February 23, 2016
    Assignee: Zafgen, Inc.
    Inventors: David Clark, Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Tricyclic pyrazole sulphonamide compunds and methods of making and using same
    Patent number: 9242997
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: January 26, 2016
    Assignee: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Sulphonamine compounds and methods of making and using same
    Patent number: 9221787
    Abstract: The invention provides sulphonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: December 29, 2015
    Assignee: Zafgen, Inc.
    Inventors: Robert Zahler, Hazel Joan Dyke, Thomas David Pallin, Susan Mary Cramp
  • Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators
    Patent number: 9187494
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2. For example, the invention relates in part to tricyclic sulfonamide compounds represented by Formula I: or pharmaceutically acceptable salts or stereoisomers thereof, wherein A, B, D, RA1, RA2, Y, X, and n are as defined herein.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: November 17, 2015
    Assignee: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Use of 4-(pyrrolidin-1-yl)quinoline compounds to kill clinically latent microorganisms
    Patent number: 8759348
    Abstract: There is provided the use of compounds of formula wherein R1, R2, R3 and E have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula (I) per se.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: June 24, 2014
    Assignee: Helperby Therapeutics Limited
    Inventors: Mandy Christine Beswick, Susan Mary Cramp, Yanmin Hu, Thomas David Pallin, Hazel Joan Dyke, Anthony Coates
  • Partially Saturated Tricyclic Compounds and Methods of Making and Using Same
    Publication number: 20140088078
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: May 7, 2012
    Publication date: March 27, 2014
    Applicant: ZAFGEN, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Tricyclic Pyrazole Sulphonamide Compounds and Methods of Making and Using Same
    Publication number: 20140080822
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: May 7, 2012
    Publication date: March 20, 2014
    Applicant: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • Tricyclic Sulfonamide Compounds and Methods of Making and Using Same
    Publication number: 20140073623
    Abstract: The invention provides tricyclic sulfonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: May 7, 2012
    Publication date: March 13, 2014
    Applicant: Zafgen, Inc.
    Inventors: Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • TETRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20130331420
    Abstract: Described herein are tetrazole compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tetrazole compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: January 26, 2012
    Publication date: December 12, 2013
    Applicant: Zafgen, Inc.
    Inventors: Hazel Joan Dyke, THomas David Pallin, Susan Mary Cramp
  • Sulphonamine Compounds and Methods of Making and Using Same
    Publication number: 20130217759
    Abstract: The invention provides sulphonamide compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various sulphone compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: October 12, 2011
    Publication date: August 22, 2013
    Applicant: Zafgen Inc.
    Inventors: Robert Zahler, Hazel Joan Dyke, Thomas David Pallin, Susan Mary Cramp
  • Tricyclic Compounds and Methods of Making and Using Same
    Publication number: 20130123235
    Abstract: The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
    Type: Application
    Filed: July 21, 2011
    Publication date: May 16, 2013
    Inventors: David Clark, Susan Mary Cramp, Hazel Joan Dyke, Thomas David Pallin, Robert Zahler
  • USE OF 4-(PYRROLIDIN-1-YL)QUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS
    Publication number: 20100305065
    Abstract: There is provided the use of compounds of formula wherein R1, R2, R3 and E have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula (I) per se.
    Type: Application
    Filed: May 16, 2008
    Publication date: December 2, 2010
    Applicant: HELPERBY THERAPEUTICS LIMITED
    Inventors: Mandy Christine Beswick, Susan Mary Cramp, Yanmin Hu, Thomas David Pallin, Hazel Joan Dyke, Anthony Coates
  • Substituted propargylamines
    Patent number: 7084158
    Abstract: The present invention relates to the use of substituted aryl- and heteroarylpropargylamines of the formula (I) where a) R1 is heteroaryl or aryl, unsubstituted or mono- or polysubstituted by identical or different radicals, b) A is a group CR4R5 or C?O, where R4 is hydrogen, halogen or alkyl; R5 is hydrogen, halogen or a substituted or unsubstituted hydrocarbon radical; c) R2 and R3 together with the nitrogen atom to which they are attached form N-heteroaryl or N-heterocyclyl, unsubstituted or mono- or polysubstituted by identical or different radicals, if appropriate also as N-oxide or salt, as pesticide against arthropods and helminths for protecting plants and animals.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: August 1, 2006
    Assignee: Bayer Cropscience S.A.
    Inventors: Harald Jakobi, Susan Mary Cramp, Joachim Dickhaut, Stephen Lindell, Jörg Tiebes, Maria Asuncion Canales, Daniela Jans, Waltraud Hempel, Reed Nathan Royalty, Susan Marie McComb, Maria-Theresia Thönessen, Jutta Maria Waibel, Vincent Lee Salgado
  • Process for preparing diketone compounds and precursors thereto
    Patent number: 6696613
    Abstract: A process for preparing compounds of the formula: wherein R2 is lower alkyl; or phenyl optionally substituted by from one to five groups, the same or different, which are lower alkyl, lower haloalkyl, halogen or —SR4; R3 is halogen, lower alkyl, lower haloalkyl, lower alkoxy, lower haloalkoxy, —S-alkyl, cycloalkyl having from 3 to 7 carbon atoms in the ring, alkenyl or alkynyl having from 3 to 7 carbon atoms, or —(CR5R6)—SR2 wherein q is one or two; R4 is lower alkyl; R5 and R6 independently represent hydrogen, lower alkyl or lower haloalkyl; and n is zero or an integer from one to three; intermediate compounds of the formula: and processes for preparing them.
    Type: Grant
    Filed: December 31, 2002
    Date of Patent: February 24, 2004
    Assignee: Rhone Poulenc Agrochimie
    Inventors: Virginie Pevere, Alain Gadras, Susan Mary Cramp, Charles Walter Ellwood
  • Substituted propargylamines
    Publication number: 20040014784
    Abstract: The present invention relates to the use of substituted aryl- and heteroarylpropargylamines of the formula (I) 1
    Type: Application
    Filed: August 22, 2002
    Publication date: January 22, 2004
    Inventors: Harald Jakobi, Susan Mary Cramp, Joachim Dickhaut, Stephen Lindell, Jorg Tiebes, Maria Asuncion Canales, Daniela Jans, Waltraud Hempel, Reed Nathan Royalty, Susan Marie McComb, Maria-Theresia Thonessen, Jutta Maria Waibel, Vincent Lee Salgado
  • Processes for preparing intermediates
    Patent number: 6642418
    Abstract: The invention relates to processes for the preparation of compounds of formula (I), wherein R1 and R2 are as defined in the description.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: November 4, 2003
    Assignee: Aventis Cropscience SA
    Inventors: Susan Mary Cramp, Neil Jonathan Geach