Abstract: A collar arranged to couple to a prosthetic component for implantation at the end of a long bone, the prosthetic component having a distal portion arranged to couple to the bone and a proximal neck portion arranged to couple to an articulation component. The collar comprises a plate including a neck hole to receive a neck portion, such that the collar can rotate about the neck portion. The collar further comprises a plurality of attachment portions for coupling the plate to bone fragments or soft tissues. The collar is lockable to the neck portion to prevent further rotation. A prosthesis comprising a combination of a collar, a prosthetic component and an articulation component, and a surgical method of using the collar are also disclosed.

Abstract: The present invention relates to the intravaginal use of sex steroid precursor (e.g. DHEA) for the reduction of the incidence or recurrence of breast cancer in postmenopausal women. The dosage of sex steroid precursor is limited to 25 mg per day or less. Further administration of selective estrogen receptor modulator is disclosed for the above-reduction.

Abstract: The present invention relates to the intravaginal use of sex steroid precursor (e.g. DHEA) for the reduction of the incidence or recurrence of breast cancer in postmenopausal women. The dosage of sex steroid precursor is limited to 25 mg per day or less. Further administration of selective estrogen receptor modulator is disclosed for the above-reduction.

Abstract: The present invention relates to the intravaginal use of sex steroid precursor (e.g. DHEA) for the reduction of the incidence or recurrence of breast cancer in postmenopausal women. The dosage of sex steroid precursor is limited to 25 mg per day or less. Further administration of selective estrogen receptor modulator is disclosed for the above-reduction.

Abstract: An implant (20), prosthesis and method of use are described. The implant comprises an articulation component (24) having a bearing surface (60) and a reverse surface (62) arranged to couple to a proximal neck portion (26) of an arthroplasty implant (22) coupled to a bone. A collar (28) is arranged to couple to the reverse surface of the articulation component. The collar defines a neck hole (70) arranged to pass around the coupling between the articulation component and the proximal neck portion of the arthroplasty implant. The collar and the articulation component comprise complementary coupling features to secure the collar to the articulation component. The collar further comprises a plurality of attachment portions (74) to couple the collar to bone fragments or soft tissues. The prosthesis comprises the implant and an arthroplasty implant having a distal portion arranged to be coupled to an end of a long bone and a proximal neck portion.

Abstract: A collar arranged to couple to a prosthetic component for implantation at the end of a long bone, the prosthetic component having a distal portion arranged to couple to the bone and a proximal neck portion arranged to couple to an articulation component. The collar comprises a plate including a neck hole to receive a neck portion, such that the collar can rotate about the neck portion. The collar further comprises a plurality of attachment portions for coupling the plate to bone fragments or soft tissues. The collar is lockable to the neck portion to prevent further rotation. A prosthesis comprising a combination of a collar, a prosthetic component and an articulation component, and a surgical method of using the collar are also disclosed.

Abstract: A collar arranged to couple to a prosthetic component for implantation at the end of a long bone, the prosthetic component having a distal portion arranged to couple to the bone and a proximal neck portion arranged to couple to an articulation component. The collar comprises a plate including a neck hole to receive a neck portion, such that the collar can rotate about the neck portion. The collar further comprises a plurality of attachment portions for coupling the plate to bone fragments or soft tissues. The collar is lockable to the neck portion to prevent further rotation. A prosthesis comprising a combination of a collar, a prosthetic component and an articulation component, and a surgical method of using the collar are also disclosed.

Abstract: Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low DHEA or low total androgens in susceptible warm-blooded animals including humans involving administration of an amount of a sex steroid precursor, particularly dehydroepiandrosterone (DHEA) and a selective estrogen receptor modulator (SERM) (particularly acolbifene), an antiestrogen or a prodrug of the two.

Abstract: A collar arranged to couple to a prosthetic component for implantation at the end of a long bone, the prosthetic component having a distal portion arranged to couple to the bone and a proximal neck portion arranged to couple to an articulation component. The collar comprises a plate including a neck hole to receive a neck portion, such that the collar can rotate about the neck portion. The collar further comprises a plurality of attachment portions for coupling the plate to bone fragments or soft tissues. The collar is lockable to the neck portion to prevent further rotation. A prosthesis comprising a combination of a collar, a prosthetic component and an articulation component, and a surgical method of using the collar are also disclosed.

Abstract: A collar arranged to couple to a prosthetic component for implantation at the end of a long bone, the prosthetic component having a distal portion arranged to couple to the bone and a proximal neck portion arranged to couple to an articulation component. The collar comprises a plate including a neck hole to receive a neck portion, such that the collar can rotate about the neck portion. The collar further comprises a plurality of attachment portions for coupling the plate to bone fragments or soft tissues. The collar is lockable to the neck portion to prevent further rotation. A prosthesis comprising a combination of a collar, a prosthetic component and an articulation component, and a surgical method of using the collar are also disclosed.

Abstract: An implant (20), prosthesis and method of use are described. The implant comprises an articulation component (24) having a bearing surface (60) and a reverse surface (62) arranged to couple to a proximal neck portion (26) of an arthroplasty implant (22) coupled to a bone. A collar (28) is arranged to couple to the reverse surface of the articulation component. The collar defines a neck hole (70) arranged to pass around the coupling between the articulation component and the proximal neck portion of the arthroplasty implant. The collar and the articulation component comprise complementary coupling features to secure the collar to the articulation component. The collar further comprises a plurality of attachment portions (74) to couple the collar to bone fragments or soft tissues. The prosthesis comprises the implant and an arthroplasty implant having a distal portion arranged to be coupled to an end of a long bone and a proximal neck portion.

Abstract: An implant, prosthesis and method of use are described. The implant comprises an articulation component having a bearing surface and a reverse surface arranged to couple to a proximal neck portion of an arthroplasty implant coupled to a bone. A collar is arranged to couple to the reverse surface of the articulation component. The collar defines a neck hole arranged to pass around the coupling between the articulation component and the proximal neck portion of the arthroplasty implant. The collar and the articulation component comprise complementary coupling features to secure the collar to the articulation component. The collar further comprises a plurality of attachment portions to couple the collar to bone fragments or soft tissues. The prosthesis comprises the implant and an arthroplasty implant having a distal portion arranged to be coupled to an end of a long bone and a proximal neck portion.

Abstract: An arthroplasty plate and method of use to repair a fractured end of a bone are described. The arthroplasty plate comprises a fixation plate arranged to be secured to a surface of a bone and a connector assembly comprising a barrel extending from the fixation plate and having a bore which opens through the fixation plate. A connector rod is arranged to slide within the bore of the barrel. An articulation component comprises a bearing surface coupled to or arranged to couple to an end of the connector rod which extends from the barrel away from the fixation plate. The connector assembly incorporates an adjustment mechanism arranged to cause the connector rod to slide into or out of the barrel and a locking mechanism arranged to lock the position of the connector rod within the barrel to rigidly space the articulation component apart from the fixation plate.

Abstract: A collar arranged to couple to a prosthetic component for implantation at the end of a long bone, the prosthetic component having a distal portion arranged to couple to the bone and a proximal neck portion arranged to couple to an articulation component. The collar comprises a plate including a neck hole to receive a neck portion, such that the collar can rotate about the neck portion. The collar further comprises a plurality of attachment portions for coupling the plate to bone fragments or soft tissues. The collar is lockable to the neck portion to prevent further rotation. A prosthesis comprising a combination of a collar, a prosthetic component and an articulation component, and a surgical method of using the collar are also disclosed.

Abstract: Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low DHEA or low total androgens in susceptible warm-blooded animals including humans involving administration of an amount of a sex steroid precursor, particularly dehydroepiandrosterone (DHEA) and a selective estrogen receptor modulator (SERM) (particularly acolbifene), an antiestrogen or a prodrug of the two.

Abstract: A collar arranged to couple to a prosthetic component for implantation at the end of a long bone, the prosthetic component having a distal portion arranged to couple to the bone and a proximal neck portion arranged to couple to an articulation component. The collar comprises a plate including a neck hole to receive a neck portion, such that the collar can rotate about the neck portion. The collar further comprises a plurality of attachment portions for coupling the plate to bone fragments or soft tissues. The collar is lockable to the neck portion to prevent further rotation. A prosthesis comprising a combination of a collar, a prosthetic component and an articulation component, and a surgical method of using the collar are also disclosed.

Abstract: Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low DHEA or low total androgens in susceptible warm-blooded animals including humans involving administration of an amount of a sex steroid precursor, particularly dehydroepiandrosterone (DHEA) and a selective estrogen receptor modulator (SERM) (particularly acolbifene), an antiestrogen or a prodrug of the two.

Abstract: An implant, prosthesis and method of use are described. The implant comprises an articulation component having a bearing surface and a reverse surface arranged to couple to a proximal neck portion of an arthroplasty implant coupled to a bone. A collar is arranged to couple to the reverse surface of the articulation component. The collar defines a neck hole arranged to pass around the coupling between the articulation component and the proximal neck portion of the arthroplasty implant. The collar and the articulation component comprise complementary coupling features to secure the collar to the articulation component. The collar further comprises a plurality of attachment portions to couple the collar to bone fragments or soft tissues. The prosthesis comprises the implant and an arthroplasty implant having a distal portion arranged to be coupled to an end of a long bone and a proximal neck portion.

Abstract: An implant (20), prosthesis and method of use are described. The implant comprises an articulation component (24) having a bearing surface (60) and a reverse surface (62) arranged to couple to a proximal neck portion (26) of an arthroplasty implant (22) coupled to a bone. A collar (28) is arranged to couple to the reverse surface of the articulation component. The collar defines a neck hole (70) arranged to pass around the coupling between the articulation component and the proximal neck portion of the arthroplasty implant. The collar and the articulation component comprise complementary coupling features to secure the collar to the articulation component. The collar further comprises a plurality of attachment portions (74) to couple the collar to bone fragments or soft tissues. The prosthesis comprises the implant and an arthroplasty implant having a distal portion arranged to be coupled to an end of a long bone and a proximal neck portion.

Abstract: A collar arranged to couple to a prosthetic component for implantation at the end of a long bone, the prosthetic component having a distal portion arranged to couple to the bone and a proximal neck portion arranged to couple to an articulation component. The collar comprises a plate including a neck hole to receive a neck portion, such that the collar can rotate about the neck portion. The collar further comprises a plurality of attachment portions for coupling the plate to bone fragments or soft tissues. The collar is lockable to the neck portion to prevent further rotation. A prosthesis comprising a combination of a collar, a prosthetic component and an articulation component, and a surgical method of using the collar are also disclosed.