Patents by Inventor Sz-Chin Steven LIN
Sz-Chin Steven LIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230330671Abstract: A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.Type: ApplicationFiled: June 28, 2023Publication date: October 19, 2023Inventors: Sz-chin Steven Lin, Richard Lemoine, Rajagopal Panchapakesan, Wesley A. Cox-Muranami, Darren Segale
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Patent number: 11724258Abstract: A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.Type: GrantFiled: May 23, 2022Date of Patent: August 15, 2023Assignee: ILLUMINA, INC.Inventors: Sz-Chin Steven Lin, Richard Lemoine, Rajagopal Panchapakesan, Wesley A. Cox-Muranami, Darren Segale
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Publication number: 20220387998Abstract: A cartridge assembly comprises a housing having an illumination chamber and a well plate. The well plate is maintained within the housing and has liquid wells to receive desired amounts of liquids. The well plate includes a fluidics analysis station aligned with the illumination chamber, and an interface window and interface ports located at the fluidics analysis station. The well plate includes a valve station and pump station. A piercer unit is provided in the housing and positioned proximate to the wells. The piercer unit includes a piercer element and is to be moved to a piercing position where the piercer element pierces a cover for the corresponding well. A pump assembly on the well plate at the pump station manages fluid flow through the channels between the pump station and the fluidics analysis station. The housing includes a flow cell chamber to receive a removable flow cell cartridge.Type: ApplicationFiled: August 15, 2022Publication date: December 8, 2022Inventors: Richard L. Lemoine, James Osmus, Sz-Chin Steven Lin, Beng Keong Ang
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Publication number: 20220371005Abstract: A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.Type: ApplicationFiled: August 3, 2022Publication date: November 24, 2022Applicant: Illumina, Inc.Inventors: Wesley A. COX-MURANAMI, Kay KLAUSING, Bradley Kent DREWS, Nicholas WATSON, Jennifer Olivia FOLEY, Murphy HITCHCOCK, Paul SANGIORGIO, Sz-Chin Steven LIN
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Patent number: 11458469Abstract: A cartridge assembly comprises a housing having an illumination chamber and a well plate. The well plate is maintained within the housing and has liquid wells to receive desired amounts of liquids. The well plate includes a fluidics analysis station aligned with the illumination chamber, and an interface window and interface ports located at the fluidics analysis station. The well plate includes a valve station and pump station. A piercer unit is provided in the housing and positioned proximate to the wells. The piercer unit includes a piercer element and is to be moved to a piercing position where the piercer element pierces a cover for the corresponding well. A pump assembly on the well plate at the pump station manages fluid flow through the channels between the pump station and the fluidics analysis station. The housing includes a flow cell chamber to receive a removable flow cell cartridge.Type: GrantFiled: June 17, 2019Date of Patent: October 4, 2022Assignees: ILLUMINA, INC., ILLUMINA SINGAPORE PTE. LTD.Inventors: Richard L. Lemoine, James Osmus, Sz-Chin Steven Lin, Beng Keong Ang
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Publication number: 20220280940Abstract: A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.Type: ApplicationFiled: May 23, 2022Publication date: September 8, 2022Inventors: Sz-Chin Steven Lin, Richard Lemoine, Rajagopal Panchapakesan, Wesley A. Cox-Muranami, Darren Segale
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Patent number: 11426723Abstract: A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.Type: GrantFiled: September 26, 2019Date of Patent: August 30, 2022Assignee: Illumina, Inc.Inventors: Wesley A. Cox-Muranami, Kay Klausing, Bradley Kent Drews, Nicholas Watson, Jennifer Olivia Foley, Murphy Hitchcock, Paul Sangiorgio, Sz-Chin Steven Lin
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Patent number: 11351541Abstract: A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.Type: GrantFiled: April 2, 2018Date of Patent: June 7, 2022Assignee: Illumina, Inc.Inventors: Sz-Chin Steven Lin, Richard Lemoine, Rajagopal Panchapakesan, Wesley A. Cox-Muranami, Darren Segale
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Publication number: 20210299661Abstract: A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path.Type: ApplicationFiled: April 2, 2018Publication date: September 30, 2021Inventors: Sz-Chin Steven LIN, Richard LEMOINE, Rajagopal PANCHAPAKESAN, Wesley A. COX-MURANAMI, Darren SEGALE
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Publication number: 20200108386Abstract: A method for testing a microfluidic device includes interfacing a microfluidic device to a fluidic parameter testing system. The microfluidic device has an internal rotary valve and internal fluidic channels. Each channel has a port with a predetermined port position that the rotary valve is to align to in order to select any one of a plurality of reagents which flow through the channels. The rotary valve is rotated via the testing system to a plurality of rotary valve position of the rotary valve. A fluidic parameter of the microfluidic device is measured at each rotary valve position. The fluidic parameter is mapped relative to the rotary valve positions. It is determined from the mapping if the rotary valve aligns with each of the predetermined port positions for a flow of the reagents through the channels.Type: ApplicationFiled: April 2, 2018Publication date: April 9, 2020Inventors: Wesley A. COX-MURANAMI, Sz-Chin Steven LIN, Rajagopal PANCHAPAKESAN, Darren SEGALE, Richard LEMOINE
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Publication number: 20200108382Abstract: A system includes a fluidic device, a flow control valve, a first reagent fluid reservoir fluidly connectable to the fluidic device by the flow control valve, a first fluid buffer reservoir fluidly connectable to the fluidic device by the flow control valve, and a common fluid buffer source fluidly connectable to the fluidic device by the flow control valve. The flow control valve permits flow comprising: (i) flow from the first reagent fluid reservoir to the fluidic device, (ii) flow from the common fluid buffer source to the fluidic device, (iii) flow from the fluidic device to the first fluid buffer reservoir, (iv) flow from the first reagent fluid reservoir to the fluidic device, and (v) flow from the first fluid buffer reservoir to the fluidic device.Type: ApplicationFiled: September 26, 2019Publication date: April 9, 2020Applicant: Illumina, Inc.Inventors: Wesley A. Cox-Muranami, Kay Klausing, Bradley Kent Drews, Nicholas Watson, Jennifer Olivia Foley, Murphy Hitchcock, Paul Sangiorgio, Sz-Chin Steven Lin
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Patent number: 10576471Abstract: Disclosed herein are devices, systems and methods for conducting a reaction using electrowetting in a vertical or substantially vertical position. Some embodiments disclosed herein provide fluidic cartridges for use in a substantially vertical position comprising: (a) a front substrate; (b) a back substrate; (c) a droplet operations gap formed between the front substrate and the back substrate; and (d) a plurality of electrodes on the front substrate or the back substrate, wherein the plurality of electrodes are configured to transport a droplet along a substantially vertical plane defined by the front substrate and the back substrate.Type: GrantFiled: March 18, 2016Date of Patent: March 3, 2020Assignee: ILLUMINA, INC.Inventors: James Osmus, Richard L. Lemoine, Jian Gong, Sz-Chin Steven Lin
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Publication number: 20190299210Abstract: A cartridge assembly comprises a housing having an illumination chamber and a well plate. The well plate is maintained within the housing and has liquid wells to receive desired amounts of liquids. The well plate includes a fluidics analysis station aligned with the illumination chamber, and an interface window and interface ports located at the fluidics analysis station. The well plate includes a valve station and pump station. A piercer unit is provided in the housing and positioned proximate to the wells. The piercer unit includes a piercer element and is to be moved to a piercing position where the piercer element pierces a cover for the corresponding well. A pump assembly on the well plate at the pump station manages fluid flow through the channels between the pump station and the fluidics analysis station. The housing includes a flow cell chamber to receive a removable flow cell cartridge.Type: ApplicationFiled: June 17, 2019Publication date: October 3, 2019Inventors: Richard L. Lemoine, James Osmus, Sz-Chin Steven Lin, Beng Keong Ang
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Patent number: 10343160Abstract: A cartridge assembly that comprises a housing, including a flow cell chamber to receive a flow cell, and a well plate having liquid wells to receive desired amounts of liquids. The well plate includes a valve station, a pump station and a fluidics analysis station, and channels associated therewith. A pump assembly to manage fluid flow through the channels between the pump station and the fluidics analysis station. A rotary valve assembly that includes a rotor shaft and rotor valve positioned to rotate about a rotational axis and to selectively couple the wells to the pump station. The rotor shaft includes a dual spline configuration at the distal end thereof. The dual spline configuration has first and second sets of splines. The first set of splines forms a drive interface and the second set of splines forms a position encoding interface.Type: GrantFiled: October 11, 2017Date of Patent: July 9, 2019Assignees: ILLUMINA, INC., ILLUMINA, SINGAPORE PTE. LTD.Inventors: Richard L. Lemoine, James Osmus, Sz-Chin Steven Lin, Beng Keong Ang
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Publication number: 20180117587Abstract: A cartridge assembly that comprises a housing, including a flow cell chamber to receive a flow cell, and a well plate having liquid wells to receive desired amounts of liquids. The well plate includes a valve station, a pump station and a fluidics analysis station, and channels associated therewith. A pump assembly to manage fluid flow through the channels between the pump station and the fluidics analysis station. A rotary valve assembly that includes a rotor shaft and rotor valve positioned to rotate about a rotational axis and to selectively couple the wells to the pump station. The rotor shaft includes a dual spline configuration at the distal end thereof. The dual spline configuration has first and second sets of splines. The first set of splines forms a drive interface and the second set of splines forms a position encoding interface.Type: ApplicationFiled: October 11, 2017Publication date: May 3, 2018Inventors: Richard L. Lemoine, James Osmus, Sz-Chin Steven Lin, Beng Keong ANG
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Publication number: 20180111126Abstract: Disclosed herein are devices, systems and methods for conducting a reaction using electrowetting in a vertical or substantially vertical position. Some embodiments disclosed herein provide fluidic cartridges for use in a substantially vertical position comprising: (a) a front substrate; (b) a back substrate; (c) a droplet operations gap formed between the front substrate and the back substrate; and (d) a plurality of electrodes on the front substrate or the back substrate, wherein the plurality of electrodes are configured to transport a droplet along a substantially vertical plane defined by the front substrate and the back substrate.Type: ApplicationFiled: March 18, 2016Publication date: April 26, 2018Applicant: ILLUMINA, INC.Inventors: James OSMUS, Richard L. LEMOINE, Jian GONG, Sz-Chin Steven LIN