Patents by Inventor Takeo Miyaki

Takeo Miyaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pradimicins l and fl, and derivatives thereof
    Patent number: 5843908
    Abstract: The present invention relates to novel antifungal antibiotics herein designated as pradimicin L and pradimicin FL, and derivatives thereof. Pradimicins L and FL are produced by Actinomadura verrucosospora subsp. neohibisca strain R103-3, ATCC No. 53930.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: December 1, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yosuke Sawada, Kyoichiro Saitoh, Masami Hatori, Takeo Miyaki, Toshikazu Oki, Koji Tomita
  • Antiviral antibiotic BU-3889V
    Patent number: 5286649
    Abstract: Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
    Type: Grant
    Filed: January 10, 1992
    Date of Patent: February 15, 1994
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Masataka Konishi, Mitsuaki Tsunakawa, Osamu Tenmyo, Takeo Miyaki, Toshikazu Oki
  • Method for treating fungal infections with serine analogs of BU-3608 antibiotics
    Patent number: 5183808
    Abstract: Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: February 2, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yosuke Sawada, Masatoshi Kakushima, Maki Nishio, Takeo Miyaki, Toshikazu Oki
  • Dynemicin C antibiotic, its triacetyl derivative and pharmaceutical composition containing same
    Patent number: 5162330
    Abstract: The novel antitumor antibiotic designated herein as dynemicin C is produced by fermentation of Micromonospora chersina M956-1 mutant F1085 (ATCC-55077). Dynemicin C and its triacetate derivative possess antibacterial and antifungal activity and also inhibit the growth of mammalian tumors.
    Type: Grant
    Filed: November 5, 1990
    Date of Patent: November 10, 1992
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Kyoichiro Saitoh, Takeo Miyaki, Haruaki Yamamoto, Nahomi Oda
  • Process for preparing antiviral antibiotic BU-3889V
    Patent number: 5124150
    Abstract: Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
    Type: Grant
    Filed: March 11, 1991
    Date of Patent: June 23, 1992
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Masataka Konishi, Mitsuaki Tsunakawa, Osamu Tenmyo, Takeo Miyaki, Toshikazu Oki
  • Actinomadura hibisca microorganism useful for preparing serine analogs of BU-3608 antibiotics
    Patent number: 5114857
    Abstract: Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
    Type: Grant
    Filed: May 14, 1991
    Date of Patent: May 19, 1992
    Assignee: Bristol-Myers Company
    Inventors: Yosuke Sawada, Masatoshi Kakushima, Maki Nishio, Takeo Miyaki, Toshikazu Oki
  • Antifungal antibiotics
    Patent number: 5110960
    Abstract: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
    Type: Grant
    Filed: October 1, 1990
    Date of Patent: May 5, 1992
    Assignee: Bristol-Myers Company
    Inventors: Toshikazu Oki, Kyoichiro Saitoh, Kozo Tomatsu, Koji Tomita, Masataka Konishi, Takeo Miyaki, Mitsuaki Tsunakawa, Maki Nishio
  • Antiviral antibiotic BU-3889V
    Patent number: 5098708
    Abstract: Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
    Type: Grant
    Filed: July 6, 1990
    Date of Patent: March 24, 1992
    Assignee: Bristol-Myers Squibb Company
    Inventors: Masataka Konishi, Mitsuaki Tsunakawa, Osamu Tenmyo, Takeo Miyaki, Toshikazu Oki
  • Process for producing antibiotics BU-3608 D and BU-3608 E
    Patent number: 5096817
    Abstract: Disclosed herein are antibiotic BU-3608 D and E isolated from Actinomadura hibisca. These compounds are active antifungal agents.
    Type: Grant
    Filed: December 14, 1990
    Date of Patent: March 17, 1992
    Assignee: Bristol-Myers Company
    Inventors: Maki Nishio, Yosuke Sawada, Takeo Miyaki, Toshikazu Oki
  • Serine analogs of BU-3608 antibiotics
    Patent number: 5061624
    Abstract: Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
    Type: Grant
    Filed: August 20, 1990
    Date of Patent: October 29, 1991
    Assignee: Bristol-Myers Company
    Inventors: Yosuke Sawada, Masatoshi Kakushima, Maki Nishio, Takeo Miyaki, Toshikazu Oki
  • BU-4146T antibiotic
    Patent number: 5037836
    Abstract: A novel antibiotic designated BU-4146T is produced by fermentation of Streptomyces amphibiosporus strain R310-104 (ATCC-53964). The antibiotic possesses both antifungal and antitumor activity.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: August 6, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Masataka Konishi, Koko Sugawara, Masaru Ohbayashi, Takeo Miyaki
  • BU-4146T antibiotic
    Patent number: 5002959
    Abstract: A novel antibiotic designated BU-4146T is produced by fermentation of Streptomyces amphibiosporus strain R310-104 (ATCC-53964). The antibiotic possesses both antifungal and antitumor activity.
    Type: Grant
    Filed: December 11, 1989
    Date of Patent: March 26, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Masataka Konishi, Koko Sugawara, Masaru Ohbayashi, Takeo Miyaki
  • BU-3839T antibiotic
    Patent number: 5001058
    Abstract: A new antibiotic having the chromophore structure of the plurmycin family of antibiotics is produced by fermentation of Streptomyces violaceus ATCC 53807. The new antibiotic designated BU-3839T, exhibits potent antibacterial activity and also inhibits the growth of tumors in experimental animal systems.
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: March 19, 1991
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Keiko Shimizu, Masaru Ohbayashi, Koji Tomita, Takeo Miyaki, Toshikazu Oki
  • Antibiotics BU-3608D and BU-3608E
    Patent number: 4992425
    Abstract: Disclosed herein are antibiotic BU-3608 D and E isolated from Actinomadura hibisca. These compounds are active antifungal agents.
    Type: Grant
    Filed: June 7, 1988
    Date of Patent: February 12, 1991
    Assignee: Bristol-Myers Company
    Inventors: Maki Nishio, Yosuke Sawada, Takeo Miyaki, Toshikazu Oki
  • Biological pure culture of Streptomyces violaceus ATCC 53807
    Patent number: 4992376
    Abstract: An new antibiotic having the chromophore structure of the pluramycin family of antibiotics is produced by fermentation of Streptomyces violaceus ATCC 53807. The new antibiotic designated BU-3839T, exhibits potent antibacterial activity and also inhibits the growth of tumors in experimental animal systems.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: February 12, 1991
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Keiko Shimizu, Masaru Ohbayashi, Koji Tomita, Takeo Miyaki, Toshikazu Oki
  • Antifungal antibiotics
    Patent number: 4990497
    Abstract: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
    Type: Grant
    Filed: June 15, 1989
    Date of Patent: February 5, 1991
    Inventors: Toshikazu Oki, Kyoichiro Saitoh, Kozo Tomatsu, Koji Tomita, Masataka Konishi, Takeo Miyaki, Mitsuaki Tsunakawa, Maki Nishio
  • Serine analogs of BU-3608 antibiotics
    Patent number: 4973673
    Abstract: Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
    Type: Grant
    Filed: November 10, 1988
    Date of Patent: November 27, 1990
    Assignee: Bristol-Myers Company
    Inventors: Yosuke Sawada, Masatoshi Kakushima, Maki Nishio, Takeo Miyaki, Toshikazu Oki
  • Polysubstituted thiazolylpyridine carboxyamide antifungal antibiotic
    Patent number: 4956374
    Abstract: Novel antifungal antibiotic compounds have the structural formula ##STR1## A preferred compound where R is 4-hydroxypentyl is denoted BU-3557B.sub.2. A complex of said compounds is produced by fermenting a culture of Sacchrothrix aerocolonigenes strain N806-4 (ATCC 53712). The complex is recovered by adsorption on nonionic porous polymer resin adsorbent and individual component compounds exhibit in vitro activity against fungi and Gram-positive bacteria and BU-3557B.sub.2 demonstrates in vitro antiprotazoal activity. BU-3557B.sub.2 demonstrates in vivo activity against C. albicans vaginal infection and BU-3557A.sub.3 (where R is 1,5-dihydroxy-5,5-dimethylpentyl) demonstrates in vivo activity against C. albicans systemic infection.
    Type: Grant
    Filed: July 29, 1988
    Date of Patent: September 11, 1990
    Assignee: Bristol-Myers Company
    Inventors: Maki Nishio, Shigeyuki Ando, Takeo Miyaki, Masataka Konishi, Toshikazu Oki
  • BMY-28121, a new antitumor antibiotic
    Patent number: 4935362
    Abstract: A new antitumor antibiotic designated herein as BMY-28121 is produced by fermentation of Streptomyces albus strain K7331-113 (ATCC 39897). BMY-28121, which may be recovered from the fermentation broth in either its natural free hydroxy form (BMY-28121A) or methyl ether form (BMY-28121B), inhibits gram-positive bacteria and anaerobes and inhibits the growth of mammalian tumors such as P-388 leukemia, L-1210 leukemia and B16 melanoma.
    Type: Grant
    Filed: March 30, 1987
    Date of Patent: June 19, 1990
    Assignee: Bristol-Myers Company
    Inventors: Mitsuaki Tsunakawa, Masataka Konishi, Takeo Miyaki
  • BU-3839T antibiotic
    Patent number: 4927848
    Abstract: A new antibiotic having the chromophore structure of the pluramycin family of antibiotics is produced by fermentation of Streptomyces ciolaceus ATCC 53807. The new antibiotic designated BU-3839T, exhibits potent antibacterial activity and also inhibits the growth of tumors in experimental animal systems.
    Type: Grant
    Filed: September 19, 1988
    Date of Patent: May 22, 1990
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Keiko Shimizu, Masaru Ohbayashi, Koji Tomita, Takeo Miyaki, Toshikazu Oki