Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: RQ-POLY-Xr-TLR7/8 AG)q??Formula I or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist.

Abstract: An electron tube includes a housing having a window having an electromagnetic wave transmitting property, an electron emission plate disposed inside the housing, the electron emission plate emitting electrons, and a holding member disposed inside the housing and configured to hold the electron emission plate and to apply a voltage to the electron emission plate. The electron emission plate has a first main surface and a second main surface facing each other. The holding member has a base portion being in contact with the first main surface, and a plurality of electron emission plate biasing portions which are in contact with an edge of the second main surface and are configured to elastically bias the electron emission plate to the base portion. The holding member is electrically connected to the second main surface through the plurality of electron emission plate biasing portions.

Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: (I) or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist. Also provided is a method of administering to a patient having cancer (a) an IL-2R?-activating amount of a long-acting, IL-2R?-selective agonist; and (b) a Toll-like receptor agonist such as a conjugate as described above, as well as related compositions, kits and methods.

Abstract: To reliably and efficiently detect an event. An imaging device includes: a plurality of photoelectric conversion elements each of which is configured to photoelectrically convert incident light to generate an electric signal; a plurality of detectors each of which is configured to output a detection signal in a case where an absolute value of an amount of change in the electric signal generated by each of the plurality of photoelectric conversion elements exceeds a predetermined threshold value; and a threshold value adjustment unit configured to adjust the threshold value on the basis of a detection situation of the respective detection signals from the plurality of detectors.

Abstract: There is provided a signal processing device, a signal processing method, and a detection sensor that enable detection of flicker information from an output indicating a luminance change. The signal processing device includes: a count unit that counts a first count number, which is a count number of pixels in which a first luminance change in a positive direction is detected, and a second count number, which is a count number of pixels in which a second luminance change in a negative direction is detected, in an image output from alight receiving unit at a predetermined frame rate and indicating a luminance change; a coefficient generation unit that generates a coefficient corresponding to a time at which the luminance change is detected; and an integrating unit that integrates a multiplication result of the count number of the pixels and the coefficient. The present technology can be applied to, for example, an event detection sensor or the like.

Abstract: Provided are methods and compositions directed to the treatment of an individual having cancer by (i) administering to the individual an adoptive cellular immunotherapy composition comprising CAR T cells and (ii) administering to the individual an interleukin-15 receptor agonist, such as, for example, a long-acting interleukin-15 receptor agonist.

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

Abstract: There is no possibility of the occurrence of an unnecessary event.

Abstract: A temperature detector (201) of an input unit (200) acquires a temperature of the input unit (200). A temperature detector (301) of an output unit (300) acquires a temperature of the output unit (300). When the temperature of the input unit (200) or the output unit (300) satisfies a preset condition, an input/output manager (101) of the CPU unit (100) controls passage/blockage of a signal from the detector (901) to the input unit (200) or a signal from the output unit (300) to a control target device (902) in accordance with preset content of signal input/output restriction.

Abstract: The instant disclosure provides a combination treatment, composition and kit comprising (a) a long-acting IL-15 receptor agonist and (b) one or more antibodies (mAb) targeting a tumor antigen, related methods of preparation and use, for example, in the treatment of conditions responsive to therapy effective to provide, for example, sustained immune activation and/or anti-tumor activity.

Abstract: A game device for playing a game includes a first display, a computing device, and a storage medium containing program instructions stored therein, execution of which by the computing device causes the game device to provide the functions of: obtaining item information including a game character which is used by the user in the video game, from a user item, receiving an input of an operation for the video game from the user, displaying a notification image for notifying the user of a timing of a first operation on the first display, while displaying a first animation that includes a plurality of frames, and in response to the reception of a first operation by the operation input unit during the displaying of the first animation, stopping displaying the rest of frames of the first animation after a timing at which the first operation is received.

Abstract: A temperature detector (201) of an input unit (200) acquires a temperature of the input unit (200). A temperature detector (301) of an output unit (300) acquires a temperature of the output unit (300). When the temperature of the input unit (200) or the output unit (300) satisfies a preset condition, an input/output manager (101) of the CPU unit (100) controls passage/blockage of a signal from the detector (901) to the input unit (200) or a signal from the output unit (300) to a control target device (902) in accordance with preset content of signal input/output restriction.

Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: (I) or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist. Also provided is a method of administering to a patient having cancer (a) an IL-2R?-activating amount of a long-acting, IL-2R?-selective agonist; and (b) a Toll-like receptor agonist such as a conjugate as described above, as well as related compositions, kits and methods.

Abstract: A workpiece for a fuel injection component is made of a steel having compositions, by mass %, of C: 0.08 to 0.16%, Si: 0.10 to 0.30%, Mn: 1.00 to 2.00%, S: 0.005 to 0.030%, Cu: 0.01 to 0.30%, Ni: 0.40 to 1.50%, Cr: 0.50 to 1.50%, Mo: 0.30 to 0.70%, V: 0.10 to 0.40%, s-Al: 0.001 to 0.100%, and Fe and unavoidable impurities as remaining components. After heating the workpiece to a temperature of 950° C. or more and 1350° C. or less, the workpiece is subjected to a hot forging, and thereafter cooled at an average cooling rate of 0.1° C./sec. or more in a temperature range from 800° C. to 500° C., and at the average cooling rate of 0.02° C./sec. or more and 10° C./sec. or less in the subsequent temperature range from 500° C. to 300° C. to set an area ratio of a bainite structure after hot forging to 85% or more.

Abstract: A slag volume evaluation method for a molten metal surface includes calculating an approximation curve indicating a correspondence between a thickness of slag and a density parameter in advance by measuring thicknesses of a plurality of pieces of the slag which float on a surface of a molten metal in a container and differ from each other in thickness, and calculating a value of the density parameter which is correlated to a density in a pixel region corresponding to the plurality of pieces of the slag in a captured image of a molten metal surface in the container; and calculating a volume of the slag by calculating and integrating the thickness of the slag for each of pixels constituting the captured image obtained by capturing an image of the molten metal surface which is an evaluation target, according to a value of the density parameter of each of the pixels and the approximation curve.

Abstract: The present invention provides an age hardening type bainitic microalloyed steel having a composition which includes, in terms of mass %: 0.06-0.35% of C; 0.01-2.00% of Si; 0.10-3.00% of Mn; 0.001-0.200% of S; 0.001-2.00% of Cu; 0.40-3.00% of Ni; 0.10-3.00% of Cr; 0.10-1.00% of Mo; 0.10-1.00% of V; and 0.001-0.100% of s-Al, with the remainder being Fe and unavoidable impurities, and which satisfies a value of the following expression (1) to be 20 or larger and a value of the following expression (2) to be 0.82 or larger: 3×[C]+10×[Mn]+2×[Cu]+2×[Ni]+12×[Cr]+9×[Mo]+2×[V]??expression (1); 1.66×[C]+0.18×[Si]+0.27×[Mn]+0.09×[Ni]+0.32×[Cr]+0.34×[Mo]+0.44×[V]??expression (2), in which each [ ] in the expression (1) and the expression (2) indicates a content of the element shown therein in terms of mass %.

Abstract: A game device for playing a game includes a first display having a first display area, and being configured to display images for the game in the first display area, the first display area including an operation area on which a user item of a user is movably placeable, a computing device, and a storage medium containing program instructions stored therein, execution of which by the computing device causes the game device to provide the functions of: obtaining item information from the user item, the item information including a game character that is used by the user in the game, executing the game using the item information, and controlling displaying of the first display, by causing an associated image that is associated with the user item that has been movably placed on the operation area to display in the first display area.

Abstract: The present technology relates to a distance measuring apparatus, a distance measuring method, and a program that enable accurate measurement of the distance to a target.

Abstract: A slag volume evaluation method for a molten metal surface includes calculating an approximation curve indicating a correspondence between a thickness of slag and a density parameter in advance by measuring thicknesses of a plurality of pieces of the slag which float on a surface of a molten metal in a container and differ from each other in thickness, and calculating a value of the density parameter which is correlated to a density in a pixel region corresponding to the plurality of pieces of the slag in a captured image of a molten metal surface in the container; and calculating a volume of the slag by calculating and integrating the thickness of the slag for each of pixels constituting the captured image obtained by capturing an image of the molten metal surface which is an evaluation target, according to a value of the density parameter of each of the pixels and the approximation curve.

Abstract: A method of detecting slag in a molten steel flow includes an image capturing step of sequentially capturing a molten steel flow which is directed from a converter toward a ladle and includes molten steel and slag to acquire a plurality of captured images of the molten steel flow, a histogram creation step of creating a histogram for each captured image, a maximum peak point detection step of detecting a maximum peak point, in which the number of pixels is an absolute maximum value, for each histogram, and a maximum peak point type determination step of determining to which of the slag or the molten steel the maximum peak point of each histogram corresponds.