Patents by Inventor Tarjei Mikkelsen

Tarjei Mikkelsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11371094
    Abstract: Provided herein are compositions, systems and methods for tagging molecular events, reactions, species, etc., but without the need for complex, highly diverse libraries of tagging molecules. Provided are tagging moieties that can have a smaller number, a few, or even a single original “tagging” structure that may be transformed or transformable, in situ, into a collection of larger numbers of unique tagging or “barcode” moieties.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: June 28, 2022
    Assignee: 10X Genomics, Inc.
    Inventors: Paul Ryvkin, Jason Underwood, Michael Schnall-Levin, Tarjei Mikkelsen, Benjamin Hindson
  • Patent number: 11274295
    Abstract: The invention provides methods for generating pools of variants of DNA templates, and methods of using pools of variants to identify sequences involved in conferring sensitivity or resistance to environmental factors.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: March 15, 2022
    Assignee: THE BROAD INSTITUTE, INC.
    Inventors: Tarjei Mikkelsen, Alexandre Melnikov
  • Publication number: 20220017938
    Abstract: In one aspect, the invention features a method for identifying a drug-modulated polypeptide substrate of cereblon (CRBN). In another aspect, the invention features a method of identifying a polypeptide target of a modulator of CRBN. In yet another aspect, the invention provides methods of monitoring or characterizing the sensitivity of a subject to a modulator of CRBN.
    Type: Application
    Filed: October 7, 2021
    Publication date: January 20, 2022
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: TARJEI MIKKELSEN, BENJAMIN LEVINE EBERT, QUINLAN SIEVERS
  • Patent number: 11168345
    Abstract: In one aspect, the invention features a method for identifying a drug-modulated polypeptide substrate of cereblon (CRBN). In another aspect, the invention features a method of identifying a polypeptide target of a modulator of CRBN. In yet another aspect, the invention provides methods of monitoring or characterizing the sensitivity of a subject to a modulator of CRBN.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: November 9, 2021
    Assignees: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Tarjei Mikkelsen, Benjamin Levine Ebert, Quinlan Sievers
  • Publication number: 20210285044
    Abstract: Provided herein are compositions, systems and methods for tagging molecular events, reactions, species, etc., but without the need for complex, highly diverse libraries of tagging molecules. Provided are tagging moieties that can have a smaller number, a few, or even a single original “tagging” structure that may be transformed or transformable, in situ, into a collection of larger numbers of unique tagging or “barcode” moieties.
    Type: Application
    Filed: March 13, 2020
    Publication date: September 16, 2021
    Inventors: Paul Ryvkin, Jason Underwood, Michael Schnall-Levin, Tarjei Mikkelsen, Benjamin Hindson
  • Publication number: 20190071731
    Abstract: In one aspect, the invention features a method for identifying a drug-modulated polypeptide substrate of cereblon (CRBN). In another aspect, the invention features a method of identifying a polypeptide target of a modulator of CRBN. In yet another aspect, the invention provides methods of monitoring or characterizing the sensitivity of a subject to a modulator of CRBN.
    Type: Application
    Filed: September 9, 2016
    Publication date: March 7, 2019
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: TARJEI MIKKELSEN, BENJAMIN LEVINE EBERT, QUINLAN SIEVERS
  • Publication number: 20170267997
    Abstract: Disclosed is a method of generating a set of sequence-verified nucleic acid elements for the combinatorial construction of genetic elements. The method includes: providing a plurality of nucleic acid parts; assembling nucleic acid parts to form a one or more nucleic acid elements, wherein the nucleic acid elements include at least two sequences selected from the plurality of parts; and determining the sequence of the nucleic acid elements. Further disclosed is pool of higher-order nucleic acid constructs or amplification products thereof, comprising one or more nucleic acid elements as well as kits including a the pool of sequence-verified nucleic acid elements of claims and/or a pool of higher-order nucleic acid constructs; and a plurality of primers for retrieving one or more sequence-verified nucleic acid elements and/or higher-order nucleic acid constructs.
    Type: Application
    Filed: May 27, 2015
    Publication date: September 21, 2017
    Inventors: Robert NICOL, Lauren WOODRUFF, Tarjei MIKKELSEN, Christopher VOIGT
  • Publication number: 20170145476
    Abstract: The present disclosure provides methods, systems and compositions that provide transformable tagging moieties for use in analytical operations, and particularly in analysis of biological systems, such as in the analysis of gene expression in cell based systems.
    Type: Application
    Filed: November 18, 2016
    Publication date: May 25, 2017
    Inventors: PAUL RYVKIN, JASON UNDERWOOD, MICHAEL SCHNALL-LEVIN, TARJEI MIKKELSEN, BENJAMIN HINDSON
  • Publication number: 20160122753
    Abstract: The present invention relates generally to methods for single-cell nucleic acid profiling, and nucleic acids useful in those methods. For example, it concerns using barcode sequences to track individual nucleic acids at single-cell resolution, utilizing template switching and sequencing reactions to generate the nucleic acid profiles. These methods and compositions are also applicable to other starting materials, such as cell and tissue lysates or extracted/purified RNA.
    Type: Application
    Filed: June 12, 2014
    Publication date: May 5, 2016
    Inventors: Tarjei Mikkelsen, Magali Soumillon
  • Publication number: 20160115455
    Abstract: The present invention relates generally to a secondary reprogramming technique and its uses. More particularly, it concerns immortalized secondary somatic cells, secondary induced pluripotent stem cells (iPSCs), secondary induced multipotent progenitor cells (iMPCs) and tertiary somatic cells derived therefrom, and methods of using these cells to assess the effects of agents on cells and for medical treatment of subjects.
    Type: Application
    Filed: May 16, 2014
    Publication date: April 28, 2016
    Inventors: Tarjei Mikkelsen, Davide Cacchiarelli
  • Publication number: 20150203838
    Abstract: The invention provides methods for generating pools of variants of DNA templates, and methods of using pools of variants to identify sequences involved in conferring sensitivity or resistance to environmental factors.
    Type: Application
    Filed: August 9, 2013
    Publication date: July 23, 2015
    Inventors: Tarjei Mikkelsen, Alexandre Melnikov
  • Publication number: 20140200163
    Abstract: The invention provides methods for determining the activity of a plurality of nucleic acid regulatory elements. These methods may facilitate, e.g., the systematic reverse engineering, and optimization of mammalian cis-regulatory elements at high resolution and at a large scale. The method may include integration of multiplexed DNA synthesis and sequencing technologies to generate and quantify the transcriptional regulatory activity of e.g., thousands of arbitrary DNA sequences in parallel in cell-based as says (e.g., mammalian cell based assays).
    Type: Application
    Filed: May 4, 2012
    Publication date: July 17, 2014
    Applicant: The Broad Institute, Inc.
    Inventors: Tarjei Mikkelsen, Andreas Gnirke, Alexandre Melnikov, Eric S. Lander, Li Wang, Xiaolan Zhang
  • Publication number: 20050021372
    Abstract: Disclosed are methods and systems that include receiving data associated with the compliance of a user with a self-care regimen, evaluating the data to determine a level of compliance of the user with the self-care regimen, and using at least one executable processor application to provide the user with an incentive based on the determined level of compliance.
    Type: Application
    Filed: June 23, 2004
    Publication date: January 27, 2005
    Applicant: Dimagi, Inc.
    Inventors: Tarjei Mikkelsen, Vikram Kumar