Patents by Inventor Teruyuki Komatsu

Teruyuki Komatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240189432
    Abstract: It could be helpful to provide albumin to which a water-soluble polymer that has high biocompatibility and is easily prepared (synthesized) is bound; and an artificial plasma expander and a hemorrhagic shock resuscitation fluid that each contain the water-soluble polymer-bound albumin. The solution is a polyoxazoline-bound albumin (100) including an albumin (10) as a core and a polyoxazoline (20) as a shell, which is covalently bound to the albumin (10) via a cross-linker; and an artificial plasma expander and a hemorrhagic shock resuscitation fluid that each contain the polyoxazoline-bound albumin (100).
    Type: Application
    Filed: February 18, 2022
    Publication date: June 13, 2024
    Applicant: CHUO UNIVERSITY
    Inventors: Teruyuki KOMATSU, Wataru OKAMOTO, Tomone USUI
  • Publication number: 20190328892
    Abstract: Provided is a therapeutic agent for ischemic disease that exhibits a tissue-protecting effect against tissue damage associated with ischemia. The therapeutic agent includes, as an active ingredient, a hemoglobin-albumin complex in which albumin serving as a shell is bound to hemoglobin serving as a core via a crosslinker. The therapeutic agent is used in treatment of ischemic disease.
    Type: Application
    Filed: July 6, 2017
    Publication date: October 31, 2019
    Applicant: CHUO UNIVERSITY
    Inventors: Teruyuki KOMATSU, Ryosuke FUNAKI, Takeo ABUMIYA, Masayuki GEKKA, Kiyohiro HOUKIN
  • Patent number: 8889830
    Abstract: A novel hemoglobin-albumin complex which has high stability of the oxygenated form, has high biocompatibility, and is easily prepared (synthesized), and an artificial plasma expander and an artificial oxygen carrier containing the complex are provided. The hemoglobin-albumin complex of the invention is characterized by having hemoglobin as the core, and albumin as the shell bound via a crosslinker to the above hemoglobin. Also, the artificial oxygen carrier of the invention is characterized by containing the hemoglobin-albumin complex of the invention.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: November 18, 2014
    Assignee: Chuo University
    Inventors: Teruyuki Komatsu, Daiki Tomita
  • Publication number: 20130338342
    Abstract: A novel hemoglobin-albumin complex which has high stability of the oxygenated form, has high biocompatibility, and is easily prepared (synthesized), and an artificial plasma expander and an artificial oxygen carrier containing the complex are provided. The hemoglobin-albumin complex of the invention is characterized by having hemoglobin as the core, and albumin as the shell bound via a crosslinker to the above hemoglobin. Also, the artificial oxygen carrier of the invention is characterized by containing the hemoglobin-albumin complex of the invention.
    Type: Application
    Filed: February 20, 2012
    Publication date: December 19, 2013
    Applicant: CHUO UNIVERSITY
    Inventors: Teruyuki Komatsu, Daiki Tomita
  • Patent number: 7754879
    Abstract: A porphyrin compound represented by general formula (A): Also disclosed are a porphyrin metal complex-albumin inclusion compound having a porphyrin compound, in which M denotes Fe or Co, included in albumin, and an artificial oxygen carrier containing the porphyrin metal complex-albumin inclusion compound as an active component.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: July 13, 2010
    Assignee: Nipro Corporation
    Inventors: Eishun Tsuchida, Teruyuki Komatsu, Akito Nakagawa, Naomi Ohmichi
  • Patent number: 7595394
    Abstract: A porphyrin compound represented by general formula (A): Also disclosed are a porphyrin metal complex-albumin inclusion compound having a porphyrin compound, in which M denotes Fe or Co, included in albumin, and an artificial oxygen carrier containing the porphyrin metal complex-albumin inclusion compound as an active component.
    Type: Grant
    Filed: August 9, 2005
    Date of Patent: September 29, 2009
    Assignee: Nipro Corporation
    Inventors: Eishun Tsuchida, Teruyuki Komatsu, Akito Nakagawa, Naomi Ohmichi
  • Publication number: 20090182125
    Abstract: A porphyrin compound represented by general formula (A): Also disclosed are a porphyrin metal complex-albumin inclusion compound having a porphyrin compound, in which M denotes Fe or Co, included in albumin, and an artificial oxygen carrier containing the porphyrin metal complex-albumin inclusion compound as an active component.
    Type: Application
    Filed: March 13, 2009
    Publication date: July 16, 2009
    Inventors: Eishun Tsuchida, Teruyuki Komatsu, Akito Nakagawa, Naomi Ohmichi
  • Patent number: 7417118
    Abstract: A pharmaceutical composition containing an artificial oxygen carrier, which has high oxygen carrying efficiency; and has a required colloid osmotic pressure, an appropriate crystalloid osmotic pressure, pH, and electrolyte balance. The composition is prepared by appropriately adding at least one substance selected from the group consisting of a compound capable of providing a colloid osmotic pressure, an electrolyte, a saccharide, an amino acid, an antioxidant, a pH adjuster, and an isotonizing agent to a preparation including a liposome-encapsulated hemoglobin in which a hemoglobin is encapsulated in a liposome or to a preparation including a conjugate of a porphyrin-iron complex and albumin.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: August 26, 2008
    Assignee: Nipro Corporation
    Inventors: Toshiya Kai, Naohisa Katayama, Yuko Azuma, Junichi Yokoe, Yoshinori Kida, Ippei Hukutomi, Makoto Sato, Eishun Tsuchida, Shinji Takeoka, Teruyuki Komatsu, Hiromi Sakai, Keitaro So
  • Publication number: 20080081801
    Abstract: A highly safe oxygen infusion for effectively increasing an oxygen partial pressure in a hypoxic region of tumor tissues, which comprises a dispersion of an albumin clathrate compound enclosing a porphyrin metal complex, dispersed in a physiologically permissible aqueous media.
    Type: Application
    Filed: October 5, 2007
    Publication date: April 3, 2008
    Inventors: Eishun TSUCHIDA, Koichi KOBAYASHI, Teruyuki KOMATSU, Hirohisa HORINOUCHI, Masumi WATANABE
  • Patent number: 7285379
    Abstract: The present invention provides a method of producing a complex of albumin and a deoxy form metal complex having a porphyrin structure, which includes mixing albumin and a metal complex having a porphyrin structure under a gas atmosphere substantially free of carbon monoxide and oxygen, as a method of producing an artificial oxygen carrier containing a complex of albumin and a metal complex having a porphyrin structure, under a deoxidation (nitrogen, other inert gases) atmosphere without using carbon monoxide.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: October 23, 2007
    Assignee: Nipro Corporation
    Inventors: Eishun Tsuchida, Shinji Takeoka, Teruyuki Komatsu, Toshiya Kai, Naohisa Katayama, Ippei Fukutomi, Makoto Sato
  • Publication number: 20070142290
    Abstract: A surface-modified serum albumin-metal porphyrin composite that contains serum albumin which clathrates a metal porphyrin and to which a polyoxyethylene group is covalently bonded to the molecular surface of the serum albumin.
    Type: Application
    Filed: February 9, 2007
    Publication date: June 21, 2007
    Applicant: Eishun Tsuchida
    Inventors: Eishun Tsuchida, Teruyuki Komatsu, Yubin Huang
  • Patent number: 7125862
    Abstract: A porphyrin metal complex that can form a stable oxygen complex and acts effectively as an oxygen infusion, which comprises: a transition metal ion M of period 4 or 5 coordinating to a porphyrin derivative represented by the following general wherein R1 is an alicyclic hydrocarbon group which may contain a substituent, R2 is an alkylene group and R3 is a group which does not hinder the coordination of an imidazolyl group to M.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: October 24, 2006
    Assignee: Japan Science and Technology Agency
    Inventors: Eishun Tsuchida, Teruyuki Komatsu, Yasuko Matsukawa
  • Publication number: 20060003923
    Abstract: A porphyrin compound represented by general formula (A): Also disclosed are a porphyrin metal complex-albumin inclusion compound having a porphyrin compound, in which M denotes Fe or Co, included in albumin, and an artificial oxygen carrier containing the porphyrin metal complex-albumin inclusion compound as an active component.
    Type: Application
    Filed: August 9, 2005
    Publication date: January 5, 2006
    Inventors: Eishun Tsuchida, Teruyuki Komatsu, Akito Nakagawa, Naomi Ohmichi
  • Publication number: 20050222116
    Abstract: A highly safe oxygen infusion for effectively increasing an oxygen partial pressure in a hypoxic region of tumor tissues, which comprises a dispersion of an albumin clathrate compound enclosing a porphyrin metal complex, dispersed in a physiologically permissible aqueous media.
    Type: Application
    Filed: June 3, 2003
    Publication date: October 6, 2005
    Inventors: Eishun Tsuchida, Koichi Kobayashi, Teruyuki Komatsu, Hirohisa Horinouchi, Masumi Watanabe
  • Publication number: 20050085410
    Abstract: The present invention provides a method of producing a complex of albumin and a deoxy form metal complex having a porphyrin structure, which includes mixing albumin and a metal complex having a porphyrin structure under a gas atmosphere substantially free of carbon monoxide and oxygen, as a method of producing an artificial oxygen carrier containing a complex of albumin and a metal complex having a porphyrin structure, under a deoxidation (nitrogen, other inert gases) atmosphere without using carbon monoxide.
    Type: Application
    Filed: August 27, 2004
    Publication date: April 21, 2005
    Applicant: NIPRO CORPORATION
    Inventors: Eishun Tsuchida, Shinji Takeoka, Teruyuki Komatsu, Toshiya Kai, Naohisa Katayama, Ippei Fukutomi, Makoto Sato
  • Publication number: 20040258745
    Abstract: A pharmaceutical composition containing an artificial oxygen carrier, which has high oxygen carrying efficiency; and has a required colloid osmotic pressure, an appropriate crystalloid osmotic pressure, pH, and electrolyte balance. The composition is prepared by appropriately adding at least one substance selected from the group consisting of a compound capable of providing a colloid osmotic pressure, an electrolyte, a saccharide, an amino acid, an antioxidant, a pH adjuster, and an isotonizing agent to a preparation including a hemoglobin-encapsulated liposome in which a hemoglobin is encapsulated in a liposome or to a preparation including a conjugate of a porphyrin-iron complex and albumin.
    Type: Application
    Filed: April 7, 2004
    Publication date: December 23, 2004
    Inventors: Toshiya Kai, Naohisa Katayama, Yuko Azuma, Junichi Yokoe, Yoshinori Kida, Ippei Hukutomi, Makoto Sato, Eishun Tsuchida, Shinji Takeoka, Teruyuki Komatsu, Hiromi Sakai, Keitaro So
  • Publication number: 20040180837
    Abstract: A porphyrin compound represented by general formula (A): 1
    Type: Application
    Filed: March 12, 2004
    Publication date: September 16, 2004
    Applicant: NIPRO CORPORATION
    Inventors: Eishun Tsuchida, Teruyuki Komatsu, Akito Nakagawa, Naomi Ohmichi
  • Publication number: 20040157820
    Abstract: A porphyrin metal complex that can form a stable oxygen complex and acts effectively as an oxygen infusion, which comprises:
    Type: Application
    Filed: April 19, 2004
    Publication date: August 12, 2004
    Inventors: Eishun Tsuchida, Teruyuki Komatsu, Yasuko Matsukawa
  • Patent number: 6008198
    Abstract: A porphyrin metal complex-albumin inclusion compound wherein a substituted porphyrin metal complex comprising, as a central, coordinated metal, a transitional metal belonging to the fourth or fifth period of the periodic law, is included in the albumin, and an oxygen carrier composition comprising said inclusion compound as an active ingredient. The compound functions as an oxygen carrier which is superior in biocompatibility, capable of adsorption and desorption of oxygen under physiological conditions, and is rather easily produced at an industrial scale.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: December 28, 1999
    Assignee: Yoshitomi Pharmaceutical Industries, Ltd.
    Inventors: Eishun Tsuchida, Hiroyuki Nishide, Teruyuki Komatsu
  • Patent number: 5194603
    Abstract: The present invention relates to a porphyrin metal complex represented by the formula (1): ##STR1## wherein R is a pivaloyloxy group, M is a transition metal ion of the group IV and the group V metals, X is a halogen ion, and n is 0 or 1.The above compound is used as a more stable artificial oxygen carrier capable of preventing the behavior of oxidation and deterioration.
    Type: Grant
    Filed: October 29, 1990
    Date of Patent: March 16, 1993
    Assignee: Nippon Oil & Fats Co., Ltd.
    Inventors: Eishun Tsuchida, Teruyuki Komatsu, Etsuo Hasegawa, Hiroyuki Nishide