Abstract: The present invention provides a compound represented by formula (I): wherein n is an integer selected from 1 to 20, Q is A is cyano or the like; B is hydrogen, halogen, or the like; X1 and X2 are each independently selected from O and S; E is a C1-4 alkyl group; and R1, R2, R3 and R4 are each independently selected from a hydrogen atom and a C1-C6 alkyl group, and a drug, a pharmaceutical composition containing the compound, and the like.

Abstract: The present invention provides novel ?-amino acid derivatives of formula (1): (wherein, R1, R2, R3, R4, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have ?ARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.

Abstract: A fuel pump for a direct injection internal combustion engine having a body with a valve seat. The valve includes a valve head and the valve is movably mounted to the body between an open position and a closed position. In its open position, the valve head is spaced from the valve seat white in its closed position, the valve head abuts against the valve seat and closes the valve. An electric coil upon energization moves the valve to an open position and, conversely, upon deenergization allows the valve to move to a closed position. A control circuit controls the energization of the coil to reduce the pump noise during operation of the engine, especially at low speeds.

Abstract: A fuel pump for a direct injection internal combustion engine having a body with a valve seat. The valve includes a valve head and the valve is movably mounted to the body between an open position and a closed position. In its open position, the valve head is spaced from the valve seat white in its closed position, the valve head abuts against the valve seat and closes the valve. An electric coil upon energization moves the valve to an open position and, conversely, upon deenergization allows the valve to move to a closed position. A control circuit controls the energization of the coil to reduce the pump noise during operation of the engine, especially at low speeds.

Abstract: By a lean burn operation, a highly efficient operation region is enlarged, the proportion of engine operation in a low torque condition is increased, and the proportion of motor operation using a battery is decreased. It is possible to provide a hybrid car of an engine-electric motor configuration which can effect a highly efficient operation without increasing the capacity of motor and that of battery.

Abstract: It is necessary to attain the combustion stability when performing ignition retarding in order to reduce exhaust gas and raise the exhaust gas temperature under a cold start condition, as well as soot reduction under a fully open throttle valve condition. An injector according to the present invention comprises: a plurality of fuel passages having an axis line inclined with respect to a valve operation axis line at a nozzle end; wherein inclined axis lines of at least three of the fuel passages have a spreading angle, none of them intersecting with each other, and three injection points are formed in a plane perpendicular to a valve operation axis line to form a triangle; and wherein at least one center-oriented fuel passage having an injection point around the center of the triangle is provided.

Abstract: A method and apparatus for attenuating fuel pump noise in a direct injection internal combustion engine. In one proposal, the direct injection fuel nozzle is suspended from a fuel rail in a fashion that avoids direct metal-to-metal contact between the injector and the engine block. The direct injection nozzle may also be connected to the fuel rail by a pair of spaced-apart seals which equalize the longitudinal pressure on the nozzle during operation. Enlarged diameter fuel reservoirs and/or a restricted orifice may be provided fluidly in series between the fuel pump and the direct injection nozzle in order to attenuate noise resulting from fuel pump pulsation.

Abstract: An engine generating two or more ignition sparks by the same spark plug, which can avoid a torque reduction caused by misfire of main ignition, can start firing and burning at proper timing depending on operating conditions, and can reduce misfires. A novel controller and a novel ignition coil adapted for realizing that engine are also provided. One spark plug and at least one ignition coil are provided per cylinder. When performing a plurality of ignitions during the compression stroke in the cylinder, before main ignition to start firing and burning at proper timing depending on operating conditions of the engine, preliminary pre-ignition is performed to form a fire seed around the spark plug. The main ignition is then performed to cause main burning. Misfire is avoided, appropriate torque can be generated, and combustion stability can be improved.

Abstract: A spark advance controller capable of controlling spark advance in an internal combustion engine with high accuracy without requiring a larger number of data maps and performing laborious optimization tests using an actual engine. In the spark advance controller, map data for controlling the spark advance is computed by a numerical simulator simulating an internal combustion engine, and the map data for spark advance control is approximated with a regression model. The spark advance is computed by using the regression model depending on the detected operating conditions.

Abstract: The present invention provides a compound represented by formula (I): wherein n is an integer selected from 1 to 20, Q is A is cyano or the like; B is hydrogen, halogen, or the like; X1 and X2 are each independently selected from O and S; E is a C1-4 alkyl group; and R1, R2, R3 and R4 are each independently selected from a hydrogen atom and a C1-C6 alkyl group, and a drug, a pharmaceutical composition containing the compound, and the like.

Abstract: The present invention provides a compound represented by formula (I): [Formula 1] wherein n is an integer selected from 1 to 20, and R1 and R2, which may be the same or different, each represent a hydrogen atom, or a linear or branched C1-C6 alkyl group, or a salt, a prodrug or a solvate thereof, as well as a drug, a pharmaceutical composition containing the compound, and the like.

Abstract: A data processor compatible for use with a CD and a DVD includes a first modulation circuit for modulating recording data for recording on a CD to generate first modulated data. A second modulation circuit modulates recording data for recording on a DVD to generate second modulated data. A write signal generation circuit generates a first write signal, which is written to the CD, from the first modulated data, and a second write signal, which is written to the DVD, from the second modulated data. The write signal generation circuit is commonly used for the CD and the DVD to reduce the circuit area of the data processor.

Abstract: A direct injection engine and a controller for the engine, which can realize super-retard combustion under high backpressure and can minimize an emission amount of HC at the startup. A cavity is formed in a piston such that fuel spray injected from a fuel injection valve is blown into the cavity. An obstacle member, such as a step, is provided in the cavity to decelerate or stop the fuel spray blown into the cavity. A mount position, mount posture, nozzle structure, injection port shape, etc. of the fuel injection valve are set such that the fuel spray injected from the fuel injection valve is made up of a lead fuel spray component directed toward the ignition plug and having a penetration to extend long beyond the ignition plug, and a main fuel spray component directed toward the piston, thereby enabling the super-retard combustion to be performed under high backpressure.

Abstract: The amount of air to be introduced is controlled for each cylinder, whereby it is intended to make it possible to control the torque generated in each cylinder, perform an ultra-lean burn operation, purify the exhaust gas, and increase the output of an engine. An air flow control valve adapted to be on-off controlled in accordance with an operated quantity of an accelerator pedal is disposed in each branch pipe or intake port. The air flow control valve may be a throttle valve disposed in each branch pipe or it may be a variable intake valve for opening and closing the intake port.

Abstract: There is provided a cylinder injection type internal combustion engine capable of performing stratified charge operation at the time of a vehicle speed of 120 km/h and/or an engine rotational speed of 3200 rpm to enhance the fuel efficiency and/or to observe the emission regulations. In the internal combustion engine, a stratum of air and/or air flow is formed between a fuel spray injected from an injection valve and the top face of a piston and/or the wall surface of a combustion chamber, and a face shape contrived to guide the air flow is formed on the top face of the piston. Also, the stratified charge operation can be performed even at the time of cold start or cranking.

Abstract: The amount of air to be introduced is controlled for each cylinder, whereby it is intended to make it possible to control the torque generated in each cylinder, perform an ultra-lean burn operation, purify the exhaust gas, and increase the output of an engine. An air flow control valve adapted to be on-off controlled in accordance with an operated quantity of an accelerator pedal is disposed in each branch pipe or intake port. The air flow control valve may be a throttle valve disposed in each branch pipe or it may be a variable intake valve for opening and closing the intake port.

Abstract: An engine generating two or more ignition sparks by the same spark plug, which can avoid a torque reduction caused by misfire of main ignition, can start firing and burning at proper timing depending on operating conditions, and can reduce misfires. A novel controller and a novel ignition coil adapted for realizing that engine are also provided. One spark plug and at least one ignition coil are provided per cylinder. When performing a plurality of ignitions during the compression stroke in the cylinder, before main ignition to start firing and burning at proper timing depending on operating conditions of the engine, preliminary pre-ignition is performed to form a fire seed around the spark plug. The main ignition is then performed to cause main burning. Misfire is avoided, appropriate torque can be generated, and combustion stability can be improved.

Abstract: A control apparatus operates a compression ignition internal combustion engine by switching between spark ignition combustion using an ignition device and compression ignition combustion which self-ignites a mixture by piston compression. Variable valve mechanisms vary at least one of the valve timings and valve lifts of an intake valve and an exhaust valve. Intake air is regulated to vary the amount of air intake into a combustion chamber on the upstream side of a combustion chamber inlet of the compression ignition internal combustion engine. The variable valve mechanisms and the intake air regulation are controlled during the compression ignition combustion so as to perform the compression ignition combustion.

Abstract: In order to provide a fuel injection method of an internal combustion engine having higher combustion stability which can direct a part of concentrated fuel spray toward an ignition plug according to a fuel injection atmosphere, a fuel injection valve thereof, and an internal combustion engine, the present invention provides a fuel injection method of an internal combustion engine for injecting fuel so as to generate a part of high spray concentration and a part of low spray concentration on the cross section of spray by giving swirling force to fuel from an injection hole at the front end of a fuel injection valve, comprising the step of setting a reference indicating the position of a axis of the fuel injection valve indicating the injection direction of the part of high spray concentration in the rotational direction when fuel is injected into an atmosphere under the atmospheric pressure.

Abstract: A fuel injection valve with high freedom to optimize the direction of fuel spray, the shape of spray, the length of penetration, the existence/absence of lead spray and the like, in correspondence with each type of internal combustion engine is provided. A swirling force about a central axis of an injection orifice is supplied by a swirler to fuel injected from the injection orifice. A central axis E of the injection orifice is slanted at a predetermined deflection angle to a central axis of a valve body. Further, a step portion is formed in an end surface of the injection orifice.