Patents by Inventor Tatsuji INOMATA

Tatsuji INOMATA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220177512
    Abstract: A method for producing a cyclic peptide, including the following step (1) and step (2): (1) a step of cyclizing a linear peptide; and (2) a step of obtaining a cyclic peptide by adding a poor solvent to a mixture of the cyclic peptide and multimeric impurity, which mixture is obtained in the above-mentioned step, and filtering off the multimeric impurity as an insoluble material can efficiently remove multimeric impurity by-produced during a cyclization reaction, improve the purity of the obtained cyclic peptide, and reduce a burden on the purification step.
    Type: Application
    Filed: December 23, 2021
    Publication date: June 9, 2022
    Applicant: AJINOMOTO CO., INC.
    Inventors: Daisuke TAKAHASHI, Tatsuji INOMATA
  • Publication number: 20210277063
    Abstract: Cyclized peptides having a crosslinked structure by one or more intramolecular S—S bonds may be prepared by: (1-A) as to a completely protected linear peptide having two or more SH groups as functional groups on the peptide, removing protecting groups of all functional groups other than the protected SH groups in the peptide, (1-B) protecting all SH groups of the linear peptide having two or more SH groups as the functional groups on the peptide by forming a temporary S—S bond, and (2) subjecting the peptide obtained by step (1-A) and step (1-B) to a folding step under oxidation and reduction conditions to obtain the cyclized peptide by re-forming an S—S bond in the peptide molecule.
    Type: Application
    Filed: May 13, 2021
    Publication date: September 9, 2021
    Applicant: AJINOMOTO CO., INC.
    Inventors: Daisuke TAKAHASHI, Tatsuji INOMATA, Yuki SHINOHARA