Patents by Inventor Tessa Mercedes SIMONE

Tessa Mercedes SIMONE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SELF-REGULATING AAV VECTORS FOR SAFE EXPRESSION OF MECP2 IN RETT SYNDROME
    Publication number: 20230416779
    Abstract: In some aspects, the disclosure relates to compositions and methods of engineering a transgene. In some embodiments, the disclosure provides self-regulating recombinant nucleic acids, viral vectors and pharmaceutical compositions comprising a MeCP2 transgene. In some embodiments, compositions and methods described by the disclosure are useful for treating diseases and disorders associated with a loss of function mutation, for example Rett syndrome.
    Type: Application
    Filed: May 3, 2023
    Publication date: December 28, 2023
    Applicant: University of Massachusetts
    Inventors: Miguel Sena Esteves, Guangping Gao, Michael R. Green, Dan Wang, Tessa Mercedes Simone
  • Self-regulating AAV vectors for safe expression of MeCP2 in rett syndrome
    Patent number: 11680275
    Abstract: In some aspects, the disclosure relates to compositions and methods of engineering a transgene. In some embodiments, the disclosure provides self-regulating recombinant nucleic acids, viral vectors and pharmaceutical compositions comprising a MeCP2 transgene. In some embodiments, compositions and methods described by the disclosure are useful for treating diseases and disorders associated with a loss of function mutation, for example Rett syndrome.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: June 20, 2023
    Assignee: University of Massachusetts
    Inventors: Miguel Sena Esteves, Guangping Gao, Michael R. Green, Dan Wang, Tessa Mercedes Simone
  • SELF-REGULATING AAV VECTORS FOR SAFE EXPRESSION OF MECP2 IN RETT SYNDROME
    Publication number: 20200181646
    Abstract: In some aspects, the disclosure relates to compositions and methods of engineering a transgene. In some embodiments, the disclosure provides self-regulating recombinant nucleic acids, viral vectors and pharmaceutical compositions comprising a MeCP2 transgene. In some embodiments, compositions and methods described by the disclosure are useful for treating diseases and disorders associated with a loss of function mutation, for example Rett syndrome.
    Type: Application
    Filed: June 6, 2018
    Publication date: June 11, 2020
    Applicant: University of Massachusetts
    Inventors: Miguel Sena ESTEVES, Guangping GAO, Michael R. GREEN, Dan WANG, Tessa Mercedes SIMONE