Abstract: A temperature detecting device (101) includes: a detecting unit (11) which detects a temperature of a heat source (1); a power generation unit (12) which includes a thermoelectric conversion element (3) and is spaced from the detecting unit (11); a first heat transfer unit (41) that transfers heat or cold of the heat source (1) to the power generation unit (12); a radiator (13) which is remote from the power generation unit (12) so as to radiate heat or cold to outside; a second heat transfer unit (42) that receives heat or cold from the power generation unit (12) and that transfers the heat or cold to the radiating unit (13); and an output unit (14) that outputs a result of the measurement made by the temperature receiving element (2). The thermoelectric conversion element (3) generates electric power by way of a temperature difference between a surface (3a) and a surface (3b) and supplies electric power to the temperature receiving element (2) and the output unit (14).

Abstract: A plurality of p-type and n-type thermoelectric conversion layers extend between opposed heat absorption and heat release surfaces such that the layers alternate between the p-type and n-type thermoelectric conversion layers with a respective insulating layer located between each adjacent pair of thermoelectric conversion layers. Each of the insulating layers extends from a respective one of the heat absorption and heat release surfaces towards, but does not reach, the other of the heat absorption and heat release surfaces such that each insulating later is spaced from the other of the heat absorption and heat release surfaces by a respective length. First and second outer sets of insulating layers are located closest to the first and second end surfaces, respectively, The insulating layers of the first and second outer sets are spaced from the other of the heat absorption and heat release surfaces by a length which is longer than the insulating layers located inwardly of the first and second outer sets.

Abstract: Novel tricyclic compounds which have JAK inhibitory activities are useful for prevention, treatment or improvement of autoimmune diseases, inflammatory diseases and allergic diseases are provided. Novel tricyclic compound represented by the formula (I), the formula (II) or the formula (III) (wherein: each of A1, A2 and A3 is a cyclohexane-1,4-diyl group or the like; each of L1, L2 and L3 is a methylene group or the like; each of X1 and X3 is 0 or NH; each of R1 and R3 is a cyano C1-6 haloalkyl group or the like; and R2 is an aromatic heterocyclic group), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.

Abstract: Novel tricyclic compounds which have JAK inhibitory activities are useful for prevention, treatment or improvement of autoimmune diseases, inflammatory diseases and allergic diseases are provided. Novel tricyclic compound represented by the formula (I), the formula (II) or the formula (III) (wherein: each of A1, A2 and A3 is a cyclohexane-1,4-diyl group or the like; each of L1, L2 and L3 is a methylene group or the like; each of X1 and X3 is O or NH; each of R1 and R3 is a cyano C1-6 haloalkyl group or the like; and R2 is an aromatic heterocyclic group), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.

Abstract: Novel tricyclic compounds which have JAK inhibitory activities are useful for prevention, treatment or improvement of autoimmune diseases, inflammatory diseases and allergic diseases are provided. Novel tricyclic compound represented by the formula (I), the formula (II) or the formula (III) (wherein each of A1, A2 and A3 is a cyclohexane-1,4-diyl group or the like; each of L1, L2 and L3 is a methylene group or the like: each of X1 and X3 is O or NH; each of R1 and R3 is a cyano C1-6 haloalkyl group or the like; and R2 is an aromatic heterocyclic group), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.

Abstract: To provide a novel tricyclic pyrrolopyridine compound having a JAK inhibitory activity and useful for prevention, treatment and/or improvement of particularly autoimmune diseases, inflammatory diseases and allergic diseases. A novel tricyclic pyrrolopyridine compound represented by the formula (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof: wherein the respective substituents are defined in detail in the specification, and R1 is a C1-6 alkyl group or the like, R2 is a hydrogen atom or the like, R3 is a hydrogen atom or the like, the ring A is C3-11 cycloalkane or the like, L1 is a C1-6 alkylene group or the like, and R4 is NRaRb or the like.

Abstract: A plurality of p-type and n-type thermoelectric conversion layers extend between opposed heat absorption and heat release surfaces such that the layers alternate between the p-type and n-type thermoelectric conversion layers with a respective insulating layer located between each adjacent pair of thermoelectric conversion layers. Each of the insulating layers extends from a respective one of the heat absorption and heat release surfaces towards, but does not reach, the other of the heat absorption and heat release surfaces such that each insulating later is spaced from the other of the heat absorption and heat release surfaces by a respective length. First and second outer sets of insulating layers are located closest to the first and second end surfaces, respectively, The insulating layers of the first and second outer sets are spaced from the other of the heat absorption and heat release surfaces by a length which is longer than the insulating layers located inwardly of the first and second outer sets.

Abstract: A laminated thermoelectric conversion element is a laminated thermoelectric conversion element that has: a first end surface and a second end surface opposed to each other; a heat absorption surface; and a heat release surface, where p-type thermoelectric conversion material layers and n-type thermoelectric conversion material layers are electrically connected and at the same time, laminated alternately in a meander form with insulating layers partially interposed there between, in an intermediate part, the p-type thermoelectric conversion material layers are laminated which have a p-type basic thickness, whereas the n-type thermoelectric conversion material layers are laminated which have an n-type basic thickness, and the thickness of the p-type thermoelectric conversion material layer or n-type thermoelectric conversion material layer outside the insulating layer located closest to any of the first end surface and second end surface is larger as compared with the basic thickness of the thermoelectric conve

Abstract: A laminated thermoelectric conversion element is configured to generate electricity from a difference in temperature with respect to a heat-transfer direction. The thermoelectric conversion element includes opposed first and second surfaces which extend in the heat-transfer direction. Respective external electrodes are provided on the first and second surfaces for outputting electricity generated from the temperature difference. At least one of the first and second surfaces is provided with a mark which makes it possible to visually determine the location of the high-temperature side and the low-temperature side with respect to the heat-transfer direction as well as the polarity of the electricity generated.

Abstract: A temperature detecting device (101) includes: a detecting unit (11) which detects a temperature of a heat source (1); a power generation unit (12) which includes a thermoelectric conversion element (3) and is spaced from the detecting unit (11); a first heat transfer unit (41) that transfers heat or cold of the heat source (1) to the power generation unit (12); a radiator (13) which is remote from the power generation unit (12) so as to radiate heat or cold to outside; a second heat transfer unit (42) that receives heat or cold from the power generation unit (12) and that transfers the heat or cold to the radiating unit (13); and an output unit (14) that outputs a result of the measurement made by the temperature receiving element (2). The thermoelectric conversion element (3) generates electric power by way of a temperature difference between a surface (3a) and a surface (3b) and supplies electric power to the temperature receiving element (2) and the output unit (14).

Abstract: To provide a novel tricyclic pyrrolopyridine compound having a JAK inhibitory activity and useful for prevention, treatment and/or improvement of particularly autoimmune diseases, inflammatory diseases and allergic diseases. A novel tricyclic pyrrolopyridine compound represented by the formula (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof: wherein the respective substituents are defined in detail in the specification, and R1 is a C1-6 alkyl group or the like, R2 is a hydrogen atom or the like, R3 is a hydrogen atom or the like, the ring A is C3-11 cycloalkane or the like, L1 is a C1-6 alkylene group or the like, and R4 is NRaRb or the like.

Abstract: A hydraulic machine having a hydro turbine runner which has a crown at a center and a band along an outer periphery, and is formed around the axis of rotation, long blades which are arranged along the circumferential direction of the axis of rotation, and whose center-side ends are supported by the crown, and periphery-side ends are supported by the band, and short blades which are arranged between the long blades, and whose center-side ends are supported by the crown, periphery-side ends are supported by the band, and rear edges are curved in a rotation direction of the hydro turbine runner in turbine operation, on a plane of projection perpendicular to the axis of rotation.

Abstract: An object of the present invention is to expand CD34+ cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34+ cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells. A method for expanding CD34+ cells, which comprises culturing CD34+ cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L1, L2, L3, L4, R1, R2, R3, X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.

Abstract: A thermoelectric conversion element, a thermoelectric conversion module, and a method for producing a thermoelectric conversion element are provided, each of the element and the module having a low contact resistance between a p-type thermoelectric conversion material and an n-type thermoelectric conversion material and being capable of being used at high temperatures without deterioration due to oxidation. A p-type oxide thermoelectric conversion material is primarily made of a substance having a layered perovskite structure represented by the formula: A2BO4, wherein A includes at least La, and B represents at least one element including at least Cu. An n-type oxide thermoelectric conversion material is primarily made of a substance having a layered perovskite structure represented by the formula: D2EO4, wherein D includes at least one of Pr, Nd, Sm, and Gd, and E represents at least one element including at least Cu.

Abstract: A thermoelectric conversion element includes a p-type metal thermoelectric conversion material containing a metal as its main constituent, an n-type oxide thermoelectric conversion material containing an oxide as its main constituent, and a composite oxide insulating material containing a composite oxide as its main constituent. The p-type metal thermoelectric conversion material and the n-type oxide thermoelectric conversion material are directly bonded in a region of a junction plane between the p-type metal thermoelectric conversion material and the n-type oxide thermoelectric conversion material, and the p-type metal thermoelectric conversion material and the n-type oxide thermoelectric conversion material are bonded to each other with the composite oxide insulating material interposed therebetween so as to define a pn conjunction pair in the other region of the junction plane. A perovskite-type oxide is used as the n-type oxide thermoelectric conversion material.

Abstract: A hydraulic turbine according to an embodiment includes a turbine body, a running water surface provided in the turbine body, the running water surface defining a channel for water, and a coating layer provided on the running water surface, the coating layer being formed by water-repellent paint or hydrophilic paint.

Abstract: Fused heterocyclic compounds useful for prevention, treatment or improvement of diseases against which activation of the thrombopoietin receptor is effective are provided. A compound represented by the formula (I) (wherein R1 is an aryl group fused to a saturated ring or the like, A, B, L1, R2, L2, L3, Y, L4, R3 and X are defined in the description), a tautomer, prodrug or a pharmaceutically acceptable salt of the compound or a solvate thereof.

Abstract: An agent for inducing production of megakaryocytes and/or platelets from pluripotent stem cells which is useful for treatment of disease accompanied by a decrease in platelets is provided. A method for producing megakaryocytes and/or platelets, including separating hematopoietic progenitor cells from the septal cells in sac-like structures produced by pluripotent stem cells, and culturing the hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) where R1 to R7, W, X, Y, Z, Ar1 and n are as defined in the description to differentiate them into megakaryocytes and/or platelets.

Abstract: In a thermoelectric conversion module having a stack structure in which one-side element (p-type thermoelectric conversion element) and an other-side element (thermoelectric conversion element) are alternately stacked; the one-side element and the other-side element are directly bonded in some regions of a bonding surface at which the one-side element and the other-side element are bonded; and the one-side element and the other-side element are bonded via insulating material in other regions of the bonding surface, at least one of the one-side element and the other-side element is a thermoelectric conversion element including a thermoelectric conversion material powder made of an intermetallic compound and a metal powder and being retained to have a predetermined shape by a cured resin.

Abstract: The present invention relates to a novel indazole- or pyrrolopyridine-derivative comprising a 5 membered heterocyclic substituent at 1 position thereof which has an agonistic action or a partial agonistic action against serotonin-4 receptor, and a pharmaceutical composition comprising the same.