Abstract: A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.

Abstract: A wiper device including a wiper member that includes a wiper arm to which a wiper blade is coupled, a base end portion of the wiper arm being supported by a support section provided at a vehicle, and the wiper member being configured to of undergo displacement relative to the vehicle, a drive wheel that is rotatably supported by the wiper member at a position of the wiper member which is separated from the support section, and that rolls across a running face provided at the vehicle so as to displace the wiper member relative to the vehicle, and a motor that is supported by the wiper member so as to undergo displacement together with the wiper member, and that drives rotation of the drive wheel.

Abstract: The present disclosure provides a vehicle wiper-washer device including: a wiper motor causing to-and-fro wiping operation on a wiping surface by a wiper blade coupled to a wiper arm; a washer pump that feeds washer fluid under pressure to a jetting portion provided to at least one of the wiper blade or the wiper arm, to cause washer fluid to be jetted from the jetting portion toward the wiping surface on an outward movement direction side of the wiper blade during the to-and-fro wiping operation; and a control unit that, when a predetermined signal is detected, controls the wiper motor and the washer pump such that the to-and-fro wiping operation is performed, and such that washer fluid is jetted from the jetting portion toward the wiping surface on the outward movement direction side while a return path wiping operation of the to-and-fro wiping operation is being performed.

Abstract: A wiper device including a wiper member that includes a wiper arm to which a wiper blade is coupled, a base end portion of the wiper arm being supported by a support section provided at a vehicle, and the wiper member being configured to of undergo displacement relative to the vehicle, a drive wheel that is rotatably supported by the wiper member at a position of the wiper member which is separated from the support section, and that rolls across a running face provided at the vehicle so as to displace the wiper member relative to the vehicle, and a motor that is supported by the wiper member so as to undergo displacement together with the wiper member, and that drives rotation of the drive wheel.

Abstract: A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.

Abstract: A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.

Abstract: The present disclosure provides a vehicle wiper-washer device including: a wiper motor causing to-and-fro wiping operation on a wiping surface by a wiper blade coupled to a wiper arm; a washer pump that feeds washer fluid under pressure to a jetting portion provided to at least one of the wiper blade or the wiper arm, to cause washer fluid to be jetted from the jetting portion toward the wiping surface on an outward movement direction side of the wiper blade during the to-and-fro wiping operation; and a control unit that, when a predetermined signal is detected, controls the wiper motor and the washer pump such that the to-and-fro wiping operation is performed, and such that washer fluid is jetted from the jetting portion toward the wiping surface on the outward movement direction side while a return path wiping operation of the to-and-fro wiping operation is being performed.

Abstract: A process for preparing a bioabsorbable sheet preparation holding thrombin is provided. A process for preparing a bioabsorbable sheet preparation holding thrombin which comprises immersing a bioabsorbable sheet consisting of polyglycolic acid in a thrombin solution containing thrombin as an active ingredient, glycerol as a softening agent, Tween 80 as a permeating agent, and optionally histidine and trehalose as a stabilizing agent followed by drying to hold thrombin on said bioabsorbable sheet, and a bioabsorbable sheet preparation holding thrombin prepared by said process.

Abstract: A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.

Abstract: A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.

Abstract: A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.

Abstract: A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.

Abstract: A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.

Abstract: A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.

Abstract: A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.

Abstract: A process for preparing a bioabsorbable sheet preparation holding thrombin is provided. A process for preparing a bioabsorbable sheet preparation holding thrombin which comprises immersing a bioabsorbable sheet consisting of polyglycolic acid in a thrombin solution containing thrombin as an active ingredient, glycerol as a softening agent, Tween 80 as a permeating agent, and optionally histidine and trehalose as a stabilizing agent followed by drying to hold thrombin on said bioabsorbable sheet, and a bioabsorbable sheet preparation holding thrombin prepared by said process.

Abstract: A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.

Abstract: A gene encoding a production amount-potentiating factor is introduced into an animal cell to transform the cell. Alternatively, a protein production gene and the gene encoding the production amount-potentiating factor are introduced into the animal cell to transform the cell. Herein, as the production amount potentiating factor, there is used a factor having caspase activity inhibiting activity and/or protein biosynthesis activity potentiating action, for example, baculovirus P35. Further, the animal cell is cultured by a culturing method under a condition that apoptosis is not induced, so that a protein is mass-produced.

Abstract: An input disk, a clutch disk and wave washers are installed to an output shaft to form an output shaft assembly of a motor apparatus. The input disk is axially non-detachable from the output shaft and is rotatable about an axis of the output shaft. The input disk is driven by a drive force supplied from a motor main body of the motor apparatus. The clutch disk is supported by the output shaft in such a manner that the clutch disk is non-rotatable relative to the output shaft and is axially movable along the output shaft relative to the input disk. The wave washers apply a resistive force against axial movement of the clutch disk from a coupled state, at which the input disk is coupled with the clutch disk to rotate together.

Abstract: Initiation of coupling between an input disk and a clutch disk at a maximum rotational coupling force without making relative rotation between the input disk and the clutch disk is enabled only when the output shaft is placed in a single engageable point within a normal reciprocal angular range of the output shaft. When a load applied to the output shaft is equal to or greater than a predetermined value, the input disk and the clutch disk are decoupled from one another, so that the relative rotation is made between the input disk and the clutch disk.