Patents by Inventor Tatchi Teddy YANG

Tatchi Teddy YANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-human LAG-3 monoclonal antibody and use thereof
    Patent number: 11685778
    Abstract: Disclosed in the present invention are an antibody targeting LAG-3, a preparation method therefor and the use thereof. In particular, disclosed in the present invention is a novel monoclonal antibody targeting LAG-3. Also disclosed in the present invention is a method for the preparation of the monoclonal antibody. The monoclonal antibody of the present invention is capable of binding LAG-3 antigens with high specificity, and has very high affinity and significant activities such as anti-tumor activity.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: June 27, 2023
    Assignee: JIANGSU HUAIYU PHARMACEUTICAL CO., LTD.
    Inventors: Ningning Song, Qing Duan, Xiaohui Shao, Peng Wang, Xiaojiao Bian, Qian Wang, Peipei Wei, Yajun Huang, Jian Wu, Meiling Wang, Yuandong Wang, Lina Xu, Tatchi Teddy Yang, Lile Liu
  • 4-1BB antibody and preparation method and use thereof
    Patent number: 11555077
    Abstract: Provided in the present invention are a 4-1BB antibody and a preparation method and the use thereof. In particular, provided in the present invention are a 4-1BB antibody, which has high affinity to 4-1BB protein, can effectively activate the signal downstream of the 4-1BB and significantly increase expression quantities of IFN-? and IL-2 in human mixed lymphocytes or T lymphocytes, and can be used to treat cancers and autoimmune diseases.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: January 17, 2023
    Assignee: Shanghai Hyamab Biotech Co., Ltd.
    Inventors: Heng Pan, Haohan Liu, Yingying Gao, Shaoping Hu, Yong Li, Mingming Pan, Tatchi Teddy Yang, Qing Duan, Lile Liu
  • FULLY HUMANIZED ANTI-GITR ANTIBODY AND PREPARATION METHOD THEREFOR
    Publication number: 20220119541
    Abstract: Disclosed are a GITR-targeting antibody, a preparation method therefor and the use thereof. In particular, disclosed is a novel GITR-targeting chimeric antibody or a fully humanized monoclonal antibody. Also disclosed is a method for preparing the monoclonal antibody. The monoclonal antibody of the present invention can bind to a GITR antigen with a high specificity, and has a very high affinity and a significant anti-tumor activity or the like.
    Type: Application
    Filed: November 29, 2019
    Publication date: April 21, 2022
    Applicant: PHARMAEXPLORER LIMITED
    Inventors: Qianqian QI, Qing DUAN, Lile LIU, Tatchi Teddy YANG, Hu LIU, Hui MA, Xinxiu YANG, Dongxu WANG, Chaohui DAI, Mengying WANG
  • CD73 ANTIBODY, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Publication number: 20220098319
    Abstract: An antibody targeting CD73, a preparation method therefor and a use thereof. The provided monoclonal antibody can bind to a CD73 antigen with high specificity, and has high affinity and significant antitumor activity.
    Type: Application
    Filed: January 13, 2020
    Publication date: March 31, 2022
    Inventors: Dongxu WANG, Qing DUAN, Lile LIU, Tatchi Teddy YANG, Hu LIU, Ye HAN, Rongrong XIE, Xiaohui SHAO, Peng WANG, Qin ZHONG, Yajun HUANG, Jian WU, Meiling WANG, Yuandong WANG
  • ANTI-HUMAN TIM-3 MONOCLONAL ANTIBODY AND APPLICATION THEREOF
    Publication number: 20220033501
    Abstract: Provided are a high-affinity full human monoclonal antibody highly specifically targeting to TIM-3 and a preparation method therefor. The monoclonal antibody has a remarkable antitumor activity, and can be used for preparing a related diagnostic reagent or a pharmaceutical composition preventing or treating diseases related to TIM-3 dysfunction.
    Type: Application
    Filed: December 2, 2019
    Publication date: February 3, 2022
    Inventors: Ningning SONG, Qing DUAN, Lile LIU, Tatchi Teddy YANG, Lina XU, Hu LIU, Peipei WEI, Qian WANG, Yuangdong WANG, Xiaohui SHAO, Shaoping HU, Yu ZHANG, Jian WU, Meilling WANG, Dongxu WANG, Chaohui DAI, Mengying WANG
  • CD47 ANTIBODY, PREPARATION METHOD THEREFOR AND USES THEREOF
    Publication number: 20220017615
    Abstract: An antibody targeting CD47, a preparation method therefor and uses thereof. A novel mouse or human-mouse chimeric antibody targeting CD47. A method for preparing the monoclonal antibody. The monoclonal antibody of the present invention can bind CD47 antigen with high specificity, has high affinity and significant activities, such as anti-tumor activity.
    Type: Application
    Filed: December 3, 2019
    Publication date: January 20, 2022
    Inventors: Lile LIU, Tatchi Teddy YANG, Shireen KHAN, Qing DUAN, Jing GAO, Jingyun YAO, Zhiqiang XU, Yali MENG, Liang WANG, Mingming PAN, Wenming ZHOU, Ke XIA, Cuicui GUO, Guozhen TONG, Lu WANG, Jiaxun ZHAO, Dongxu WANG, Chaohui DAI, Mengying WANG
  • OX40 ANTIBODY, PREPARATION METHOD THEREOF AND USE THEREOF
    Publication number: 20220017629
    Abstract: Provided are a murine or human-mouse chimeric antibody targeting OX40 and a preparation method therefor, wherein the antibody binds to the OX40 antigen and has an anti-tumor activity and other activities.
    Type: Application
    Filed: November 19, 2019
    Publication date: January 20, 2022
    Inventors: Xiaojuan CHAI, Wenfang XIN, Yanyun CAO, Hui XU, Yu ZHANG, Ke XIA, Qing DUAN, Tatchi Teddy YANG, Lile LIU
  • ANTIBODY TARGETING CTLA-4 , PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20210324080
    Abstract: Disclosed by the present invention are an antibody targeting CTLA-4, a preparation method therefor and a use thereof. In particular, disclosed by the present invention is a novel fully human monoclonal antibody that targets CTLA-4. Further disclosed by the present invention is a method for preparing the monoclonal antibody. The monoclonal antibody of the present invention is capable of binding a CTLA-4 antigen with high specificity, has a high affinity, remarkable anti-tumor activity, and so on.
    Type: Application
    Filed: March 13, 2019
    Publication date: October 21, 2021
    Inventors: Lina XU, Lile LIU, Tatchi Teddy YANG, Yuxing WEI, Xiaohui SHAO, Qian WANG, Jie ZHANG, Meiling WANG, Yu ZHANG, Qing DUAN, Ningning SONG
  • ANTI-HUMAN LAG-3 MONOCLONAL ANTIBODY AND USE THEREOF
    Publication number: 20210155689
    Abstract: Disclosed in the present invention are an antibody targeting LAG-3, a preparation method therefor and the use thereof. In particular, disclosed in the present invention is a novel monoclonal antibody targeting LAG-3. Also disclosed in the present invention is a method for the preparation of the monoclonal antibody. The monoclonal antibody of the present invention is capable of binding LAG-3 antigens with high specificity, and has very high affinity and significant activities such as anti-tumor activity.
    Type: Application
    Filed: April 2, 2019
    Publication date: May 27, 2021
    Applicants: SHANGHAI PHARMAEXPLORER CO., LTD., PHARMAEXPLORER LIMITED
    Inventors: Ningning SONG, Qing DUAN, Xiaohui SHAO, Peng WANG, Xiaojiao BIAN, Qian WANG, Peipei WEI, Yajun HUANG, Jian WU, Meiling WANG, Yuandong WANG, Lina XU, Tatchi Teddy YANG, Lile LIU
  • Anti-PD-1 antibodies and uses thereof
    Patent number: 10973915
    Abstract: Anti-PD-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancers and autoimmune diseases.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: April 13, 2021
    Assignee: SHANGHAI YUNYI HEALTHCARE AND TECHNOLOGY CO., LTD.
    Inventors: Lile Liu, Xinxiu Yang, Haishan Luo, Hu Liu, Zhengrong Shuai, Jian Wang, Qin Zhong, Qing Duan, Hongzhuan Gu, Tatchi Teddy Yang
  • Anti-PD-L1 antibodies and uses thereof
    Patent number: 10889648
    Abstract: Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: January 12, 2021
    Assignee: JIANGSU HYAMAB PHARMACEUTICAL CO., LTD.
    Inventors: Lile Liu, Xinxiu Yang, Haishan Luo, Zhengrong Shuai, Hu Liu, Shaoping Hu, Xiaolan Sun, Hongzhuan Gu, Qing Duan, Tatchi Teddy Yang
  • Anti-PCSK9 antibodies and uses thereof
    Patent number: 10858446
    Abstract: Anti-PCSK9 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as lipid disorders, metabolic diseases, hypercholesterolemia, inflammatory diseases and infectious diseases.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: December 8, 2020
    Assignee: PHARMAEXPLORER LIMITED
    Inventors: Lile Liu, Jing Gao, Xinxiu Yang, Zhiqiang Xu, Shaoping Hu, Lini Huang, Hongzhuan Gu, Yu Zhang, Yangyang Zhai, Tatchi Teddy Yang
  • 4-1BB ANTIBODY AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20200347144
    Abstract: Provided in the present invention are a 4-1BB antibody and a preparation method and the use thereof. In particular, provided in the present invention are a 4-1BB antibody, which has high affinity to 4-1BB protein, can effectively activate the signal downstream of the 4-1BB and significantly increase expression quantities of IFN-? and IL-2 in human mixed lymphocytes or T lymphocytes, and can be used to treat cancers and autoimmune diseases.
    Type: Application
    Filed: November 8, 2018
    Publication date: November 5, 2020
    Applicant: SHANGHAI HYAMAB BIOTECH CO., LTD.
    Inventors: Heng PAN, Haohan LIU, Yingying GAO, Shaoping HU, Yong LI, Mingming PAN, Tatchi Teddy YANG, Qing DUAN, Lile LIU
  • ANTI-PD-L1 ANTIBODIES AND USES THEREOF
    Publication number: 20190010233
    Abstract: Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.
    Type: Application
    Filed: December 27, 2016
    Publication date: January 10, 2019
    Inventors: Lile LIU, Xinxiu YANG, Haishan LUO, Zhengrong SHUAI, Hu LIU, Shaoping HU, Xiaolan SUN, Hongzhuan GU, Qing DUAN, Tatchi Teddy YANG
  • ANTI-PCSK9 ANTIBODIES AND USES THEREOF
    Publication number: 20180355059
    Abstract: Anti-PCSK9 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as lipid disorders, metabolic diseases, hypercholesterolemia, inflammatory diseases and infectious diseases.
    Type: Application
    Filed: October 14, 2016
    Publication date: December 13, 2018
    Inventors: Lile LIU, Jing GAO, Xinxiu YANG, Zhiqiang XU, Shaoping HU, Lini HUANG, Hongzhuan GU, Yu ZHANG, Yangyang ZHAI, Tatchi Teddy YANG
  • ANTI-PD-1 ANTIBODIES AND USES THEREOF
    Publication number: 20180214548
    Abstract: Anti-PD-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancers and autoimmune diseases.
    Type: Application
    Filed: July 27, 2016
    Publication date: August 2, 2018
    Inventors: Lile LIU, Xinxiu YANG, Haishan LUO, Hu LIU, Zhengrong SHUAI, Jian WANG, Qin ZHONG, Qing DUAN, Hongzhuan GU, Tatchi Teddy YANG