Patents by Inventor Susana Castro-Obregon

Susana Castro-Obregon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of paraptosis and related methods
    Patent number: 6994981
    Abstract: The invention is directed to a method of identifying a compound that modulates SP-induced paraptosis by (a) contacting a population of cells with an effective amount of substance P to induce SP-induced paraptosis; (b) contacting a first sub-population of the cells with a test-compound, and a second sub-population of the cells with a control-compound; and (c) comparing the amount of cell death between the first and second sub-populations of cells, where a difference in the amount of cell death between the first and second sub-populations of cells indicates that the test-compound is a compound that modulates SP-induced paraptosis. The invention is also directed to a method of treating a condition associated with excessive cell accumulation by administering to a subject in need of such treatment an effective amount of a compound identified from the method described above where the effective amount of the compound increases SP-induced paraptosis.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: February 7, 2006
    Assignee: The Buck Institute
    Inventors: Sabina Sperandio, Susana Castro-Obregon, Dale E. Bredesen
  • MODULATORS OF PARAPTOSIS AND RELATED METHODS
    Publication number: 20050244894
    Abstract: The invention is directed to a method of identifying a compound that modulates SP-induced paraptosis by (a) contacting a population of cells with an effective amount of substance P to induce SP-induced paraptosis; (b) contacting a first sub-population of the cells with a test-compound, and a second sub-population of the cells with a control-compound; and (c) comparing the amount of cell death between the first and second sub-populations of cells, where a difference in the amount of cell death between the first and second sub-populations of cells indicates that the test-compound is a compound that modulates SP-induced paraptosis. The invention is also directed to a method of treating a condition associated with excessive cell accumulation by administering to a subject in need of such treatment an effective amount of a compound identified from the method described above where the effective amount of the compound increases SP-induced paraptosis.
    Type: Application
    Filed: July 23, 2002
    Publication date: November 3, 2005
    Inventors: Sabina Sperandio, Susana Castro-Obregon, Dale Bredesen