Patents by Inventor Sydney Gordon

Sydney Gordon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11814419
    Abstract: High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: November 14, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Aaron Michael Ring, Andrew Kruse, Aashish Manglik, Irving L. Weissman, Roy Louis Maute, Melissa N. McCracken, Sydney Gordon
  • Publication number: 20210040176
    Abstract: High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.
    Type: Application
    Filed: May 26, 2020
    Publication date: February 11, 2021
    Inventors: Aaron Michael Ring, Andrew Kruse, Aashish Manglik, Irving L. Weissman, Roy Louis Maute, Melissa N. McCracken, Sydney Gordon
  • Patent number: 10800830
    Abstract: High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: October 13, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Aaron Michael Ring, Andrew Kruse, Aashish Manglik, Irving L. Weissman, Roy Louis Maute, Melissa N. McCracken, Sydney Gordon
  • Publication number: 20170233451
    Abstract: High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.
    Type: Application
    Filed: August 7, 2015
    Publication date: August 17, 2017
    Inventors: Aaron Michael Ring, Andrew Kruse, Aashish Manglik, Irving L. Weissman, Roy Louis Maute, Melissa N. McCracken, Sydney Gordon
  • Patent number: 9562087
    Abstract: High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: February 7, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Aaron Michael Ring, Andrew Kruse, Aashish Manglik, Irving L. Weissman, Roy Louis Maute, Melissa N. McCracken, Sydney Gordon
  • Patent number: 9546206
    Abstract: High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: January 17, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Aaron Michael Ring, Andrew Kruse, Aashish Manglik, Irving L. Weissman, Roy Louis Maute, Melissa N. McCracken, Sydney Gordon
  • Publication number: 20160337292
    Abstract: A message processing system is disclosed herein. A client computing device may receive an electronic message from a server via a network and via a forwarding operation on a condition that the electronic message is approved to be forwarded to a recipient. The client computing device may then receive from the server a message that the electronic message is unapproved, wherein the message includes a URL to view the unapproved electronic message and the electronic message is stored on the server with an indication that the electronic message is unapproved. The client computing device may then receive a list of unapproved electronic messages to display, wherein associated with the list are selectable options including to send the unapproved electronic message, to add a sender of the unapproved electronic message to an approved sender list, and to delete the unapproved electronic message.
    Type: Application
    Filed: July 29, 2016
    Publication date: November 17, 2016
    Applicant: III Holdings 1, LLC
    Inventors: Sydney Gordon Low, William Dennis Lang
  • Patent number: 9407588
    Abstract: A message processing system is disclosed herein. A client computing device may receive an electronic message from a server via a network and via a forwarding operation on a condition that the electronic message is approved to be forwarded to a recipient. The client computing device may then receive from the server a message that the electronic message is unapproved, wherein the message includes a URL to view the unapproved electronic message and the electronic message is stored on the server with an indication that the electronic message is unapproved. The client computing device may then receive a list of unapproved electronic messages to display, wherein associated with the list are selectable options including to send the unapproved electronic message, to add a sender of the unapproved electronic message to an approved sender list, and to delete the unapproved electronic message.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: August 2, 2016
    Assignee: III Holdings 1, LLC
    Inventors: Sydney Gordon Low, William Dennis Lang
  • Patent number: 9331918
    Abstract: A method, performed by a computer system, of providing usage data for a plurality of hyperlinks in a resource is disclosed. In one aspect, the method includes maintaining hyperlink usage data for each of the hyperlinks within the resource and adjusting a copy of the resource to incorporate the hyperlink usage data associated with each hyperlink, wherein the hyperlink usage data represents the number of times users have selected a hyperlink of the resource. The method also includes sending the adjusted copy of the resource to a networked device to provide a display representing the hyperlink usage data with each associated hyperlink. The hyperlink usage data is incorporated into the copy of the resource so as to be displayed adjacent to the corresponding hyperlinks of the resource.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: May 3, 2016
    Assignee: Connexity, Inc.
    Inventor: Sydney Gordon Low
  • Publication number: 20160052990
    Abstract: High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.
    Type: Application
    Filed: November 3, 2015
    Publication date: February 25, 2016
    Inventors: Aaron Michael Ring, Andrew Kruse, Aashish Manglik, Irving L. Weissman, Roy Louis Maute, Melissa N. McCracken, Sydney Gordon
  • Publication number: 20160039903
    Abstract: High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an increased affinity for PD-L1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity PD-1 mimic polypeptide, which blocks the physiological binding interaction between PD-1 and its ligand PD-L1 and/or PD-L2.
    Type: Application
    Filed: August 7, 2015
    Publication date: February 11, 2016
    Inventors: Aaron Michael Ring, Andrew Kruse, Aashish Manglik, Irving L. Weissman, Roy Louis Maute, Melissa N. McCracken, Sydney Gordon
  • Publication number: 20150372956
    Abstract: A message processing system is disclosed herein. A client computing device may receive an electronic message from a server via a network and via a forwarding operation on a condition that the electronic message is approved to be forwarded to a recipient. The client computing device may then receive from the server a message that the electronic message is unapproved, wherein the message includes a URL to view the unapproved electronic message and the electronic message is stored on the server with an indication that the electronic message is unapproved. The client computing device may then receive a list of unapproved electronic messages to display, wherein associated with the list are selectable options including to send the unapproved electronic message, to add a sender of the unapproved electronic message to an approved sender list, and to delete the unapproved electronic message.
    Type: Application
    Filed: August 28, 2015
    Publication date: December 24, 2015
    Applicant: III Holdings 1, LLC
    Inventors: Sydney Gordon Low, William Dennis Lang
  • Patent number: 9124542
    Abstract: A message processing system, including an e-mail server for receiving and storing e-mails for a recipient, and an e-mail manager for processing e-mails for a recipient to determine if the e-mails are approved based on stored criteria, sending approved e-mails for the recipient to a location for access by the recipient, and storing and sending a notification to the recipient of unapproved messages.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: September 1, 2015
    Assignee: III Holdings 1, LLC
    Inventors: Sydney Gordon Low, William Dennis Lang
  • Publication number: 20140325003
    Abstract: A message processing system, including an e-mail server for receiving and storing e-mails for a recipient, and an e-mail manager for processing e-mails for a recipient to determine if the e-mails are approved based on stored criteria, sending approved e-mails for the recipient to a location for access by the recipient, and storing and sending a notification to the recipient of unapproved messages.
    Type: Application
    Filed: July 8, 2014
    Publication date: October 30, 2014
    Applicant: III Holdings 1, LLC
    Inventors: Sydney Gordon Low, William Dennis Lang
  • Publication number: 20140025815
    Abstract: A method, performed by a computer system, of providing usage data for a plurality of hyperlinks in a resource is disclosed. In one aspect, the method includes maintaining hyperlink usage data for each of the hyperlinks within the resource and adjusting a copy of the resource to incorporate the hyperlink usage data associated with each hyperlink, wherein the hyperlink usage data represents the number of times users have selected a hyperlink of the resource. The method also includes sending the adjusted copy of the resource to a networked device to provide a display representing the hyperlink usage data with each associated hyperlink. The hyperlink usage data is incorporated into the copy of the resource so as to be displayed adjacent to the corresponding hyperlinks of the resource.
    Type: Application
    Filed: September 24, 2013
    Publication date: January 23, 2014
    Applicant: Hitwise Pty. Ltd.
    Inventor: Sydney Gordon Low
  • Patent number: 8560666
    Abstract: A method for providing usage data for links in a resource is disclosed. The method involves maintaining a link usage data for each of the links within a resource, such as a web page, and adjusting a copy of the resource to incorporate the link usage data associated with each link. A user can access the adjusted copy of the resource from a device connected to a network, such as the Internet, to display the link usage data with each associated link. The link usage data can be collected for a selected period of time by the user.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: October 15, 2013
    Assignee: Hitwise Pty Ltd.
    Inventor: Sydney Gordon Low
  • Patent number: 8484456
    Abstract: An electronic messaging system, including: a first message transfer server for receiving a message for a party, mapping the destination address of the message to a trusted address for the party, and substituting the trusted address for the destination address; and a second message transfer server for establishing an authenticated transport session with the first message transfer server to receive the message and transfer the message to a location corresponding to the trusted address.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: July 9, 2013
    Assignee: Alien Camel Pty Ltd.
    Inventors: Sydney Gordon Low, Matthew Iain Walker
  • Publication number: 20130132495
    Abstract: A message processing system, including an e-mail server for receiving and storing e-mails for a recipient, and an e-mail manager for processing e-mails for a recipient to determine if the e-mails are approved based on stored criteria, sending approved e-mails for the recipient to a location for access by the recipient, and storing and sending a notification to the recipient of unapproved messages.
    Type: Application
    Filed: January 18, 2013
    Publication date: May 23, 2013
    Inventor: Sydney Gordon Low
  • Patent number: 8401531
    Abstract: A messaging service system, including a call component for receiving a voice call from a caller and transmitting call data associated with the call, the call data including caller identification (ID) data; and a subscription server for receiving the call data, causing the call component to send a subscription acceptance message to the caller, and storing the caller ID data in association with data representing a messaging service identified by the called number of the call data.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: March 19, 2013
    Assignee: redtxt.com.au Pty Ltd.
    Inventors: Sydney Gordon Low, Matthew Iain Walker, Peter Yandell
  • Patent number: 8359289
    Abstract: A method of handling messages determines if a message is approved for a recipient of the message. If the message is approved, the method processes the message for subsequent viewing by the recipient. If the message is unapproved, the method notifies the recipient and stores the message.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: January 22, 2013
    Assignee: Sydney Gordon Low
    Inventors: Sydney Gordon Low, William Dennis Lang