Patents by Inventor Takuma Sasaki

Takuma Sasaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200001840
    Abstract: This control device which serves as a brake control device is provided with: a valve control unit for controlling a differential pressure regulation valve and a holding valve; and a motor control unit for controlling an electric motor serving as a power source of a pump. When a predetermined condition is satisfied during an automatic braking process to decelerate a vehicle, the valve control unit implements a valve opening change control routine wherein the holding valve is set to a lower opening degree than that before the predetermined condition.
    Type: Application
    Filed: March 20, 2018
    Publication date: January 2, 2020
    Applicant: ADVICS CO., LTD.
    Inventors: Masanao SAWADA, Takuma SASAKI
  • Patent number: 6613799
    Abstract: New derivatives of platinum (II) complex are herein provided, which are liposoluble and applicable as antimicrobial agents and anticancer agents specific to the affected parts of patients and selectively transferred to the parts if they are used in combination with a contrast medium such as lipiodol, the derivatives being represented by the following general formula: (wherein R1 and R2 may be identical or different with each other and represent an ammine optionally substituted with an organic substituent and they may be bonded together through a bivalent organic group and R3 is a saturated or unsaturated higher fatty acid, these derivatives being prepared by nitrifying a cis-dichloro-di-(substituted or unsubstituted)-ammine platinum (II) and then reacting the resulting aqua type product with a corresponding alkali metal salt of higher fatty acid.
    Type: Grant
    Filed: March 5, 1986
    Date of Patent: September 2, 2003
    Assignee: Sumitomo Pharmaceuticals Company Ltd.
    Inventors: Mitsuaki Maeda, Takuma Sasaki
  • Patent number: 6365610
    Abstract: The invention provides a urokinase production inhibitor or angiogenesis inhibitor comprising as an active component an ozonide derivative represented by the formula (1), and method of prevention or therapy using the inhibitor wherein A is an oxygen atom or N—R (wherein R is phenyl or phenyl having as a substituent lower alkyl having 1 to 6 carbon atoms, lower alkoxyl having 1 to 6 carbon atoms or a halogen atom); B is an oxo group or —R4; and (1) when A is an oxygen atom, R1 is a hydrogen atom, etc., R2 is phenyl, etc., R3 is a hydrogen atom, etc., B is an oxo group or —R4, R4 is a hydrogen atom, etc., R5 is a hydrogen atom, etc.; (2) when A is N—R, R1 is a hydrogen atom, etc., R2 is a hydrogen atom, etc., R3 is a hydrogen atom, etc., B is —R4, R4 is a hydrogen atom, etc., R5 is a hydrogen atom, etc.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: April 2, 2002
    Assignee: Taiho Pharmaceutical Company Ltd.
    Inventors: Takuma Sasaki, Masatomo Nojima
  • Patent number: 5811408
    Abstract: The present invention relates to 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides having excellent antitumor activity, represented by formula ?I!: ##STR1## wherein B represents a pyrimidine or purine base, R.sub.1 and R.sub.2, which may be the same or different, represent hydrogen, a cyano group or alkyl group, and R.sub.3 represents hydrogen or a phosphoric acid residue, and a method for producing the same, and a use of the same.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: September 22, 1998
    Assignee: Yamasa Corporation
    Inventors: Yuichi Yoshimura, Akira Matsuda, Shinji Miura, Takuma Sasaki, Hiroshi Satoh
  • Patent number: 5705630
    Abstract: 2'-Methylidenepyrimidine nucleoside compounds of the general formula: ##STR1## wherein R.sup.1 stands for amino or hydroxy group; R.sup.2 stands for a halogen or a lower alkyl when R.sup.1 is amino or R.sup.2 stands for an alkyl having 2 to 4 carbon atoms, an alkynyl having 2 to 4 carbon atoms or a haloalkyl when R.sup.1 is hydroxy group; and R.sup.3 stands for hydrogen or a phosphoric acid residue, or salts thereof, anticancer compositions containing one or more of these compounds and methods for production of these compounds.Said compounds and salts thereof exhibit noticeable antitumor activities and are useful as anticancer agents.
    Type: Grant
    Filed: January 7, 1992
    Date of Patent: January 6, 1998
    Assignees: Yoshitomi Pharmaceutical Industries, Ltd., Yamasa Shoyu Co., Ltd.
    Inventors: Tohru Ueda, Takuma Sasaki, Akira Matsuda, Keiji Yamagami, Akihiro Fujii
  • Patent number: 5696097
    Abstract: Novel 2'-methylidenenucleotide compounds of the formula (I) ##STR1## wherein R is a hydrogen or a halogen, R.sup.1 and R.sup.2 are the same or different and each is a fatty acid residue or a hydrocarbon residue, and R.sup.3 and R.sup.4 are the same or different and each is a hydrogen, a halogen or an alkyl; salts thereof; methods for production thereof; and pharmaceutical use thereof. The compounds and salts thereof show an excellent antitumor effect in mammals. More specifically, they show a remarkable activity of inhibiting growth of mouse tumors, cultured human tumor cells, and human tumors transplanted to nude mice, and are useful for the treatment and prevention of recurrence of lung cancer, gastrointestinal cancer, breast cancer, cervical cancer, gynecological cancer, urinological cancer, leukemia, melanoma, lymphogenous metastatic tumor and the like in mammals. They are also useful as antitumor agents since they have an increased bioavailability and low toxicity.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: December 9, 1997
    Assignees: Yamasa Corporation, Akira Matsuda, Takuma Sasaki
    Inventors: Akira Matsuda, Takuma Sasaki, Satoshi Shutou, Akihiro Fujii, Takashi Ono, Shinji Sakata, Takanori Miyashita
  • Patent number: 5691319
    Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen atoms, optionally substituted alkanoyl groups and alkenylcarbonyl groups, PROVIDED THAT at least one of R.sup.1, R.sup.2 and R.sup.3 represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R.sup.4 and R.sup.5 represents a hydrogen atom and the other represents a cyano group; have valuable anti-tumor activity.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 25, 1997
    Assignee: Sankyo Company, Limited
    Inventors: Masakatsu Kaneko, Hitoshi Hotoda, Tomoyuki Shibata, Tomowo Kobayashi, Yoshihiro Mitsuhashi, Akira Matsuda, Takuma Sasaki
  • Patent number: 5616567
    Abstract: The pyrimidine compounds of the present invention are represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein, R.sup.1 represents a hydroxyl or an amino which may be substituted by an acyl group; R.sup.2 represents a hydrogen atom or an alkyl having 1 to 4 carbons; R.sup.3 represents a hydrogen or a hydroxyl; and R.sup.4 and R.sup.5 each represent a hydrogen or together form a group --R.sup.6 R.sup.7 Si--O--SiR.sup.6' R.sup.7' --, wherein R.sup.6, R.sup.7, R.sup.6' and R.sup.7' are the same or different from one another and each represent an alkyl having 1 to 4 carbons. The compounds of the present invention exhibit an excellent antitumor effect.
    Type: Grant
    Filed: September 7, 1994
    Date of Patent: April 1, 1997
    Assignee: Sankyo Company, Limited
    Inventors: Takuma Sasaki, Akira Matsuda, Tohru Ueda, deceased
  • Patent number: 5401726
    Abstract: 2'-Methylidenepyrimidine nucleoside compounds of the general formula: ##STR1## wherein R.sup.1 stands for amino or hydroxy group; R.sup.2 stands for a halogen or a lower alkyl when R.sup.1 is amino or R.sup.2 stands for an alkyl having 2 to 4 carbon atoms, an alkynyl having 2 to 4 carbon atoms or a haloalkyl when R.sup.1 is hydroxy group; and R.sup.3 stands for hydrogen or a phosphoric acid residue, or salts thereof, compositions containing one or more of these compounds and methods for production of these compounds are disclosed.Said compounds and salts thereof exhibit noticeable antitumor activities.
    Type: Grant
    Filed: April 8, 1993
    Date of Patent: March 28, 1995
    Assignees: Yoshitomi Pharaceutical Industries, Ltd., Yamasa Shoyu Co., Ltd.
    Inventors: Tohru Ueda, Takuma Sasaki, Akira Matsuda, Keiji Yamagami, Akihiro Fujii
  • Patent number: 5126361
    Abstract: Disclosed are imidazole derivatives represented by formula [I]: ##STR1## wherein R is a hydrogen atom or ##STR2## wherein R.sup.2 is a hydrogen atom or a hydroxy protecting group, R.sup.2 protecting either a single hydroxy or two hydroxies together when R.sup.2 is a hydroxy protecting group, and R.sup.3 is a hydrogen atom or OR.sup.2 ; A is CONH.sub.2 or CN; and R.sup.1 is a hydrogen atom, lower alkyl, hydroxy lower alkyl, or phenyl.Also disclosed are six processes for producing these novel compounds among which a typical process comprises reacting a starting imidazole compound having a halogen at the 5-position thereof with an acetylene derivative to alkynylate the 5-position.Furthermore, the compounds have remarkable antitumor activities and therefore can provide novel antitumor agents.
    Type: Grant
    Filed: May 15, 1991
    Date of Patent: June 30, 1992
    Assignee: Yamasa Shoyu Kabushiki Kaisha
    Inventors: Tohru Ueda, Akira Matsuda, Noriaki Minakawa, Takuma Sasaki, Yoshikazu Yanagi
  • Patent number: 5059590
    Abstract: Disclosed are imidazole derivatives represented by formula [I]: ##STR1## wherein R is a hydrogen atom or ##STR2## wherein R.sup.2 is a hydrogen atom or a hydroxy protecting group, R.sup.2 protecting either a single hydroxy or two hydroxies together when R.sup.2 is a hydroxy protecting group, and R.sup.3 is a hydrogen atom or OR.sup.2 ; A is CONH.sub.2 or CN; and R.sup.1 is a hydrogen atom, lower alkyl, hydroxy lower alkyl, or phenyl.Also disclosed are six processes for producing these novel compounds among which a typical process comprises reacting a starting imidazole compound having a halogen at the 5-position thereof with an acetylene derivative to alkynylate the 5-position.Furthermore, the compounds having remarkable antitumor activities and therefore can provide novel antitumor agents.
    Type: Grant
    Filed: February 28, 1989
    Date of Patent: October 22, 1991
    Assignees: Yamasa Shoyu Kabushiki Kaisha, Sumitomo Pharmaceuticals Company Limited
    Inventors: Tohru Ueda, Akira Matsuda, Noriaki Minakawa, Takuma Sasaki, Yoshikazu Yanagi
  • Patent number: 5026835
    Abstract: Pyrimidine 2'-deoxy-2'-methylidene nucleoside compounds: ##STR1## wherein R.sup.1 represents amino, hydroxy, silylamino, silyloxy, acylamino or acyloxy; R.sup.2 represents hydrogen, halogen, a lower alkyl, a lower alkenyl, a lower alkynyl or haloalkyl; R.sup.3 and R.sup.4 represent the same or different hydrogen, silyl, acyl or aminoacyl, or a pharmaceutically acceptable salt or hydrate thereof, except that R.sup.1 is amino or hydroxy, and both of R.sup.3 and R.sup.4 are hydrogen.Said compounds possess excellent antitumor and antiviral activities, thus providing novel anticancer and antiviral agent.
    Type: Grant
    Filed: December 7, 1989
    Date of Patent: June 25, 1991
    Assignees: Yamasa Shoyu Co., Ltd., Yoshitomi Pharmaceutical Industries, Ltd.
    Inventors: Tohru Ueda, Takuma Sasaki, Akira Matsuda, Takanori Miyashita, Shinji Sakata, Keiji Yamagami, Akihiro Fujii
  • Patent number: 4880832
    Abstract: New delivatives of platinum (IT) complex which are liposoluble and applicable as antibacterial agents or anticancer agents specific to the affected parts of patients and selectively transferred to the parts when they are used in combination with lipidol, the delivatives being represented by the general formula of: ##STR1## (wherein R.sub.1 and R.sub.2 each stands for a ligand ammine which may have an organic substituent or may be bonded to each other through a bivalent organic group and R.sub.3 represents a bile acid residue). These delivatives being prepared by nitrifying a cis-dichloro-di-(substituted or unsubstituted)-ammine platinum (II) and then reacting the resulting aqua type product with a corresponding alkali metal salt of bile acid.
    Type: Grant
    Filed: February 18, 1988
    Date of Patent: November 14, 1989
    Assignee: Sumitomo Pharmaceuticals Company, Ltd.
    Inventors: Mitsuaki Maeda, Takuma Sasaki
  • Patent number: 4454315
    Abstract: It has been found that water-insoluble, thermogelable .beta.-1,3-glucan produced by microorganisms, lower polymers obtainable upon partial hydrolysis of the glucan or, carboxymethylated derivatives of said glucan or of said lower polymers are useful for inhibiting growth of tumors in a warm-blooded animal. The inhibitory activity against various tumors of these polysaccharides is very strong and significant whenever administered to warm-blooded animals from the early to very late stage of tumor progression or even when administered prior to plantation of tumors. The carboxymethylated derivatives above-mentioned are novel water-soluble compounds which can be produced by carboxymethylation of said glucan and partial hydrolyzate thereof.
    Type: Grant
    Filed: January 14, 1981
    Date of Patent: June 12, 1984
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Takuma Sasaki, Yukio Sugino
  • Patent number: 4454289
    Abstract: The invention relates to a high molecular weight .beta.-1,3-glucan composed of repeated glucopyranose units, each unit being represented by the formula: ##STR1## The .beta.-1,3-glucan exhibits anticarcinogenic activity. A process for producing said glucan is also claimed.
    Type: Grant
    Filed: February 23, 1982
    Date of Patent: June 12, 1984
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Kazuo Nakajima, Yoshiaki Hirata, Hiroyuki Uchida, Tomoko Shiomi, Tsutomu Taniguchi, Akira Obayashi, Osamu Tanabe, Takuma Sasaki
  • Patent number: 4436656
    Abstract: A novel glycoprotein substance possessing a high antitumor activity is provided, which is recovered and isolated from the liquid portion coming from cooking of raw scallop shellfish with a hot aqueous solvent or vapor of such solvent and which is amphoteric electrolyte in nature with an average molecular weight of about 5000 and with an isoelectric point of pH 5.2.
    Type: Grant
    Filed: August 2, 1983
    Date of Patent: March 13, 1984
    Assignee: Maruzen Oil Co., Ltd.
    Inventors: Takuma Sasaki, Kazuya Nakamichi, Yakudo Tachibana, Kiyoshi Minami
  • Patent number: 4436657
    Abstract: A novel glycoprotein substance possessing a high antitumor activity is provided, which is recovered and isolated from the liquid portion coming from cooking of raw scallop with a hot aqueous solvent or vapor of such solvent and which is amphoteric electrolyte in nature with an average molecular weight of about 470,000 and with an isoelectric point of pH 5.5.
    Type: Grant
    Filed: August 2, 1983
    Date of Patent: March 13, 1984
    Assignee: Maruzen Oil Co., Ltd.
    Inventors: Takuma Sasaki, Kazuya Nakamichi, Yakudo Tachibana, Kiyoshi Minami
  • Patent number: 4390468
    Abstract: A new antitumor agent is provided which consists essentially of water-soluble, macromolecular glycoprotein substances having a range of molecular weights within the limits of from 10,000 to 300,000 and which is prepared from shellfish or mollusc by taking up the liquid portion which comes from the cooking of raw shellfish in an aqueous solvent, typically water or a saline solution, or vapor of such solvent and which is to be discarded as waste, concentrating the liquid portion to a smaller volume or to dryness, dissolving the resulting concentrate or dry powder in an aqueous solvent and isolating the desired water-soluble, macromolecular glycoprotein substances therefrom. The isolation of the desired substances is preferably carried out by an ion-exchange chromatography with a basic anion-exchanger followed by a gel-filtration.
    Type: Grant
    Filed: August 4, 1982
    Date of Patent: June 28, 1983
    Assignee: Maruzen Oil Co., Ltd.
    Inventors: Takuma Sasaki, Kazuya Nakamichi
  • Patent number: RE38090
    Abstract: The invention relates to a 3′-substituted nucleoside derivative represented by the following general formula (1): wherein B means a nucleic acid base which may have a substituent, Z represents a lower alkynyl or lower alkenyl group which may be substituted by a group represented by the formula: in which Ra, Rb and Rc are individually a lower alkyl group or a phenyl group, or an oxiranyl group which may have at least one lower alkyl group, R1 and R2 individually represent H or an ester-forming residue capable of easily leaving in a living body, and R3 is H, a mono- or polyphosphoric acid residue, or an ester-forming residue capable of easily leaving in a living body, with the proviso that the sugar moiety is ribose, or a pharmaceutically acceptable salt thereof. The 3′-substituted nucleoside derivative according to the invention has an excellent antitumor activity and is hence useful for treatment for and prevention of cancers.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: April 22, 2003
    Assignees: Taiho Pharmaceutical Co., Ltd.
    Inventors: Akira Matsuda, Takuma Sasaki