Patents by Inventor Takaki Hiwasa

Takaki Hiwasa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210373032
    Abstract: The present invention provides a method for acquiring data relating to the onset of cerebral infarction, characterized in that the method includes determining the level of an antibody to DIDO1 protein or a portion thereof, and/or the level of an antibody to CPSF2 protein or a portion thereof, the antibody or antibodies being present in a body fluid sample collected from a living body. The invention also provides a kit for acquiring data for carrying out the method of the present invention. The invention can accurately discern signs linked to the onset of cerebral infarction.
    Type: Application
    Filed: November 22, 2018
    Publication date: December 2, 2021
    Applicants: FUJIKURA KASEI CO., LTD., NATIONAL CANCER CENTER, UNIVERSITY OF TSUKUBA, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY, OSAKA UNIVERSITY
    Inventors: Hideyuki KURODA, Rika NAKAMURA, Go TOMIYOSHI, Takaki HIWASA, Kazumasa YAMAGISHI, Shoichiro TSUGANE, Norie SAWADA, Hiroyasu ISO
  • Publication number: 20190277860
    Abstract: Objects of the present invention are to find a marker by which progression of arteriosclerosis can be directly grasped, to thereby provide motivation for prevention or treatment of arteriosclerosis itself, and to provide means for accurately grasping condition of arteriosclerosis-related disease including arteriosclerotic disease. The invention provides a method for acquiring data on progression of arteriosclerosis, the method including determining a level of an antibody against SH3BP5 protein or a part thereof in a body fluid sample collected from a biological body, and a data acquisition kit for performing the data acquisition method.
    Type: Application
    Filed: November 10, 2017
    Publication date: September 12, 2019
    Applicants: FUJIKURA KASEI CO., LTD., National University Corporation Chiba University
    Inventors: Hideyuki KURODA, Rika NAKAMURA, Go TOMIYOSHI, Takaki HIWASA
  • Publication number: 20170343547
    Abstract: The present inventors have surprisingly found that a deoxyhypusine synthase (DHPS) gene, which was previously reported to correlate with prostate cancer and cervical cancer, is highly responsive to arteriosclerosis or digestive system cancer, whereby the gene can be used as a desired marker for arteriosclerosis or digestive system cancer. The present invention has been accomplished on the basis of this finding. Specifically, the present invention provides a method for determining arteriosclerosis or digestive system cancer, which method includes detecting expression of a deoxyhypusine synthase gene in a test sample (preferably a blood sample), and determining arteriosclerosis or digestive system cancer of a test subject from which the test sample has been obtained, on the basis of an increase in the gene expression as an index.
    Type: Application
    Filed: November 5, 2015
    Publication date: November 30, 2017
    Applicants: FUJIKURA KASEI CO., LTD., National University Corporation Chiba University
    Inventors: Rika NAKAMURA, Hideyuki KURODA, Go TOMIYOSHI, Takaki HIWASA, Masaki TAKIGUCHI, Naokatsu SAEKI
  • Patent number: 9366681
    Abstract: Disclosed are: a polypeptide marker for diagnosing arteriosclerosis; a gene marker for diagnosing arteriosclerosis; an antibody; a probe for detecting an arteriosclerosis marker gene; a DNA microarray or a DNA chip for detecting an arteriosclerosis marker gene; a method for detecting arteriosclerosis; and a kit for diagnosing arteriosclerosis; with which an arteriosclerotic lesion can be detected with much improved accuracy.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: June 14, 2016
    Assignees: Fujikura Kasei Co., Ltd., National University Corporation Chiba University
    Inventors: Rika Nakamura, Hideyuki Kuroda, Go Tomiyoshi, Takaki Hiwasa, Masaki Takiguchi, Naokatsu Saeki, Toshio Machida
  • Publication number: 20110287955
    Abstract: Disclosed are: a polypeptide marker for diagnosing arteriosclerosis; a gene marker for diagnosing arteriosclerosis; an antibody; a probe for detecting an arteriosclerosis marker gene; a DNA microarray or a DNA chip for detecting an arteriosclerosis marker gene; a method for detecting arteriosclerosis; and a kit for diagnosing arteriosclerosis; with which an arteriosclerotic lesion can be detected with much improved accuracy.
    Type: Application
    Filed: August 14, 2009
    Publication date: November 24, 2011
    Applicants: National UNiversity Corporation Chiba University, Fujikura Kasei Co., Ltd.
    Inventors: Rika Nakamura, Hideyuki Kuroda, Go Tomiyoshi, Takaki Hiwasa, Masaki Takiguchi, Naokatsu Saeki, Toshio Machida
  • Publication number: 20100330554
    Abstract: The present invention provides novel solid cancer antigenic proteins, and diagnostic kits for solid cancer and therapeutic agents for solid cancer based on the antigenic proteins. Specifically, the present invention provides a human solid cancer antigenic polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 48, 50, 52, 54, 56, 59, 61, 63, 65, 67, 69, 71, 73, and 75.
    Type: Application
    Filed: May 18, 2009
    Publication date: December 30, 2010
    Applicants: MEDICAL & BIOLOGICAL LABORATORIES CO., LTD., HIDEAKI SHIMADA
    Inventors: HIDEKI SHIMADA, TAKESHI TOMONAGA, TAKAKI HIWASA, KAZUYUKI MATSUSHITA, TAKENORI OCHIAI, FUMIO NOMURA, MASAKI TAKIGUCHI
  • Publication number: 20090024334
    Abstract: A method of constructing a gene function database comprising measuring the cell viabilities, against a plural number of drugs at various concentrations, of transformed eukaryotic cells overexpressing a plural number of function-known genes and parental cell line thereof, calculating the ratios of IC40 values of the transformed cells to the IC40 values of the parental cell line from the viabilities, calculating the logarithmic values of the ratios, and calculating the correlation coefficients among the known genes based on these logarithmic values; the database constructed by such a method; and a method of analyzing gene function of unknown genes is elucidated from the correlation coefficients of the function-unknown gene to each of the known genes in the database.
    Type: Application
    Filed: May 1, 2008
    Publication date: January 22, 2009
    Inventor: Takaki Hiwasa
  • Publication number: 20080219981
    Abstract: The present invention provides novel solid cancer antigenic proteins, and diagnostic kits for solid cancer and therapeutic agents for solid cancer based on the antigenic proteins. Specifically, the present invention provides a human solid cancer antigenic polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 48, 50, 52, 54, 56, 59, 61, 63, 65, 67, 69, 71, 73, and 75.
    Type: Application
    Filed: March 24, 2005
    Publication date: September 11, 2008
    Inventors: Hideki Shimada, Takeshi Tomonaga, Takaki Hiwasa, Kazuyuki Matsushita, Takenori Ochiai, Fumio Nomura, Masaki Takiguchi
  • Publication number: 20070122810
    Abstract: The present invention provides a brain tumor marker, characterized in that the brain tumor marker is at least one protein expressed in a brain tumor tissue and selected from the group of proteins having the amino acid sequences represented by SEQ ID NOS: 1 to 16, respectively, wherein the protein is expressed in at least one tissue selected from the group of the tissues of a highly malignant brain tumor, a low malignant brain tumor, a drug-sensitive brain tumor, and a drug-resistant brain tumor; a polynucleotide encoding the brain tumor marker; and a method of diagnosing brain tumors by using the brain tumor marker or the polynucleotide as an indicator.
    Type: Application
    Filed: April 30, 2004
    Publication date: May 31, 2007
    Applicant: Japan Science And Technology Agency
    Inventors: Yasuo Iwadate, Takaki Hiwasa, Masaki Takiguchi, Akira Yamaura
  • Publication number: 20040086901
    Abstract: A method of constructing a gene function database comprising measuring the cell viabilities, against a plural number of drugs at various concentrations, of transformed eukaryotic cells overexpressing a plural number of function-known genes and parental cell line thereof, calculating the ratios of IC40 values of the transformed cells to the IC40 values of the parental cell line from the viabilities, calculating the logarithmic values of the ratios, and calculating the correlation coefficients among the known genes based on these logarithmic values; the database constructed by such a method; and a method of analyzing gene function of unknown genes is elucidated from the correlation coefficients of the function-unknown gene to each of the known genes in the database.
    Type: Application
    Filed: July 21, 2003
    Publication date: May 6, 2004
    Inventor: Takaki Hiwasa