Patents by Inventor Takehiko Iida

Takehiko Iida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for Producing 4(3H)-Quinazolinone Derivative
    Publication number: 20090131664
    Abstract: This invention is related to a method for producing 3-{4-[3-(1-pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone comprising a step for reacting 2-methyl-5-trifluoromethyl-4H-3,1-benzoxazin-4-one with 4-[3-(1-pyrrolidinyl)propoxy]aniline or an acid-addition salt thereof, or 4-(1-cyclobutyl-4-piperidinoy9oxyaniline or acid addition salt thereof in the presence of an acid catalyst.
    Type: Application
    Filed: July 4, 2006
    Publication date: May 21, 2009
    Inventors: Atsushi Akao, Takehiko Iida, Takahiro Itoh, Toshiaki Mase, Kimihiko Sato, Naotaka Sawada, Chie Kadowaki, Takayuki Tsuritani, Nobuyoshi Yasuda
  • Process for making spirolactone compounds
    Patent number: 7482449
    Abstract: This invention relates to a process for making spirolactone compounds analogous to formula I.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: January 27, 2009
    Assignees: Merck & Co., Inc., Banyu Pharmaceutical Co., Ltd.
    Inventors: Ralph P. Volante, David M. Tschaen, Steven A. Weissman, Matthew Heileman, Toshiaki Mase, Takehiko Iida, Kenji Maeda, Toshihiro Wada, Hiroki Sato, Kenichi Asakawa
  • Process for exchanging functional groups by halogen-metal exchange reaction
    Patent number: 7439535
    Abstract: A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group. Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixture of a magnesium compound represented by the formula R1—Mg—X (I) (wherein R1 represents a halogen atom or an optionally substituted hydrocarbon residue; and X1 represents a halogen atom) and an organolithium compound represented by the formula R2—Li (II)(wherein R2 represents an optionally substituted hydrocarbon residue) or a product of the reaction of the magnesium compound with the organolithium compound; and a process for producing with the reagent a compound in which a halogen atom of a halogen compound has been replaced with an electrophilic group.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: October 21, 2008
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Takehiko Iida, Toshihiro Wada, Toshiaki Mase
  • Process for making spirolactone compounds
    Publication number: 20080171888
    Abstract: This invention relates to a process for making spirolactone compounds analogous to formula I.
    Type: Application
    Filed: March 19, 2008
    Publication date: July 17, 2008
    Inventors: Ralph P. Volante, David M. Tschaen, Steven A. Weissman, Matthew Heileman, Toshiaki Mase, Takehiko Iida, Kenji Maeda, Toshihiro Wada, Hiroki Sato, Kenichi Asakawa
  • Process for making spirolactone compounds
    Patent number: 7368569
    Abstract: This invention relates to a process for making spirolactone compounds analogous to formula I
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: May 6, 2008
    Assignees: Merck & Co., Inc., Banyu Pharmaceutical Co., Ltd.
    Inventors: Ralph P. Volante, David M. Tschaen, Steven A. Weissman, Matthew Heileman, Toshiaki Mase, Takehiko Iida, Kenji Maeda, Toshihiro Wada, Hiroki Sato, Kenichi Asakawa
  • Process for producing indolopyrrolocarbazole derivative
    Publication number: 20070197796
    Abstract: The present invention relates to an industrially preferable process for producing an indolopyrrolocarbazole derivative represented by the formula (I): or a pharmaceutically acceptable salt thereof, which is useful as an anti-cancer agent. The above process comprises treating a compound represented by the formula (V): or a pharmaceutically acceptable salt thereof, a solvate thereof or a salt thereof, with a base in an inert solvent, followed by treatment with an acid, and further treating the resulting reaction solution with a base in an inert solvent and subsequently with an acid, and then reacting the resulting compound with an acid addition salt of hydrazine diol in the presence of an acid scavenger, followed by removal of protecting group(s) from the resulting compound.
    Type: Application
    Filed: May 26, 2005
    Publication date: August 23, 2007
    Applicant: BANYU PHARMACEUTICALS, CO., LTD.
    Inventors: Takehiko Iida, Shouichi Hiraga, Akihiro Takezawa, Toshiaki Mase
  • Process for making spirolactone compounds
    Publication number: 20060241299
    Abstract: This invention relates to a process for making spirolactone compounds of general formula I, having an improved IA/IB ratio, according to the following shceme.
    Type: Application
    Filed: May 14, 2004
    Publication date: October 26, 2006
    Inventors: Ralph Volante, Steven Weissman, Takehiko Iida, Yuhei Yamamoto, Hiroki Sato, Kenji Maeda, Naotaka Sawada, Toshiaki Mase
  • Process for Making Spirolactone Compounds
    Publication number: 20060014950
    Abstract: This invention relates to a process for making spirolactone compounds analogous to formula I.
    Type: Application
    Filed: October 14, 2003
    Publication date: January 19, 2006
    Inventors: Ralph Volante, David Tschaen, Steven Weissman, Mathew Heileman, Toshiaki Mase, Takehiko Iida, Kenji Maeda, Toshihiro Wada, Hiroki Sato, Kenichi Asakawa
  • Process for making pyrazole compounds
    Publication number: 20060014815
    Abstract: This invention relates to a process for making pyrazole compounds of formula I.
    Type: Application
    Filed: October 22, 2003
    Publication date: January 19, 2006
    Inventors: Toshiaki Mase, Takehiko Iida, Masashi Kawasaki, Kenichi Asakawa
  • Method of converting functional group through halogen-metal exchange reaction
    Patent number: 6946559
    Abstract: A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group. Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixture of a magnesium compound represented by the formula R1—Mg—X (I) (wherein R1 represents a halogen atom or an optionally substituted hydrocarbon residue; and X1 represents a halogen atom) and an organolithium compound represented by the formula R2—Li (II) (wherein R2 represents an optionally substituted hydrocarbon residue) or a product of the reaction of the magnesium compound with the organolithium compound; and a process for producing with the reagent a compound in which a halogen atom of a halogen compound has been replaced with an electrophilic group.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: September 20, 2005
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Takehiko Iida, Toshihiro Wada, Toshiaki Mase
  • Process for exchanging functional groups by halogen-metal exchange reaction
    Publication number: 20050156336
    Abstract: A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group. Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixture of a magnesium compound represented by the formula R1—Mg—X (I) (wherein R1 represents a halogen atom or an optionally substituted hydrocarbon residue; and X1 represents a halogen atom) and an organolithium compound represented by the formula R2—Li (II)(wherein R2 represents an optionally substituted hydrocarbon residue) or a product of the reaction of the magnesium compound with the organolithium compound; and a process for producing with the reagent a compound in which a halogen atom of a halogen compound has been replaced with an electrophilic group.
    Type: Application
    Filed: March 11, 2005
    Publication date: July 21, 2005
    Inventors: Takehiko Iida, Toshihiro Wada, Toshiaki Mase
  • Preparation and isolation of indolocarbazole glycosides
    Publication number: 20040116688
    Abstract: The present invention relates to a novel process to make indolocarbazole glycosides in high purity which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, and the like.
    Type: Application
    Filed: September 25, 2003
    Publication date: June 17, 2004
    Inventors: Steven Weissman, David Tschaen, Asayuki Kamatani, Shouichi Hiraga, Masashi Kawasaki, Takehiko Iida
  • Process for making spirolactone compounds
    Patent number: 6605720
    Abstract: This invention relates to processes for making spirolactone compounds analogous to formula I:
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: August 12, 2003
    Assignees: Merck & Co., Inc., Banyu Pharmaceutical Co., Ltd.
    Inventors: Kenji Maeda, Shinji Kato, Takehiko Iida, David M. Tschaen
  • PROCESS FOR MAKING SPIROLACTONE COMPOUNDS
    Publication number: 20030144515
    Abstract: This invention relates to processes for making spirolactone compounds analogous to formula I: 1
    Type: Application
    Filed: January 23, 2003
    Publication date: July 31, 2003
    Inventors: Kenji Maeda, Shinji Kato, Takehiko Iida, David M. Tschaen
  • Method of converting functional group through halogen-metal exchange reaction
    Publication number: 20030130511
    Abstract: A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group.
    Type: Application
    Filed: September 5, 2002
    Publication date: July 10, 2003
    Inventors: Takehiko Iida, Toshihiro Wada, Toshiaki Mase
  • Preparation and isolation of indolocarbazole glycosides
    Patent number: 6559299
    Abstract: The present invention relates to a novel process to make indolocarbazole glycosides in high purity which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, and the like.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: May 6, 2003
    Assignees: Merck & Co., Inc., Banyu Pharmaceutical Co., Ltd.
    Inventors: Steven Weissman, David Tschaen, Asayuki Kamatani, Shouichi Hiraga, Masashi Kawasaki, Takehiko Iida
  • Preparation and isolation of indolocarbazole glycosides
    Publication number: 20020193324
    Abstract: The present invention relates to a novel process to make indolocarbazole glycosides in high purity which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, and the like.
    Type: Application
    Filed: March 21, 2002
    Publication date: December 19, 2002
    Inventors: Steven Weissman, David Tschaen, Asayuki Kamatani, Shouichi Hiraga, Masashi Kawasaki, Takehiko Iida