Patents by Inventor Takafumi Nakamura

Takafumi Nakamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200200197
    Abstract: A sealing device includes: an annular seal that is disposed on an outer periphery of a rod of a hydraulic cylinder further on a side of an extending direction than a cylinder head of the hydraulic cylinder and that has a pair of opposing first facing surfaces; a holding member disposed on an outer periphery of the seal; and a fixing member disposed on an outer periphery of the holding member, the fixing member having a tapered inner surface that contacts an outer surface of the holding member and that has an inner diameter increasing toward a retracting direction.
    Type: Application
    Filed: January 17, 2019
    Publication date: June 25, 2020
    Inventors: Yoshio Hoshino, Hisatoshi Odaka, Kenichi Ajiki, Takafumi Nakamura, Yoshiyuki Abe
  • Patent number: 10514327
    Abstract: An autosampler includes a pressure release operation unit for performing, by controlling operation of a needle drive mechanism and a switching mechanism, before a tip end of a needle is pulled out from an injection port following a state where a sampling channel is disposed between a feeding device and an analytical column, a pressure release operation of switching the switching mechanism in such a way that the sampling channel is not disposed between the feeding device and the analytical column and a system including the sampling channel is made an open system, and of performing standby until a pressure inside the sampling channel is returned to atmospheric pressure.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: December 24, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Takafumi Nakamura
  • Publication number: 20190367886
    Abstract: The present invention has an object to provide a vaccinia virus expressing a foreign gene and capable of killing cancer cells, and a cancer therapy drug comprising the vaccinia virus. The present invention relates to a vaccinia virus, wherein a suicide gene as a foreign gene selected from the group consisting of cytosine deaminase (CD) gene, uracil phosphoribosyltransferase (UPRT) gene, and herpes simplex virus thymidine kinase (HSV-tk) gene is introduced.
    Type: Application
    Filed: July 13, 2017
    Publication date: December 5, 2019
    Applicant: National University Corporation Tottori Tottori University
    Inventors: Takafumi Nakamura, Motomu Nakatake, Hajime Kurosaki, Kousuke Horita
  • Publication number: 20190359010
    Abstract: A pneumatic tire comprising a magnetic body provided in a tread portion, a magnetic sensor for detecting a magnetic flux density of a magnetic field formed by the magnetic body disposed at a radially inward position corresponding to the magnetic body, wherein a magnetic body is formed by dispersing powdery particles of a hard magnetic material in a polymeric material and is magnetized in one direction and is provided in the tread portion so that the magnetization direction and the tire radial direction coincide with each other; a method of tire wear measuring for measuring a wear state in the pneumatic tire; a tire wear measuring system for measuring a wear state in the pneumatic tire; and a sensor module installable inside the pneumatic tire.
    Type: Application
    Filed: May 16, 2019
    Publication date: November 28, 2019
    Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., ALPS ALPINE CO., LTD.
    Inventors: Hiroto Setokawa, Jun Ochi, Tokuo Nakamura, Takafumi Noguchi
  • Publication number: 20190352514
    Abstract: Disclosed herein is an antifouling coating composition containing a resin composition and an antifouling agent, where the resin composition includes a polymer (A) containing at least one monomer-derived structural unit having the structure represented by formula (1), (2) or (3) below, and after the resin composition is stored at 40° C. for 30 days, the decomposition rate of the structure represented by formula (1), (2) or (3) in the polymer (A) is 20% or lower.
    Type: Application
    Filed: August 1, 2019
    Publication date: November 21, 2019
    Applicant: Mitsubishi Chemical Corporation
    Inventors: Sho Katsumata, Kana Taniguchi, Junichi Nakamura, Masatoshi Ura, Yoshihiro Kamon, Takafumi Asai, Ryuichi Ansai
  • Patent number: 10478943
    Abstract: A grinder (100) includes a motor (12), a housing (4, 6, 30), a spindle (24), a first cover (120), and a second cover (170). The spindle protrudes downward from the housing, is driven by the motor, and thereby rotates. The first cover is provided in the circumferential direction of the spindle, is fixed to the housing, and at least partially covers a tool accessory (40), which is mounted on the spindle, from above. The second cover is detachably mounted on the housing (6) independently of the first cover.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: November 19, 2019
    Assignee: MAKITA CORPORATION
    Inventors: Shin Nakamura, Takafumi Kotsuji, Ken Goto, Akira Mizutani, Junya Ishikawa
  • Publication number: 20190336552
    Abstract: The present invention provides a genetically recombinant vaccinia virus effective in preventing or treating cancer. Specifically, the present invention provides a recombinant vaccinia virus lacking functions of VGF and O1L and having a gene encoding B5R in which an SCR domain has been deleted. Specifically, the present invention provides a vaccinia virus comprising two polynucleotides, a polynucleotide encoding IL-7 and a polynucleotide encoding IL-12; a combination kit of two vaccinia viruses, a vaccinia virus comprising a polynucleotide encoding IL-7 and a vaccinia virus comprising a polynucleotide encoding IL-12; and use of the two vaccinia viruses in combination.
    Type: Application
    Filed: April 8, 2019
    Publication date: November 7, 2019
    Applicants: Astellas Pharma Inc., National University Corporation Tottori University
    Inventors: Takafumi Nakamura, Hajime KUROSAKI, Motomu NAKATAKE
  • Patent number: 10443085
    Abstract: Disclosed is a method for detecting a nucleic acid using a substance that suppresses, in the labeling step of the post-staining method, detachment of a target nucleic acid that has once hybridized with a capture probe immobilized on a support, which method enables detection of the target nucleic acid with a sensitivity equivalent to or higher than that achieved by a method using sodium ion even in cases where the substance is used at a lower concentration. The method for detecting a nucleic acid comprises the steps of: (1) hybridizing a capture probe with a target nucleic acid to form a double-stranded nucleic acid; bringing the formed double-stranded nucleic acid into contact with a solution containing a labeling substance and a divalent metal cation at a concentration of not less than 10 mM to introduce the labeling substance into the double-stranded nucleic acid; and detecting the labeling substance introduced into the double-stranded nucleic acid.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: October 15, 2019
    Assignee: TORAY INDUSTRIES, INC.
    Inventors: Fumio Nakamura, Yoji Ueda, Takafumi Arike
  • Patent number: 10421760
    Abstract: Provided are a novel compound or a salt thereof, and a pharmaceutical composition comprising the same, which selectively and strongly inhibit JAK3, exhibit an excellent activity for suppressing the growth of human peripheral blood monocytes and an excellent oral absorbability, and exhibits an activity of inhibiting IL-2-induced IFN-? production in vivo. A compound represented by formula (I) [wherein X represents —CH?CH—, —NH—, a sulfur atom or an oxygen atom; and n represents an integer of 0 to 2], or a salt thereof.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: September 24, 2019
    Assignee: TAIHO PHARMACEUTICAL CO., LTD.
    Inventors: Masayuki Nakamura, Hiroyoshi Yamanaka, Morihiro Mitsuya, Takafumi Harada
  • Publication number: 20190268679
    Abstract: The waterproof sound-transmissive cover is characterized by providing a frequency response curve with a difference between a maximum sound pressure level and a minimum sound pressure level of 13.0 dB or less in the range of frequencies from 3 kHz to 8 kHz, and an insertion loss at 1 kHz of less than 14.0 dB, and said cover comprising: a porous film having (1) a water pressure resistance measured according to JIS L1092 water penetration test method B (high pressure method) of 20 kPa or more, and air permeability measured according to JIS L1096 method A (Frazier type method) of 3.0 cc/cm2·sec or more, and (2) a tensile strength measured according to ASTM standards D412 of 5.5N or more.
    Type: Application
    Filed: July 7, 2017
    Publication date: August 29, 2019
    Inventors: Yasuhiro Kurihara, Ryan Kenaley, Nobuyuki Osugi, Takayuki Saeki, Ryosuke Nakamura, Takafumi Namba
  • Publication number: 20190246906
    Abstract: In an optical coherence tomography apparatus that generates a full-color optical coherence tomographic image, an image generation unit includes a correction processing unit that calculates an attenuation related value related to attenuation of signal intensity of the interference light of three R, G, and B colors in a first depth region and corrects the signal intensity of a second depth region deeper than the first depth region according to the attenuation related value to calculate a correction signal for the interference light and generates a full-color optical coherence tomographic image using the correction signals calculated for each of R, G, and B.
    Type: Application
    Filed: April 25, 2019
    Publication date: August 15, 2019
    Applicant: FUJIFILM Corporation
    Inventors: Sohichiro NAKAMURA, Heijiro Hirayama, Takafumi Noguchi
  • Publication number: 20190253640
    Abstract: To improve user operability. Provided is a Next change operating section that receives a changing operation on each item in a Next control data set being in a control state of a Next-use M/E of a switcher (vision mixer). When a changing operation is received in the Next change operating section, that is, when there is a changing operation, a control section changes contents of the Next control data set, and in accordance with the changed contents of the Next control data set, sends a control signal concerning the Next-use M/E to the switcher. A user can simply and easily change the contents of the Next control data set by operating the Next change operating section, and operability can be improved.
    Type: Application
    Filed: July 19, 2017
    Publication date: August 15, 2019
    Inventors: SENSABURO NAKAMURA, HIDEHITO YAKUSHIJI, NORIMASA OZAKI, TAKAFUMI ITO, NAOMI EGASHIRA
  • Patent number: 10370647
    Abstract: It is an object of the present invention to provide utilization of a UCA1 gene that is a host regulatory factor that enhances replication and/or propagation of a vaccinia virus, in order to effectively carry out cancer virotherapy using the vaccinia virus. The present invention relates to: a method for predicting and evaluating the cancer therapeutic effects of a vaccinia virus, which comprises measuring the expression of a UCA1 gene in the cancer cells of a cancer patient, and then predicting that a vaccinia virus exhibits cancer therapeutic effects on the patient, when the UCA1 gene has been expressed therein; and a vaccinia virus into which a UCA1 gene has been expressibly introduced.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: August 6, 2019
    Assignee: National University Corporation Tottori University
    Inventors: Takafumi Nakamura, Kousuke Horita, Hajime Kurosaki, Motomu Nakatake
  • Publication number: 20190025161
    Abstract: An autosampler includes a pressure release operation unit for performing, by controlling operation of a needle drive mechanism and a switching mechanism, before a tip end of a needle is pulled out from an injection port following a state where a sampling channel is disposed between a feeding device and an analytical column, a pressure release operation of switching the switching mechanism in such a way that the sampling channel is not disposed between the feeding device and the analytical column and a system including the sampling channel is made an open system, and of performing standby until a pressure inside the sampling channel is returned to atmospheric pressure.
    Type: Application
    Filed: July 18, 2017
    Publication date: January 24, 2019
    Applicant: SHIMADZU CORPORATION
    Inventor: Takafumi NAKAMURA
  • Publication number: 20180208904
    Abstract: It is an object of the present invention to provide utilization of a UCA1 gene that is a host regulatory factor that enhances replication and/or propagation of a vaccinia virus, in order to effectively carry out cancer virotherapy using the vaccinia virus. The present invention relates to: a method for predicting and evaluating the cancer therapeutic effects of a vaccinia virus, which comprises measuring the expression of a UCA1 gene in the cancer cells of a cancer patient, and then predicting that a vaccinia virus exhibits cancer therapeutic effects on the patient, when the UCA1 gene has been expressed therein; and a vaccinia virus into which a UCA1 gene has been expressibly introduced.
    Type: Application
    Filed: July 22, 2016
    Publication date: July 26, 2018
    Inventors: Takafumi Nakamura, Kousuke Horita, Hajime Kurosaki, Motomu Nakatake
  • Patent number: 10023284
    Abstract: An outboard motor includes an electric power source, a mechanical power source auxiliary machine, an electric circuit, an electric supply port, and a switch. The mechanical power source auxiliary machine assists driving a mechanical power source. The electric circuit electrically connects the electric power source and the mechanical power source auxiliary machine. The electric supply port is electrically connected to the electric power source through the electric circuit, and supplies an electric power to an accessory device to be connected thereto. The switch is disposed between the electric power source and the electric supply port in the electric circuit, and is switchable between an on state and an off state. The switch allows a flow of an electric current when switched to the on state, and interrupts the flow of the electric current when switched to the off state.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: July 17, 2018
    Assignee: YAMAHA HATSUDOKI KABUSHIKI KAISHA
    Inventors: Takafumi Nakamura, Yuki Yamaguchi
  • Publication number: 20180136174
    Abstract: A preparative chromatograph for collecting target components in a sample temporally separated in a column of a chromatograph in respective preparative containers is provided with: a detection unit having a flow cell accommodated in a housing and a detector for detecting a component that passes through the flow cell; a first pipe that connects the column and an inlet end of the flow cell; a flow path switching unit accommodated in the housing and configured to selectively flow the components that passed through the flow cell through a preparative flow path that is a flow path connected to the preparative containers or a waste liquid flow path; and a second pipe accommodated in the housing and connecting an outlet end of the flow cell and the flow path switching unit.
    Type: Application
    Filed: June 1, 2015
    Publication date: May 17, 2018
    Inventors: Takafumi Nakamura, Tadayuki Yamaguchi, Yusuke Nagai
  • Publication number: 20180058586
    Abstract: A buffer ring includes an annular body portion 11 that makes close contact with a side wall face 131b of an annular groove 131; an inner peripheral lip 12 that extends toward a sealed fluid side O from an inner peripheral end portion of the body portion 11; and an outer peripheral lip 13 that extends toward the sealed fluid side O from an outer peripheral end portion of the body portion 11 and having an outer peripheral end portion making close contact with a groove bottom face 131a of the annular groove 131, the outer peripheral lip 13 being lower in stiffness than the inner peripheral lip 12, wherein a plurality of protrusions 14 that make close contact with the groove bottom face 131a of the annular groove 131 are provided on an outer peripheral face of the body portion 11 at intervals in a circumferential direction.
    Type: Application
    Filed: October 24, 2017
    Publication date: March 1, 2018
    Inventor: Takafumi NAKAMURA
  • Publication number: 20170340687
    Abstract: The present invention provides a genetically recombinant vaccinia virus effective in preventing or treating cancer. Specifically, the present invention provides a vaccinia virus comprising two polynucleotides, a polynucleotide encoding IL-7 and a polynucleotide encoding IL-12; a combination kit of two vaccinia viruses, a vaccinia virus comprising a polynucleotide encoding IL-7 and a vaccinia virus comprising a polynucleotide encoding IL-12; and use of the two vaccinia viruses in combination.
    Type: Application
    Filed: July 31, 2017
    Publication date: November 30, 2017
    Applicants: Astellas Pharma Inc., National University Corporation Tottori University
    Inventors: Shinsuke Nakao, Tatsuya Kawase, Takafumi Nakamura
  • Patent number: 9809803
    Abstract: This invention provides a vaccinia virus that grows specifically in a cancer cell and damages such cancer cell and the use of such virus for treatment of cancer. Such mitogen-activated protein kinase-dependent vaccinia virus strain lacks functions of vaccinia virus growth factor (VGF) and O1L, it does not grow in normal cells but grows specifically in cancer cells, and it has oncolytic properties that specifically damage cancer cells.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: November 7, 2017
    Assignees: National University Corporation Tottori University, The Chemo-Sero-Therapeutic Research Institute
    Inventor: Takafumi Nakamura