Patents by Inventor Tattanahalli L. Nagabhushan
Tattanahalli L. Nagabhushan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8679472Abstract: This application covers a novel PEGylated interferon and a novel crystalline form of interferon which are useful, inter alia, for detailed structural analysis of interferon as well as treatment and prevention of viral infections and hyperproliferative diseases such as leukemia.Type: GrantFiled: October 5, 2007Date of Patent: March 25, 2014Assignee: Merck, Sharp & Dohme Corp.Inventors: Paul Reichert, Marianna Marshall Long, Alan W. Hruza, Peter Orth, Tattanahalli L. Nagabhushan
-
Patent number: 8022044Abstract: A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I: wherein: n is an integer from 2-8; X1 is a cholic acid group or deoxycholic acid group; and X2 and X3 are each independently selected from the group consisting of a cholic acid group, a deoxycholic acid group, and a saccharide group, wherein the saccharide group is selected from the group consisting of pentose monosaccharide groups, hexose monosaccharide groups, pentose-pentose disaccharide groups, hexose-hexose disaccharide groups, pentose-hexose disaccharide groups, and hexose-pentose disaccharide groups; and wherein at least one of X2 and X3 is a saccharide group.Type: GrantFiled: April 13, 2009Date of Patent: September 20, 2011Assignee: Canji, Inc.Inventors: Heidrun Engler, Tattanahalli L. Nagabhushan, Stephen Kenneth Youngster
-
Publication number: 20100028431Abstract: A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I: wherein: n is an integer from 2-8; X1 is a cholic acid group or deoxycholic acid group; and X2 and X3 are each independently selected from the group consisting of a cholic acid group, a deoxycholic acid group, and a saccharide group, wherein the saccharide group is selected from the group consisting of pentose monosaccharide groups, hexose monosaccharide groups, pentose-pentose disaccharide groups, hexose-hexose disaccharide groups, pentose-hexose disaccharide groups, and hexose-pentose disaccharide groups; and wherein at least one of X2 and X3 is a saccharide group.Type: ApplicationFiled: April 13, 2009Publication date: February 4, 2010Applicants: Canji Inc.,, Schering Corporation,Inventors: Heidrun Engler, Tattanahalli L. Nagabhushan, Stephen Kenneth Youngster
-
Patent number: 7538093Abstract: A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I: wherein: n is an integer from 2-8; X1 is a cholic acid group or deoxycholic acid group; and X2 and X3 are each independently selected from the group consisting of a cholic acid group, a deoxycholic acid group, and a saccharide group, wherein the saccharide group is selected from the group consisting of pentose monosaccharide groups, hexose monosaccharide groups, pentose-pentose disaccharide groups, hexose-hexose disaccharide groups, pentose-hexose disaccharide groups, and hexose-pentose disaccharide groups; and wherein at least one of X2 and X3 is a saccharide group.Type: GrantFiled: February 21, 2006Date of Patent: May 26, 2009Assignees: Schering Corporation, Canji, Inc.Inventors: Heidrun Engler, Tattanahalli L. Nagabhushan, Stephen Kenneth Youngster
-
Patent number: 7534769Abstract: This invention provides methods and compositions for enhancing transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The methods and compositions are useful for introducing agents into individual cells, as well as cells that are present as a tissue or organ.Type: GrantFiled: January 22, 2002Date of Patent: May 19, 2009Assignees: Canji, Inc., Schering CorporationInventors: Heidrun Engler, Tattanahalli L. Nagabhushan, Stephen Kenneth Youngster
-
Publication number: 20080166373Abstract: The present invention is directed to compositions and methods for the delivery of interferon polypeptides. The invention provides recombinant viral and non-viral vectors for the selective expression of interferon polypeptides in particular cell or tissue types. The invention further provides pharmaceutically acceptable formulations of such vectors for administration to mammalian subjects. The invention further provides methods of treatment of diseases in mammalian organisms through the delivery of recombinant vectors selectively expressing interferon polypeptides.Type: ApplicationFiled: March 21, 2008Publication date: July 10, 2008Applicant: Canji, Inc.Inventors: Tattanahalli L. Nagabhushan, Deba P. Saha
-
Patent number: 7002027Abstract: The present invention is directed to compositions and methods of treating cancer by gene therapy using a therapeutic gene formulated in a buffer comprising a delivery-enhancing agent. The delivery-enhancing agents of the invention can be used to formulate therapeutic or diagnostic agents, such as proteins, nucleic acids, antisense RNA, small molecules, etc., for administration to any tissue or organ having an epithelial membrane. The delivery-enhancing agents include detergents, alcohols, surfactants and other molecules.Type: GrantFiled: July 8, 1997Date of Patent: February 21, 2006Assignees: Canji, Inc., Schering CorporationInventors: Heidrun Engler, Tattanahalli L. Nagabhushan, Stephen Kenneth Youngster
-
Publication number: 20040014709Abstract: Methods and pharmaceutical compositions for administering interferon therapy to tissues or organs having an epithelial cell layer are provided. A recombinant adenoviral vector encoding an interferon gene is administered to the target tissue or organ in combination with treatment with a delivery enhancing agent which increases the transduction of the cells of the target tissues or organs by the vector. The methods and combinations are useful in the treatment of cancers and other conditions responsive to interferon therapy. An exemplary method comprises the transurethral intravesical administration to the bladder of a therapeutically effective amount of a pharmaceutical composition comprising an adenoviral vector encoding alpha-interferon and SYN3 or a SYN3 homolog or analog. In the urinary bladder, as much as a 1,000 to 10,000 fold increase in interferon gene expression has been achieved by use of the combination of SYN3 with the recombinant adenoviral vector as compared to the use of the vector without SYN3.Type: ApplicationFiled: June 4, 2003Publication date: January 22, 2004Applicant: Canji, Inc.Inventors: Heidrun Engler, Tattanahalli L. Nagabhushan, Stephen Youngster
-
Publication number: 20020155095Abstract: The present invention is directed to compositions and methods for the delivery of interferon polypeptides. The invention provides recombinant viral and non-viral vectors for the selective expression of interferon polypeptides in particular cell or tissue types. The invention further provides pharmaceutically acceptable formulations of such vectors for administration to mammalian subjects. The invention further provides methods of treatment of diseases in mammalian organisms through the delivery of recombinant vectors selectively expressing interferon polypeptides.Type: ApplicationFiled: July 15, 1999Publication date: October 24, 2002Inventors: TATTANAHALLI L. NAGABHUSHAN, DEBA P. SAHA
-
Publication number: 20020111502Abstract: This invention provides methods and compositions for enhancing transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The methods and compositions are useful for introducing agents into individual cells, as well as cells that are present as a tissue or organ.Type: ApplicationFiled: January 22, 2002Publication date: August 15, 2002Applicant: Canji, Inc.Inventors: Heidrun Engler, Tattanahalli L. Nagabhushan, Stephen Kenneth Youngster
-
Patent number: 6392069Abstract: This invention provides methods and compositions for enhancing transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The methods and compositions are useful for introducing agents into individual cells, as well as cells that are present as a tissue or organ.Type: GrantFiled: July 8, 1998Date of Patent: May 21, 2002Assignee: Canji, Inc.Inventors: Heidrun Engler, Tattanahalli L. Nagabhushan, Stephen Kenneth Youngster
-
Patent number: 6316462Abstract: Methods are provided for treating cancer, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an additional Ras signaling pathway inhibitor to induce cancer cell death and tumor regression.Type: GrantFiled: April 9, 1999Date of Patent: November 13, 2001Assignee: Schering CorporationInventors: Walter R. Bishop, Diana L. Brassard, Tattanahalli L. Nagabhushan
-
Publication number: 20010006946Abstract: This invention provides methods and compositions for enhancing transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The methods and compositions are useful for introducing agents into individual cells, as well as cells that are present as a tissue or organ.Type: ApplicationFiled: July 8, 1998Publication date: July 5, 2001Inventors: HEIDRUN ENGLER, TATTANAHALLI L. NAGABHUSHAN
-
Patent number: 5741485Abstract: A method for making crystals of zinc interferon alpha-2, and the use thereof in depot formulations, are disclosed.Type: GrantFiled: June 6, 1995Date of Patent: April 21, 1998Assignee: Schering CorporationInventors: Paul Reichert, Gerald S. Hammond, Hung V. Le, Tattanahalli L. Nagabhushan, Paul P. Trotta
-
Patent number: 5616555Abstract: This invention provides a crystalline form of recombinant human granulocyte-macrophage colony-stimulating factor (r-h-GM-CSF) and methods for making such crystals.Type: GrantFiled: June 7, 1995Date of Patent: April 1, 1997Assignee: Schering CorporationInventors: Paul Reichert, Gerald S. Hammond, Hung V. Le, Tattanahalli L. Nagabhushan, Paul P. Trotta
-
Patent number: 5460956Abstract: A method for making crystals of interferon alpha-2 and the use thereof in depot formulations are disclosed.Type: GrantFiled: December 1, 1992Date of Patent: October 24, 1995Assignee: Schering CorporationInventors: Paul Reichert, Gerald S. Hammond, Hung V. Le, Tattanahalli L. Nagabhushan, Paul P. Trotta
-
Patent number: 5441734Abstract: The present invention provides for crystalline zinc-interferon alfa-2 (IFN .alpha.-2) having a monoclinic morphology. The present invention further provides for crystalline cobalt-IFN .alpha.-2, crystalline calcium-IFN .alpha.-2, and crystalline IFN .alpha.-2 having a serum half-life of at least about 12 hours when injected into a primate. The present invention further provides for a method for producing a crystalline IFN .alpha.-2 comprising forming a soluble metal-IFN .alpha.-2 complex, and equilibrating the soluble metal-IFN .alpha.-2 complex in solution with an acetate salt of the metal under conditions that will cause the metal-IFN .alpha.-2 solution to become supersaturated and form crystalline metal-IFN .alpha.-2. The present invention also includes crystalline metal-alfa interferon having monoclinic, plate and needle morphologies.Type: GrantFiled: February 25, 1993Date of Patent: August 15, 1995Assignee: Schering CorporationInventors: Paul Reichert, Charles McNemar, Nagamani Nagabhushan, Tattanahalli L. Nagabhushan, Stephen Tindall, Alan Hruza
-
Patent number: 5109119Abstract: This invention provides a crystalline form of recombinant human granulocyte-macrophage colony-stimulating factor (r-h-GM-CSF) and methods for making such crystals.Type: GrantFiled: June 6, 1989Date of Patent: April 28, 1992Assignee: Schering CorporationInventors: Paul Reichert, Gerald S. Hammond, Hung V. Le, Tattanahalli L. Nagabhushan, Paul P. Trotta
-
Patent number: 4921941Abstract: Antiandrogenic peptidyl esters, particularly tri-peptidyl esters, of the active metabolite of flutamide are disclosed.Type: GrantFiled: July 1, 1987Date of Patent: May 1, 1990Assignee: Schering CorporationInventors: Tattanahalli L. Nagabhushan, Martin F. Haslanger, Michael F. Czarniecki
-
Patent number: 4828990Abstract: A method of purifying a polypeptide having a physiological activity such as one having interferon activities from a culture mixture of a microorganism obtained by a recombinant DNA technique and capable of producing the polypeptide is disclosed. The method comprises subjecting the cultured cells to extraction and purification in the presence of a salt of zinc or copper and polyethyleneimine thereby inhibiting decomposition and denaturation of the polypeptide. The extracted polypeptide can be further purified by column chromatographies using a column containing an anion exchange resin, column containing a cation exchange resin and column containing a gel filtration resin.Type: GrantFiled: October 10, 1986Date of Patent: May 9, 1989Inventors: Naoki Higashi, Shunjiro Sugimoto, Masafumi Tsujimoto, Hounai Shirasawa, Tsutomu Okada, Kazumori Yamamoto, Tattanahalli L. Nagabhushan, Paul P. Trotta