Patents by Inventor Tattanahali L. Nagabhushan

Tattanahali L. Nagabhushan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of human interleukin-4 from a secreted escherichia coli mutant
    Patent number: 5077388
    Abstract: Active recombinant human IL-4 is purified from a crude fermentation broth of a secreted E. coli mutant by subjecting said solution to selective chromatogrphy on a zinc-chelating agarose column at pH 7.2 in a buffer containing a high concentration of sodium chloride, i.e., about 1M sodium chloride, washing first with a phosphate buffer at pH 7.2 containing 1.0M sodium chloride then with a buffer containing 10% glycerol and eluting at pH 5.0. The resulting purified active recombinant human IL-4 solution is further treated by cation exchange chromatography, concentration by diafiltration up to 20 mg/mL and size exclusion gel chromatography using a citrate buffer at pH 4.5.
    Type: Grant
    Filed: May 31, 1990
    Date of Patent: December 31, 1991
    Assignee: Schering Corporation
    Inventors: John C. T. Tang, David Naveh, Tattanahali L. Nagabhushan
  • Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
    Patent number: 4973750
    Abstract: A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols is disclosed. Preparation of D-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanol antibacterial agents including the D-(threo)-3-fluoro-3-deoxy derivatives of chloramphenicol and thiamphenicol is also disclosed.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: November 27, 1990
    Assignee: Schering Corporation
    Inventors: Tattanahali L. Nagabhushan, Stuart W. McCombie
  • Conversion of aristeromycin into cyclaradine
    Patent number: 4740598
    Abstract: A process for the conversion of aristeromycin into cyclaradine via. The stereoselective reduction of a 3',5'-di-O-protected-2'-keto derivative of aristeromycin is disclosed.
    Type: Grant
    Filed: May 20, 1986
    Date of Patent: April 26, 1988
    Assignee: Schering Corporation
    Inventors: Tattanahali L. Nagabhushan, Doris P. Schumacher
  • Intermediates for preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
    Patent number: 4677214
    Abstract: A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols is disclosed. Preparation of D-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanol antibacterial agents including the D-(threo)-3-fluoro-3-deoxy derivatives of chloramphenicol and thiamphenicol is also disclosed.
    Type: Grant
    Filed: January 27, 1986
    Date of Patent: June 30, 1987
    Assignee: Schering Corporation
    Inventors: Tattanahali L. Nagabhushan, Stuart W. McCombie
  • Interferon-cyclaradine combination
    Patent number: 4636383
    Abstract: Treatment of viral infections with combinations of cyclaradine and interferon and compositions and kits used therein are disclosed.
    Type: Grant
    Filed: August 29, 1984
    Date of Patent: January 13, 1987
    Assignee: Schering Corporation
    Inventors: Tattanahali L. Nagabhushan, George H. Miller, Jerome Schwartz, Michael R. Ostrander
  • Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
    Patent number: 4582918
    Abstract: A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols is disclosed. Preparation of D-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanol antibacterial agents including the D-(threo)-3-fluoro-3-deoxy derivatives of chloramphenicol and thiamphenicol is also disclosed.
    Type: Grant
    Filed: September 19, 1984
    Date of Patent: April 15, 1986
    Assignee: Schering Corporation
    Inventors: Tattanahali L. Nagabhushan, Stuart W. McCombie