Patents by Inventor Teruo Nakamura
Teruo Nakamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7816316Abstract: The present invention aims to provide completely biodegradable and biocompatible sustained-release carriers for proteins or peptides, which allow encapsulation of the proteins or peptides at high encapsulation rates without inhibiting their biological activity. The present invention provides a method for preparing a sustained-release carrier, wherein in a solution in the presence of a protein or a peptide, a hyaluronic acid derivative having an unsaturated bond(s) or a mercapto group(s) introduced into hyaluronic acid is chemically crosslinked with a mercapto group-containing compound or an unsaturated bond-containing compound, respectively, to give a hydrogel. The method of the present invention enables efficient encapsulation of proteins or peptides while retaining their biological activity.Type: GrantFiled: November 21, 2003Date of Patent: October 19, 2010Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Sei Kwang Hahn, Teruo Nakamura, Tsuyoshi Shimoboji
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Patent number: 7767806Abstract: A hyaluronic acid modification product includes a polymer bonded to hyaluronic acid, the polymer being polylactic acid, polyglycolic acid or lactic acid-glycolic acid copolymer, providing a drug carrier which efficiently encapsulates low molecular weight drugs and provides sustained-release over a long term, control of blood residence, is well dispersible in an aqueous solution, and has excellent biocompatibility.Type: GrantFiled: September 8, 2004Date of Patent: August 3, 2010Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Tai Hirakura, Teruo Nakamura, Tsuyoshi Shimoboji
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Publication number: 20090193826Abstract: There is provided a temperature switching compartment 3 which can switch the internal temperature thereof between a low temperature side at which a storage material is kept in cold storage and a high temperature side maintained at 50° C., to 80° C. at which cooked food is kept warm, by cooling with a cooler 17 and heating with a heater 15.Type: ApplicationFiled: September 7, 2005Publication date: August 6, 2009Inventors: Kenji Yasugi, Teruo Nakamura, Tsuyoshi Shimoboji, Mika Sato
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Publication number: 20090148534Abstract: The present invention provides a water-soluble modified HA practically used as a drug carrier and a production method thereof. The present invention provides: a water-soluble modified hyaluronic acid, the residence time in blood of which is elongated to a practical level, which is produced by introducing a substituent into the carboxy group of the glucuronic acid of hyaluronic acid or a derivative thereof, via an amide bond, at a lower limit of an introduction rate of 5 mole % or more, using a BOP condensing agent in an aprotic polar solvent; and a production method thereof. Moreover, by cross-linking the modified hyaluronic acid, the present invention provides a hyaluronic acid gel capable of extremely long drug sustained-release even at the same cross-linking functional group introduction rate as that of the conventionally known gel.Type: ApplicationFiled: September 7, 2005Publication date: June 11, 2009Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Kenji Yasugi, Teruo Nakamura, Tsuyoshi Shimoboji, Mika Sato
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Publication number: 20090082266Abstract: To provide a GLP-1 analogue long-acting prophylactic or therapeutic agent for diabetes, diabetic complications and/or obesity due to diabetes which provides an extended half-life of a GLP-1 analogue in the blood to prevent frequent administration, and is biodegradable and safe. The present invention provides a conjugate obtained by binding, to a GLP-1 analogue into which a mercapto group is incorporated, water soluble hyaluronic acid modification product obtained by incorporating a substituent via an amide bond to the carboxyl group of glucuronic acid portion of hyaluronic acid as a derivative thereof, using a specific condensing agent in an aprotic polar solvent; and a prophylactic or therapeutic agent having a durable blood glucose lowering effect for diabetes, diabetic complications or obesity.Type: ApplicationFiled: March 8, 2006Publication date: March 26, 2009Inventors: Teruo Nakamura, Tatsuya Kato, Hideyuki Togawa, Kenji Yasugi, Hiroko Konishi, Yasuo Sekimori, Tsuyoshi Shimoboji
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Publication number: 20070031503Abstract: There is provided a drug carrier which has solved the problems of conventional drug carriers, which can encapsulate a low molecular drug efficiently, which can control a sustained release period for a long term, which can control blood residence, which has high dispersibility in an aqueous solution, and which is not problematical in safety. A drug carrier, which comprises injectable fine particles minimal in agglomeration between the particles, and which has excellent biocompatibility, is also provided.Type: ApplicationFiled: September 8, 2004Publication date: February 8, 2007Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Tai Hirakura, Teruo Nakamura
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Publication number: 20060276634Abstract: The present invention provides a polyethylene glycol-conjugated erythropoietin (PEG-conjugated EPO) prepared by PEG conjugation on the lysine residue at position 52 of native erythropoietin (native EPO). In order to achieve more sustained efficacy without losing physiological activities of native EPO, a glycoprotein rich in sugar chains, there has been a need to develop a PEG-conjugated EPO with significantly sustained efficacy by introducing a controlled number of PEG molecules at controlled positions. This PEG-conjugated EPO addresses such a need and provides more sustained efficacy.Type: ApplicationFiled: August 3, 2006Publication date: December 7, 2006Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Teruo Nakamura, Yasuo Sekimori, Minoru Machida, Hiromitsu Kawata, Hajime Miyamoto
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Publication number: 20060110458Abstract: The present invention aims to provide completely biodegradable and biocompatible sustained-release carriers for proteins or peptides, which allow encapsulation of the proteins or peptides at high encapsulation rates without inhibiting their biological activity. The present invention provides a method for preparing a sustained-release carrier, wherein in a solution in the presence of a protein or a peptide, a hyaluronic acid derivative having an unsaturated bond(s) or a mercapto group(s) introduced into hyaluronic acid is chemically crosslinked with a mercapto group-containing compound or an unsaturated bond-containing compound, respectively, to give a hydrogel. The method of the present invention enables efficient encapsulation of proteins or peptides while retaining their biological activity.Type: ApplicationFiled: November 21, 2003Publication date: May 25, 2006Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Sei Hahn, Teruo Nakamura, Tsuyoshi Shimoboji
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Publication number: 20050185637Abstract: Protocol control devices each have a database for storing application information concerning each of a number of IP (Internet Protocol) terminals controlled by the protocol control device. A dedicated maintenance terminal has a database for temporarily storing application information possessed by each protocol control device. An IP-capable PBX receives the application information of a designated IP terminal from the relevant protocol control device in response to a back-up command from the dedicated maintenance terminal. The dedicated maintenance terminal receives this application information and saves it temporarily for back-up purposes in a database.Type: ApplicationFiled: February 18, 2005Publication date: August 25, 2005Applicant: NEC CorporationInventor: Teruo Nakamura
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Publication number: 20050148763Abstract: The object of the present invention is to provide PTH or a PTH derivative, which is modified to attain increased bioavailability without losing PTH activity and to have a reduced risk of side effects. PEG conjugation to PTH or a PTH derivative increases the bioavailability while maintaining PTH activity and also reduces side effects.Type: ApplicationFiled: February 3, 2003Publication date: July 7, 2005Inventors: Yasuo Sekimori, Teruo Nakamura, Masaru Shimizu
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Publication number: 20040082765Abstract: The present invention provides a polyethylene glycol-conjugated erythropoietin (PEG-conjugated EPO) prepared by PEG conjugation on the lysine residue at position 52 of native erythropoietin (native EPO). In order to achieve more sustained efficacy without losing physiological activities of native EPO, a glycoprotein rich in sugar chains, there has been a need to develop a PEG-conjugated EPO with significantly sustained efficacy by introducing a controlled number of PEG molecules at controlled positions. This PEG-conjugated EPO addresses such a need and provides more sustained efficacy.Type: ApplicationFiled: April 16, 2003Publication date: April 29, 2004Inventors: Teruo Nakamura, Yasuo Sekimori, Minoru Machida, Hiromitsu Kawata, Hajime Miyamoto
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Patent number: 6584187Abstract: The invention provides a transfer service method for a telephone network by which, even if physical accommodation position information of a telephone set of a transfer destination is not registered in an electronic exchange connected by a wire or wireless to a telephone set on the originating side from which a telephone call is to be transferred, a transfer service to the telephone set of the transfer destination corresponding to a logic number can be enjoyed.Type: GrantFiled: October 28, 1998Date of Patent: June 24, 2003Assignee: NEC CorporationInventor: Teruo Nakamura
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Patent number: 6526040Abstract: An interface connected to a local area network is mounted in each of data transfer circuits 19, 1a to 1c, 28, 29 and 36 for establishing logical connection of exchanges to one another such that it can connect a plurality of data transfer circuits provided in each exchange to one another. It is thus possible to obtain joint establishment of a logical mesh structure by individual data transfer circuits and, when a data transfer circuit receives data to be transferred to a different exchange from its own, obtain alleviation of the load in the own exchange with a process of data transfer between the data transfer circuits that is executed by using the local area network side interface.Type: GrantFiled: June 15, 1999Date of Patent: February 25, 2003Assignee: NEC CorporationInventor: Teruo Nakamura
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Publication number: 20020041669Abstract: The invention provides a transfer service method for a telephone network by which, even if physical accommodation position information of a telephone set of a transfer destination is not registered in an electronic exchange connected by a wire or wireless to a telephone set on the originating side from which a telephone call is to be transferred, a transfer service to the telephone set of the transfer destination corresponding to a logic number can be enjoyed.Type: ApplicationFiled: October 28, 1998Publication date: April 11, 2002Inventor: TERUO NAKAMURA
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Patent number: 6090317Abstract: This invention provides a heterotelechelic oligomer or polymer which is represented by the following formula: ##STR1## wherein A denotes a sugar residue, L denotes a linkage group represented by the following formula ##STR2## wherein R.sup.1 and R.sup.2 independently denote lower alkyl, aralkyl or aryl,X denotes a single bond or --CH.sub.2 CH.sub.2 --, Z denotes a group forming an unsaturated ester or ether, or a functional group such as halogen which binds to --CH.sub.2 CH.sub.2 --, n denotes an integer of 5-10,000, and m denotes an integer of 0 or 2-10,000.This invention also provides a process to produce the above oligomer or polymer, and further a high molecular-micelle with use of a polyethylene oxide-polyester block polymer which has a sugar residue at its terminal. Said oligomer or polymer is expected to exhibit excellent bioavailability, and is also expected to be utilized in the field such as carriers for drug delivery or diagnostic reagents.Type: GrantFiled: July 27, 1999Date of Patent: July 18, 2000Assignee: Kazunori KataokaInventors: Kazunori Kataoka, Yukio Nagasaki, Masao Kato, Teruo Okano, Teruo Nakamura
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Patent number: 6012898Abstract: A submerged motor pump (4) has an auxiliary bearing assembly (19, 20) for supporting a rotatable main shaft (9) when the submerged motor pump is not in an operating condition or operates in a transient condition. The submerged motor pump includes a pump casing (6), at least one impeller (12), a motor (10,11), and a thrust balancing mechanism (15) for balancing thrust forces. The submerged motor pump further includes hydrostatic bearings (16, 17, 18) for supporting the main shaft at axially spaced locations by a pressurized fluid pumped by the submerged motor pump. The auxiliary bearing assembly has tapered support surfaces (FL, FU) for supporting the main shaft at the axially spaced locations.Type: GrantFiled: February 16, 1999Date of Patent: January 11, 2000Assignee: Ebara CorporationInventors: Teruo Nakamura, Fumio Kobayashi, Hideharu Watanabe
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Patent number: 5973069Abstract: This invention provides a heterotelechelic oligomer or polymer which is represented by the following formula: ##STR1## wherein A denotes a sugar residue, L denotes a linkage group represented by the following formula ##STR2## wherein R.sup.1 and R.sup.2 independently denote lower alkyl, aralkyl or aryl,X denotes a single bond or --CH.sub.2 CH--, Z denotes a group forming an unsaturated ester or ether, or a functional group such as halogen which binds to --CH.sub.2 CH.sub.2 --, n denotes an integer of 5-10,000, and m denotes an integer of 0 or 2-10,000.This invention also provides a process to produce the above oligomer or polymer, and further a high molecular-micelle with use of a polyethylene oxide-polyester block polymer which has a sugar residue at its terminal. Said oligomer or polymer is expected to exhibit excellent bioavailability, and is also expected to be utilized in the field such as carriers for drug delivery or diagnostic reagents.Type: GrantFiled: December 18, 1997Date of Patent: October 26, 1999Assignee: Kazunori KataokaInventors: Kazunori Kataoka, Yukio Nagasaki, Masao Kato, Teruo Okano, Teruo Nakamura
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Patent number: 5688686Abstract: The fermentation apparatus according to the invention is of a vertically oriented, multistage type comprising one or more fermentation tanks, an outlet port provided at the top of the fermentation tank, a maturation tank disposed below the fermentation tank, and a preliminary fermentation tank disposed below the maturation tank. Each fermentation tank includes a support member rotatable in the circumferential direction, an agitation member removably connected to the support member and including a plurality of agitation blades rotatable in the horizontal direction relative to the bottom surface of the fermentation apparatus, a gas intake device disposed below the agitation member, a transfer opening member for open-close movement, and a filter member provided at the top of the fermentation tank.Type: GrantFiled: November 6, 1995Date of Patent: November 18, 1997Inventors: Shigeji Nakajima, Teruo Nakamura, Shigeru Sato
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Patent number: 5586254Abstract: A system for operating and managing the network equipment is so adapted as to operate and manage a network in which plural computers and network devices are connected to each other. The system is provided with database storing data corresponding to the computers and the network devices and with means for preparing a network specification drawing which satisfies conditions required by the user from the data, for checking the physical data as to whether the network specification satisfies the physical data, for checking the logical data as to whether the network specification satisfies the logical data, and for displaying the network specification drawing in a two-dimensional or three-dimensional manner on the basis of the data stored in the database. The system for operating and managing the network equipment can reduce and simplify management business for network managers as well as management business for managing materials and products by managers managing the materials and products.Type: GrantFiled: February 16, 1993Date of Patent: December 17, 1996Assignee: Hitachi Software Engineering Co., Ltd.Inventors: Mariko Kondo, Teruo Nakamura, Yumiko Mori, Toshiyuki Tsutsumi
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Patent number: 5538243Abstract: A tennis racket frame comprising a string-installing portion (10), T-shaped in cross section, formed along the entire periphery of a ball-hitting surface thereof. The string-installing portion (10) comprises a projection (20) formed toward the ball-hitting surface in which strings are installed and a base (21) perpendicular to the projection (20). A plurality of gut holes (25) are formed on the projection (20) such that each of the gut holes (25) penetrates through the center thereof. A plurality of gut holes (24) is formed on the bottom surface of a concave (23) of the base (21) such that each of the gut holes (24) penetrates through the center of the base (21).Type: GrantFiled: March 14, 1994Date of Patent: July 23, 1996Assignee: Sumitomo Rubber Industries, Ltd.Inventors: Ken Yamamoto, Teruo Nakamura