Abstract: To provide an optical module that can synchronize a vibration frequency and a swing angle without complicating a system. An optical module including: a double-sided mirror that rotates or undergoes pendulum motion about at least one rotation axis; a plane mirror disposed at an angle of 45 degrees from a horizontal surface on a back surface side of the double-sided mirror; and a uniaxial retroreflective mirror disposed at an angle of 45 degrees from the horizontal surface on a front surface side of the double-sided mirror, in which an axis of retroreflective is perpendicular to the horizontal surface and a normal line of the uniaxial retroreflective mirror.

Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.

Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.

Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.

Abstract: An object of the present invention is to provide lipid particles which have low cytotoxicity, can stably hold nucleic acid molecules outside cells, and can promptly release nucleic acids in cytoplasm after escaping from endosome, and a nucleic acid delivery carrier. According to the present invention, there are provided lipid particles containing a compound represented by the following General Formula (1), sterol, at least one lipid selected from the group consisting of a neutral lipid and a lipid having a polyethylene glycol chain, and nucleic acids, and a nucleic acid delivery carrier. In the formula, R1 and R2 are the same as or different from each other, and are alkyl groups having 10 to 22 carbon atoms.

Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.

Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.

Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.

Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.

Abstract: An object of the present invention is to provide a method for producing lipid particles which can hold nucleic acids or the like at a high inclusion rate, and a nucleic acid delivery carrier having the lipid particles. According to the present invention, there is provided a method for producing lipid particles including nucleic acids, the method including the following steps of (1) to (4): (1) a step of heating an oil phase containing a phospholipid, an alcohol, and an ester; (2) a step of mixing an oil phase prepared in step (1) with a water phase containing nucleic acids; (3) a step of cooling the mixed liquid which contains the oil phase and the water phase and has been obtained in step (2), and crystallizing lipid particles; and (4) a step of removing the alcohol and the ester from the mixed liquid Which contains the oil phase and the water phase and has been obtained in step (3).

Abstract: An object of the present invention is to provide lipid particles which have low cytotoxicity, can stably hold nucleic acid molecules outside cells, and can promptly release nucleic acids in cytoplasm after escaping from endosome, and a nucleic acid delivery carrier. According to the present invention, there are provided lipid particles containing a compound represented by the following General Formula (1), sterol, at least one lipid selected from the group consisting of a neutral lipid and a lipid having a polyethylene glycol chain, and nucleic acids, and a nucleic acid delivery carrier. In the formula, R1 and R2 are the same as or different from each other, and are alkyl groups having 10 to 22 carbon atoms.

Abstract: An applicator for applying functional substances, such as cosmetic powder, food color marking, India ink effect marks, or drugs into human skin, having a base, a plurality of microneedles fixed to and projecting from the base a distance only sufficient to penetrate into the stratum corneum or dermis, with the microneedles being of a material that is capable of disintegration and dispersion into the stratum corneum or dermis, such as maltose. The needles contain the functional substance for delivery into the stratum corneum or dermis. The microneedles are of a length approximately 0.5 to 500 ?m when used to apply a functional substance to the stratum corneum, or are of a length of approximately 500 to 5,000 ?m when used to apply a functional substance to the dermis.

Abstract: A manufacturing method for variable shape mirrors, which is suitable for mass production, includes a bonding step for sandwiching support pillars and piezoelectric elements between a support substrate and a mirror substrate, and bonding at least the support substrate and the support pillar to each other, the support substrate and the piezoelectric element to each other, and the mirror substrate and the support pillars to each other, respectively, and an elastic film forming step for forming a flat elastic film on the outer surface of the mirror substrate, and a reflection film forming step for forming a reflection film on the elastic film.

Abstract: A cellulose acylate film, which has a film thickness of from 20 to 70 ?m and an elastic modulus of from 3.5 to 10 GPa in at least one direction of a film casting direction and a width direction.

Abstract: A liquid crystal display device comprising a liquid crystal panel in which liquid crystals having negative dielectric anisotropy are interposed between upper substrate and lower substrate that have been vertically oriented on the surface, the orientation of the liquid crystals being almost vertical with no applied voltage, almost horizontal when a predetermined voltage is applied, and tilted when a smaller voltage than the predetermined voltage is applied; a first polarizer and a second polarizer disposed on both sides of the liquid crystal panel such that the absorption axes of the polarizers are perpendicular to each other; a first retardation film disposed between the liquid crystal panel and the first polarizer; and a second retardation film disposed between the liquid crystal panel and the second polarizer, wherein the polarizer comprises a polarizing film and a pair of protective films having the polarizing film in between, and wherein at least one of the protective films is a cellulose acylate film sat

Abstract: A cellulose acylate film comprising a retardation developing agent consisting of a rod-shaped compound, wherein Re is 50 to 100 nm, Rth is 130 to 250 nm, and the thickness is 40 to 90 ?m. A liquid crystal display device comprising the film shows reduced the corner irregularity.

Abstract: A plate material cutting unit is equipped with: support devices for supporting the lower edge of an upright plate material; fluid guides for applying fluid pressure on a surface of the plate material which is held upright on the support devices, to support the plate material in a non-contact manner; a scribe forming device, equipped with a scribing blade for forming a scribe for cutting on the plate material, by moving along the surface of the plate material, which is supported by the fluid guides; a clamp, for gripping a portion of the plate material adjacent to the movement trajectory of the scribing blade along the plate material; and a cutting device, equipped with a pressing member for pressing a portion of the plate material opposite the scribe in a planar direction with respect to the portion of the plate material which is gripped by the clamp.

Abstract: A cellulose acylate film, which has a film thickness of from 20 to 70 ?m and an elastic modulus of from 3.5 to 10 GPa in at least one direction of a film casting direction and a width direction.

Abstract: A cellulose acylate film, which has a film thickness of from 20 to 70 ?m and an elastic modulus of from 3.5 to 10 GPa in at least one direction of a film casting direction and a width direction.

Abstract: In a variable-shape mirror provided with a support base, a mirror portion that is disposed to face the support base and that has, on a side thereof facing away from the support base, a mirror surface which is irradiated with a light beam, and piezoelectric elements that are sandwiched between the support base and the mirror portion and that vary the shape of the mirror surface, the piezoelectric elements are bonded, by means of a thin layer of metal, to at least one of the support base and the mirror portion by the application of heat and pressure.