Patents by Inventor Takao Kurihara

Takao Kurihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process
    Patent number: 11492663
    Abstract: The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library generating step utilizes specific primer mixtures and a DNA polymerase, wherein the specific primer mixtures are designed to eliminate ability to self-hybridize and/or hybridize to other primers within a mixture but efficiently and frequently prime nucleic acid templates.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: November 8, 2022
    Assignee: Takara Bio USA, Inc.
    Inventors: Emmanuel Kamberov, Tong Sun, Eric Bruening, Jonathon H. Pinter, Irina Sleptsova, Takao Kurihara, Vladimir L. Makarov
  • Barcoding Nucleic Acids
    Publication number: 20210189382
    Abstract: Methods of barcoding nucleic acids, such as genomic DNA, are provided herein. In some embodiments, a fragment of genomic DNA may comprise a first and a second barcode.
    Type: Application
    Filed: February 24, 2021
    Publication date: June 24, 2021
    Inventors: Takao Kurihara, Emmanuel Kamberov, Tim Tesmer, John Langmore
  • Barcoding nucleic acids
    Patent number: 10961529
    Abstract: Methods of barcoding nucleic acids, such as genomic DNA, are provided herein. In some embodiments, a fragment of genomic DNA may comprise a first and a second barcode.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: March 30, 2021
    Assignee: Takara Bio USA, Inc.
    Inventors: Takao Kurihara, Emmanuel Kamberov, Tim Tesmer, John Langmore
  • Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process
    Patent number: 10837049
    Abstract: The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library generating step utilizes specific primer mixtures and a DNA polymerase, wherein the specific primer mixtures are designed to eliminate ability to self-hybridize and/or hybridize to other primers within a mixture but efficiently and frequently prime nucleic acid templates.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: November 17, 2020
    Assignee: Takara Bio USA, Inc.
    Inventors: Emmanuel Kamberov, Tong Sun, Eric Bruening, Jonathon H. Pinter, Irina Sleptsova, Takao Kurihara, Vladimir L. Makarov
  • Amplification and Analysis of Whole Genome and Whole Transcriptome Libraries Generated by a DNA Polymerization Process
    Publication number: 20190271033
    Abstract: The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library generating step utilizes specific primer mixtures and a DNA polymerase, wherein the specific primer mixtures are designed to eliminate ability to self-hybridize and/or hybridize to other primers within a mixture but efficiently and frequently prime nucleic acid templates.
    Type: Application
    Filed: February 15, 2019
    Publication date: September 5, 2019
    Inventors: Emmanuel KAMBEROV, Tong SUN, Eric BRUENING, Jonathon H. PINTER, Irina SLEPTSOVA, Takao KURIHARA, Vladimir L. MAKAROV
  • Barcoding Nucleic Acids
    Publication number: 20190153434
    Abstract: Methods of barcoding nucleic acids, such as genomic DNA, are provided herein. In some embodiments, a fragment of genomic DNA may comprise a first and a second barcode.
    Type: Application
    Filed: November 7, 2018
    Publication date: May 23, 2019
    Inventors: Takao Kurihara, Emmanuel Kamberov, Tim Tesmer, John Langmore
  • Barcoding nucleic acids
    Patent number: 10155942
    Abstract: Methods of barcoding nucleic acids, such as genomic DNA, are provided herein. In some embodiments, a fragment of genomic DNA may comprise a first and a second barcode.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: December 18, 2018
    Assignee: Takara Bio USA, Inc.
    Inventors: Takao Kurihara, Emmanuel Kamberov, Tim Tesmer, John Langmore
  • AMPLIFICATION AND ANALYSIS OF WHOLE GENOME AND WHOLE TRANSCRIPTOME LIBRARIES GENERATED BY A DNA POLYMERIZATION PROCESS
    Publication number: 20180030522
    Abstract: The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library generating step utilizes specific primer mixtures and a DNA polymerase, wherein the specific primer mixtures are designed to eliminate ability to self-hybridize and/or hybridize to other primers within a mixture but efficiently and frequently prime nucleic acid templates.
    Type: Application
    Filed: August 10, 2017
    Publication date: February 1, 2018
    Inventors: Emmanuel KAMBEROV, Tong SUN, Eric BRUENING, Jonathon H. PINTER, Irina SLEPTSOVA, Takao KURIHARA, Vladimir L. MAKAROV
  • METHODS AND COMPOSITIONS FOR GENERATING AND AMPLIFYING DNA LIBRARIES FOR SENSITIVE DETECTION AND ANALYSIS OF DNA METHYLATION
    Publication number: 20180030527
    Abstract: The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as DNA methylation patterns, through the preparation, amplification and analysis of Methylome libraries.
    Type: Application
    Filed: June 12, 2017
    Publication date: February 1, 2018
    Inventors: Vladimir L. MAKAROV, Emmanuel KAMBEROV, Tong SUN, Jonathan H. PINTER, Brendan J. TARRIER, Eric E. BRUENING, Takao KURIHARA, Tim TESMER, Joseph M'Mwirichia
  • Methods and compositions for generating and amplifying DNA libraries for sensitive detection and analysis of DNA methylation
    Patent number: 9708652
    Abstract: The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as DNA methylation patterns, through the preparation, amplification and analysis of Methylome libraries.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: July 18, 2017
    Assignee: RUBICON GENOMICS, INC.
    Inventors: Vladimir L. Makarov, Emmanuel Kamberov, Tong Sun, Jonathan H. Pinter, Brendan J. Tarrier, Eric E. Bruening, Takao Kurihara, Tim Tesmer, Joseph M'Mwirichia
  • AMPLIFICATION AND ANALYSIS OF WHOLE GENOME AND WHOLE TRANSCRIPTOME LIBRARIES GENERATED BY A DNA POLYMERIZATION PROCESS
    Publication number: 20160355879
    Abstract: The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library generating step utilizes specific primer mixtures and a DNA polymerase, wherein the specific primer mixtures are designed to eliminate ability to self-hybridize and/or hybridize to other primers within a mixture but efficiently and frequently prime nucleic acid templates.
    Type: Application
    Filed: July 22, 2016
    Publication date: December 8, 2016
    Applicant: Rubicon Genomics, Inc.
    Inventors: Emmanuel KAMBEROV, Tong SUN, Eric BRUENING, Jonathon H. PINTER, Irina SLEPTSOVA, Takao KURIHARA, Vladimir L. MAKAROV
  • BARCODING NUCLEIC ACIDS
    Publication number: 20150284712
    Abstract: Methods of barcoding nucleic acids, such as genomic DNA, are provided herein. In some embodiments, a fragment of genomic DNA may comprise a first and a second barcode.
    Type: Application
    Filed: November 5, 2013
    Publication date: October 8, 2015
    Applicant: Rubicon Genomics, Inc.
    Inventors: Takao Kurihara, Emmanuel Kamberov, Tim Tesmer, John Langmore
  • Methods and compositions for generating and amplifying DNA libraries for sensitive detection and analysis of DNA methylation
    Patent number: 8440404
    Abstract: The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as DNA methylation patterns, through the preparation, amplification and analysis of Methylome libraries.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: May 14, 2013
    Assignee: Rubicon Genomics
    Inventors: Vladimir L. Makarov, Emmanuel Kamberov, Tong Sun, Jonathon H. Pinter, Brendan J. Tarrier, Eric E. Bruening, Takao Kurihara, Tim Tesmer, Joseph M'Mwirichia
  • SUBSTANTIALLY NON-SELF COMPLEMENTARY PRIMERS
    Publication number: 20130085083
    Abstract: The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library generating step utilizes specific primer mixtures and a DNA polymerase, wherein the specific primer mixtures are designed to eliminate ability to self-hybridize and/or hybridize to other primers within a mixture but efficiently and frequently prime nucleic acid templates.
    Type: Application
    Filed: June 4, 2012
    Publication date: April 4, 2013
    Applicant: Rubicon Genomics
    Inventors: Emmanuel Kamberov, Tong Sun, Eric Bruening, Jonathon H. Pinter, Irina Sleptsova, Takao Kurihara, Vladimir L. Makarov
  • Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process
    Patent number: 8206913
    Abstract: The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library generating step utilizes specific primer mixtures and a DNA polymerase, wherein the specific primer mixtures are designed to eliminate ability to self-hybridize and/or hybridize to other primers within a mixture but efficiently and frequently prime nucleic acid templates.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: June 26, 2012
    Assignee: Rubicon Genomics, Inc.
    Inventors: Emmanuel Kamberov, Tong Sun, Eric Bruening, Jonathon H. Pinter, Irina Sleptsova, Takao Kurihara, Vladimir L. Makarov
  • Dynamic damper
    Patent number: 7946925
    Abstract: A dynamic damper in which the inner diameter (D2) of a first hole part formed at the axial one end part of a body part overlapped with a weight part in the radial direction is set smaller than the inner diameter (D3) of a second hole part formed at the axial other end part of the body part not overlapped with the weight part in the radial direction and tightened with a band member (D3>D2). The outer diameter (D1) of a drive shaft to be press-fitted into the first and second hole parts is set larger than the inner diameter (D2) of the first hole part and the inner diameter (D3) of the second hole part (D1>D3>D2).
    Type: Grant
    Filed: September 21, 2006
    Date of Patent: May 24, 2011
    Assignee: Honda Motor Co., Ltd.
    Inventors: Tsutomu Kawakatsu, Shouichi Nakao, Susumu Suzuki, Takao Kurihara
  • Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process
    Patent number: 7718403
    Abstract: The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library generating step utilizes specific primer mixtures and a DNA polymerase, wherein the specific primer mixtures are designed to eliminate ability to self-hybridize and/or hybridize to other primers within a mixture but efficiently and frequently prime nucleic acid templates.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: May 18, 2010
    Assignee: Rubicon Genomics, Inc.
    Inventors: Emmanuel Kamberov, Tong Sun, Eric Bruening, Jonathon H. Pinter, Irina Sleptsova, Takao Kurihara, Vladimir L. Makarov
  • Dynamic Damper
    Publication number: 20090270189
    Abstract: A dynamic damper in which the inner diameter (D2) of a first hole part formed at the axial one end part of a body part overlapped with a weight part in the radial direction is set smaller than the inner diameter (D3) of a second hole part formed at the axial other end part of the body part not overlapped with the weight part in the radial direction and tightened with a band member (D3>D2). The outer diameter (D1) of a drive shaft to be press-fitted into the first and second hole parts is set larger than the inner diameter (D2) of the first hole part and the inner diameter (D3) of the second hole part (D1>D3>D2).
    Type: Application
    Filed: September 21, 2006
    Publication date: October 29, 2009
    Inventors: Tsutomu Kawakatsu, Shouichi Nakao, Susumu Suzuki, Takao Kurihara
  • Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process
    Publication number: 20070054311
    Abstract: The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library generating step utilizes specific primer mixtures and a DNA polymerase, wherein the specific primer mixtures are designed to eliminate ability to self-hybridize and/or hybridize to other primers within a mixture but efficiently and frequently prime nucleic acid templates.
    Type: Application
    Filed: November 6, 2006
    Publication date: March 8, 2007
    Inventors: Emmanuel Kamberov, Tong Sun, Eric Bruening, Jonathon Pinter, Irina Sleptsova, Takao Kurihara, Vladimir Makarov
  • Methods and compositions for generating and amplifying DNA libraries for sensitive detection and analysis of DNA methylation
    Publication number: 20050202490
    Abstract: The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as DNA methylation patterns, through the preparation, amplification and analysis of Methylome libraries. In several aspects of the present invention, there are methods based on methylation-dependent enrichment or depletion of genomic DNA isolated from cellular and cell-free sources. In additional embodiments, there are methods and compositions for single-step high throughput preparations of Methylome libraries.
    Type: Application
    Filed: March 3, 2005
    Publication date: September 15, 2005
    Inventors: Vladimir Makarov, Emmanuel Kamberov, Tong Sun, Jonathon Pinter, Brendan Tarrier, Eric Bruening, Takao Kurihara, Tim Tesmer, Joseph M'Mwirichia