Patents by Inventor Takashi Tsuji
Takashi Tsuji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11534377Abstract: The present invention is directed to a hair growth agent for external use comprising chiro-inositol, which is provided as an excellent hair growth agent.Type: GrantFiled: January 26, 2021Date of Patent: December 27, 2022Assignee: KOBAYASHI PHARMACEUTICAL CO., LTD.Inventors: Kosuke Tanaka, Mihoko Kawasaki, Hironori Tomi, Takashi Tsuji
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Publication number: 20220387283Abstract: To provide a hair growth agent which is a topical agent that exhibits effect in terms of causing increase in hair shaft diameter and improving maximum hair shaft length and improving hair shaft elongation rate and new hair growth and increasing expression of genes contributing to hair growth in dermal papilla cells and promoting hair shaft growth at head hair, eyelashes, and/or eyebrows, a hair growth agent which is a topical agent is made to contain active ingredients in the form of palmitoyl dipeptide-5 diaminobutyloyl hydroxythreonine and palmitoyl dipeptide-5 diaminohydroxybutyrate.Type: ApplicationFiled: September 23, 2020Publication date: December 8, 2022Applicants: ADJUVANT HOLDINGS CO., LTD., RIKENInventors: Sota Nakamura, Hideki Takahashi, Yukimi Nakaike, Takahiro Nagaya, Yuki Kanazawa, Takashi Tsuji, Miho Ogawa
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Publication number: 20220348852Abstract: A culture container (1) having a guide thread (31) and a plurality of cells (32) that is capable of culturing a regenerative hair follicle germ (30), wherein the culture container (1) is equipped with a first recess (10) and a second recess (20) and the second recess (20) has a second bottom (22) where the guide thread (31) can be positioned in the center of an opening (23) and a method for producing a regenerative hair follicle germ that includes a step for aggregating a cell population including epithelial cells (32a) within the second recess (20) of the culture container (1), a step for aggregating a cell population including mesenchymal cells (32b) within the second recess (20), a step for inserting the guide thread (31) into the second recess (20), and a step for culturing the cell population including epithelial cells (32a) and the mesenchymal cells (32b).Type: ApplicationFiled: June 25, 2020Publication date: November 3, 2022Applicants: RIKEN, ORGAN TECHNOLOGIES, INC.Inventors: Yutaka Mori, Kyosuke Kishimoto, Hisashi Sakai, Ryo Ueno, Takashi Tsuji, Naokazu Okamoto, Miho Ogawa
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Publication number: 20220285483Abstract: A semiconductor device includes: a high-concentration layer of a first conductivity-type provided on a drift layer of the first conductivity-type; a buried layer of a second conductivity-type provided in the high-concentration layer; an injection regulation region of the second conductivity-type provided on the high-concentration layer; a high-concentration region of the second conductivity-type provided inside the injection regulation region; a carrier supply region of the first conductivity-type provided at an upper part of the injection regulation region; and an insulated gate structure provided inside a trench, wherein a ratio of the impurity concentration of the injection regulation region to an impurity concentration of an upper part of the high-concentration layer is 0.5 or greater and 2 or smaller.Type: ApplicationFiled: January 31, 2022Publication date: September 8, 2022Applicant: FUJI ELECTRIC CO., LTD.Inventor: Takashi TSUJI
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Publication number: 20220144784Abstract: The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X1 represents —N? or —CH?, X2 represents —CH? or —N?, R1 and R2 each represent a C1 to C6 alkoxy group or the like, R3 represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R4 represents a C1 to C6 alkylthio group or a C2 to C6 alkenyl group (the C1 to C6 alkylthio group and the C2 to C6 alkenyl group are each optionally substituted by one carboxy group or the like) or the like.Type: ApplicationFiled: October 20, 2021Publication date: May 12, 2022Inventors: Takuya IKEDA, Yoshiyuki KOBAYASHI, Naoki MIYOSHI, Osamu SUZUKI, Takahiro NAGAYAMA, Takashi TSUJI, Layton H. SMITH, Anthony B. PINKERTON
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Patent number: 11209348Abstract: Provided are a hair observation method, a phase contrast microscope system, and a preparation. The hair observation method includes capturing an infrared image of the hair using an image sensor that is capable of detecting infrared light. A phase contrast microscope system includes: a stage having a sample placed thereon; an infrared light irradiation source for irradiating infrared light to the sample placed on the stage; an image sensor that is capable of detecting infrared light and configured to capture an infrared image of the sample; and a display apparatus configured to display the infrared image captured by the image sensor. The preparation includes a microscope glass and a plurality of hair pieces that are obtained by cutting one hair and arranged on the microscope glass in a manner parallel with one another from one end to another end in a cutting order.Type: GrantFiled: April 18, 2018Date of Patent: December 28, 2021Assignees: KYOCERA CORPORATION, RIKEN, ORGAN TECHNOLOGIES, INC.Inventors: Takashi Tsuji, Koh-ei Toyoshima, Kazuto Miyazaki, Takashi Saotome
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Publication number: 20210380940Abstract: To provide means for efficient growth of epithelial cells capable of being used to manufacture regenerated hair follicle germs. Provided are a culture medium for growth of epithelial cells capable of being used to manufacture regenerated hair follicle germs, the culture medium comprising basal medium and at least (1) through (3), below: and a method for growing the epithelial cells using the culture medium: (1) at least one species of BMP inhibitor: (2) at least one species of fibroblast growth factor: and (3) at least one species of sonic hedgehog (SHH) and/or SHH agonist.Type: ApplicationFiled: September 19, 2019Publication date: December 9, 2021Applicants: ORGAN TECHNOLOGIES, INC., RIKENInventors: Takashi Tsuji, Kyosuke Asakawa, Makoto Takeo, Koh-ei Toyoshima, Miho Ogawa, Yutaka Mori, Kyosuke Kishimoto
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Publication number: 20210361636Abstract: The present invention relates to a novel fused ring compound having urea structure that exhibits excellent NAMPT activating effect, and a method using the same for treating/preventing metabolic disorder, cardiovascular and kidney disease, mitochondrial disease, neurodegenerative disease, ocular disease, and muscle wasting disorder. The present invention provides a compound represented by following formula (I) or a pharmacologically acceptable salt: Formula (I) wherein A, B, R, R2 and R3 represent the same meanings as in the claims.Type: ApplicationFiled: July 3, 2019Publication date: November 25, 2021Inventors: Tsuyoshi NAKAMURA, Mayuko AKIU, Takashi TSUJI, Jun TANAKA, Koji TERAYAMA, Mika YOKOYAMA, Anthony B. PINKERTON, Edward Hampton SESSIONS
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Publication number: 20210355087Abstract: The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the following formula (I): wherein X1 represents a nitrogen atom or CR9, R1 represents a hydrogen atom, a C1-C6 alkyl group, or a C1-C6 alkoxy group, R2 represents a halogen atom, R3 represents a hydrogen atom or a halogen atom, R4 represents a hydrogen atom or a halogen atom, and R5 represents a C1-C3 alkylsulfonyl group, a substituted C1-C6 alkyl group, a substituted C1-C6 haloalkyl group, a substituted C1-C6 alkoxy group, or a substituted C1-C6 alkylamino group, or a pharmacologically acceptable salt thereof.Type: ApplicationFiled: October 22, 2019Publication date: November 18, 2021Applicants: DAIICHI SANKYO COMPANY, LIMITED, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTEInventors: Takashi Tsuji, Yasunobu Kurosaki, Koutaro Ishibashi, Anthony B. Pinkerton
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Patent number: 11155525Abstract: The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X1 represents —N? or —CH?, X2 represents —CH? or —N?, R1 and R2 each represent a C1 to C6 alkoxy group or the like, R3 represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R4 represents a C1 to C6 alkylthio group or a C2 to C6 alkenyl group (the C1 to C6 alkylthio group and the C2 to C6 alkenyl group are each optionally substituted by one carboxy group or the like) or the like.Type: GrantFiled: April 20, 2020Date of Patent: October 26, 2021Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTEInventors: Takuya Ikeda, Yoshiyuki Kobayashi, Naoki Miyoshi, Osamu Suzuki, Takahiro Nagayama, Takashi Tsuji, Layton H. Smith, Anthony B. Pinkerton
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Publication number: 20210282390Abstract: A perfusion lumen is connected to at least one perfusion blood vessel among a plurality of blood vessels that extends from a branch of a plurality of blood vessels protruding from a liver, the branch existing on a distal side viewed from the liver, to a further distal side viewed from the liver. The perfusion lumen is supplied with perfusate to perfuse the liver and maintain the condition of the liver. Among blood vessels that are not connected to the perfusion lumen, at least one conserved blood vessel is obstructed and conserved for anastomosis to a blood vessel of the living body. Accordingly, the perfusion state of the liver is maintained even during anastomosis to the blood vessels of the living body. This enables anastomosis to the blood vessels of the living body while maintaining the perfusion state of the liver.Type: ApplicationFiled: July 31, 2017Publication date: September 16, 2021Inventors: Eiji KOBAYASHI, Takashi TSUJI, Jun ISHIKAWA, Syuhei YOSHIMOTO, Shinji TORAI
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Publication number: 20210196861Abstract: The present invention provides a method for producing regenerated hair follicle primordium that allows production of regenerated hair follicle primordium more easily and in larger amounts compared to conventional production methods. A method for producing regenerated hair follicle primordium comprising a step of obtaining hair follicle primordium by culturing a first population of cells comprising epithelial cells and a second population of cells comprising mesenchymal cells while allowing them to be in contact is provided. The production method of the present invention is characterized in that at least either one of said first population of cells and said second population of cells has formed cell aggregates before said contact, and a culture support is not used when contacting the other population of cells with said cell aggregate.Type: ApplicationFiled: May 31, 2019Publication date: July 1, 2021Applicants: ORGAN TECHNOLOGIES, INC., RIKENInventors: Takashi Tsuji, Yutaka Mori, Koh-ei Toyoshima
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Publication number: 20210145713Abstract: The present invention is directed to a hair growth agent for external use comprising chiro-inositol, which is provided as an excellent hair growth agent.Type: ApplicationFiled: January 26, 2021Publication date: May 20, 2021Applicant: KOBAYASHI PHARMACEUTICAL CO., LTD.Inventors: Kosuke TANAKA, Mihoko KAWASAKI, Hironori TOMI, Takashi TSUJI
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Publication number: 20210102890Abstract: Provided are a hair observation method, a phase contrast microscope system, and a preparation. The hair observation method includes capturing an infrared image of the hair using an image sensor that is capable of detecting infrared light. A phase contrast microscope system includes: a stage having a sample placed thereon; an infrared light irradiation source for irradiating infrared light to the sample placed on the stage; an image sensor that is capable of detecting infrared light and configured to capture an infrared image of the sample; and a display apparatus configured to display the infrared image captured by the image sensor. The preparation includes a microscope glass and a plurality of hair pieces that are obtained by cutting one hair and arranged on the microscope glass in a manner parallel with one another from one end to another end in a cutting order.Type: ApplicationFiled: April 18, 2018Publication date: April 8, 2021Inventors: Takashi TSUJI, Koh-ei TOYOSHIMA, Kazuto MIYAZAKI, Takashi SAOTOME
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Patent number: 10933001Abstract: The present invention is directed to a hair growth agent for external use comprising chiro-inositol, which is provided as an excellent hair growth agent.Type: GrantFiled: April 27, 2017Date of Patent: March 2, 2021Assignee: KOBAYASHI PHARMACEUTICAL CO., LTD.Inventors: Kosuke Tanaka, Mihoko Kawasaki, Hironori Tomi, Takashi Tsuji
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Patent number: 10886371Abstract: A silicon carbide semiconductor device, including a semiconductor substrate having first and second epitaxial layers. The second epitaxial layer is formed on a first main surface of the semiconductor substrate, and includes first and second semiconductor regions, selectively provided in a surface layer of the second epitaxial layer respectively in the active region and the border region, and a third semiconductor region. The semiconductor device further includes a trench penetrating the first and third semiconductor regions to reach the first epitaxial layer, a gate electrode provided in the trench via a gate insulating film, a first electrode electrically connected to the first and third semiconductor regions, and a second electrode provided at a second main surface of the semiconductor substrate. The second semiconductor region is separate from the first semiconductor region.Type: GrantFiled: April 19, 2019Date of Patent: January 5, 2021Assignee: FUJI ELECTRIC CO., LTD.Inventors: Takashi Tsuji, Akimasa Kinoshita
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Publication number: 20200347022Abstract: The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X represents —N? or —CH?, X2 represents —CH? or —N?, R1 and R2 each represent a C1 to C6 alkoxy group or the like, R3 represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R4 represents a C1 to C6 alkylthio group or a C2 to C6 alkenyl group (the C1 to C6 alkylthio group and the C2 to C6 alkenyl group are each optionally substituted by one carboxy group or the like) or the like.Type: ApplicationFiled: April 20, 2020Publication date: November 5, 2020Inventors: Takuya IKEDA, Yoshiyuki KOBAYASHI, Naoki MIYOSHI, Osamu SUZUKI, Takahiro NAGAYAMA, Takashi TSUJI, Layton H. SMITH, Anthony B. PINKERTON
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Publication number: 20200340915Abstract: Provided is a flow path that can easily feed a liquid in the flow path. A flow path (210) is the flow path (210) for feeding a liquid, at least a portion of the flow path (210) includes a first region having a plurality of first through-holes for maintaining a pressure in the flow path (210) at atmospheric pressure, and a second region having an affinity for the liquid, and the liquid is fed by a force caused by affinity for the second region.Type: ApplicationFiled: January 18, 2019Publication date: October 29, 2020Applicant: NITTO DENKO CORPORATIONInventors: Kazuya MIWA, Ryota MASUDA, Makoto MIYAHARA, Takashi TSUJI, Mitsuhiko HORI
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Patent number: 10765806Abstract: The present invention relates to a dosing mechanism including: a body (2); and a disposable portion (3) that is removably attached to the body (2), in which the disposable portion (3) includes: a pump that sucks a medicine from a medicine vessel and discharges the medicine to a patient; a suction-side tube (33) that extends from the pump toward the medicine vessel; a discharge-side tube (34) that extends from the pump toward the patient; and a connector (331, 341) that is located at a front end of at least one of the suction-side tube (33) and the discharge-side tube (34), and the body (2) includes a sensor (24) in a position corresponding to the suction-side tube (33) or the discharge-side tube (34) attached to the body (2).Type: GrantFiled: November 26, 2015Date of Patent: September 8, 2020Assignee: NITTO DENKO CORPORATIONInventors: Toru Mizutani, Takashi Tsuji, Hiroyuki Shinohara
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Publication number: 20200188065Abstract: The present invention provides a dental implant device comprising a dental implant body and an implant fixture. Said implant fixture is characterized in that it comprises a portion to be fixed to said implant body and a portion to be fixed to a tooth adjacent to the transplantation site of said implant body in a subject, and is configured so that mechanical stimulation from the tooth adjacent to said transplantation site is transmissible to said implant body, and said implant device is characterized in that it is placed into the oral cavity of said subject so that said implant body is inserted at said transplantation site while said implant fixture is fixed to said implant body and the tooth adjacent to said transplantation site.Type: ApplicationFiled: August 14, 2017Publication date: June 18, 2020Inventors: Takashi Tsuji, Masamitsu Oshima, Takuo Kuboki, Yoshiki Ando, Miho Ogawa