Patents by Inventor Takayoshi Fukushima
Takayoshi Fukushima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240092890Abstract: A bispecific antibody including a first domain which specifically binds to a mutant calreticulin protein and a second domain which specifically binds to a CD3 antigen. A pharmaceutical composition including the bispecific antibody or a functional fragment thereof. A diagnostic method for a myeloproliferative neoplasm, including detecting a polypeptide in a biological sample with the bispecific antibody.Type: ApplicationFiled: August 26, 2021Publication date: March 21, 2024Applicants: JUNTENDO EDUCATIONAL FOUNDATION, MEIJI SEIKA PHARMA CO., LTD.Inventors: Norio KOMATSU, Marito ARAKI, Yoshihiko KIHARA, Yoji ISHIDA, Koichi KITAMURA, Takayoshi FUKUSHIMA, Kaori YASUI
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Publication number: 20160367585Abstract: The present invention relates to novel aminoglycoside antibiotics, a process for producing the same, and pharmaceutical use thereof. More specifically, the present invention relates to compounds represented by formula (I), a process for producing the same, and use of the same as antimicrobial agents. wherein R represents amino or hydroxyl.Type: ApplicationFiled: September 6, 2016Publication date: December 22, 2016Inventors: Naomi SUMIDA, Koji YANAI, Masato TANI, Takayoshi FUKUSHIMA, Yasumasa OTA, Shuichi GOMI, Akitaka NAKANE
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Patent number: 9512409Abstract: An object is to efficiently produce thermostable catalase at low cost by expressing it as a recombinant protein in large quantity. A recombinant microorganism capable of efficiently expressing thermostable catalase can be provided by obtaining a DNA necessary for efficiently producing it as a recombinant protein, and the thermostable catalase can be efficiently produced at low cost by cultivating the obtained recombinant microorganism. Hydrogen peroxide can be efficiently decomposed at low cost, even at high temperature, by treating a solution containing hydrogen peroxide with the thermostable catalase of the present invention.Type: GrantFiled: January 27, 2015Date of Patent: December 6, 2016Assignee: MEIJI SEIKA PHARMA CO., LTD.Inventors: Kaoru Okakura, Fusuke Mazuka, Takayoshi Fukushima, Koichiro Murashima
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Patent number: 9469863Abstract: The present invention relates to novel aminoglycoside antibiotics, a process for producing the same, and pharmaceutical use thereof. More specifically, the present invention relates to compounds represented by formula (I), a process for producing the same, and use of the same as antimicrobial agents. wherein R represents amino or hydroxyl.Type: GrantFiled: December 1, 2008Date of Patent: October 18, 2016Assignee: MEIJI SEIKA KAISHA, LTD.Inventors: Naomi Sumida, Koji Yanai, Masato Tani, Takayoshi Fukushima, Yasumasa Ota, Shuichi Gomi, Akitaka Nakane
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Publication number: 20150132820Abstract: An object is to efficiently produce thermostable catalase at low cost by expressing it as a recombinant protein in large quantity. A recombinant microorganism capable of efficiently expressing thermostable catalase can be provided by obtaining a DNA necessary for efficiently producing it as a recombinant protein, and the thermostable catalase can be efficiently produced at low cost by cultivating the obtained recombinant microorganism. Hydrogen peroxide can be efficiently decomposed at low cost, even at high temperature, by treating a solution containing hydrogen peroxide with the thermostable catalase of the present invention.Type: ApplicationFiled: January 27, 2015Publication date: May 14, 2015Applicant: MEIJI SEIKA PHARMA CO., LTD.Inventors: Kaoru OKAKURA, Fusuke MAZUKA, Takayoshi FUKUSHIMA, Koichiro MURASHIMA
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Patent number: 8975053Abstract: An object is to efficiently produce thermostable catalase at low cost by expressing it as a recombinant protein in large quantity. A recombinant microorganism capable of efficiently expressing thermostable catalase can be provided by obtaining a DNA necessary for efficiently producing it as a recombinant protein, and the thermostable catalase can be efficiently produced at low cost by cultivating the obtained recombinant microorganism. Hydrogen peroxide can be efficiently decomposed at low cost, even at high temperature, by treating a solution containing hydrogen peroxide with the thermostable catalase of the present invention.Type: GrantFiled: February 18, 2009Date of Patent: March 10, 2015Assignee: Meiji Seika Pharma Co., Ltd.Inventors: Kaoru Okakura, Fusuke Mazuka, Takayoshi Fukushima, Koichiro Murashima
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Patent number: 8697409Abstract: Disclosed are a ketoreductase mutant which can be used for an efficient production of daunorubicin derivatives, a DNA encoding the mutant, a transformant prepared by introducing the DNA thereinto to produce a daunorubicin derivative, and a process of producing a daunorubicin derivative using the transformant. The ketoreductase mutant has an amino acid sequence in which one amino acid residue or two or more amino acid residues selected from the group consisting of amino acids located at positions corresponding to the 42nd, 149th, 153rd, 270th, and 306th amino acids in the amino acid sequence of a ketoreductase (EvaE) from a chlororemomycin-producing bacterium (Amycolatopsis orientalis) are substituted with another amino acid residues.Type: GrantFiled: May 21, 2010Date of Patent: April 15, 2014Assignee: Meiji Seika Pharma Co., Ltd.Inventors: Fusuke Mazuka, Takayoshi Fukushima, Naomi Sumida, Koji Yanai
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Publication number: 20130116416Abstract: Disclosed are a ketoreductase mutant which can be used for an efficient production of daunorubicin derivatives, a DNA encoding the mutant, a transformant prepared by introducing the DNA thereinto to produce a daunorubicin derivative, and a process of producing a daunorubicin derivative using the transformant. The ketoreductase mutant has an amino acid sequence in which one amino acid residue or two or more amino acid residues selected from the group consisting of amino acids located at positions corresponding to the 42nd, 149th, 153rd, 270th, and 306th amino acids in the amino acid sequence of a ketoreductase (EvaE) from a chlororemomycin-producing bacterium (Amycolatopsis orientalis) are substituted with another amino acid residues.Type: ApplicationFiled: May 21, 2010Publication date: May 9, 2013Applicant: MEIJI SEIKA PHARMA, CO., LTD.Inventors: Fusuke Mazuka, Takayoshi Fukushima, Naomi Sumida, Koji Yanai
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Patent number: 8257955Abstract: A novel endoglucanase PPCE derived from Penicillium pinophilum, a cellulase preparation containing the endoglucanase PPCE, and a method of treating a cellulose-containing fabric utilizing the endoglucanase PPCE or the cellulase preparation, are disclosed. The endoglucanase PPCE is highly active to a fabric, and has a low optimum temperature and a strongly acidic optimum pH.Type: GrantFiled: March 12, 2008Date of Patent: September 4, 2012Assignee: Meiji Seika Pharma Co., Ltd.Inventors: Tatsuki Moriya, Akitaka Nakane, Goh Tsujiuchi, Takayoshi Fukushima
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Publication number: 20110294192Abstract: A fusion collagenase in which an affinity tag is added to the carboxyl terminal of a collagenase was expressed as a recombinant protein. It was found that a collagenase having a collagen-binding domain can be selectively collected by purifying the obtained fusion collagenase by affinity chromatography.Type: ApplicationFiled: November 6, 2009Publication date: December 1, 2011Applicants: TOHOKU UNIVERSITY, MEIJI SEIKA PHARMA CO., LTD.Inventors: Takayoshi Fukushima, Kengo Yokoyama, Koichiro Murashima, Masafumi Goto, Youhei Yamagata
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Publication number: 20110034405Abstract: The present invention relates to novel aminoglycoside antibiotics, a process for producing the same, and pharmaceutical use thereof. More specifically, the present invention relates to compounds represented by formula (I), a process for producing the same, and use of the same as antimicrobial agents. wherein R represents amino or hydroxyl.Type: ApplicationFiled: December 1, 2008Publication date: February 10, 2011Inventors: Naomi Sumida, Koji Yanai, Masato Tani, Takayoshi Fukushima, Yasumasa Ota, Shuichi Gomi, Akitaka Nakane
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Publication number: 20100330646Abstract: An object is to efficiently produce thermostable catalase at low cost by expressing it as a recombinant protein in large quantity. A recombinant microorganism capable of efficiently expressing thermostable catalase can be provided by obtaining a DNA necessary for efficiently producing it as a recombinant protein, and the thermostable catalase can be efficiently produced at low cost by cultivating the obtained recombinant microorganism. Hydrogen peroxide can be efficiently decomposed at low cost, even at high temperature, by treating a solution containing hydrogen peroxide with the thermostable catalase of the present invention.Type: ApplicationFiled: February 18, 2009Publication date: December 30, 2010Inventors: Kaoru Okakura, Fusuke Mazuka, Takayoshi Fukushima, Koichiro Murashima
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Publication number: 20100098807Abstract: A novel endoglucanase PPCE derived from Penicillium pinophilum, a cellulase preparation containing the endoglucanase PPCE, and a method of treating a cellulose-containing fabric utilizing the endoglucanase PPCE or the cellulase preparation, are disclosed. The endoglucanase PPCE is highly active to a fabric, and has a low optimum temperature and a strongly acidic optimum pH.Type: ApplicationFiled: March 12, 2008Publication date: April 22, 2010Applicant: MEIJI SEIKA KAISHA, LTD.Inventors: Tatsuki Moriya, Akitaka Nakane, Goh Tsujiuchi, Takayoshi Fukushima