Abstract: The present invention relates to a method and apparatus for pulverizing a material to produce a fine powdery material such as silica powder as a material for a filler for sealing semiconductors. It has a shell and a screw shaft mounted in the shell. A disk having an inverted conical bottom surface is coaxially secured to the bottom of the screw shaft. The disk serves to protect the blade of the screw shaft from wear. Also owing to the inverted conical bottom surface, a centripetal force acts on the screw shaft while in rotation, thus preventing it from running out of true. By providing a plurality of screw shafts in the shell, the fluid in the shell flows in a complicated manner, thus increasing the pulverizing efficiency. A partitioning plate formed with a hole in the upper or lower part thereof may be provided between the adjacent screw shafts to minimize the possibility of shortcircuiting of the material from the inlet of the shell to its outlet.

Abstract: Novel derivatives of glyoxal-2-oxim represented by the chemical formula ##STR1## wherein R is hydrogen or a lower alkyl or phenyl group, are provided in accordance with the present invention. These derivatives are prepared by reacting the corresponding isoxazole-5-carbaldehyde with nitromethane in the presence of a metal alkoxide, or the corresponding 5-acetylisoxazole with a nitrate. They have anti-inflammatory and/or analgesic activities.

Abstract: Novel derivatives of glyoxal-2-oxim represented by the chemical formula ##STR1## wherein R is hydrogen or a lower alkyl or phenyl group, are provided in accordance with the present invention. These derivatives are prepared by reacting the corresponding isoxazole-5-carbaldehyde with nitromethane in the presence of a metal alkoxide, or the corresponding 5-acetylisoxazole with a nitrite. They have anti-inflammatory and/or analgesic activities.

Abstract: Novel derivatives of glyoxal-2-oxim represented by the chemical formula ##STR1## wherein R is hydrogen or a lower alkyl or phenyl group, are provided in accordance with the present invention. These derivatives are prepared by reacting the corresponding isoxazole-5-carbaldehyde with nitromethane in the presence of a metal alkoxide, or the corresponding 5-acetylisoxazole with a nitrite. They have anti-inflammatory and/or analgesic activities.