Patents by Inventor Takeshi Haraguchi

Takeshi Haraguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11479769
    Abstract: Provided is a novel technique for treating cancer using structurally-reinforced S-TuD. Provided are: a composition for the prevention or treatment of tumors, said composition comprising an miRNA inhibitory complex including RNA of analog thereof; and a method for preventing or treating tumors using said composition. The miRNA inhibitory complex preferably includes at least one double-stranded structure and an miRNA-binding sequence. Two strands of the miRNA binding sequence preferably bind individually to two strands on at least one end of the double-stranded structure. According to some of the aspects of the present invention, there is provided a delivery system for delivering such an miRNA inhibitory complex.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: October 25, 2022
    Assignees: National University Corporation Chiba University, GeneDesign, Inc., NOF Corporation
    Inventors: Hideo Iba, Takeshi Haraguchi, Hirokazu Nankai, Hideaki Sato
  • Patent number: 11285168
    Abstract: Tumor growth was found to be significantly suppressed in vivo by inhibiting both miRNA containing 5?-AACACUG-3? as a seed sequence and miRNA containing 5?-AAUACUG-3? as a seed sequence. The inhibition significantly altered the proportion of subpopulations of tumor cells and reduced the tumorigenicity in all subpopulations. The inhibition also exerted a remarkable tumor-shrinking effect on already-formed tumors. The present invention provides novel therapeutic potential against tumor.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: March 29, 2022
    Assignee: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Hideo Iba, Takeshi Haraguchi
  • Patent number: 10844376
    Abstract: The present invention pertains to the improvement of a miRNA inhibitor (a synthesized Tough Decoy (S-TuD)). The present invention provides a miRNA inhibitory complex including RNA or an analog thereof, wherein the RNA inhibitory complex includes at least one double-stranded structure and a miRNA binding sequence, each of two strands of the miRNA binding sequence being bound to two strands of at least one end of the double-stranded structure, and the miRNA inhibitory complex further includes at least one crosslinked nucleic acid.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: November 24, 2020
    Assignees: University of Tokyo, GeneDesign, Inc.
    Inventors: Hideo Iba, Takeshi Haraguchi, Hirokazu Nankai, Hideaki Sato
  • Publication number: 20200032262
    Abstract: Provided is a novel technique for treating cancer using structurally-reinforced S-TuD. Provided are: a composition for the prevention or treatment of tumors, said composition comprising an miRNA inhibitory complex including RNA of analog thereof; and a method for preventing or treating tumors using said composition. The miRNA inhibitory complex preferably includes at least one double-stranded structure and an miRNA-binding sequence. Two strands of the miRNA binding sequence preferably bind individually to two strands on at least one end of the double-stranded structure. According to some of the aspects of the present invention, there is provided a delivery system for delivering such an miRNA inhibitory complex.
    Type: Application
    Filed: March 16, 2018
    Publication date: January 30, 2020
    Inventors: Hideo Iba, Takeshi Haraguchi, Hirokazu Nankai, Hideaki Sato
  • Publication number: 20180271895
    Abstract: Tumor growth was found to be significantly suppressed in vivo by inhibiting both miRNA containing 5?-AACACUG-3? as a seed sequence and miRNA containing 5?-AAUACUG-3? as a seed sequence. The inhibition significantly altered the proportion of subpopulations of tumor cells and reduced the tumorigenicity in all subpopulations. The inhibition also exerted a remarkable tumor-shrinking effect on already-formed tumors. The present invention provides novel therapeutic potential against tumor.
    Type: Application
    Filed: September 27, 2016
    Publication date: September 27, 2018
    Applicant: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Hideo IBA, Takeshi HARAGUCHI
  • Publication number: 20180240087
    Abstract: A checkout system includes a registration apparatus for registering items in a sales transaction, a first settlement apparatus through which settlement processing of a first type can be performed, and a second settlement apparatus through which settlement processing of a second type can be performed. The registration apparatus is configured to designate a settlement method type for the registered sales transaction as one of the first type or second type and to transmit transaction information to the first or second settlement apparatus according to the designated settlement method type.
    Type: Application
    Filed: January 18, 2018
    Publication date: August 23, 2018
    Inventor: Takeshi HARAGUCHI
  • Publication number: 20180232717
    Abstract: A checkout system according to an embodiment includes a registration apparatus in communication with a plurality of checkout apparatuses. The checkout apparatuses each include a display device, a communication interface, a payment device, and a controller. The display device displays an instruction to provide an input to start a checkout processing. When the input to start the checkout processing is received, the communication interface transmits a checkout processing request to the registration apparatus. The checkout processing request includes identification information for identifying the checkout apparatus. The checkout apparatus receives, from the registration apparatus in response to the checkout processing request, transaction information generated by the registration apparatus. The payment device processes payment in accordance with the received transaction information.
    Type: Application
    Filed: January 11, 2018
    Publication date: August 16, 2018
    Inventor: Takeshi HARAGUCHI
  • Publication number: 20180223281
    Abstract: The present invention pertains to the improvement of a miRNA inhibitor (a synthesized Tough Decoy (S-TuD)). The present invention provides a miRNA inhibitory complex including RNA or an analog thereof, wherein the RNA inhibitory complex includes at least one double-stranded structure and a miRNA binding sequence, each of two strands of the miRNA binding sequence being bound to two strands of at least one end of the double-stranded structure, and the miRNA inhibitory complex further includes at least one crosslinked nucleic acid.
    Type: Application
    Filed: September 16, 2016
    Publication date: August 9, 2018
    Inventors: Hideo Iba, Takeshi Haraguchi, Hirokazu Nankai, Hideaki Sato
  • Publication number: 20170224134
    Abstract: A money depositing/dispensing apparatus comprises a coin depositing/dispensing device, configured to store coins acquired through a coin reception port, which includes a first path along which the stored coins travel to a coin dispensing port and a second path along which the stored coins travel to be saved, a bill depositing/dispensing device, configured to store bills acquired through a bill reception port and discharge the stored bills to a bill dispensing port, which is arranged at the lower side of the coin depositing/dispensing device in a space formed at the lower part of the coin dispensing port, and a container, configured to store coins traveling along the second path, which is detachably attached to the coin depositing/dispensing device in the space.
    Type: Application
    Filed: February 1, 2017
    Publication date: August 10, 2017
    Inventors: Osamu WATANABE, Yuki Kawaguchi, Takeshi Haraguchi
  • Publication number: 20170231054
    Abstract: According to an embodiment, a money handling apparatus has an illuminating unit and a controller. The illuminating unit illuminates a support that holds dispensed money by illuminating thereon with light emitted from a light emitting source. The controller turns on the light emitting source of the illuminating unit according to a timing in a money dispensing process.
    Type: Application
    Filed: January 12, 2017
    Publication date: August 10, 2017
    Inventors: Takeshi HARAGUCHI, Osamu WATANABE
  • Publication number: 20170221292
    Abstract: A coin depositing device comprises a coin depositing port including a funnel-shaped inclined surface and a hole, arranged at the lowermost part of the inclined surface, through which a coin slid down along the inclined surface is deposited, and a money placing section including a money placing surface connecting with an upper end of a part of the inclined surface and a guide wall arranged at an edge part of the money placing surface, wherein the inclined surface includes a first inclined surface connecting with the money placing surface and a second inclined surface facing the first inclined surface across the hole, and a lower end of the first inclined surface is located at the bottom side of the hole below a lower end of the second inclined surface.
    Type: Application
    Filed: January 24, 2017
    Publication date: August 3, 2017
    Inventors: Osamu WATANABE, Takeshi HARAGUCHI
  • Publication number: 20160321639
    Abstract: A customer management apparatus comprises a registration processing section configured to register customer management data containing commodity information indicating a commodity purchased by a customer and a customer image for specifying the customer; a selection processing section configured to acquire the customer image for specifying the customer to select, from all the customer management data registered by the registration processing section, customer management data containing a customer image matching with the acquired customer image; and a settlement processing section configured to carry out a settlement processing based on the commodity information contained in the customer management data selected by the selection processing section.
    Type: Application
    Filed: April 18, 2016
    Publication date: November 3, 2016
    Inventors: Takeshi Haraguchi, Toshiyasu Terahara, Takahiro Shimura, Yuki Kawaguchi
  • Publication number: 20160260074
    Abstract: According to the embodiment, the sales data processing apparatus includes an input interface, a bagging stand, a settlement unit, and a display. The bagging stand is disposed below the input interface. The settlement unit is a body separate from the bagging stand, and is disposed at a side of the bagging stand. The display is detachably disposed on the upper portion of the input interface, and is detachably disposed in the settlement unit.
    Type: Application
    Filed: February 1, 2016
    Publication date: September 8, 2016
    Inventors: Takeshi HARAGUCHI, Toshiyasu TERAHARA, Takahiro SHIMURA, Yuki KAWAGUCHI
  • Patent number: 8563709
    Abstract: A miRNA-inhibiting RNA complex has a double-stranded structure, in which at least one RNA strand that includes a miRNA-binding sequence is linked to the two strands at at least one end of the double-stranded structure. The complex can efficiently inhibit miRNAs. In particular, RNAs in which two RNAs containing a miRNA binding sequence are positioned between two double-stranded structures were able to strongly inhibit miRNA. These RNAs can be expressed from, for example, a PolIII promoter, and by integration into a vector, miRNAs can be stably inhibited for a long period of time.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: October 22, 2013
    Assignee: The University of Tokyo
    Inventors: Hideo Iba, Takeshi Haraguchi
  • Patent number: 8390201
    Abstract: A multi-column electron beam exposure apparatus includes: multiple column cells; an electron beam converging unit in which two annular permanent magnets and electromagnetic coils are surrounded by a ferromagnetic frame, the two annular permanent magnets being magnetized in an optical axis direction and symmetrical about the optical axis, where the electromagnetic coils adjust magnetic fields of the annular permanent magnets; and a substrate provided with circular apertures through which electron beams used in the column cells pass, respectively, where the electron beam converging unit is disposed in each of the circular apertures. The two annular permanent magnets may be disposed one above the other in the optical axis direction, and the electromagnetic coils may be provided inside or outside the annular permanent magnets in their radial direction.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: March 5, 2013
    Assignee: Advantest Corp.
    Inventors: Hiroshi Yasuda, Yoshihisa Ooae, Takeshi Haraguchi
  • Patent number: 8330344
    Abstract: An electron gun includes: an electron source; an accelerating electrode; an extraction electrode for extracting electrons from an electron emission surface of the electron source; a suppressor electrode for suppressing emission of electrons from a side surface of the electron source; and an electron beam converging unit for converging an electron beam of thermal field emission electrons emitted from the electron emission surface by applying an electric field to the electron emission surface. The electron beam converging unit is an electrostatic lens electrode which is placed between the extraction electrode and the accelerating electrode and having an opening portion in its center. A voltage is applied to the electrostatic lens electrode to converge the electron beam.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: December 11, 2012
    Assignee: Advantest Corp.
    Inventors: Hiroshi Yasuda, Takeshi Haraguchi, Hiroshi Shimoyama, Hidekazu Murata
  • Publication number: 20110245481
    Abstract: A miRNA-inhibiting RNA complex has a double-stranded structure, in which at least one RNA strand that includes a miRNA-binding sequence is linked to the two strands at at least one end of the double-stranded structure. The complex can efficiently inhibit miRNAs. In particular, RNAs in which two RNAs containing a miRNA binding sequence are positioned between two double-stranded structures were able to strongly inhibit miRNA. These RNAs can be expressed from, for example, a PolIII promoter, and by integration into a vector, miRNAs can be stably inhibited for a long period of time.
    Type: Application
    Filed: March 2, 2011
    Publication date: October 6, 2011
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Hideo Iba, Takeshi Haraguchi
  • Publication number: 20110148297
    Abstract: A multi-column electron beam exposure apparatus includes: multiple column cells; an electron beam converging unit in which two annular permanent magnets and electromagnetic coils are surrounded by a ferromagnetic frame, each of the two annular permanent magnets being magnetized in an optical axis direction and being symmetrical about the optical axis, the electromagnetic coils disposed near the annular permanent magnets and used to adjust magnetic fields of the annular permanent magnets; and a substrate provided with circular apertures through which electron beams used in the column cells pass, respectively, the substrate having the electron beam converging unit disposed in a side portion of each of the circular apertures. The two annular permanent magnets may be disposed one above the other in the optical axis direction with same polarities facing each other, and the electromagnetic coils may be provided inside or outside the annular permanent magnets in their radial direction.
    Type: Application
    Filed: December 22, 2010
    Publication date: June 23, 2011
    Inventors: Hiroshi Yasuda, Yoshihisa Ooae, Takeshi Haraguchi
  • Patent number: 7919750
    Abstract: An electron gun includes an electron source configured to emit electrons. The electron source includes an electron emission region configured to emit the electrons and an electron emission restrictive region configured to restrict emission of the electrons. The electron emission restrictive region is located on a side surface of the electron source except an electron emission surface on a tip of the electron source and is covered with a different material from the electron source. The electron gun emits thermal field-emitted electrons by applying an electric field to the tip while maintaining a sufficiently low temperature to avoid sublimation of a material of the electron source. The material of the electron source may be lanthanum hexaboride (LaB6) or cerium hexaboride (CeB6). The electron emission restrictive region may be covered with carbon.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: April 5, 2011
    Assignees: Advantest Corporation, Denki Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hiroshi Yasuda, Takeshi Haraguchi, Yoshihisa Ooae, Takamasa Satoh, Yoshinori Terui, Seiichi Sakawa, Ryozo Nonogaki
  • Publication number: 20100019648
    Abstract: An electron gun includes: an electron source; an accelerating electrode; an extraction electrode for extracting electrons from an electron emission surface of the electron source; a suppressor electrode for suppressing emission of electrons from a side surface of the electron source; and an electron beam converging unit for converging an electron beam of thermal field emission electrons emitted from the electron emission surface by applying an electric field to the electron emission surface. The electron beam converging unit is an electrostatic lens electrode which is placed between the extraction electrode and the accelerating electrode and having an opening portion in its center. A voltage is applied to the electrostatic lens electrode to converge the electron beam.
    Type: Application
    Filed: September 28, 2009
    Publication date: January 28, 2010
    Inventors: Hiroshi Yasuda, Takeshi Haraguchi, Hiroshi Shimoyama, Hidekazu Murata