Patents by Inventor Tatsuo Hoshino

Tatsuo Hoshino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10968186
    Abstract: An object of the present invention is to provide a novel ascochlorin derivative which activates adenosine monophosphate-activated protein kinase (AMPK), and is useful in the treatment or prevention of diseases or conditions that involve AMPK dysregulation. The present invention provides a compound presented by formula I, a pharmaceutically acceptable salt or a solvate thereof.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: April 6, 2021
    Inventor: Tatsuo Hoshino
  • Publication number: 20200270220
    Abstract: An object of the present invention is to provide a novel ascochlorin derivative which activates adenosine monophosphate-activated protein kinase (AMPK), and is useful in the treatment or prevention of diseases or conditions that involve AMPK dysregulation. The present invention provides a compound presented by formula I, a pharmaceutically acceptable salt or a solvate thereof.
    Type: Application
    Filed: January 4, 2017
    Publication date: August 27, 2020
    Inventors: Nobuo SHIMMA, Tatsuo HOSHINO
  • Publication number: 20190081342
    Abstract: A method of producing a membrane electrode assembly including an electrolyte film, including: a process of obtaining a membrane body by forming an electrolyte resin precursor which is a precursor of an electrolyte resin used in the electrolyte film into a film form; and a hydrolysis process of obtaining the electrolyte film by hydrolyzing the membrane body, wherein the hydrolysis process includes a process of passing the membrane body through a first tank in which an alkaline aqueous solution is accommodated and a process of passing the membrane body through second tanks in which an aqueous solution in which a water-soluble hydroxy radical elimination accelerator is dissolved in advance is accommodated after the membrane body is passed through the first tank.
    Type: Application
    Filed: September 5, 2018
    Publication date: March 14, 2019
    Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Satoshi KADOTANI, Kazuki FUJII, Tatsuo HOSHINO
  • Publication number: 20180264703
    Abstract: Provided is a method for forming resin film capable maximizing the effective width of the resin film while suppressing neck-in and so increasing the material utilization. The method includes: drawing molten resin extruded downward from a die exit by a cooling roll; blowing air to both ends of the molten resin from an air-blowing nozzle to cure the both ends of the molten resin while cooling the molten resin on a surface of the cooling roll for solidification. For an effective width of the resin film to be formed having a thickness in a predetermined thickness range, a target effective width is set. An amount of air to be blown and a distance from the air-blowing nozzle to the molten resin are set to form the resin film having an effective width of the target effective width or more. The resin film is formed while blowing air under the conditions.
    Type: Application
    Filed: March 16, 2018
    Publication date: September 20, 2018
    Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Tatsuo Hoshino, Yasuhiro Akita
  • Patent number: 9279138
    Abstract: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of the polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of the polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in the microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: March 8, 2016
    Assignee: DSM ASSETS B.V.
    Inventors: Tatsuo Hoshino, Masako Shinjoh, Christine Toepfer, Noribumi Tomiyama
  • Publication number: 20120058563
    Abstract: The present invention relates to the production of recombinant microorganisms, in particular of the genus Gluconobacter, for production of 2-keto-L-gulonic acid (2-KGA) and/or L-ascorbic acid (hereinafter also referred to as Vitamin C), wherein the microorganism has been modified to overexpress L-sorbose dehydrogenase (SDH). This overexpression has been achieved by introducing of one or more copies of a polynucleotide encoding SDH into the genome of the host microorganism resulting in enhanced yield, production, and/or efficiency of 2-KGA production and/or Vitamin C compared to a non-modified microorganism. Expression of said one or more extra-copies of sdh is dependent on the integration site. The invention also relates to genetically engineered microorganisms and their use for the production of 2-KGA and/or Vitamin C.
    Type: Application
    Filed: March 4, 2010
    Publication date: March 8, 2012
    Inventors: Tatsuo Hoshino, Nigel John Mouncey, Akiko Shimizu, Masako Shinjoh
  • Patent number: 7842483
    Abstract: The present invention is directed to a novel cytochrome c oxidase complex, genetic materials useful for the preparation of the said complex, such as recombinant polypeptides involved in cytochrome c oxidase complex, recombinant DNA fragments, expression vectors, recombinant organisms and the like. Those novel cytochrome c oxidase complex and genetic materials may be originated from a microorganism having the identifying characteristics of Gluconobacter oxydans DSM 4025. The present invention also provides a method for the preparation of the said novel recombinant cytochrome c oxidase complex and a process for the production of 2-keto-L-gulonic acid (2KGA).
    Type: Grant
    Filed: January 26, 2005
    Date of Patent: November 30, 2010
    Assignee: DSM Nutritional Products, Inc.
    Inventors: Akira Asakura, Tatsuo Hoshino, Masako Shinjoh
  • Patent number: 7687246
    Abstract: The present invention relates to a biological process for producing carotenoids utilizing a microorganism which is capable of producing carotenoids and belonging to the genus Xanthophyllomyces (Phaffia) in the presence of an inhibitor for biosynthesis of sterols from farnesyl pyrophosphate.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: March 30, 2010
    Assignee: DSM IP Assets B. V.
    Inventors: Tatsuo Hoshino, Setsuko Masuda, Yutaka Setoguchi
  • Patent number: 7670814
    Abstract: The present invention provides a process for the production of vitamin C from a substrate, such as for instance L-sorbosone using a microorganism belonging to the genus Ketogulonicigenium.
    Type: Grant
    Filed: January 22, 2005
    Date of Patent: March 2, 2010
    Assignee: DSM IP Assets B.V.
    Inventors: Tatsuo Hoshino, Teruhide Sugisawa
  • Patent number: 7598066
    Abstract: Disclosed is an isolated DNA encoding vitamin B6 phosphate phosphatase selected from the group consisting of: (a) a DNA sequence represented in SEQ ID NO:9; (b) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and hybridizes under standard conditions to the DNA sequence defined in (a) or a fragment of thereof; (c) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity, wherein said polypeptide is at least 70% identical to the amino acid sequence represented in SEQ ID NO:10; (d) a DNA sequence which encodes a polypeptide having vitamin B6 phosphate phosphatase activity and is at least 70% identical to the DNA sequence represented in SEQ ID NO:9; (e) a degenerate DNA sequence of any one of (a) to (c).
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: October 6, 2009
    Assignee: DSM IP Assets B.V.
    Inventors: Tatsuo Hoshino, Yoshie Nagahashi, Masaaki Tazoe
  • Patent number: 7544494
    Abstract: The present invention relates to a process for the production of vitamin C from L sorbosone using an aldehyde dehydrogenase which is isolated from Gluconobacter oxydans DSM 4025 (FERM BP-3812), said enzyme having the following physicochemical properties: (a) molecular weight of 150,000±6,000 Da or 230,000±9,000 Da (consisting of 2 or 3 homologous subunits, each subunit having a molecular weight of 75,000±3,000 Da); (b) substrate specificity as active on aldehyde compounds; (c) Cofactors are pyrroloquinoline quinone and heme c; (d) Optimum pH between 6.4 and 8.2 for vitamin C production from L-sorbosone; and (e) as inhibitors Co2+, Cu2+, Fe2+, Ni2+, Zn2+, monoiodoacetate and ethylendiamine tetraacetic acid. The process is performed in the presence of a suitable electron acceptor and the vitamin C isolated from the reaction mixture.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: June 9, 2009
    Assignee: DSM IP Assets B.V.
    Inventors: Tatsuo Hoshino, Taro Miyazaki, Teruhide Sugisawa
  • Publication number: 20090142815
    Abstract: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms.
    Type: Application
    Filed: February 10, 2006
    Publication date: June 4, 2009
    Inventors: Tatsuo Hoshino, Masako Shinjoh, Christine Toepfer, Noribumi Tomiyama
  • Patent number: 7465563
    Abstract: A process for producing L-ascorbic acid from 2-keto-L-gulonic acid or D-erythorbic acid from 2-keto-D-gluconic acid by contacting 2-keto-L-gulonic acid or 2-keto-D-gluconic acid, respectively, with an enzym having ?-amylase activity in solution. The solvent for this reaction can be water, an aqueous alcohol, an organic solvent or a mixture thereof. In each case, the starting material can be in the form of the free acid, the sodium salt, or the calcium salt.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: December 16, 2008
    Assignee: DSM IP Assets B.V.
    Inventors: Tatsuo Hoshino, Tatsuya Kiyasu, Masako Shinjoh
  • Patent number: 7432076
    Abstract: Disclosed is a fermentation method of astaxanthin using Phaffia rhodozyma comprising the steps of: (a) in the growing phase, feeding of a nutrient medium containing glucose or sucrose based on the specific growth rate (?) of Phaffia rhodozyma cells, and (b) in the astaxanthin production phase, feeding of the nutrient medium based on the astaxanthin production rate, while keeping the glucose concentration in the fermentation broth almost 0 g/L during the whole fermentation period.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: October 7, 2008
    Assignee: DSM IP Assets B.V.
    Inventors: Tatsuo Hoshino, Yutaka Setoguchi, Yoshinori Takagi
  • Patent number: 7432089
    Abstract: The present invention relates to a DNA encoding a novel flavin adenine dinucleotide (FAD)-dependent D-erythronate 4-phosphate (EN4P) dehydrogenase originated from Sinorhizobium meliloti, which is involved in vitamin B6 biosynthesis, and a recombinant microorganism transformed with a vector having the DNA. It also relates to a process for production of vitamin B6 by using the recombinant microorganism. “Vitamin B6” as used in this invention includes pyridoxol (PN), pyridoxal and pyridoxamine. Vitamin B6 is a vitamin indispensable to human beings or other animals, and is used as a raw material of medicines or as feed additives.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: October 7, 2008
    Assignee: DSM IP Assets B.V.
    Inventors: Tatsuo Hoshino, Keiko Ichikawa, Masaaki Tazoe
  • Publication number: 20080113417
    Abstract: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms.
    Type: Application
    Filed: February 10, 2006
    Publication date: May 15, 2008
    Inventors: Tatsuo Hoshino, Masako Shinjoh, Noribumi Tomiyama
  • Patent number: 7371547
    Abstract: Disclosed is a mutant of a recombinant microorganism of the genus Sinorhizobium capable of producing vitamin B6 having a recombinant plasmid with pdxJ gene that acquired histidine requirement of glycine resistance, or its combination thereof.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: May 13, 2008
    Assignee: DSM IP Assets B.V.
    Inventors: Tatsuo Hoshino, Yoichiro Nagatani, Keiko Ichikawa, Masaaki Tazoe
  • Patent number: 7351564
    Abstract: The present invention relates to a gene useful in a process to increase the microbial production of carotenoids. The carotenoids astaxanthin is distributed in a wide variety of organisms such as animals, algae and microorganisms. It has a strong antioxidation property against reactive oxygen species. Astaxanthin is used as a coloring reagent, especially in the industry of farmed fish, such as salmon, because astaxanthin imparts distinctive orange-red coloration to the animals and contributes to consumer appeal in the marketplace.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: April 1, 2008
    Assignee: DSM IP Assets B.V.
    Inventors: Tatsuo Hoshino, Kazuyuki Ojima, Yutaka Setoguchi
  • Patent number: 7341854
    Abstract: The present invention provides a process for the production of vitamin C from different substrates like D-sorbitol, L-sorbose, L-sorbosone or L-gulose using a microorganism selected from the group consisting of Gluconobacter oxydans DMS 4025 (FERM BP-3812), a microorganism belonging to the genus Gluconobacter and having identifying characteristics of G. oxydans DSM 4025 (FERM BP-3812) and mutants thereof.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: March 11, 2008
    Assignee: DSM IP Assets B.V.
    Inventors: Tatsuo Hoshino, Teruhide Sugisawa
  • Patent number: 7288395
    Abstract: The present invention relates to a gene useful in a process to increase the microbial production of carotenoids. The carotenoids astaxanthin is distributed in a wide variety of organisms such as animals, algae and microorganisms. It has a strong antioxidation property against reactive oxygen species. Astaxanthin is used as a coloring reagent, especially in the industry of farmed fish, such as salmon, because astaxanthin imparts distinctive orange-red coloration to the animals and contributes to consumer appeal in the marketplace.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: October 30, 2007
    Assignee: DSM IP Assets B.V.
    Inventors: Tatsuo Hoshino, Kazuyuki Ojima, Yutaka Setoguchi