Patents by Inventor Tatsuo Yanagisawa

Tatsuo Yanagisawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210107997
    Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.
    Type: Application
    Filed: December 22, 2020
    Publication date: April 15, 2021
    Applicants: RIKEN, KYOWA KIRIN CO., LTD.
    Inventors: Kensaku Sakamoto, Kazumasa Ohtake, Yoshimi Yamaguchi, Shigeyuki Yokoyama, Tatsuo Yanagisawa, Akiko Matsumoto, Akifumi Kato, Yasuhisa Shiraishi, Kaname Kimura, Masakazu Homma
  • Patent number: 10906990
    Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: February 2, 2021
    Assignees: RIKEN, KYOWA KIRIN CO., LTD.
    Inventors: Kensaku Sakamoto, Kazumasa Ohtake, Yoshimi Yamaguchi, Shigeyuki Yokoyama, Tatsuo Yanagisawa, Akiko Matsumoto, Akifumi Kato, Yasuhisa Shiraishi, Kaname Kimura, Masakazu Homma
  • Publication number: 20190127488
    Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.
    Type: Application
    Filed: August 18, 2016
    Publication date: May 2, 2019
    Applicants: RIKEN, KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Kensaku SAKAMOTO, Kazumasa OHTAKE, Yoshimi YAMAGUCHI, Shigeyuki YOKOYAMA, Tatsuo YANAGISAWA, Akiko MATSUMOTO, Akifumi KATO, Yasuhisa SHIRAISHI, Kaname KIMURA, Masakazu HOMMA
  • Patent number: 9133449
    Abstract: Method for incorporating a lysine derivative (particularly an N?-benzyloxycarbonyl-lysine (Z-Lys) derivative) having useful functional group such as heavy atom, selenium, reactive functional group, fluorescent group or crosslinker, which is suitable as a non-natural amino acid, into a desired protein in a site-specific manner. A mutant pyrrolysyl-tRNA synthetase has substitution of at least one amino acid residue selected from tyrosine residue at position 306, leucine residue at position 309 and cysteine residue at position 348 each constituting a pyrrolysine-binding site in the amino acid sequence for pyrrolysyl-tRNA synthetase of SEQ ID NO:2. The substitution of the amino acid residue is: of tyrosine residue at position 306 by glycine or alanine residue, of leucine residue at position 309 by glycine or alanine residue, and/or of a cysteine residue at position 348 by valine, serine or alanine residue.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: September 15, 2015
    Assignee: RIKEN
    Inventors: Shigeyuki Yokoyama, Kensaku Sakamoto, Tatsuo Yanagisawa, Takatsugu Kobayashi
  • Publication number: 20140322751
    Abstract: Method for incorporating a lysine derivative (particularly an N?-benzyloxycarbonyl-lysine (Z-Lys) derivative) having useful functional group such as heavy atom, selenium, reactive functional group, fluorescent group or crosslinker, which is suitable as a non-natural amino acid, into a desired protein in a site-specific manner. A mutant pyrrolysyl-tRNA synthetase has substitution of at least one amino acid residue selected from tyrosine residue at position 306, leucine residue at position 309 and cysteine residue at position 348 each constituting a pyrrolysine-binding site in the amino acid sequence for pyrrolysyl-tRNA synthetase of SEQ ID NO:2. The substitution of the amino acid residue is: of tyrosine residue at position 306 by glycine or alanine residue, of leucine residue at position 309 by glycine or alanine residue, and/or of a cysteine residue at position 348 by valine, serine or alanine residue.
    Type: Application
    Filed: April 8, 2014
    Publication date: October 30, 2014
    Applicant: Riken
    Inventors: Shigeyuki YOKOYAMA, Kensaku SAKAMOTO, Tatsuo YANAGISAWA, Takatsugu KOBAYASHI
  • Patent number: 8785152
    Abstract: A non-natural protein having at least one ester bond in its polypeptide main chain is synthesized by using an in vivo translation system in a ribosome. The following components (a) to (c) are expressed in a cell or an cell extraction solution in the presence of an ?-hydroxy acid: (a) an aminoacyl-tRNA synthetase which can activate the ?-hydroxy acid; (b) suppressor tRNA which can bind to the ?-hydroxy acid in the presence of the aminoacyl-tRNA synthetase; and (c) a gene encoding a desired protein having a nonsense mutation or a frame-shift mutation at a desired site.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: July 22, 2014
    Assignee: Riken
    Inventors: Shigeyuki Yokoyama, Kensaku Sakamoto, Tatsuo Yanagisawa, Takahito Mukai, Takatsugu Kobayashi
  • Patent number: 8735093
    Abstract: Method for incorporating a lysine derivative (particularly an N?-benzyloxycarbonyl-lysine (Z-Lys) derivative) having useful functional group such as heavy atom, selenium, reactive functional group, fluorescent group or crosslinker, which is suitable as a non-natural amino acid, into a desired protein in a site-specific manner. A mutant pyrrolysyl-tRNA synthetase has substitution of at least one amino acid residue selected from tyrosine residue at position 306, leucine residue at position 309 and cysteine residue at position 348 each constituting a pyrrolysine-binding site in the amino acid sequence for pyrrolysyl-tRNA synthetase of SEQ ID NO:2. The substitution of the amino acid residue is: of tyrosine residue at position 306 by glycine or alanine residue, of leucine residue at position 309 by glycine or alanine residue, and/or of a cysteine residue at position 348 by valine, serine or alanine residue.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: May 27, 2014
    Assignee: Riken
    Inventors: Shigeyuki Yokoyama, Kensaku Sakamoto, Tatsuo Yanagisawa, Takatsugu Kobayashi
  • Publication number: 20110136168
    Abstract: A non-natural protein having at least one ester bond in its polypeptide main chain is synthesized by using an in vivo translation system in a ribosome. The following components (a) to (c) are expressed in a cell or an cell extraction solution in the presence of an ?-hydroxy acid: (a) an aminoacyl-tRNA synthetase which can activate the ?-hydroxy acid; (b) suppressor tRNA which can bind to the ?-hydroxy acid in the presence of the aminoacyl-tRNA synthetase; and (c) a gene encoding a desired protein having a nonsense mutation or a frame-shift mutation at a desired site.
    Type: Application
    Filed: November 21, 2008
    Publication date: June 9, 2011
    Inventors: Shigeyuki Yokoyama, Kensaku Sakamoto, Tatsuo Yanagisawa, Takahito Mukai, Takatsugu Kobayashi
  • Publication number: 20100304431
    Abstract: The present invention relates to a process for producing a protein having an unnatural amino acid introduced therein, the process including: expressing in a eukaryotic cell an aminoacyl-tRNA synthetase, a nucleic acid having a sequence containing a eukaryote-derived tRNA nucleotide sequence linked to the 5? end of a tRNA nucleotide sequence that is ligated with to an unnatural amino acid in the presence of the aminoacyl-tRNA synthetase, an unnatural amino acid, and a gene of a desired protein having a nonsense mutation at a predetermined position, to integrate the unnatural amino acid at the nonsense mutation position into the protein, thereby expressing a protein having an unnatural amino acid introduced therein.
    Type: Application
    Filed: August 2, 2006
    Publication date: December 2, 2010
    Inventors: Shigeyuki Yokoyama, Kensaku Sakamoto, Tatsuo Yanagisawa, Takatsugu Kobayashi
  • Publication number: 20100267087
    Abstract: Method for incorporating a lysine derivative (particularly an N?-benzyloxycarbonyl-lysine (Z-Lys) derivative) having useful functional group such as heavy atom, selenium, reactive functional group, fluorescent group or crosslinker, which is suitable as a non-natural amino acid, into a desired protein in a site-specific manner. A mutant pyrrolysyl-tRNA synthetase has substitution of at least one amino acid residue selected from tyrosine residue at position 306, leucine residue at position 309 and cysteine residue at position 348 each constituting a pyrrolysine-binding site in the amino acid sequence for pyrrolysyl-tRNA synthetase of SEQ ID NO:2. The substitution of the amino acid residue is: of tyrosine residue at position 306 by glycine or alanine residue, of leucine residue at position 309 by glycine or alanine residue, and/or of a cysteine residue at position 348 by valine, serine or alanine residue.
    Type: Application
    Filed: March 18, 2010
    Publication date: October 21, 2010
    Applicant: RIKEN
    Inventors: SHIGEYUKI YOKOYAMA, KENSAKU SAKAMOTO, TATSUO YANAGISAWA, TAKATSUGU KOBAYASHI
  • Patent number: 5499796
    Abstract: To safely and quickly exchange a seal of a shock strut of a selected shock absorbing apparatus of an airplane, an apparatus is provided whereby the main body of the airplane is lifted by pressurizing and extending at least one other shock absorbing apparatus in order to extend the selected shock absorbing apparatus and expose the seal thereof. A shock strut of the selected shock absorbing apparatus is then lifted away from the associated wheels so that a new seal may be inserted from below the strut. To lift the strut, an apparatus is provided which includes a main body portion having an inclined surface substantially complementary to a downward-facing inclined surface of the strut, and a cylindrical portion which inserts into an attachment hole of the strut.
    Type: Grant
    Filed: March 21, 1995
    Date of Patent: March 19, 1996
    Assignee: All Nippon Airways Co., Ltd.
    Inventors: Kazuya Kigawa, Kenji Furukawa, Tetsu Deguchi, Sachiharu Inoue, Norikatsu Endo, Tatsuo Yanagisawa, Shinji Ikegami, Yasuyuki Omagari, Koji Kihara, Tachiki Sugawara, Kenzo Shimizu
  • Patent number: 5419034
    Abstract: To safely and quickly exchange a seal of a shock strut of a selected shock absorbing apparatus of an airplane, an apparatus is provided whereby the main body of the airplane is lifted by pressurizing and extending at least one other shock absorbing apparatus in order to extend the selected shock absorbing apparatus and expose the seal thereof. A shock strut of the selected shock absorbing apparatus is then lifted away from the associated wheels so that a new seal may be inserted from below the strut.
    Type: Grant
    Filed: December 15, 1993
    Date of Patent: May 30, 1995
    Assignee: All Nippon Airways Co., Ltd.
    Inventors: Kazuya Kigawa, Kenji Furukawa, Tetsu Deguchi, Sachiharu Inoue, Norikatsu Endo, Tatsuo Yanagisawa, Shinji Ikegami, Yasuyuki Omagari, Koji Kihara, Tachiki Sugawara, Kenzo Shimizu
  • Patent number: 5323522
    Abstract: To safety and quickly exchange a seal of a shock strut of a selected shock absorbing apparatus of an airplane, the main body of the airplane is lifted by pressurizing and extending at least one other shock absorbing apparatus in order to extend the selected shock absorbing apparatus and expose the seal thereof. A shock strut of the selected shock absorbing apparatus is then lifted away from the associated wheels so that a new seal may be inserted from below the strut.
    Type: Grant
    Filed: September 22, 1992
    Date of Patent: June 28, 1994
    Assignee: All Nippon Airways, Co., Ltd.
    Inventors: Kazuya Kigawa, Kenji Furukawa, Tetsu Deguchi, Sachiharu Inoue, Norikatsu Endo, Tatsuo Yanagisawa, Shinji Ikegami, Yasuyuki Omagari, Koji Kihara, Tachiki Sugawara, Kenzo Shimizu