Patents by Inventor Teresa A. Martin

Teresa A. Martin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10787446
    Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: September 29, 2020
    Assignees: GENENTECH, INC., XENON PHARMACEUTICALS INC.
    Inventors: Philippe Bergeron, Kristen Burford, Sultan Chowdhury, Christoph Martin Dehnhardt, Thilo Focken, Michael Edward Grimwood, Abid Hasan, Kwong Wah Lai, Zhiguo Liu, Steven McKerrall, Teresa Phuongtram Nguyen, Brian Safina, Daniel Sutherlin, Tao Wang
  • Patent number: 10779657
    Abstract: The adjustable foot stool comprises a platform, a pad, a plurality of lighting elements, and a pair of adjustable legs. The platform may be adapted to elevate and tilt a foot of a user. An inclination angle of the platform may be changed using the pair of adjustable legs. The pad may cushion the foot 910. The plurality of lighting elements may be adapted to provide illumination of the foot. As a non-limiting example, illumination may be provided for grooming the foot. The plurality of lighting elements may be powered by one or more batteries housed within the platform and may be turned on or off using an on/off switch located on the platform.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: September 22, 2020
    Inventor: Teresa Martin
  • Patent number: 10736992
    Abstract: The invention provides methods and compositions for making and using collagen-glycosaminoglycan three-dimensional scaffolds immobilized with biomolecules that are spatially and temporally patterned. The method comprises adding benzophenone to a collagen-glycosaminoglycan three dimensional scaffold in the dark; adding one or more biomolecules to one or more areas of the collagen-glycosaminoglycan three-dimensional scaffold (which can be done optionally in the dark or in the light); and exposing the collagen-2glycosaminoglycan three-dimensional scaffold to light at a wavelength of about 350 to about 365 nm.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: August 11, 2020
    Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Ryan C. Bailey, Brendan A. Harley, Teresa A. Martin, Steven R. Caliari
  • Publication number: 20200048187
    Abstract: The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of pain disorders such as visceral pain. Studying the mechanisms implicated in analgesic properties of the probiotic Escherichia coli strain Nissle 1917 (EcN), inventors characterized, the amino fatty acids produced by EcN, which display the Ecn analgesic properties. One of these compounds inhibits the hypersensitivity to colorectal distension induced by capsaicin, which is a very powerful nociceptive compound and acts via the GABA B receptor. Furthermore, inventors demonstrate that this compound is able to cross the cellular epithelial barrier (such as the intestinal epithelium). Thus, the invention relates to a lipopetide compound, derived from gamma-aminobutyric acid. The invention also relates to a lipopeptide compound according to the invention for the treatment of treating pain disorder, such as somatic pain and visceral pain.
    Type: Application
    Filed: April 27, 2018
    Publication date: February 13, 2020
    Inventors: Nicolas CENAC, Justine BERTRAND-MICHEL, Teresa PEREZ-BEREZO, Thierry DURAND, Jean-Marie GALANO, Julien PUJO, Eric OSWALD, Patricia MARTIN, Pauline LE FAOUDER, Alexandre GUY
  • Patent number: 10526276
    Abstract: The present invention relates to a group of compounds with a structural nucleus derived from phenylacetamide, having the following formula (I): that can modulate the DREAM neuronal calcium sensor. Consequently, the present invention also relates to the use of these compounds for the treatment or prevention of disorders or diseases in which DREAM levels are above or below physiologically normal levels.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: January 7, 2020
    Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS, CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES NEURODEGENERATIVAS (CIBERNED), UNIVERSIDAD AUTÓNOMA DE MADRID
    Inventors: Marta Gutiérrez Rodríguez, Pilar Cercos Pita, María Rosario Herranz Herranz, María Teresa García López, María Carmen Valenzuela Miranda, José Ramón Naranjo Orovio, Britt Mellstrom, Paz González Pérez, María Mercedes Martín Martínez, José Manuel Dopazo Santos
  • Publication number: 20190192735
    Abstract: The invention provides methods and compositions for making and using collagen-glycosaminoglycan three-dimensional scaffolds immobilized with biomolecules that are spatially and temporally patterned. The method comprises adding benzophenone to a collagen-glycosaminoglycan three dimensional scaffold in the dark; adding one or more biomolecules to one or more areas of the collagen-glycosaminoglycan three-dimensional scaffold (which can be done optionally in the dark or in the light); and exposing the collagen-2glycosaminoglycan three-dimensional scaffold to light at a wavelength of about 350 to about 365 nm.
    Type: Application
    Filed: February 27, 2012
    Publication date: June 27, 2019
    Inventors: Ryan C. Bailey, Brendan A. Harley, Teresa A. Martin, Steven R. Caliari
  • Patent number: 9868705
    Abstract: The present disclosure provides tetra-substituted cyclobutane inhibitors of Androgen Receptor Action, and methods of using such inhibitors, for the treatment of hormone-refractory cancers.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: January 16, 2018
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, DUKE UNIVERSITY
    Inventors: John Katzenellenbogen, Donald McDonnell, John D. Norris, Alexander Parent, Julie Pollock, Jillian Gunther, Kathryn E. Carlson, Teresa Martin
  • Publication number: 20160229811
    Abstract: The present disclosure provides tetra-substituted cyclobutane inhibitors of Androgen Receptor Action, and methods of using such inhibitors, for the treatment of hormone-refractory cancers.
    Type: Application
    Filed: September 25, 2014
    Publication date: August 11, 2016
    Inventors: John Katzenelienbogen, Donald McDonneli, John D, Norris, Alexander Parent, Julie Pollock, Jillian Gunther, Kathryn E. Carlson, Teresa Martin
  • Patent number: 7303873
    Abstract: T-DNA tagging with a promoterless ?-glucuronidase (GUS) gene generated transgenic Nicotiana tabacum plants that expressed GUS activity either only in developing seed coats, or constitutively. Cloning and deletion analysis of the GUS fusion revealed that the promoter responsible for seed coat specificity was located in the plant DNA proximal to the GUS gene. Analysis of the region demonstrated that the seed coat-specificity of GUS expression in this transgenic plant resulted from T-DNA insertion next to a cryptic promoter. This promoter is useful in controlling the expression of genes to the developing seed coat in plant seeds. Similarly, cloning and characterization of the cryptic constitutive promoter revealed the occurrence of several cryptic regulatory regions. These regions include promoter, negative regulatory elements, transcriptional enhancers, core promoter regions, and translational enhancers and other regulatory elements.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: December 4, 2007
    Assignee: Her Majesty the Queen in Right of Canada as Represented by the Minister of Agriculture and Agri-Food
    Inventors: Brian Miki, Thérèse Ouellet, Jiro Hattori, Elizabeth Foster, Hélène Labbé, Teresa Martin-Heller, Lining Tian, Daniel Charles William Brown, Peijun Zhang, Keqiang Wu
  • Patent number: 6939958
    Abstract: This invention is directed to a regulatory region obtained from a wheat aleurone gene LtpW1. This regulatory region, truncated derivatives, mutations, or deletions of this regulatory region, can be used to express heterologous genes of interest within aleurone cells of a plant. Furthermore, this invention is directed to a truncated LtpW1 regulatory region that exhibits constitutive activity with both monocot and dicot plants. This invention is also directed to vectors comprising these regulatory regions operatively linked with a heterologous gene of interest, as well as plant cell cultures and transgenic plants comprising these vectors. A method for the preparation of a plant using the regulatory regions of this invention are also disclosed.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: September 6, 2005
    Assignee: Her Majesty the Queen in Right of Canada, as represented by the Minister of Agriculture and Agri-Food
    Inventors: John Simmonds, Leslie Cass, Linda Harris, Sharon Allard, Kamal Malik, Teresa Martin-Heller, Dan Brown, Ming Hu, Brian Miki, Keqiang Wu
  • Publication number: 20050055742
    Abstract: An nucleotide sequence and that exhibits regulatory element activity is disclosed. The nucleotide sequence may be defined by SEQ ID NO:22, a nucleotide sequence that hybridizes to the nucleic acid sequence of SEQ ID NO:22, or a compliment thereof. Also disclosed is a chimeric construct comprising the nucleotide sequence operatively linked with a coding region of interest. A method of expressing a coding region of interest within a plant by introducing the chimeric construct described above, into the plant, and expressing the coding region of interest is also provided. Also disclosed are plants, seed, or plant cells comprising the chimeric construct as defined above.
    Type: Application
    Filed: June 10, 2004
    Publication date: March 10, 2005
    Inventors: Brian Miki, Jiro Hattori, Teresa Martin-Heller, Helene Labbe, Kamal Malik, Elizabeth Foster, Keqiang Wu, Daniel Brown, Lining Tian, Therese Ouellet, Peijun Zhang, Elizabeth James, Pierre Fobert, Venkatram Iyer
  • Patent number: 6784289
    Abstract: The present invention is directed to translational regulatory elements that mediate the amount of protein produced within a host capable of expressing a construct comprising one or more translational regulatory elements in operative association with a gene of interest. These translational regulatory elements were derived from T1275 (tCUP) and exhibit a high degree of similarity with members of the RENT family of repetitive elements. Translational regulatory elements are disclosed that either increase or decrease he amount of protein produced within the host organism. These translational elements are operative in a wide range of hosts including plant, animals, yeast, fungi and bacteria. Analogs, derivatives and fragments of these translational elements are also disclosed.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: August 31, 2004
    Assignee: Her Majesty the Queen in Right of Canada, as represented by the Minister of Agriculture and Agri-Food
    Inventors: Thérèse Ouellet, Brian M. Miki, Elizabeth Foster, Teresa Martin-Heller, Lining Tian, Daniel C. Brown, Peijun Zhang, Jiro Hattori, Kamal Malik, Keqiang Wu, David A. Theilmann, Raymond Tropiano
  • Publication number: 20040073022
    Abstract: T-DNA tagging with a promoterless &bgr;-glucuronidase (GUS) gene generated transgenic Nicotiana tabacum plants that expressed GUS activity either only in developing seed coats, or constitutively. Cloning and deletion analysis of the GUS fusion revealed that the promoter responsible for seed coat specificity was located in the plant DNA proximal to the GUS gene. Analysis of the region demonstrated that the seed coat-specificity of GUS expression in this transgenic plant resulted from T-DNA insertion next to a cryptic promoter. This promoter is useful in controlling the expression of genes to the developing seed coat in plant seeds. Similarly, cloning and characterization of the cryptic constitutive promoter revealed the occurrence of several cryptic regulatory regions. These regions include promoter, negative regulatory elements, transcriptional enhancers, core promoter regions, and translational enhancers and other regulatory elements.
    Type: Application
    Filed: May 13, 2003
    Publication date: April 15, 2004
    Applicant: Her Majesty the Queen in Right of Canada as Rep.by the Minister of Agriculture and Agri-Food Canada
    Inventors: Brian Miki, Therese Ouellet, Jiro Hattori, Elizabeth Foster, Helene Labbe, Teresa Martin-Heller, Lining Tian, Daniel Charles William Brown, Peijun Zhang, Keqiang Wu
  • Publication number: 20020073444
    Abstract: The present invention is directed to translational regulatory elements that mediate the amount of protein produced within a host capable of expressing a construct comprising one or more translational regulatory elements in operative association with a gene of interest. These translational regulatory elements were derived from T1275 (tCUP) and exhibit a high degree of similarity with members of the RENT family of repetitive elements. Translational regulatory elements are disclosed that either increase or decrease he amount of protein produced within the host organism. These translational elements are operative in a wide range of hosts including plant, animals, yeast, fungi and bacteria. Analogs, derivatives and fragments of these translational elements are also disclosed.
    Type: Application
    Filed: December 21, 2000
    Publication date: June 13, 2002
    Inventors: Therese Ouellet, Brian M. Miki, Elizabeth Foster, Teresa Martin-Heller, Lining Tian, Daniel C. Brown, Peijun Zhang, Jiro Hattori, Kamal Malik, Keqiang Wu, David A. Theilmann, Raymond Tropiano
  • Patent number: 6376747
    Abstract: A mitogen-activated protein (MAP) kinase kinase gene, tMEK2, was isolated from tomato cv. Bonny Best. By mutagenesis, a permanently-active variant, tMEK2MUT, was created. Both wild type tMEK2 and mutant tMEK2MUT were driven by a strong constitutive promoter, tCUP&Dgr;, in a tomato protoplast transient expression system. Pathogenesis-related genes, PR1b1 and PR3, and a wound-inducible gene, ER5, were activated by tMEK2MUT expression revealing the convergence of the signal transduction pathways for pathogen attack and mechanical stress at the level of MAPKK. Activation of biotic and abiotic stress response genes downstream of tMEK2 occurred through divergent pathways involving at least two classes of mitogen-activated protein kinase. This study shows that tMEK2 may play an important role in the interaction of signal transduction pathways that mediate responses to both biotic (eg disease) and abiotic (wound responsiveness) stresses.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: April 23, 2002
    Assignee: Her Majesty the Queen in right of Canada as represented by the Minister of Agriculture and Agri-Food Canada
    Inventors: Ti Xing, Kamal Malik, Teresa Martin-Heller, Brian L. Miki
  • Publication number: 20010047091
    Abstract: T-DNA tagging with a promoterless &bgr;-glucuronidase (GUS) gene generated transgenic Nicotiana tabacum plant that expressed GUS activity either only in developing seed coats, or constitutively. Cloning and deletion analysis of the GUS fusion revealed that the promoter responsible for seed coat specificity was located in the plant DNA proximal to the GUS gene. Analysis of the region demonstrated that the seed coat-specificity of GUS expression in this transgenic plant resulted from T-DNA insertion next to a cryptic promoter. This promoter is useful in controlling the expression of genes to the developing seed coat in plant seeds. Similarly, cloning and characterization of the cryptic constitutive promoter revealed the occurrence of several cryptic regulatory regions. These regions include promoter, negative regulatory elements, transcriptional enhancers, core promoter regions, and translational enhancers and other regulatory elements.
    Type: Application
    Filed: December 22, 2000
    Publication date: November 29, 2001
    Inventors: Brian Miki, Therese Ouellet, Jiro Hattori, Elizabeth Foster, Helene Labbe, Teresa Martin-Heller, Lining Tian, Daniel Charles William Brown, Peijun Zhang, Keqiang Wu
  • Patent number: 5340067
    Abstract: Provided is a method and apparatus for supporting the hand and wrist of a user of a computer mouse. The apparatus comprises a support block for supporting the hand and wrist and a retainer for retaining the mouse in fixed relation with the support block. In a preferred embodiment, the support block comprises a raised central area for pressing into the palm of the user's hand, an extended wrist rest for supporting the user's wrist, and a finger support area for supporting the user's fingers. The finger support comprises two extensions from the support block which grip the mouse, forming the retainer. The apparatus also trains the user to hold his hand in proper position while operating the mouse.
    Type: Grant
    Filed: March 27, 1992
    Date of Patent: August 23, 1994
    Inventors: Teresa A. Martin, Beth M. Donovan