Patents by Inventor Tatsuo Yanagisawa
Tatsuo Yanagisawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11787877Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.Type: GrantFiled: December 22, 2020Date of Patent: October 17, 2023Assignees: RIKEN, KYOWA KIRIN CO., LTD.Inventors: Kensaku Sakamoto, Kazumasa Ohtake, Yoshimi Yamaguchi, Shigeyuki Yokoyama, Tatsuo Yanagisawa, Akiko Matsumoto, Akifumi Kato, Yasuhisa Shiraishi, Kaname Kimura, Masakazu Homma
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Publication number: 20210324363Abstract: Obtained is: a method for efficiently producing a polypeptide containing a non-canonical amino acid; a method for incorporating a non-canonical amino acid into a polypeptide; a method for producing tRNA bound to a non-canonical amino acid; a a non-canonical amino acid incorporation system; a material for use in these methods; or the like.Type: ApplicationFiled: August 30, 2019Publication date: October 21, 2021Inventors: Kensaku SAKAMOTO, Atsushi YAMAGUCHI, Fumie KIMURA, Shigeyuki YOKOYAMA, Tatsuo YANAGISAWA, Eiko SEKI, Mitsuo KURATANI
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Publication number: 20210107997Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.Type: ApplicationFiled: December 22, 2020Publication date: April 15, 2021Applicants: RIKEN, KYOWA KIRIN CO., LTD.Inventors: Kensaku Sakamoto, Kazumasa Ohtake, Yoshimi Yamaguchi, Shigeyuki Yokoyama, Tatsuo Yanagisawa, Akiko Matsumoto, Akifumi Kato, Yasuhisa Shiraishi, Kaname Kimura, Masakazu Homma
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Patent number: 10906990Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.Type: GrantFiled: August 18, 2016Date of Patent: February 2, 2021Assignees: RIKEN, KYOWA KIRIN CO., LTD.Inventors: Kensaku Sakamoto, Kazumasa Ohtake, Yoshimi Yamaguchi, Shigeyuki Yokoyama, Tatsuo Yanagisawa, Akiko Matsumoto, Akifumi Kato, Yasuhisa Shiraishi, Kaname Kimura, Masakazu Homma
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Publication number: 20190127488Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.Type: ApplicationFiled: August 18, 2016Publication date: May 2, 2019Applicants: RIKEN, KYOWA HAKKO KIRIN CO., LTD.Inventors: Kensaku SAKAMOTO, Kazumasa OHTAKE, Yoshimi YAMAGUCHI, Shigeyuki YOKOYAMA, Tatsuo YANAGISAWA, Akiko MATSUMOTO, Akifumi KATO, Yasuhisa SHIRAISHI, Kaname KIMURA, Masakazu HOMMA
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Patent number: 9133449Abstract: Method for incorporating a lysine derivative (particularly an N?-benzyloxycarbonyl-lysine (Z-Lys) derivative) having useful functional group such as heavy atom, selenium, reactive functional group, fluorescent group or crosslinker, which is suitable as a non-natural amino acid, into a desired protein in a site-specific manner. A mutant pyrrolysyl-tRNA synthetase has substitution of at least one amino acid residue selected from tyrosine residue at position 306, leucine residue at position 309 and cysteine residue at position 348 each constituting a pyrrolysine-binding site in the amino acid sequence for pyrrolysyl-tRNA synthetase of SEQ ID NO:2. The substitution of the amino acid residue is: of tyrosine residue at position 306 by glycine or alanine residue, of leucine residue at position 309 by glycine or alanine residue, and/or of a cysteine residue at position 348 by valine, serine or alanine residue.Type: GrantFiled: April 8, 2014Date of Patent: September 15, 2015Assignee: RIKENInventors: Shigeyuki Yokoyama, Kensaku Sakamoto, Tatsuo Yanagisawa, Takatsugu Kobayashi
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Publication number: 20140322751Abstract: Method for incorporating a lysine derivative (particularly an N?-benzyloxycarbonyl-lysine (Z-Lys) derivative) having useful functional group such as heavy atom, selenium, reactive functional group, fluorescent group or crosslinker, which is suitable as a non-natural amino acid, into a desired protein in a site-specific manner. A mutant pyrrolysyl-tRNA synthetase has substitution of at least one amino acid residue selected from tyrosine residue at position 306, leucine residue at position 309 and cysteine residue at position 348 each constituting a pyrrolysine-binding site in the amino acid sequence for pyrrolysyl-tRNA synthetase of SEQ ID NO:2. The substitution of the amino acid residue is: of tyrosine residue at position 306 by glycine or alanine residue, of leucine residue at position 309 by glycine or alanine residue, and/or of a cysteine residue at position 348 by valine, serine or alanine residue.Type: ApplicationFiled: April 8, 2014Publication date: October 30, 2014Applicant: RikenInventors: Shigeyuki YOKOYAMA, Kensaku SAKAMOTO, Tatsuo YANAGISAWA, Takatsugu KOBAYASHI
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Patent number: 8785152Abstract: A non-natural protein having at least one ester bond in its polypeptide main chain is synthesized by using an in vivo translation system in a ribosome. The following components (a) to (c) are expressed in a cell or an cell extraction solution in the presence of an ?-hydroxy acid: (a) an aminoacyl-tRNA synthetase which can activate the ?-hydroxy acid; (b) suppressor tRNA which can bind to the ?-hydroxy acid in the presence of the aminoacyl-tRNA synthetase; and (c) a gene encoding a desired protein having a nonsense mutation or a frame-shift mutation at a desired site.Type: GrantFiled: November 21, 2008Date of Patent: July 22, 2014Assignee: RikenInventors: Shigeyuki Yokoyama, Kensaku Sakamoto, Tatsuo Yanagisawa, Takahito Mukai, Takatsugu Kobayashi
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Patent number: 8735093Abstract: Method for incorporating a lysine derivative (particularly an N?-benzyloxycarbonyl-lysine (Z-Lys) derivative) having useful functional group such as heavy atom, selenium, reactive functional group, fluorescent group or crosslinker, which is suitable as a non-natural amino acid, into a desired protein in a site-specific manner. A mutant pyrrolysyl-tRNA synthetase has substitution of at least one amino acid residue selected from tyrosine residue at position 306, leucine residue at position 309 and cysteine residue at position 348 each constituting a pyrrolysine-binding site in the amino acid sequence for pyrrolysyl-tRNA synthetase of SEQ ID NO:2. The substitution of the amino acid residue is: of tyrosine residue at position 306 by glycine or alanine residue, of leucine residue at position 309 by glycine or alanine residue, and/or of a cysteine residue at position 348 by valine, serine or alanine residue.Type: GrantFiled: March 18, 2010Date of Patent: May 27, 2014Assignee: RikenInventors: Shigeyuki Yokoyama, Kensaku Sakamoto, Tatsuo Yanagisawa, Takatsugu Kobayashi
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Publication number: 20110136168Abstract: A non-natural protein having at least one ester bond in its polypeptide main chain is synthesized by using an in vivo translation system in a ribosome. The following components (a) to (c) are expressed in a cell or an cell extraction solution in the presence of an ?-hydroxy acid: (a) an aminoacyl-tRNA synthetase which can activate the ?-hydroxy acid; (b) suppressor tRNA which can bind to the ?-hydroxy acid in the presence of the aminoacyl-tRNA synthetase; and (c) a gene encoding a desired protein having a nonsense mutation or a frame-shift mutation at a desired site.Type: ApplicationFiled: November 21, 2008Publication date: June 9, 2011Inventors: Shigeyuki Yokoyama, Kensaku Sakamoto, Tatsuo Yanagisawa, Takahito Mukai, Takatsugu Kobayashi
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Publication number: 20100304431Abstract: The present invention relates to a process for producing a protein having an unnatural amino acid introduced therein, the process including: expressing in a eukaryotic cell an aminoacyl-tRNA synthetase, a nucleic acid having a sequence containing a eukaryote-derived tRNA nucleotide sequence linked to the 5? end of a tRNA nucleotide sequence that is ligated with to an unnatural amino acid in the presence of the aminoacyl-tRNA synthetase, an unnatural amino acid, and a gene of a desired protein having a nonsense mutation at a predetermined position, to integrate the unnatural amino acid at the nonsense mutation position into the protein, thereby expressing a protein having an unnatural amino acid introduced therein.Type: ApplicationFiled: August 2, 2006Publication date: December 2, 2010Inventors: Shigeyuki Yokoyama, Kensaku Sakamoto, Tatsuo Yanagisawa, Takatsugu Kobayashi
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Publication number: 20100267087Abstract: Method for incorporating a lysine derivative (particularly an N?-benzyloxycarbonyl-lysine (Z-Lys) derivative) having useful functional group such as heavy atom, selenium, reactive functional group, fluorescent group or crosslinker, which is suitable as a non-natural amino acid, into a desired protein in a site-specific manner. A mutant pyrrolysyl-tRNA synthetase has substitution of at least one amino acid residue selected from tyrosine residue at position 306, leucine residue at position 309 and cysteine residue at position 348 each constituting a pyrrolysine-binding site in the amino acid sequence for pyrrolysyl-tRNA synthetase of SEQ ID NO:2. The substitution of the amino acid residue is: of tyrosine residue at position 306 by glycine or alanine residue, of leucine residue at position 309 by glycine or alanine residue, and/or of a cysteine residue at position 348 by valine, serine or alanine residue.Type: ApplicationFiled: March 18, 2010Publication date: October 21, 2010Applicant: RIKENInventors: SHIGEYUKI YOKOYAMA, KENSAKU SAKAMOTO, TATSUO YANAGISAWA, TAKATSUGU KOBAYASHI
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Patent number: 5499796Abstract: To safely and quickly exchange a seal of a shock strut of a selected shock absorbing apparatus of an airplane, an apparatus is provided whereby the main body of the airplane is lifted by pressurizing and extending at least one other shock absorbing apparatus in order to extend the selected shock absorbing apparatus and expose the seal thereof. A shock strut of the selected shock absorbing apparatus is then lifted away from the associated wheels so that a new seal may be inserted from below the strut. To lift the strut, an apparatus is provided which includes a main body portion having an inclined surface substantially complementary to a downward-facing inclined surface of the strut, and a cylindrical portion which inserts into an attachment hole of the strut.Type: GrantFiled: March 21, 1995Date of Patent: March 19, 1996Assignee: All Nippon Airways Co., Ltd.Inventors: Kazuya Kigawa, Kenji Furukawa, Tetsu Deguchi, Sachiharu Inoue, Norikatsu Endo, Tatsuo Yanagisawa, Shinji Ikegami, Yasuyuki Omagari, Koji Kihara, Tachiki Sugawara, Kenzo Shimizu
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Patent number: 5419034Abstract: To safely and quickly exchange a seal of a shock strut of a selected shock absorbing apparatus of an airplane, an apparatus is provided whereby the main body of the airplane is lifted by pressurizing and extending at least one other shock absorbing apparatus in order to extend the selected shock absorbing apparatus and expose the seal thereof. A shock strut of the selected shock absorbing apparatus is then lifted away from the associated wheels so that a new seal may be inserted from below the strut.Type: GrantFiled: December 15, 1993Date of Patent: May 30, 1995Assignee: All Nippon Airways Co., Ltd.Inventors: Kazuya Kigawa, Kenji Furukawa, Tetsu Deguchi, Sachiharu Inoue, Norikatsu Endo, Tatsuo Yanagisawa, Shinji Ikegami, Yasuyuki Omagari, Koji Kihara, Tachiki Sugawara, Kenzo Shimizu
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Patent number: 5323522Abstract: To safety and quickly exchange a seal of a shock strut of a selected shock absorbing apparatus of an airplane, the main body of the airplane is lifted by pressurizing and extending at least one other shock absorbing apparatus in order to extend the selected shock absorbing apparatus and expose the seal thereof. A shock strut of the selected shock absorbing apparatus is then lifted away from the associated wheels so that a new seal may be inserted from below the strut.Type: GrantFiled: September 22, 1992Date of Patent: June 28, 1994Assignee: All Nippon Airways, Co., Ltd.Inventors: Kazuya Kigawa, Kenji Furukawa, Tetsu Deguchi, Sachiharu Inoue, Norikatsu Endo, Tatsuo Yanagisawa, Shinji Ikegami, Yasuyuki Omagari, Koji Kihara, Tachiki Sugawara, Kenzo Shimizu