Abstract: The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH2; Y1, Y2, Y3, Y4 and Y5, which may be identical or different, are each CH or N; however, at least one of Y1, Y2, Y3, Y4 and Y5 is N; Z1 and Z2, which may be identical or different, are each CH or N; n is an integer from 1 to 3; R1 is a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aliphatic heterocyclic ring or an aromatic heterocyclic ring, or a bicyclic aliphatic saturated hydrocarbon group; R2 and R3, which may be identical or different, are each a hydrogen atom, a lower alkyl group, a lower alkenyl group, a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aromatic heterocyclic ring, or the like; and R4 is a hydrogen atom, a lower alkyl group, a C3-C6 cycloalkyl group or the like, or a pharmaceutically acceptable salt or ester thereof, and a selective inhibitor against Cdk4 and/or Cdk6 or an anticancer agent containing the compound or a pharmaceutically acceptable salt or ester thereof.

Abstract: The present invention relates to a compound of formula I: wherein: R1 is a hydrogen atom, F, CN, etc.; R1? is a hydrogen atom or lower alkyl which may be substituted; R2 is O, S, SO, SO2, etc.; R3 is a phenyl which may be substituted; X1, X2, and X3 each independently CH, N, etc. provided, however, that among X1, X2 and X3, the number of nitrogen is 0 or 1; W is the following residue: wherein: W1, W2, and W3 each independently CH, N, etc., or a pharmaceutically acceptable salt or ester thereof.

Abstract: The present invention relates to a compound represented by the general formula (I): wherein m1 and m2 are 1, 2, or 3; n1 and n2 are 0 or 1; i is an integer of any of 1 to m1; j is an integer of 1 to m2; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; Rai and Rai? is hydrogen atom, etc. and Rbj and Rbj? is hydrogen atom, etc.; Rc, Rd, and Re are hydrogen atom, etc; X1 is CH, CX1a, or N; X2 is CH, N, etc.; X3 is CH, N, etc.; X4 is CH or N; Y1, Y2, and Y3 are each independently CH or N; Z1 and Z2 are each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).

Abstract: The present invention relates to a compound represented by the general formula (I): wherein m1 and m2 are 1, 2, or 3; n1 and n2 are 0 or 1; i is an integer of any of 1 to m1; j is an integer of 1 to m2; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; Rai and Rai? is hydrogen atom, etc. and Rbj and Rbj? is hydrogen atom, etc.; Rc, Rd, and Re are hydrogen atom, etc; X1 is CH, CX1a, or N; X2 is CH, N, etc.; X3 is CH, N, etc.; X4 is CH or N; Y1, Y2, and Y3 are each independently CH or N; Z1 and Z2 are each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).

Abstract: A FPGA data module to be referred to as a LUT by a logic block (43) is divided into a plurality of modules. Each of a plurality of data registers (41a to 41d) stores one of the plurality of FPGA data modules. By referring to the FPGA data module(s) stored in one or more of the plurality of data registers (41a to 41d), a gate circuit (43a) and flip flop (43b) of the logic block (43) generates a logical function value of logic input data. The logical function value of the logic input data is provided as logic output data.

Abstract: A computing unit (42) executes a second computing in the middle of a first computing. At this time, the hardware structure of the computing unit (42) is switched in accordance with a computing which is a target of execution. A controller (46) stores the internal state of the computing unit (42) in a memory (44) when a computing to be executed by the computing unit (42) changes from the first computing to the second computing. And the controller (46) controls execution of the first computing to be continued by returning the internal state stored in the memory (44) to the computing unit (42), when a computing to be executed by the computing unit (42) returns from the second computing to the first computing.

Abstract: A skill determination method, a skill determination system, a skill determination server, a skill determination client and a skill determination evaluation board are disclosed for objectively determine one or more skills of a user as a design engineer without use of much time and cost. The skill determination method includes steps of: supplying a question file to determine one or more skills of a user from a skill determination server to a skill determination client; providing one or more answers to the question file to the skill determination client through input manipulation of the user and supplying an answer file corresponding to the answers from the skill determination client to the skill determination server; and evaluating knowledge of the user based on a comparison result between the answer file and a correct answer file corresponding to the question file and determining the skills of the user by using the skill determination server.

Abstract: It is an object of the present invention to provide a text input device with excellent operability. The text input device is a text input device for causing a letter corresponding to a press of an operating portion to be displayed on a display by the press of the operating portion. The device includes a main body having a multifunction key switch actuated by operating the operating portion to tilt it in a plurality of directions and a plurality of letters provided to the main body and marked on an outside of the multifunction key switch and in the respective plurality of directions. The multifunction key switch is actuated and the letter corresponding to one direction is displayed on the display when the operating portion is tilted in the one direction of the plurality of directions.

Abstract: A photopolymerizable composition comprising (A) 100 parts by weight of a mixture of (meth)acrylic acid ester monomers, (B) from 0.1 to 5 parts by weight of a surfactant having a perfluoroalkyl group and represented by the general formula (1) CF3(CF2)nAM  (1) wherein A represents —CO2— or —SO3—, M represents an alkali metal, and n is an integer of 3 to 9, and (C) from 0.2 to 10 parts by weight of a photopolymerization initiator, and a plastic optical disk provided with a cured coating of the photopolymerizable composition on at least one side thereof.

Abstract: A photopolymerizable composition comprising(A) 100 parts by weight of a mixture of (meth)acrylic acid ester monomers,(B) from 0.1 to 5 parts by weight of a surfactant having a perfluoroalkyl group and represented by the general formula (1)CF.sub.3 (CF.sub.2).sub.n AM (1)wherein A represents --CO.sub.2 -- or --SO.sub.3 --, M represents an alkali metal, and n is an integer of 3 to 9, and(C) from 0.2 to 10 parts by weight of a photopolymerization initiator, and a plastic optical disk provided with a cured coating of the photopolymerizable composition on at least one side thereof.

Abstract: A molded article containing an outer decorative film and a support, and a method and composition for making the same are disclosed. The outer film has a decorative layer and a protective layer, the protective layer being formed from a photopolymerizable resin composition. In an uncured state, the composition includes (a) an acrylic copolymer containing a backbone and at least one side chain linked to the backbone, the at least one side group having at least one (meth)acryloyl group, the backbone having a glass transition temperature of about 40.degree. C. to about 120.degree. C. and a weight-average molecular weight of about 10,000 to about 200,000; (b) a compound other than the copolymer (a), the compound having at least three (meth)acryloyl groups; and a photopolymerization initiator. The at least one (meth)acryloyl group is preferably linked to the backbone by a reacted glycidyl group.