Abstract: A display device displays information image related to an excavation work, in an ambient environment image in a view of a work area or an attachment viewed from a shovel, or in a field of view of an operator viewing the work area or the attachment from the shovel. The shovel may include the display device. A management device may include a display apparatus, a communication device which communicates with the shovel, and a remote control device operated by a user to remotely control the shovel via the communication device.

Abstract: A support system includes a first storage unit configured to store information related to a plurality of processes performed by a work machine in a time series, the information including information associating previous and subsequent processes among the plurality of processes, and the plurality of processes including movement of earth and sand on the ground, movement of earth and sand from the ground, or both; and a display unit configured to display the information related to the plurality of processes.

Abstract: Provided is the present invention focusing on roles of IL-26 present in humans but not in mice by characterizing molecular mechanisms involved in interspecies differences in terms of efficacy of EGFR-TKI. The present inventors found that human cancers are exposed to IL-26 in a tumor microenvironment (TME), activating the EGFR-TKI bypass pathway, while suppression of IL-26 overcomes EGFR-TKI resistance in cancers. Furthermore, the present inventors identified EphA3 as a new functional receptor for IL-26 of TNBC. Therefore, the present invention provides a pharmaceutical composition for use in combination with an anticancer drug for treating cancer in a patient, the pharmaceutical composition containing a drug that reverses resistance to the anticancer drug by IL-26 as an active ingredient. Furthermore, the present invention provides a humanized anti-IL-26 antibody, and a therapeutic or preventive agent for refractory immune disorders or cancer using the antibody.

Abstract: A shovel includes a lower traveling body, an upper turning body turnably mounted on the lower traveling body, and a controller configured to control a projection device that projects light onto a ground surface. The controller is attached to the upper turning body, and is configured to control the projection device so as to enable visualization of the relationship between the current shape of the ground surface and the shape of a target surface.

Abstract: A shovel includes a lower traveling body, an upper turning body turnably mounted on the lower traveling body, and a controller configured to control a projection device that projects light onto a ground surface. The controller is attached to the upper turning body, and is configured to control the projection device so as to enable visualization of the relationship between the current shape of the ground surface and the shape of a target surface.

Abstract: A work machine includes a traveling body, a work attachment, and a processing circuitry configured to receive a reservation of an execution of a predetermined function in accordance with an input received by the work machine or in accordance with a signal received from an external apparatus and execute the predetermined function of the reservation, based on an execution condition designated by the reservation.

Abstract: A display device displays information image related to an excavation work, in an ambient environment image in a view of a work area or an attachment viewed from a shovel, or in a field of view of an operator viewing the work area or the attachment from the shovel. The shovel may include the display device. A management device may include a display apparatus, a communication device which communicates with the shovel, and a remote control device operated by a user to remotely control the shovel via the communication device.

Abstract: A shovel includes a lower traveling body, an upper turning body turnably mounted on the lower traveling body, a link unit attached to the upper turning body, and a processing circuitry configured to align an end of the link unit with an end attachment to be attached.

Abstract: A shovel includes a lower traveling structure, an upper swing structure swingably mounted on the lower traveling structure, an attachment attached to the upper swing structure and including a boom, an arm, and a bucket, and processing circuitry. The processing circuitry is configured to cause the shovel to automatically perform work by causing the upper swing structure and the attachment to automatically operate. The work is at least one of the work of banking earth and the work of filling with earth.

Abstract: A construction machine includes a hydraulic cylinder configured to drive an attachment, a hydraulic circuit configured to supply hydraulic oil to the hydraulic cylinder, an input device that is operated by an operator, and a controller configured to control the hydraulic circuit in at least one of a first control mode where the attachment is caused to generate a force corresponding to an operation amount of the input device and a second control mode where the attachment is driven at a velocity corresponding to the operation amount of the input device.

Abstract: A shovel includes a lower traveling body, an upper turning body turnably mounted on the lower traveling body, and a controller configured to control a projection device that projects light onto a ground surface. The controller is attached to the upper turning body, and is configured to control the projection device so as to enable visualization of the relationship between the current shape of the ground surface and the shape of a target surface.

Abstract: A construction machine includes a hydraulic cylinder configured to drive an attachment, a hydraulic circuit configured to supply hydraulic oil to the hydraulic cylinder, an input device that is operated by an operator, and a controller configured to control the hydraulic circuit in at least one of a first control mode where the attachment is caused to generate a force corresponding to an operation amount of the input device and a second control mode where the attachment is driven at a velocity corresponding to the operation amount of the input device.

Abstract: With an aim to provide a novel factor inducing proliferation of neural stem cells and differentiation of these cells into nerve cells, a pharmaceutical composition comprising 1) CRBN, 2) a nucleic acid encoding CRBN, or 3) a stem cell or a neural progenitor cell in which CRBN is expressed, a method including administering the pharmaceutical composition to a non-human animal and inducing proliferation of neural stem cells or neural progenitor cells of the non-human animal and differentiation of these cells into nerve cells, and a method for screening for a therapeutic drug for a disease of cerebral cortex or a surgical injury of cerebral cortex, using CRBN, are provided.

Abstract: A radio communication apparatus for generating a pulse signal corresponding to a data signal, amplifying the generated pulse signal, and transmitting the amplified pulse signal as a radio signal, the apparatus including: a reference pulse signal generation unit which generates a reference pulse signal of opposite phase to the pulse signal and amplifies the reference pulse signal; and a combining unit which combines the amplified pulse signal and the amplified reference pulse signal, wherein a combined pulse signal output from the combining unit is transmitted as the radio signal.

Abstract: With an aim to provide means for developing a compound devoid of teratogenicity but retaining beneficial actions, a screening method for a non-teratogenic substance comprising bringing a test substance into contact with cereblon or a fragment of cereblon, evaluating the bindability of the test substance with cereblon or the fragment of cereblon, and selecting a test substance that does not bind to cereblon or the fragment of cereblon or a test substance exhibiting lower bindability with cereblon or the fragment of cereblon than does thalidomide is provided.

Abstract: A communication apparatus includes: a pulse generation unit configured to alternately generate a positive pulse and a negative pulse indicating presence or absence of a pulse in accordance with a value of a data signal; a band-pass filter configured to filter the pulse generated by the pulse generator; and a transmission amplifier configured to amplify a signal filtered by the band-pass filter, and to output the signal as a transmission signal.

Abstract: A motor drive apparatus of an electric forklift includes first and second torque command value generation units that individually generate a torque command value indicating torque of a corresponding traveling motor in response to a gap between a speed command value and a speed detection value; and first and second slip detectors that individually generate a slip ratio estimation value showing a slip state of a corresponding drive wheel based on the speed detection value and the torque command value. The slip detectors individually have a first arithmetic unit which generates an inertial force estimation value proportional to a differential value of the speed detection value of the corresponding traveling motor and a second arithmetic unit which generates the slip ratio estimation value in response to a relationship between the corresponding inertial force estimation value and the torque command value of the corresponding traveling motor.

Abstract: With an aim to provide a novel factor inducing proliferation of neural stem cells and differentiation of these cells into nerve cells, a pharmaceutical composition comprising 1) CRBN, 2) a nucleic acid encoding CRBN, or 3) a stem cell or a neural progenitor cell in which CRBN is expressed, a method including administering the pharmaceutical composition to a non-human animal and inducing proliferation of neural stem cells or neural progenitor cells of the non-human animal and differentiation of these cells into nerve cells, and a method for screening for a therapeutic drug for a disease of cerebral cortex or a surgical injury of cerebral cortex, using CRBN, are provided.

Abstract: A motor drive apparatus, mounted to a forklift and controlling at least one motor configured to rotate a drive wheel of the forklift, based on a speed command value indicative of a target speed of the forklift, includes a turn speed limit unit in which a speed limit curve configured to stipulate an upper limit value of a speed of the forklift is defined as a function of a turning angle of the forklift such that an angular velocity with respect to a center of rotation of the forklift does not exceed a threshold value, the turn speed limit unit being configured to limit the speed command value to be equal to or less than an upper limit value determined according to the speed limit curve and the turning angle, and a drive unit configured to drive the at least one motor according to the speed command value.

Abstract: A communication device includes: a converting part converting a data signal from a non-return-to-zero signal to a return-to-zero signal; a trigger flip-flop inverting an output signal every time the return-to-zero signal changes in one cycle; a first filter outputting a positive pulse and a negative pulse alternately, which indicate existence and absence of the pulse corresponding to a value of the data signal, by removing a low frequency component of an output signal of the trigger flip-flop.