Patents by Inventor Takeshi Kuboyama
Takeshi Kuboyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11298326Abstract: The present invention provides nucleic acid-containing lipid nanoparticles containing a lipid (lipid A) which has a hydrophilic unit having a single quaternary ammonium group, and three independent, optionally substituted hydrocarbon groups, a lipid derivative or fatty acid derivative of a water-soluble polymer, and a nucleic acid.Type: GrantFiled: March 24, 2016Date of Patent: April 12, 2022Assignee: KYOWA KIRIN CO., LTD.Inventors: Kentaro Hatanaka, Nobuhiro Yagi, Takeshi Kuboyama, Kaori Yagi, Shintaro Hosoe
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Patent number: 10723872Abstract: The present invention addresses the problem of reducing the hardness of a molded article obtained by cross-linking a cross-linking elastomer. The problem addressed by the present invention is solved by cross-linking a cross-linking elastomer composition including at least a cross-linking elastomer and a fluorine oligomer (a) not including hydrogen.Type: GrantFiled: November 29, 2016Date of Patent: July 28, 2020Assignee: NICHIAS CORPORATIONInventors: Kojiro Otani, Takeshi Kuboyama, Tomoya Shimizu
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Patent number: 10342758Abstract: Provided are a cationic lipid which facilitates the introduction of a nucleic acid into, for example, a cell or the like; a composition containing the cationic lipid and a nucleic acid; a method for introducing a nucleic acid into a cell by using a composition containing the cationic lipid and the nucleic acid; and the like. The cationic lipid is, for example, a cationic lipid represented by formula (A): formula (A): (wherein R1 is alkenyl or the like, R2 is alkenyl or the like, R3 and R4 are each alkyl, or are combined together to form alkylene, or R3 and R5 are combined together to form alkylene, R5 is a hydrogen atom or the like, or is combined together with R3 to form alkylene, X1 is alkylene, and X2 is a single bond or alkylene).Type: GrantFiled: July 8, 2013Date of Patent: July 9, 2019Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Takeshi Kuboyama, Tomohiro Era, Tomoyuki Naoi, Kaori Yagi, Shintaro Hosoe
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Publication number: 20180353434Abstract: The present invention provides nucleic acid-containing lipid nanoparticles containing a lipid (lipid A) which has a hydrophilic unit having a single quaternary ammonium group, and three independent, optionally substituted hydrocarbon groups, a lipid derivative or fatty acid derivative of a water-soluble polymer, and a nucleic acid.Type: ApplicationFiled: March 24, 2016Publication date: December 13, 2018Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Kentaro HATANAKA, Nobuhiro YAGI, Takeshi KUBOYAMA, Kaori YAGI, Shintaro HOSOE
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Publication number: 20180346703Abstract: The present invention addresses the problem of reducing the hardness of a molded article obtained by cross-linking a cross-linking elastomer. The problem addressed by the present invention is solved by cross-linking a cross-linking elastomer composition including at least a cross-linking elastomer and a fluorine oligomer (a) not including hydrogen.Type: ApplicationFiled: November 29, 2016Publication date: December 6, 2018Applicants: NICHIAS CORPORATION, NICHIAS CORPORATIONInventors: Kojiro OTANI, Takeshi KUBOYAMA, Tomoya SHIMIZU
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Publication number: 20180193471Abstract: The present invention provides a nucleic acid conjugate comprising: a double-stranded nucleic acid consisting of a sense strand and an antisense strand and comprising a duplex region of at least 11 base pairs; and a ligand part, wherein an oligonucleotide with a strand length of 17 to 30 nucleotides in the antisense strand is complementary to a target ?2GPI mRNA sequence, and the 3? end or 5? end of the sense strand has a ligand part represented by following formula (I), formula (II), formula (III), formula (IV) or formula (V).Type: ApplicationFiled: July 15, 2016Publication date: July 12, 2018Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Kazutaka NAGATOMO, Kazuhiro MASUDA, Minako KANDA, Yoji YAMADA, Hiroto IWAI, Asana MAKINO, Shintaro HOSOE, Takeshi KUBOYAMA, Keiji UEHARA, Yasuhiro SUZUKI
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Patent number: 9920028Abstract: The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X1 and X2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L3 is a single bond, etc, R3 is alkyl, etc, L1 and L2 are —O—, —CO—O— or —O—CO—), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.Type: GrantFiled: July 1, 2016Date of Patent: March 20, 2018Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Takeshi Kuboyama, Tomohiro Era, Tomoyuki Naoi
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Patent number: 9913907Abstract: The present invention provides a composition for suppressing the expression of a KRAS gene, comprising a lipid particle containing, as a drug, a double-stranded nucleic acid having an antisense strand having a sequence of bases complementary to the sequence of at least 19 continuous bases of any one KRAS gene's mRNA of sequence Nos. 1 to 3; and a cationic lipid represented by the following formula (I): wherein R1 and R2, which are the same or different, are each linear or branched alkyl, alkenyl or alkynyl having a carbon number of from 12 to 24; L1 and L2, which are the same or different, are each —CO—O— or —O—CO—; a and b, which are the same or different, are each 1 to 3; and R3 is a hydrogen atom, alkyl having a carbon number of from 1 to 6, or alkenyl having a carbon number of from 3 to 6, and the like.Type: GrantFiled: July 16, 2013Date of Patent: March 13, 2018Assignees: KYOWA HAKKO KIRIN CO., LTD., DICERNA PHARMACEUTICALS, INC.Inventors: Tomoyuki Naoi, Takeshi Kuboyama, Junichi Enokizono, Toshihiko Ishii, Akihiro Tokunaga, Kentarou Hatanaka
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Patent number: 9845306Abstract: The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X1 and X3 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L3 is a single bond, etc, R3 is alkyl, etc, L1 and L2 are —O—, —CO—O— or —O—CO—), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.Type: GrantFiled: August 18, 2015Date of Patent: December 19, 2017Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Takeshi Kuboyama, Tomohiro Era, Tomoyuki Naoi
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Patent number: 9839616Abstract: The present invention provides a lipid nano-particles, which allow nucleic acids to be easily introduced into cells, comprising a cationic lipid represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X3 is absent or is alkyl, etc, X1 and X2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and Y1 is absent or anion, L1 is a single bond, etc, R3 is alkyl, etc), and the like.Type: GrantFiled: December 12, 2012Date of Patent: December 12, 2017Assignee: KYOWA HAKKO KIRIN CO., LTD.Inventors: Takeshi Kuboyama, Tomohiro Era, Tomoyuki Naoi
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Publication number: 20170349532Abstract: The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X1 and X2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L3 is a single bond, etc, R3 is alkyl, etc, L1 and L2 are —O—, —CO—O— or —O—CO—), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.Type: ApplicationFiled: August 18, 2017Publication date: December 7, 2017Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Takeshi KUBOYAMA, Tomohiro ERA, Tomoyuki NAOI, Nobuhiro YAGI
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Publication number: 20170042825Abstract: The present invention provides a lipid nano-particles, which allow nucleic acids to be easily introduced into cells, comprising a cationic lipid represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X3 is absent or is alkyl, etc, X1 and X2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and Y1 is absent or anion, L1 is a single bond, etc, R3 is alkyl, etc), and the like.Type: ApplicationFiled: October 27, 2016Publication date: February 16, 2017Inventors: Takeshi KUBOYAMA, Tomohiro ERA, Tomoyuki NAOI
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Patent number: 9475805Abstract: The invention provides a method of activating PPAR ? and a method of treating or preventing a disease associated with PPAR ? by administering a tricyclic compound having a PPAR ? agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:Type: GrantFiled: May 26, 2015Date of Patent: October 25, 2016Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Arata Yanagisawa, Keiji Uehara, Masahiro Matsubara, Kimihisa Ueno, Michihiko Suzuki, Takeshi Kuboyama, Keisuke Yamamoto, Tomohiro Tamura
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Publication number: 20160304487Abstract: The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X1 and X2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L3 is a single bond, etc, R3 is alkyl, etc, L1 and L2 are —O—, —CO—O— or —O—CO—), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.Type: ApplicationFiled: July 1, 2016Publication date: October 20, 2016Inventors: Takeshi KUBOYAMA, Tomohiro ERA, Tomoyuki NAOI
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Patent number: 9408914Abstract: The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X1 and X2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L3 is a single bond, etc, R3 is alkyl, etc, L1 and L2 are —O—, —CO—O— or —O—CO—), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.Type: GrantFiled: April 28, 2011Date of Patent: August 9, 2016Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Takeshi Kuboyama, Tomohiro Era, Tomoyuki Naoi
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Publication number: 20150343062Abstract: The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X1 and X3 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L3 is a single bond, etc, R3 is alkyl, etc, L1 and L2 are —O—, —CO—O— or —O—CO—), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.Type: ApplicationFiled: August 18, 2015Publication date: December 3, 2015Inventors: Takeshi KUBOYAMA, Tomohiro ERA, Tomoyuki NAOI
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Publication number: 20150291587Abstract: The invention provides a method of activating PPAR ? and a method of treating or preventing a disease associated with PPAR ? by administering a tricyclic compound having a PPAR ? agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:Type: ApplicationFiled: May 26, 2015Publication date: October 15, 2015Inventors: Arata YANAGISAWA, Keiji UEHARA, Masahiro MATSUBARA, Kimihisa UENO, Michihiko SUZUKI, Takeshi KUBOYAMA, Keisuke YAMAMOTO, Tomohiro TAMURA
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Publication number: 20150174261Abstract: Provided are a cationic lipid which facilitates the introduction of a nucleic acid into, for example, a cell or the like; a composition containing the cationic lipid and a nucleic acid; a method for introducing a nucleic acid into a cell by using a composition containing the cationic lipid and the nucleic acid; and the like. The cationic lipid is, for example, a cationic lipid represented by formula (A): formula (A): (wherein R1 is alkenyl or the like, R2 is alkenyl or the like, R3 and R4 are each alkyl, or are combined together to form alkylene, or R3 and R5 are combined together to form alkylene, R5 is a hydrogen atom or the like, or is combined together with R3 to form alkylene, X1 is alkylene, and X2 is a single bond or alkylene).Type: ApplicationFiled: July 8, 2013Publication date: June 25, 2015Inventors: Takeshi Kuboyama, Tomohiro Era, Tomoyuki Naoi, Kaori Yagi, Shintaro Hosoe
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Publication number: 20140294978Abstract: The present invention provides a cationic lipid and the like. The cationic lipid is for delivering a medicament containing a cationic lipid which facilitates the introduction of a nucleic acid into a cell or the like, and is represented by formula (I).Type: ApplicationFiled: March 12, 2014Publication date: October 2, 2014Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Takeshi KUBOYAMA, Kaori YAGI, Tomoyuki NAOI, Tomohiro ERA
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Patent number: 8722780Abstract: The present invention provides a perfluoroelastomer composition comprising: a perfluoroelastomer having a nitrogen-containing curing site; and a catalyst mixture comprising: a tertiary amine; and an organic dicarboxylic acid represented by general formula (1) or (2) in an amount of 0.4 to 2 mol per mol of the tertiary amine: HOOC—COOH??(1) HOOC-A-COOH??(2) wherein A in formula (2) is an alkyl group having 1 to 10 carbon atoms or a phenyl group, which may be partially or fully fluorinated. Also disclosed is a perfluoroelastomer molded article obtained from the composition.Type: GrantFiled: February 26, 2009Date of Patent: May 13, 2014Assignee: Nichias CorporationInventors: Tomoya Shimizu, Naoya Kuzawa, Takeshi Kuboyama, Hideyuki Shishitani