Patents by Inventor Tetsuji Kuwahara

Tetsuji Kuwahara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190381300
    Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.
    Type: Application
    Filed: February 20, 2018
    Publication date: December 19, 2019
    Inventors: Toru KOBAYASHI, Toshiyuki MATSUDO, Shinpei NISHIMURA, Seiji TOKUMOTO, Tetsuji KUWAHARA
  • Patent number: 9028463
    Abstract: The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: May 12, 2015
    Assignees: Hisamitsu Pharmaceutical Co., Inc., The Chemo-Sero-Therapeutic Research Institute
    Inventors: Chikateru Nozaki, Kazuyoshi Kaminaka, Junichi Matsuda, Takaaki Terahara, Tetsuji Kuwahara, Seiji Tokumoto
  • Publication number: 20150071970
    Abstract: An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
    Type: Application
    Filed: July 28, 2014
    Publication date: March 12, 2015
    Inventors: Seiji Tokumoto, Hirotoshi Adachi, Tetsuji Kuwahara
  • Patent number: 8911422
    Abstract: An object of the present invention is to efficiently inject a drug (physiologically active substance). Therefore, a micro-needle device 1 comprises a base plate 2 and a micro-needle 3 installed on the base plate 2. A coating agent containing the physiologically active substance is coated at least at a part of the micro-needle 3, and a coating range thereof is 100 to 230 ?m including the top of the micro-needle 3. A load due to the energy of 0.2 to 0.7 J/cm2 is applied to the micro-needle device 1 which is in contact with the skin.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: December 16, 2014
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Tetsuji Kuwahara, Seiji Tokumoto, Kazuya Machida
  • Patent number: 8858962
    Abstract: An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: October 14, 2014
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Seiji Tokumoto, Hirotoshi Adachi, Tetsuji Kuwahara
  • Patent number: 8771781
    Abstract: The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device (22) with a plurality of microneedles (21) is mounted on a table (23), while a mask plate (25) with a plurality of apertures (24) is fixed to a frame member (26), and a coating solution (27) is drawn in the direction of arrow A on the mask plate (25) using a spatula (28) to fill the apertures (24) with the coating solution. The microneedles (21) are inserted in the apertures (24) before or after the filling of the apertures (24) with the coating solution (27) to coat the microneedles (21).
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: July 8, 2014
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Tetsuji Kuwahara
  • Patent number: 8419708
    Abstract: It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device (50) comprising a microneedle substrate (53) having a plurality of microneedles (51) capable of piercing the skin, an absorbent (11) disposed thereon, the absorbent (11) comprising a material capable of absorbing a liquid, and a dissolving solution reservoir (18) disposed on the absorbent (11), the dissolving solution reservoir (18) containing a dissolving solution (16) for dissolving a drug and being capable of disrupting a diaphragm (20) provided the dissolving solution reservoir (18) and the absorbent (11) by pressing. A coating containing a dry drug is disposed on the microneedles (51) and/or the microneedle substrate (53).
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: April 16, 2013
    Assignee: Hisamitsu Pharmaceuticals Co., Inc.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Tetsuji Kuwahara
  • Publication number: 20120330250
    Abstract: An object of the present invention is to efficiently inject a drug (physiologically active substance). Therefore, a micro-needle device 1 comprises a base plate 2 and a micro-needle 3 installed on the base plate 2. A coating agent containing the physiologically active substance is coated at least at a part of the micro-needle 3, and a coating range thereof is 100 to 230 ?m including the top of the micro-needle 3. A load due to the energy of 0.2 to 0.7 J/cm2 is applied to the micro-needle device 1 which is in contact with the skin.
    Type: Application
    Filed: February 24, 2011
    Publication date: December 27, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Tetsuji Kuwahara, Seiji Tokumoto, Kazuya Machida
  • Publication number: 20120283642
    Abstract: A microneedle device having a coating including a high molecular weight pharmaceutical compound substantially uniformly is provided. A microneedle device (1) includes a plurality of microneedles (3) on a microneedle substrate (2), which are capable of piercing the skin. A portion of or entire surface of the microneedles (3) and/or the microneedle substrate (2) has a coating including a coating carrier in a solid state. The coating carrier includes a high molecular weight pharmaceutical compound and polysaccharides compatible with the high molecular weight pharmaceutical compound. Herein, as the polysaccharide, for example, pullulan or hydroxypropylcellulose can be used.
    Type: Application
    Filed: April 30, 2012
    Publication date: November 8, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Toshiyuki MATSUDO, Tetsuji KUWAHARA, Seiji TOKUMOTO
  • Publication number: 20120156258
    Abstract: An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
    Type: Application
    Filed: February 7, 2012
    Publication date: June 21, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiji Tokumoto, Hirotoshi Adachi, Tetsuji Kuwahara
  • Publication number: 20120004626
    Abstract: The present invention aims to allow high molecular weight active ingredients to be contained in a coating agent substantially uniformly. For this purpose, a microneedle device 1 includes a microneedle base 2, and microneedles 3 capable of piercing a skin and being disposed on the microneedle base 2, wherein at least a part of a surface of the microneedles 3 and/or the microneedle base 2 is coated with a coating agent containing a high molecular weight active ingredient and a water-soluble polymer, and the content of the water-soluble polymer in the coating agent is 0.1 to 30% by weight, and the ratio of the content of the water-soluble polymer to the content of the high molecular weight active ingredient in the coating agent is 5:1 to 1:100.
    Type: Application
    Filed: January 25, 2010
    Publication date: January 5, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Tetsuji Kuwahara, Seiji Tokumoto, Toshiyuki Matsudo
  • Publication number: 20110288485
    Abstract: Provided is a microneedle device having a microneedle base and microneedles capable of piercing the skin and being from 300 ?m to 500 ?m in height disposed on the base, where at least a part of the surface of the microneedles and/or the microneedle base is coated with a coating agent containing an active ingredient and a coating carrier, and a blending ratio of the active ingredient and the coating carrier is 10:0.1 to 1:10. Also provided are methods for administering active ingredients efficiently and simply through the skin using the microneedle device.
    Type: Application
    Filed: December 25, 2009
    Publication date: November 24, 2011
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Tetsuji Kuwahara, Shuji Ishitsuka
  • Publication number: 20110112509
    Abstract: The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
    Type: Application
    Filed: May 22, 2009
    Publication date: May 12, 2011
    Applicants: HISAMITSU PHARMACEUTICAL CO., INC., JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RE
    Inventors: Chikateru Nozaki, Kazuyoshi Kaminaka, Junichi Matsuda, Takaaki Terahara, Tetsuji Kuwahara, Seiji Tokumoto
  • Publication number: 20100311700
    Abstract: A transdermal preparation for external use which contains a photosensitive NSAID and a UV blocker having a high ability to migrate into the skin. Thus, it becomes possible to ensure, in a transdermal preparation for external use containing a NSAID, the inhibition of the onset of light-induced non-immunological or immunological skin symptoms by the above-described component.
    Type: Application
    Filed: April 29, 2010
    Publication date: December 9, 2010
    Applicant: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Kazuhisa Yoshitake, Kenji Atarashi, Tetsuji Kuwahara, Koichi Ikesue, Michinori Sakai, Yoshiaki Hashimoto, Kiyomi Tsuruda
  • Publication number: 20100280457
    Abstract: The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device (22) with a plurality of microneedles (21) is mounted on a table (23), while a mask plate (25) with a plurality of apertures (24) is fixed to a frame member (26), and a coating solution (27) is drawn in the direction of arrow A on the mask plate (25) using a spatula (28) to fill the apertures (24) with the coating solution. The microneedles (21) are inserted in the apertures (24) before or after the filling of the apertures (24) with the coating solution (27) to coat the microneedles (21).
    Type: Application
    Filed: October 18, 2007
    Publication date: November 4, 2010
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Tetsuji Kuwahara
  • Publication number: 20100240758
    Abstract: An external preparation for percutaneous administration which contains a light-sensitive nonsteroidal anti-inflammatory analgesic and a UVA-shielding agent which inhibits the analgesic to cause light toxicity and a light allergy. This external preparation for percutaneous administration, which contains a nonsteroidal anti-inflammatory analgesic, can be prevented, with higher certainty, from causing the hypersensitivity to light attributable to light toxicity and a light allergy.
    Type: Application
    Filed: June 3, 2010
    Publication date: September 23, 2010
    Applicant: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Kazuhisa YOSHITAKE, Kenji ATARASHI, Tetsuji KUWAHARA, Koichi IKESUE, Michinori SAKAI, Yoshiaki HASHIMOTO, Kiyomi TSURUDA
  • Publication number: 20100221314
    Abstract: A microneedle device having a coating including a high molecular weight pharmaceutical compound substantially uniformly is provided. A microneedle device (1) includes a plurality of microneedles (3) on a microneedle substrate (2), which are capable of piercing the skin. A portion of or entire surface of the microneedles (3) and/or the microneedle substrate (2) has a coating including a coating carrier in a solid state. The coating carrier includes a high molecular weight pharmaceutical compound and polysaccharides compatible with the high molecular weight pharmaceutical compound. Herein, as the polysaccharide, for example, pullulan or hydroxypropylcellulose can be used.
    Type: Application
    Filed: October 15, 2008
    Publication date: September 2, 2010
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Toshiyuki Matsudo, Tetsuji Kuwahara, Seiji Tokumoto
  • Publication number: 20100047327
    Abstract: It is intended to provide a low molecular weight adjuvant which can be administered safely without inducing skin irritation or the like by transdermal or transmucosal administration and is for enhancing immunogenicity of an antigen efficiently. It can be achieved by an immunostimulant adjuvant containing at least one substance selected from the group consisting of aliphatic alcohols, free fatty acids and fatty acid derivatives but does not contain a substance represented by the following formula. (In the formula, R3 and R4 may be combined to form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
    Type: Application
    Filed: January 31, 2008
    Publication date: February 25, 2010
    Inventors: Tetsuji Kuwahara, Seiji Tokumoto, Toshiyuki Matsudo
  • Patent number: D617463
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: June 8, 2010
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Seiji Tokumoto, Tetsuji Kuwahara, Toshiyuki Matsudo
  • Patent number: D634017
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: March 8, 2011
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Seiji Tokumoto, Tetsuji Kuwahara, Toshiyuki Matsudo