Patents by Inventor Taro Toyoda

Taro Toyoda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11117348
    Abstract: Provided is a high-strength hot-rolled coated steel sheet with excellent formability, A high-strength hot-rolled coated steel sheet has a constituent composition containing, in a mass percent, C: 0.03% to 0.15%, Si: 0.4% or less, Mn: 1.2% to 1.9%, Ti: 0.05% to 0.25%, B: 0.0005% to 0.0050%, P: 0.03% or less, S: 0.005% or less, Al: 0.005% to 0.4%, and N: 0.01% or less, the balance being Fe and incidental impurities. The total area fraction of one or more of ferrite and tempered bainite is 90% or more. The steel sheet has a structure in which the volume fraction of Ti carbides having particle sizes of 20 nm or less is 0.05 vol % or more.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: September 14, 2021
    Assignee: JFE STEEL CORPORATION
    Inventors: Sota Goto, Kazuhiko Yamazaki, Taro Kizu, Shunsuke Toyoda
  • Publication number: 20210254014
    Abstract: The present invention relates to a method for producing an insulin-producing cell population or a pancreatic ? cell population having the reduced number of Ki67-positive cells, comprising treating a population of endocrine progenitor cells or cells at a later stage of differentiation with an FGFR1 inhibitor.
    Type: Application
    Filed: April 22, 2019
    Publication date: August 19, 2021
    Applicants: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Noriko YAMAZOE, Hideyuki HIYOSHI, Taisuke MOCHIDA, Ryo ITO, Taro TOYODA, Azuma KIMURA
  • Publication number: 20210060210
    Abstract: An object of the present invention is to provide a method for removing highly proliferative Ki67-positive cells co-present in insulin-secreting cells obtained by differentiation induction. A method for producing an insulin-producing cell population or a pancreatic beta cell population containing less than 3% of Ki67-positive cells, comprising: embedding an endocrine progenitor cell population or a cell population at a later stage of differentiation into a gel containing alginic acid; and differentiating the cell population.
    Type: Application
    Filed: March 18, 2019
    Publication date: March 4, 2021
    Applicants: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Taro TOYODA, Taisuke MOCHIDA, Yutaka TANOUE, Ryo ITO, Koya KIMOTO, Yusuke KOIKE, Hikaru UENO
  • Publication number: 20200392445
    Abstract: Provided is a cell suspension culturing apparatus suitable for large-scale culture of cells, the cell culturing apparatus comprising a culture solution aspirator having a double-tube structure comprising an outer tube and an inner tube inserted in a lumen of the outer tube, and a suspension culture vessel, wherein in the culture solution aspirator, the outer tube comprises a filter through which a culture solution is passed, the inner tube comprises a suction port for the culture solution passed through the filter, and an air hole which communicates the lumen of the outer tube with the outside is disposed distally in a direction of insertion of the outer tube into the suspension culture vessel.
    Type: Application
    Filed: December 21, 2018
    Publication date: December 17, 2020
    Applicants: Kyoto University, Takeda Phamaceutical Company Limited
    Inventors: Junji YAMAURA, Shinobu KUWAE, Taro TOYODA, Shuhei KONAGAYA
  • Publication number: 20200102542
    Abstract: Provided is a method for generating pancreatic bud cells, having the step of culturing PDX1+/NKX6.1+ cells in a medium containing KGF, EGF and a BMP inhibitor. The culturing step may be performed in suspension cultures or in adherent cultures. When the cells are cultured in adherent cultures, the cells may be cultured in a medium further containing a ROCK inhibitor or a nonmuscie myosin II inhibitor.
    Type: Application
    Filed: October 1, 2019
    Publication date: April 2, 2020
    Inventors: Kenji OSAFUNE, Taro TOYODA
  • Publication number: 20190390169
    Abstract: The present invention relates to a method for producing pancreatic progenitor cells from pluripotent stem cells. More specifically, the present invention relates to a method for producing pancreatic progenitor cells, comprising causing the action of a factor having the inhibitory activity for cyclin-dependent kinase 8 and/or cyclin-dependent kinase 19 (hereinafter, also abbreviated to CDK8/19).
    Type: Application
    Filed: March 2, 2018
    Publication date: December 26, 2019
    Applicants: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Kenji OSAFUNE, Taro TOYODA, Shiro TAKEKAWA, Goshi NAKAMURA, Ryo ITO
  • Patent number: 10472610
    Abstract: Provided is a method for generating pancreatic bud cells, having the step of culturing PDX1+/NKX6.1? cells in a medium containing KGF, EGF and a BMP inhibitor. The culturing step may be performed in suspension cultures or in adherent cultures. When the cells are cultured in adherent cultures, the cells may be cultured in a medium further containing a ROCK inhibitor or a nonmuscle myosin II inhibitor.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: November 12, 2019
    Assignee: KYOTO UNIVERSITY
    Inventors: Kenji Osafune, Taro Toyoda
  • Publication number: 20180327719
    Abstract: Provided is a method for generating pancreatic bud cells, comprising the step of culturing PDX1+/NKX6.1? cells in a medium comprising KGF, EGY, a DMP inhibitor and an Akt inhibitor. The cells may be cultured under adherent culture conditions. PDX1+/NKX6.1? cells may be induced from pluripotent stem cells in vitro. The method of this application makes it possible to generate pancreatic bud cells from pluripotent stem cells.
    Type: Application
    Filed: September 16, 2016
    Publication date: November 15, 2018
    Inventors: Kenji OSAFUNE, Taro TOYODA, Azuma KIMURA
  • Patent number: 9796962
    Abstract: Provided is a method for inducing pancreatic hormone-producing cells from pancreatic progenitor cells efficiently. The method comprises a step of culturing the cells in a culture medium comprising sodium cromoglicate.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: October 24, 2017
    Assignee: KYOTO UNIVERSITY
    Inventors: Kenji Osafune, Nobuya Inagaki, Taro Toyoda, Yasushi Kondo
  • Publication number: 20170175082
    Abstract: Provided is a method for generating pancreatic bud cells, having the step of culturing PDX1+/NKX6.1? cells in a medium containing KGF, EGF and a BMP inhibitor. The culturing step may be performed in suspension cultures or in adherent cultures. When the cells are cultured in adherent cultures, the cells may be cultured in a medium further containing a ROCK inhibitor or a nonmuscle myosin II inhibitor.
    Type: Application
    Filed: May 20, 2015
    Publication date: June 22, 2017
    Inventors: Kenji OSAFUNE, Taro TOYODA
  • Publication number: 20160289642
    Abstract: Provided is a method for inducing pancreatic hormone-producing cells from pancreatic progenitor cells efficiently. The method comprises a step of culturing the cells in a culture medium comprising sodium cromoglicate.
    Type: Application
    Filed: August 6, 2014
    Publication date: October 6, 2016
    Inventors: Kenji Osafune, Nobuya Inagaki, Taro Toyoda, Yasushi Kondo
  • Publication number: 20130225443
    Abstract: The present invention provides a method of examining polycystic kidney disease or a complication of polycystic kidney disease using a gene(s) selected from the group consisting of NTNG1, POSTN, TNC, KAL1, BST1, ACAT2, INSIG1, SCD, HSD3B1, KRT7, USP40, SULT1E1, BMP6, CD274, CTGF, E2F7, EDN1, FAM43A, FRMD3, MMP10, MYEOV, NR2F1, NRCAM, PDCK1, PLXNA2, SLC30A3, SNAI1, SPOCD1, MMP1, TFPI2, HMGA2, KRTAP4-7, KRTAP4-8, KRTAP4-9, MYPN, RPPH1, and SIAE, and a method of screening for a therapeutic agent or a preventive agent therefore, and further vascular endothelial cells or vascular mural cells obtained via differentiation induction from iPS cells formed from a somatic cell of a subject suffered from polycystic kidney disease and having cerebral aneurysm as a complication.
    Type: Application
    Filed: November 7, 2011
    Publication date: August 29, 2013
    Applicant: KYOTO UNIVERSITY
    Inventors: Kenji Osafune, Taro Toyoda, Fumihiko Shiota, Kazuwa Nakao, Masakatsu Sone, Daisuke Taura
  • Patent number: 4671651
    Abstract: A temperature detecting device employing as a temperature detecting element a CdInGaS.sub.4 compound semiconductor material. The temperature of a body in thermal contact with the temperature detecting element is determined using either a reflecting or an absorbing technique. CdInGaS.sub.4 semiconductor material used as a light detecting element provides a temperature measuring range of about -200.degree. C. to about 400.degree. C.
    Type: Grant
    Filed: December 19, 1983
    Date of Patent: June 9, 1987
    Assignee: Fuji Electric Corporate Research and Development Ltd.
    Inventors: Taro Toyoda, Yasukazu Seki