Patents by Inventor Takashi Nakae
Takashi Nakae has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240108578Abstract: The present invention provides a composition comprising an ionic liquid and a poorly absorbable drug, wherein the ionic liquid is prepared from an anion and a cation, the anion is an organic acid having 3 to 7 carbon atoms, and the cation is selected from the group consisting of arginine, meglumine, trometamol and diethanolamine, which remarkably improves the absorbability of the poorly absorbable drug.Type: ApplicationFiled: February 10, 2022Publication date: April 4, 2024Applicant: MEDRx Co., Ltd.Inventors: Tatsuhiro Ishida, Noboru Tatsumi, Takashi Nakae, Yasushi Miwa, Hidetoshi Hamamoto
-
Publication number: 20230414912Abstract: The present invention provides a microneedle array having microneedles coated with a composition comprising a poorly water-soluble or water-insoluble particle with a mean particle size of 1 ?m or less, 2% to 20% by weight of a binding agent and 60% by weight or more of water in which the poorly water-soluble or water-insoluble particle is loaded on the microneedles in equal amounts that shows good puncturability.Type: ApplicationFiled: November 11, 2021Publication date: December 28, 2023Applicant: MEDRx Co., Ltd.Inventors: Hidetoshi Hamamoto, Masaki Ishibashi, Takashi Nakae, Haruka Kawahara, Jun Nakamura
-
Publication number: 20230019988Abstract: The present invention relates to antifouling compositions comprising compounds of formula IA and/or IB that are highly effective against marine biofouling of surfaces of ships and marine structures, their use for inhibiting marine biofouling, as well as antifouling paints comprising said compositions.Type: ApplicationFiled: December 4, 2020Publication date: January 19, 2023Inventors: Takashi Nakae, Paul Kappock, Yoshiyuki Iwase, Josef Schroeer, Jurgen Riegler, Peter Van Aken
-
Publication number: 20220095625Abstract: The present invention relates to antifouling compositions comprising copper di(ethyl 4,4,4-trifluoroacetoacetate) (Cu(ETFAA)2) that are highly effective against marine biofouling of surfaces of ships and marine structures, their use for inhibiting marine biofouling, as well as antifouling paints comprising said compositions.Type: ApplicationFiled: December 6, 2019Publication date: March 31, 2022Inventors: Takashi Nakae, Paul Kappock, Yoshiyuki Iwase, Josef Schroeer, Juergen Riegler, Peter Van Aken
-
Patent number: 10654891Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: GrantFiled: May 17, 2016Date of Patent: May 19, 2020Assignee: Jitsubo Co., Ltd.Inventors: Yusuke Kono, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
-
Patent number: 10633418Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: GrantFiled: May 17, 2016Date of Patent: April 28, 2020Assignee: JITSUBO CO., LTD.Inventors: Yusuke Kono, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
-
Patent number: 10508709Abstract: In a vibration damping device 20, the moment of inertia J1 of a driven member 15, the moment of inertia J2 of an inertial mass body 23, the mass m of crank members 22, the distance L3 between the center of gravity G of the crank member 22 and the fulcrum of swinging of the crank member 22 with respect to the inertial mass body 23, and the distance L4 between this fulcrum and the center of rotation RC are determined so that torque fluctuation of an object for which vibration is to be damped, which is derived based on angular displacement and angles obtained by solving an equation of motion for the driven member 15 and an equation of motion for the entire vibration damping device 20 is equal to a target value.Type: GrantFiled: September 29, 2017Date of Patent: December 17, 2019Assignees: AISIN AW CO., LTD., NATIONAL UNIVERSITY CORPORATION OITA UNIVERSITY, Kagoshima UniversityInventors: Yoichi Oi, Masaki Wajima, Hiroki Nagai, Takao Sakamoto, Takahiro Ryu, Takashi Nakae, Kenichiro Matsuzaki
-
Publication number: 20190226552Abstract: In a vibration damping device 20, the moment of inertia J1 of a driven member 15, the moment of inertia J2 of an inertial mass body 23, the mass m of crank members 22, the distance L3 between the center of gravity G of the crank member 22 and the fulcrum of swinging of the crank member 22 with respect to the inertial mass body 23, and the distance L4 between this fulcrum and the center of rotation RC are determined so that torque fluctuation of an object for which vibration is to be damped, which is derived based on angular displacement and angles obtained by solving an equation of motion for the driven member 15 and an equation of motion for the entire vibration damping device 20 is equal to a target value.Type: ApplicationFiled: September 29, 2017Publication date: July 25, 2019Applicants: AISIN AW CO., LTD., NATIONAL UNIVERSITY CORPORATION OITA UNIVERSITY, Kagoshima UniversityInventors: Yoichi OI, Masaki WAJIMA, Hiroki NAGAI, Takao SAKAMOTO, Takahiro RYU, Takashi NAKAE, Kenichiro MATSUZAKI
-
Publication number: 20180187744Abstract: A vibration damping device 20 includes: a crank member 22 that is coupled to a driven member 15 via a first coupling shaft A1 and that is swingable about the first coupling shaft A1 along with rotation of the driven member 15; and an inertial mass body 24 that is coupled to the driven member 15 via the crank member 22 and a connecting rod 23 and that is swung about a center of rotation RC in conjunction with the crank member 22 along with rotation of the driven member 15. A component force of a centrifugal force that acts on the crank member 22 along with rotation of the driven member 15 in a direction that is orthogonal to the direction from the center of the first coupling shaft A1 toward the center of gravity G always acts on the crank member 22 as a restoring force that acts to return the inertial mass body 24 to the center of the swing range. The component force is maximum when the inertial mass body 24 is positioned at the center of the swing range.Type: ApplicationFiled: July 15, 2016Publication date: July 5, 2018Applicants: AISIN AW CO., LTD., NATIONAL UNIVERSITY CORPORATION OITA UNIVERSITY, KAGOSHIMA UNIVERSITYInventors: Yoshihiro TAKIKAWA, Hiroki NAGAI, Masaki WAJIMA, Takao SAKAMOTO, Takahiro RYU, Takashi NAKAE, Kenichiro MATSUZAKI
-
Publication number: 20160333052Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: ApplicationFiled: May 17, 2016Publication date: November 17, 2016Inventors: Yusuke KONO, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
-
Publication number: 20160333050Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: ApplicationFiled: May 17, 2016Publication date: November 17, 2016Inventors: Yusuke KONO, Shuji FUJITA, Hideaki SUZUKI, Mari OKUMOTO, Takashi NAKAE, Kazuhiro CHIBA
-
Patent number: 9376467Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: GrantFiled: February 28, 2012Date of Patent: June 28, 2016Assignee: JITSUBO CO., LTD.Inventors: Yusuke Kono, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
-
Patent number: 9365615Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: GrantFiled: September 9, 2013Date of Patent: June 14, 2016Assignee: JITSUBO CO., LTD.Inventors: Yusuke Kono, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
-
Publication number: 20150073121Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: ApplicationFiled: September 9, 2013Publication date: March 12, 2015Applicant: JITSUBO Co., Ltd.Inventors: Yusuke Kono, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
-
Publication number: 20130345393Abstract: The purpose of the present invention is to provide a cross-linked peptide containing a novel non-peptide cross-linked structure, and a method for synthesizing the same. A cross-linked peptide having a novel non-peptide cross-linked structure, a useful intermediate for synthesizing the cross-linked peptide, and a method for synthesizing the novel cross-linked peptide and the intermediate are provided. The cross-linked peptide is characterized by having an —NR— bond in the cross-linked structure. By using the method for synthesizing the cross-linked peptide, a cross-link can be freely designed and an change can be freely made to a cross-link.Type: ApplicationFiled: February 28, 2012Publication date: December 26, 2013Applicant: JITSUBO Co., Ltd.Inventors: Yusuke Kono, Shuji Fujita, Hideaki Suzuki, Mari Okumoto, Takashi Nakae, Kazuhiro Chiba
-
Publication number: 20110014141Abstract: The objective of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe and stable topical agents for dermatological use. For that purpose 4-Hydroxyphenyl-?-D-glucopyranoside was combined with auxiliary agents such as ascorbic acid and its derivatives, crude drugs and its extracts, hydroxycarboxylic acid and its salts, oil soluble glycyrrhiza extract, gentian extract, phenol derivatives and their salts, placenta extract, kojic acid and its derivatives, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxin and its derivatives, tocopherol and its derivatives, chitosan and its decomposition products, caffeic acid derivatives, hydroxycinnamate and its derivatives, Umbelliferae plant extracts, mycelial cultures and their extracts, plant leaves and their extracts.Type: ApplicationFiled: June 21, 2010Publication date: January 20, 2011Applicants: DSM IP ASSETS B.V., EZAKI GLICO COMPANY LIMITEDInventors: Hiroki Nakayama, Takashi Kuriki, Takashi Nakae, Takahisa Nishimura
-
Patent number: 7033800Abstract: A method of producing a phenol derivative glycoside is provided. The method comprises the step of allowing a saccharide and a phenol derivative to react with each other in the presence of an enzyme to produce the phenol derivative glycoside. The enzyme is selected from the group consisting of neopullulanase, cyclomaltodextrinase, maltogenic ?-amylase, and saccharifying amylase having cyclodextrin synthesizing capability.Type: GrantFiled: March 28, 2001Date of Patent: April 25, 2006Assignee: Ezaki Glico Co., Ltd.Inventors: Shigetaka Okada, Takashi Kometani, Takahisa Nishimura, Takashi Nakae, Hiroshi Takii
-
Publication number: 20030198610Abstract: The objetive of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe and stable topical agents for dermatological use. For that purpose 4-Hydroxyphenyl-&agr;-D-glucopyranoside was combined with auxiliary agents such as ascorbic acid and its derivatives, crude drugs and its extracts, hydroxycarboxylic acid and its salts, oil soluble glycyrrhiza extract, gentian extract, phenol derivatives and their salts, placenta extract, kojic acid and its derivative, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxin and its derivatives, tocopherol and its derivatives, chitosan and its decomposition products, caffeic acid derivatives, hydroxycinnamate and its derivatives, Umbelliferae plant extracts, mycelial cultures and their extracts, plant leaves and their extracts.Type: ApplicationFiled: June 4, 2003Publication date: October 23, 2003Inventors: Hiroki Nakayama, Takashi Kuriki, Takashi Nakae, Takahisa Nishimura
-
Publication number: 20030082751Abstract: A method of producing a phenol derivative glycoside is provided. The method comprises the step of allowing a saccharide and a phenol derivative to react with each other in the presence of an enzyme to produce the phenol derivative glycoside. The enzyme is selected from the group consisting of neopullulanase, cyclomaltodextrinase, maltogenic &agr;-amylase, and saccharifying amylase having cyclodextrin synthesizing capability.Type: ApplicationFiled: September 27, 2002Publication date: May 1, 2003Inventors: Shigetaka Okada, Takashi Kometani, Takahisa Nishimura, Takashi Nakae, Hiroshi Takii