Abstract: Provided are: a novel marker useful for measuring hypoxia or predicting the risk of exacerbation of a hypoxia-related pathological condition; a hypoxia measurement method or a method for predicting the risk of exacerbation of a pathological condition using the marker as an indicator; a composition for measuring hypoxia or predicting the risk of exacerbation of a pathological condition; a method for screening a candidate substance for a therapeutic agent for a hypoxia-related pathological condition; a composition for ameliorating a hypoxia-related pathological condition; and the like. A method for measuring hypoxia in a subject or a method for predicting the risk of exacerbation of a pathological condition, each method comprising the step of measuring the amount of SPINK1 in a sample collected from a subject. Use of SPINK1 as a biomarker for measuring hypoxia or for predicting the risk of exacerbation of a pathological condition.

Abstract: A case database is stored with values in a plurality of fields with respect to symptoms of past patients. A CPU, when new patient data are inputted, calculates a degree of similarity of each piece of case data to the new patient data as a total sum of a values obtained by weighting a difference between each value in the case data and its corresponding value in the new patient data in accordance with an influence degree of the value in the patient data, obtains a degree of similarity of each disease name as a total sum of degrees of similarity in the all pieces of case data having this disease name, and displays the disease name exhibiting the maximum degree of similarity together with the value in the new patient data that exhibits the maximum influence degree used for calculating the degree of similarity.