Patents by Inventor Takayuki KANAGAWA

Takayuki KANAGAWA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUND, METHOD AND PHARMACEUTICAL COMPOSITION FOR MODULATING EXPRESSION OF DUX4
    Publication number: 20220228140
    Abstract: An object of the present invention is to provide a compound, a method and a pharmaceutical composition for normalizing double homeobox 4 (DUX4) of an individual in which the DUX4 gene has abnormally expressed. Provided is a modified oligonucleotide consisting of 12-30 residues. The modified oligonucleotide includes a nucleobase sequence that includes at least 8 contiguous nucleobase sequences and is complementary to an equal length portion at positions 126-147, 232-248, 1306-1325 or 1472-1495 from a 5? end of a nucleobase of a mature mRNA of DUX4 of SEQ ID NO: 1. The nucleobase sequence of the modified oligonucleotide has at least 90% complementarity to the equal length portion in the nucleobase sequence of the mature mRNA of DUX4 of SEQ ID NO: 1.
    Type: Application
    Filed: March 27, 2020
    Publication date: July 21, 2022
    Applicant: MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Shinji KUMAGAI, Takashi YASHIRO, Tomo ARAKI, Takayuki KANAGAWA, Chieko OKAGAKI, Hiroyuki FURUKAWA