Patents by Inventor Takuji Nakashima

Takuji Nakashima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10559403
    Abstract: A composition having an oil film retention function which an oil film can be stably retained on surfaces of various metals, an anticorrosive agent using same, and insulated terminated electric wire. A composition having oil film retention function for being added to base oil to be applied onto a metal surface and retaining base oil on metal surface, and composition contains a component that is an adduct of an azole compound and acidic alkyl phosphate ester including one or more compounds represented by General Formulae (1) (Chemical Formula 1) P(?O)(—OR1)(—OH)2 . . . (1) or General Formula (2) (Chemical Formula 2) P(?O)(—OR1)2(—OH) . . . (2) where R1 represents an organic group having four or more carbon atoms, and component that is an adduct of a metal and/or organic amine compound and acidic alkyl phosphate ester including one or more compounds represented by General Formulae (1) or (2).
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: February 11, 2020
    Assignees: AUTONETWORKS TECHNOLOGIES, LTD., SUMITOMO WIRING SYSTEMS, LTD., SUMITOMO ELECTRIC INDUSTRIES, LTD., KYUSHU UNIVERSITY
    Inventors: Tatsuya Hase, Takehiro Hosokawa, Kazuo Nakashima, Kazuhiro Goto, Hiroki Hirai, Junichi Ono, Takuji Otsuka, Hideki Nomura, Makoto Mizoguchi
  • Patent number: 10480479
    Abstract: A control device for an engine in which partial compression-ignition combustion including SI combustion performed by forcibly combusting a portion of mixture gas inside a cylinder followed by CI combustion performed by causing the rest of the mixture gas inside the cylinder to self-ignite is executed within a part of an operating range of the engine, is provided. The device includes a detector configured to detect a parameter related to noise caused by the combustion inside the cylinder, a memory configured to store a characteristic defining a relationship between a start timing of the CI combustion and a combustion noise index, and a processor configured to specify a given combustion noise index value based on the detection value of the detector, and control the start timing of the CI combustion.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: November 19, 2019
    Assignee: Mazda Motor Corporation
    Inventors: Kenichi Nakashima, Keitaro Ezumi, Yuichiro Tsumura, Daisuke Tanaka, Taiki Maiguma, Takuji Okumura, Kensuke Ashikaga, Masayoshi Higashio
  • Patent number: 10202627
    Abstract: An object of the present invention is to provide enzymes and a DNA encoding the enzymes that are involved in biosynthesis of trehangelin which has the potential to be a therapeutic agent for photosensitivity disorder and cosmetics, and to provide a method for producing trehangelin by utilizing the enzymes and a recombinant microorganism. The present invention is directed to a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9, or a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 in which one to several amino acids are deleted, substituted, added and/or inserted or an amino acid sequence having 60% or more homology with the amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 and having an enzyme activity involved in biosynthesis of trehangelin; and a DNA encoding said protein.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: February 12, 2019
    Assignees: The Kitasato Institute, Nagase & Co., Ltd.
    Inventors: Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Yuki Inahashi
  • Publication number: 20170306371
    Abstract: An object of the present invention is to provide enzymes and a DNA encoding the enzymes that are involved in biosynthesis of trehangelin which has the potential to be a therapeutic agent for photosensitivity disorder and cosmetics, and to provide a method for producing trehangelin by utilizing the enzymes and a recombinant microorganism. The present invention is directed to a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9, or a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 in which one to several amino acids are deleted, substituted, added and/or inserted or an amino acid sequence having 60% or more homology with the amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 and having an enzyme activity involved in biosynthesis of trehangelin; and a DNA encoding said protein.
    Type: Application
    Filed: February 28, 2017
    Publication date: October 26, 2017
    Inventors: Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Yuki Inahashi
  • Patent number: 9000194
    Abstract: The present invention addresses the problem of providing an anti-trypanosomal drug having a novel skeleton, in order to solve issues that occur with conventional technologies. The present invention is based on the discovery of a microbe that produces an anti-trypanosomal drug having a novel skeleton. Specifically, this invention provides: a compound indicated by formula (I) having a trypanosomal inhibitory activity; an analog thereof; a production method therefor; and a Lechevalieria sp. K10-0216 strain that produces said compound.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: April 7, 2015
    Assignee: The Kitasato Institute
    Inventors: Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Kazuhiko Otoguro, Kazuro Shiomi, Masato Iwatsuki, Atsuko Matsumoto
  • Publication number: 20140206889
    Abstract: [Problem] The present invention addresses the problem of providing an anti-trypanosomal drug having a novel skeleton, in order to solve issues that occur with conventional technologies. [Solution] The present invention is based on the discovery of a microbe that produces an anti-trypanosomal drug having a novel skeleton. Specifically, this invention provides: a compound indicated by formula (I) having a trypanosomal inhibitory activity; an analog thereof; a production method therefor; and a Lechevalieria sp. Kl0-0216 strain that produces said compound.
    Type: Application
    Filed: August 31, 2012
    Publication date: July 24, 2014
    Applicant: THE KITASATO INSTITUTE
    Inventors: Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Kazuhiko Otoguro, Kazuro Shiomi, Masato Iwatsuki, Atsuko Matsumoto
  • Patent number: 8741941
    Abstract: An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-forming agent; (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: June 3, 2014
    Assignee: Pola Pharma Inc.
    Inventors: Hideaki Sasagawa, Madoka Ito, Takuji Nakashima, Akira Nozawa
  • Publication number: 20120015996
    Abstract: An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-forming agent; (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof.
    Type: Application
    Filed: September 22, 2011
    Publication date: January 19, 2012
    Applicant: Pola Pharma Inc.
    Inventors: Hideaki Sasagawa, Madoka Ito, Takuji Nakashima, Akira Nozawa
  • Patent number: 8039452
    Abstract: An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-forming agent; (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: October 18, 2011
    Assignee: Pola Pharma Inc.
    Inventors: Hideaki Sasagawa, Madoka Ito, Takuji Nakashima, Akira Nozawa
  • Patent number: 7052866
    Abstract: A correct viable cell number of a microorganism in a biological tissue is measured by cultivating a fragment of the biological tissue such as skin infected with the microorganism and administered with an antimicrobial agent, in a medium containing a phospholipid, a nonionic surfactant, or both of the phospholipid and the nonionic surfactant.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: May 30, 2006
    Assignee: Pola Chemical Industries Inc.
    Inventors: Takuji Nakashima, Akira Nozawa, Takao Ito
  • Publication number: 20050250174
    Abstract: A correct viable cell number of a microorganism in a biological tissue is measured by cultivating a fragment of the biological tissue such as skin infected with the microorganism and administered with an antimicrobial agent, in a medium containing a phospholipid, a nonionic surfactant, or both of the phospholipid and the nonionic surfactant.
    Type: Application
    Filed: June 15, 2005
    Publication date: November 10, 2005
    Inventors: Takuji Nakashima, Akira Nozawa, Takao Ito
  • Publication number: 20050232879
    Abstract: An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-forming agent; (2) a water-soluble plasticizer in a form of a solid or a paste at 20° C. at 1 atm; and (3) an antifungal compound represented by a general formula (1) and/or a physiologically acceptable salt thereof.
    Type: Application
    Filed: June 10, 2003
    Publication date: October 20, 2005
    Inventors: Hideaki Sasagawa, Madoka Ito, Takuji Nakashima, Akira Nozawa
  • Patent number: 6929927
    Abstract: A correct viable cell number of a microorganism in a biological tissue is measured by cultivating a fragment of the biological tissue such as skin infected with the microorganism and administered with an antimicrobial agent, in a medium containing a phospholipid, a nonionic surfactant, or both of the phospholipid and the nonionic surfactant.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: August 16, 2005
    Assignee: Pola Chemical Industries Inc.
    Inventors: Takuji Nakashima, Akira Nozawa, Takao Ito
  • Publication number: 20040101866
    Abstract: A correct viable cell number of a microorganism in a biological tissue is measured by cultivating a fragment of the biological tissue such as skin infected with the microorganism and administered with an antimicrobial agent, in a medium containing a phospholipid, a nonionic surfactant, or both of the phospholipid and the nonionic surfactant.
    Type: Application
    Filed: January 31, 2003
    Publication date: May 27, 2004
    Inventors: Takuji Nakashima, Akira Nozawa, Takao Ito
  • Patent number: 6586633
    Abstract: The present invention relates to amine derivatives represented by formula (1) or salts thereof. R3 represents C1-C3 alkyl, hydroxylated C1-C5 alkyl, C1-C5 acyl; C2-C5 alkenyl, or a halogen atom; and k, l, and m are each an integer of 1 to 4.) Exhibiting excellent antifungal effect, these compounds are highly useful as antifungal agents, antifungal compositions, drugs, etc.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: July 1, 2003
    Assignee: Pola Chemical Industries, Inc.
    Inventors: Masayuki Yuasa, Yukio Kawazu, Toshimitsu Suzuki, Toshiro Majima, Takao Itoh, Takuji Nakashima, Akira Nozawa, Hiroyuki Takimoto, Kouji Yokoyama
  • Patent number: 6329399
    Abstract: Novel amine derivatives having an excellent antimycotic effect represented by general formula (1) below and salts thereof are provided. [in the formula (1, R1 represents a C1-5 alkyl group which may be halogenated, R2 represents 4-(1,1-dimethylalkyl)benzyl group, 4-(1-methyl-phenylethyl)benzyl group, 1-or 2-naphthylmethyl group, or a hydrocarbon group having 3,3-dimethyl-1-butynyl group or a phenyl group at its terminal and 1 to 3 double bonds; R3 represents oxygen atom or a methylene group which may be substituted by a C1-4 alkyl group; and R4 represents 1-or 2 naphthyl group or a phenyl group which may be substituted.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: December 11, 2001
    Assignee: Pola Chemical Industries, Inc.
    Inventors: Takao Itoh, Takuji Nakashima, Akira Nozawa, Kouji Yokoyama, Hiroyuki Takimoto, Masayuki Yuasa, Yukio Kawazu, Toshimitsu Suzuki, Toshiro Majima
  • Patent number: 6136863
    Abstract: This invention relates to compounds represented by the following formula (1): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted phenyl group, R.sup.2 represents a substituted or unsubstituted phenylene group, R.sup.3 represents a substituted or unsubstituted phenyl group or an aliphatic hydrocarbon group containing at least four .pi. electrons, R.sup.4 represents an alkyl group having 1 to 4 carbon atoms, and m and n individually represent integers of from 1 to 4, or salts thereof, and also to compositions containing the same. These compounds have antifungal activities and are useful as drugs.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: October 24, 2000
    Assignee: Pola Chemical Industries, Inc.
    Inventors: Yukio Kawazu, Masayuki Yuasa, Toshimitsu Suzuki, Takuji Nakashima, Takao Itoh, Toshiro Majima
  • Patent number: 6015925
    Abstract: This invention relates to compounds represented by the following formula (1): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aromatic hydrocarbon group having 6 to 18 carbon atoms, R.sup.2 represents a hydrogen atom or a substituted or unsubstituted aromatic hydrocarbon group having 6 to 18 carbon atoms, R.sup.3 represents an alkyl group having 1 to 4 carbon atoms, R.sup.4 represents a substituted or unsubstituted phenyl group or an aliphatic hydrocarbon group containing at least four .pi. electrons, and m and n individually represent integers of from 1 to 4, or salts thereof, and also to compositions containing the same. These compounds have antifungal activities and are useful as drugs and the like.
    Type: Grant
    Filed: September 22, 1998
    Date of Patent: January 18, 2000
    Assignee: Pola Chemical Industries, Inc.
    Inventors: Yukio Kawazu, Toshimitsu Suzuki, Masayuki Yuasa, Yuichi Yokomizo, Toshiro Majima, Takao Ito, Takuji Nakashima, Akira Nozawa