Patents by Inventor Takushi Kaneko

Takushi Kaneko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amidine process
    Patent number: 4567256
    Abstract: 9a-Methoxymitosane derivatives having the amidino group at one or both of the 7-position and the carbamoyl-N positions are prepared by reaction of mitomycin A, mitomycin C, or an N.sup.1a -substituted analog thereof with an amide acetal, iminothioether, halomethyleniminium halide, or iminohalide salt.
    Type: Grant
    Filed: October 5, 1984
    Date of Patent: January 28, 1986
    Assignee: Bristol-Myers Company
    Inventors: Dolatrai M. Vyas, Takushi Kaneko, Terrence W. Doyle
  • 3.alpha.,15-Bis(chloroacetoxy)-4.beta .-hydroxy-12,13-epoxytrichothec-9-ene useful as an antitumor agent
    Patent number: 4552971
    Abstract: Novel mono-, di- and triacylated derivatives of scirpentriol are provided for use as antitumor agents. Also provided are methods for the production of such derivatives.
    Type: Grant
    Filed: February 27, 1984
    Date of Patent: November 12, 1985
    Assignee: Bristol-Myers Company
    Inventors: Henry Schmitz, Takushi Kaneko, John M. Essery, Terrence W. Doyle
  • Amidines
    Patent number: 4487769
    Abstract: Mitomycin A, mitomycin C, and porfiromycin react with amide acetals and other amide derivatives to produce amidine derivatives having antitumor activity against experimental animal tumors. The amidines derived from mitomycin C are useful intermediates in reactions with primary amines to produce both known and novel 7-amino-9a-methoxymitosanes having antitumor activity against experimental animal tumors.
    Type: Grant
    Filed: May 9, 1983
    Date of Patent: December 11, 1984
    Assignee: Bristol-Myers Company
    Inventors: Dolatrai M. Vyas, Takushi Kaneko, Terrence W. Doyle
  • Trichothec-9-ene-3,4,15-triol,12,13-epoxy-3-chloroacetate useful as an anti-tumor agent
    Patent number: 4456765
    Abstract: Novel mono-, di- and triacylated derivatives of scirpentriol are provided for use as antitumor agents. Also provided are methods for the production of such derivatives.
    Type: Grant
    Filed: June 20, 1983
    Date of Patent: June 26, 1984
    Assignee: Bristol-Myers Company
    Inventors: Henry Schmitz, Takushi Kaneko, John M. Essery, Terrence W. Doyle
  • 3-Hydroxyiminoscirpen-4.beta., 15-diol esters useful as antitumor agents
    Patent number: 4433158
    Abstract: Novel 3-hydroxyiminoscirpen-4.beta., 15-diol esters and derivatives thereof are provided for use as antitumor agents. Also provided are processes for producing the above compounds and methods for using them to inhibit malignant tumors in mammals.
    Type: Grant
    Filed: December 28, 1981
    Date of Patent: February 21, 1984
    Assignee: Bristol-Myers Company
    Inventors: Takushi Kaneko, John M. Essery, Henry Schmitz, Terrence W. Doyle
  • Total synthesis of antitumor antibiotics BBM-2040A and BBM-2040B
    Patent number: 4427587
    Abstract: A new chemical synthesis of the pyrrolobenzodiazepine antibiotics BBM-2040A and B is disclosed. The disclosed total synthesis uses readily available starting materials and provides a useful alternative to the microbiological procedure previously used to prepare these antibiotics.
    Type: Grant
    Filed: November 10, 1982
    Date of Patent: January 24, 1984
    Assignee: Bristol-Myers Company
    Inventors: Takushi Kaneko, Henry S. L. Wong
  • Process for conversion of oxotomaymycin to tomaymycin
    Patent number: 4427588
    Abstract: A new chemical procedure for conversion of the biologically inactive fermentation product, oxotomaymycin, to the antibiotic, tomaymycin is disclosed as well as novel intermediates employed in such procedure.
    Type: Grant
    Filed: November 8, 1982
    Date of Patent: January 24, 1984
    Assignee: Bristol-Myers Company
    Inventors: Takushi Kaneko, Henry S. L. Wong
  • Triacylated derivative of scirpentriol
    Patent number: 4413134
    Abstract: Novel mono-, di- and triacylated derivatives of scirpentriol are provided for use as antitumor agents. Also provided are methods for the production of such derivatives.
    Type: Grant
    Filed: January 15, 1982
    Date of Patent: November 1, 1983
    Assignee: Bristol-Myers Company
    Inventors: Henry Schmitz, Takushi Kaneko, John M. Essery, Terrence W. Doyle
  • Antitumor agents
    Patent number: 4352936
    Abstract: A novel series of 3,8-dihydroxy-scirpen-4.beta.,15-diol esters is provided for use as antitumor agents. The compounds are also useful as intermediates in the preparation of other trichothecene antitumor agents.
    Type: Grant
    Filed: January 16, 1981
    Date of Patent: October 5, 1982
    Assignee: Bristol-Myers Company
    Inventor: Takushi Kaneko
  • Antitumor agents
    Patent number: 4332951
    Abstract: Novel 3-hydroxyiminoscirpen-4.beta., 15-diol esters and derivatives thereof are provided for use as antitumor agents. Also provided are processes for producing the above compounds and methods for using them to inhibit malignant tumors in mammals.
    Type: Grant
    Filed: January 9, 1981
    Date of Patent: June 1, 1982
    Assignee: Bristol-Myers Company
    Inventors: Takushi Kaneko, John M. Essery, Henry Schmitz, Terrence W. Doyle
  • Antitumor agents
    Patent number: 4332732
    Abstract: Novel mono-, di- and triacylated derivatives of scirpentriol are provided for use as antitumor agents. Also provided are methods for the production of such derivatives.
    Type: Grant
    Filed: March 4, 1981
    Date of Patent: June 1, 1982
    Assignee: Bristol-Myers Company
    Inventors: Henry Schmitz, Takushi Kaneko, John M. Essery, Terrence W. Doyle
  • Antitumor agents
    Patent number: 4284568
    Abstract: Novel mono-, di- and triacylated derivatives of scirpentriol are provided for use as antitumor agents. Also provided are methods for the production of such derivatives.
    Type: Grant
    Filed: April 4, 1980
    Date of Patent: August 18, 1981
    Assignee: Bristol-Myers Company
    Inventors: Henry Schmitz, Takushi Kaneko, John M. Essery, Terrence W. Doyle
  • Antitumor agents
    Patent number: 4267113
    Abstract: Novel 3-oxoscirpen-4.beta.,15-diol esters and derivatives thereof are provided for use as antitumor agents. Also provided are processes for producing the above compounds and methods for using them to inhibit malignant tumors in mammals.
    Type: Grant
    Filed: November 19, 1979
    Date of Patent: May 12, 1981
    Assignee: Bristol-Myers Company
    Inventors: Takushi Kaneko, John M. Essery, Henry Schmitz, Terrence W. Doyle
  • 3,8-Dioxo-scirpen-4.beta.,15-diol esters and their use as antitumor agents
    Patent number: 4244874
    Abstract: A novel series of 3,8-dioxo-scirpen-4.beta.,15-diol esters is provided for use as antitumor agents. Also provided are various novel intermediates used in the production of such compounds.
    Type: Grant
    Filed: July 27, 1979
    Date of Patent: January 13, 1981
    Assignee: Bristol-Myers Company
    Inventor: Takushi Kaneko