Abstract: An injection molding machine system includes an injection molding machine, a mold, heater device, and a pressing device. The mold includes a fixed side mold and a slide mold. When the slide mold is clamped at a first mold clamping position, one primary molding cavity is formed by a slide side recessed portion, and one primary molding cavity is formed by a fixed side recessed portion. A pair of primary molded articles, are molded by injection molding. The mold is opened, and bonding end surfaces of the primary molded article remaining in the slide side recessed portion and the primary molded article remaining in the fixed side recessed portion are melted by the heating device. When the slide mold is clamped at a second mold clamping position, a secondary molding cavity is formed by the slide side recessed portion and the fixed side recessed portion.

Abstract: An injection molding machine system includes an injection molding machine, a mold, a heating heater device, and a pressing device. When the mold is closed or clamped, two or more primary molding cavities and one or more secondary molding cavities are formed. Primary molded articles are molded through injection molding when injected into the primary molding cavities. The pair of primary molded articles are placed in the secondary molding cavity, bonding end surfaces are melted by the heating heater device, and the mold is closed or clamped. When the pair of primary molded articles are pressed together by the pressing device, the primary molded articles are fused to each other to form a molded article.

Abstract: A mold includes a guide pin configured to guide mold closing. The guide pin is housed in a guide pin housing hole formed in a parting line and is configured to be driven by a predetermined drive mechanism. The guide pin is configured to protrude its tip end from the parting line and to retract into the guide pin housing hole by the drive mechanism.

Abstract: In an air conditioner of the present embodiment capable of selecting either a fan rotation speed determined on the basis of a static pressure value and an air volume or a required fan rotation speed, motor control means determines, on the basis of the static pressure Pt, the fan rotation speed Rm of a fan motor that provides the air volume Av required by the user, and transmits the determined fan rotation speed Rm to an indoor unit control means. When the fan rotation speed Rm received from the motor control means is a prohibited rotation speed, the indoor unit control means transmits a correction fan rotation speed different from the prohibited rotation speed to the motor control means, and the motor control means drives the fan motor at the received correction fan rotation speed.

Abstract: The present invention provides a liposome preparation containing a population of liposomes containing a CD1d ligand compound, wherein the average particle size of the population of liposomes is 90 to 110 nm and the polydispersity index of particle size distribution is 0.2 or less. and the polydispersity index of the particle size distribution is 0.2 or less. The present invention also provides the use of the liposome preparation in the prevention or treatment of graft-versus-host disease and organ transplant rejection.

Abstract: A valve structure that may control the flow rate of a fluid when the fluid starts to be released is provided. In a valve structure including a valve sheet having two outlets to release a fluid and a valve body arranged to be rotational against the valve sheet to regulate a degree of opening of the outlet, the valve body has a fluid control recess formed in the circumferential direction whose area overlapping the outlet is changed by rotation of the valve body, and the center of the outlet is forced to deviate from a rotation trajectory of a front end portion of the fluid control recess that starts to overlap the outlet by the rotation of the valve body.

Abstract: By administering a liposome formulation in which an antibacterial agent is bound to a liposome, in particular, a lipid-soluble side chain of the antibacterial agent is bound to a lipid of the liposome, and the antibacterial agent extends outward from a surface of the liposome, it is possible to provide a liposome formulation in which blood retention of an active ingredient is increased, an amount of the active ingredient taken by a reticuloendothelial system such as a liver is reduced, an amount of the active ingredient transferred into a kidney is reduced, and antibacterial activity can also be increased with little resistance.

Abstract: The present invention provides a method for producing lipid particles that have a desired particle diameter, the method comprising: (A) a step for preparing, in a first mixing region, a primary dilution by mixing a first solution containing a lipid and an alcohol with a second solution containing water; (B) a step for feeding the primary dilution from the first mixing region to a second mixing region through a liquid feed pipe within a prescribed time; and (C) a step for preparing a secondary dilution by mixing the primary dilution with a third solution containing water in the second mixing region, wherein the steps (A)-(C) are continuously carried out, and the particle diameter of the lipid particles is controlled by adjusting at least one condition selected from the group consisting of the concentration of the alcohol and the concentration of the lipid in the primary dilution, the prescribed time, and the temperature during mixing.

Abstract: A dialyzer (15) includes a hollow fiber dialysis column (20), a liquid tubing section (12a), and a flow rate changing section (16a). The hollow fiber dialysis column (20) includes a hollow fiber membrane, a first flow channel that allows a dialysis target to flow internally of the hollow fiber membrane, and a second flow channel that allows an external liquid to flow externally of the hollow fiber membrane. The liquid tubing section (12a) tubes the dialysis target to an inlet (20a) of the first flow channel. The flow rate changing section (16a) is capable of changing a flow rate of the dialysis target at the dialysis target flowing out of an outlet (20b) of the first flow channel.

Abstract: In an air conditioner of the present embodiment capable of selecting either a fan rotation speed determined on the basis of a static pressure value and an air volume or a required fan rotation speed, motor control means determines, on the basis of the static pressure Pt, the fan rotation speed Rm of a fan motor that provides the air volume Av required by the user, and transmits the determined fan rotation speed Rm to an indoor unit control means. When the fan rotation speed Rm received from the motor control means is a prohibited rotation speed, the indoor unit control means transmits a correction fan rotation speed different from the prohibited rotation speed to the motor control means, and the motor control means drives the fan motor at the received correction fan rotation speed.

Abstract: The present invention provides: a composition for reconstituting human skin tissue having hair follicles, the composition characterized by containing human epidermal cells and human dermal cells, the human dermal cells containing cell groups of human hair papilla derived from non-embryos via spheroid formation; and a human skin tissue model animal to which said composition is applied. The invention also provides a method for producing said composition and animal.

Abstract: The present invention provides a method for producing lipid particles that have a desired particle diameter, the method comprising: (A) a step for preparing, in a first mixing region, a primary dilution by mixing a first solution containing a lipid and an alcohol with a second solution containing water; (B) a step for feeding the primary dilution from the first mixing region to a second mixing region through a liquid feed pipe within a prescribed time; and (C) a step for preparing a secondary dilution by mixing the primary dilution with a third solution containing water in the second mixing region, wherein the steps (A)-(C) are continuously carried out, and the particle diameter of the lipid particles is controlled by adjusting at least one condition selected from the group consisting of the concentration of the alcohol and the concentration of the lipid in the primary dilution, the prescribed time, and the temperature during mixing.

Abstract: Disclosed herein are a refrigeration cycle device and three-way flow rate control valve. In a refrigeration cycle device including a compressor, first and second coolers configured to cool first and second storage compartments at least, respectively, and a mixer configured to mix refrigerants that have passed through the first and second coolers, a refrigerant flow path is switched so that refrigerants of first and second flow rates are circulated to the first and second coolers, respectively, while the first and second storage compartments are being cooled, and a refrigerant flow path is switched so that a refrigerant of a specific flow rate, which is smaller than a first flow rate but is not zero, is circulated to the first cooler after cooling of the first storage compartment is completed.

Abstract: A valve structure that may control the flow rate of a fluid with high precision when the fluid starts to be released is provided. In a valve structure 20 including a valve sheet 3 having two outlets 3a to release a fluid and a valve body 4 arranged to be rotational against the valve sheet 3 to regulate a degree of opening of the outlet 3a, the valve body 4 has a fluid control recess 4d formed in the circumferential direction whose area overlapping the outlet 3a is changed by rotation of the valve body 4, and the center O of the outlet 3a is forced to deviate from a rotation trajectory of a front end portion 4b of the fluid control recess 4d that starts to overlap the outlet 3a by the rotation of the valve body 4.

Abstract: Disclosed herein are a refrigeration cycle device and three-way flow rate control valve. In a refrigeration cycle device including a compressor, first and second coolers configured to cool first and second storage compartments at least, respectively, and a mixer configured to mix refrigerants that have passed through the first and second coolers, a refrigerant flow path is switched so that refrigerants of first and second flow rates are circulated to the first and second coolers, respectively, while the first and second storage compartments are being cooled, and a refrigerant flow path is switched so that a refrigerant of a specific flow rate, which is smaller than a first flow rate but is not zero, is circulated to the first cooler after cooling of the first storage compartment is completed.

Abstract: A dialyzer (15) includes a hollow fiber dialysis column (20), a liquid tubing section (12a), and a flow rate changing section (16a). The hollow fiber dialysis column (20) includes a hollow fiber membrane, a first flow channel that allows a dialysis target to flow internally of the hollow fiber membrane, and a second flow channel that allows an external liquid to flow externally of the hollow fiber membrane. The liquid tubing section (12a) tubes the dialysis target to an inlet (20a) of the first flow channel. The flow rate changing section (16a) is capable of changing a flow rate of the dialysis target at the dialysis target flowing out of an outlet (20b) of the first flow channel.

Abstract: A tracking error covariance matrix updating unit 6 that updates a tracking error covariance matrix Pk (?) before update at a sampling time k by using a nominal distance difference error parameter ??rnom and that outputs the tracking error covariance matrix Pk (+) after update is disposed, and a TrackDOP calculating unit 7 calculates an evaluation index TrackDOP for tracking accuracy for a target by using both the tracking error covariance matrix Pk (+) after update, and the nominal observation error parameter ??rnom.

Abstract: A pharmaceutical composition which comprises, as an active ingredient, a liposome encapsulating an immunosuppressant such as FK506, FTY720 and cyclosporin A is effective in the treatment of cardiovascular inflammatory diseases such as my ocardial infarction, myocarditis and vasculitis syndrome, allows the immunosuppressant at a low dose to produce stronger effects than those of the same dose of the immunosuppressant used alone, and causes fewer side effects.

Abstract: A tracking error covariance matrix updating unit 6 that updates a tracking error covariance matrix Pk (?) before update at a sampling time k by using a nominal distance difference error parameter ??rnom and that outputs the tracking error covariance matrix Pk (+) after update is disposed, and a TrackDOP calculating unit 7 calculates an evaluation index TrackDOP for tracking accuracy for a target by using both the tracking error covariance matrix Pk (+) after update, and the nominal observation error parameter ??rnom.

Abstract: To provide a light irradiation device capable of easily removing and reducing hair with low power light without burden on skin. The light irradiation device according to the present invention includes a light source giving pulses of light in a wavelength range from 400 to 1200 nm and a light guide distributing the pulses of light given from the light source with energy intensity of 0.2 to 10 J/cm2 at a predetermined distance from the light outgoing surface.